Clinical Trials

Inclusion Criteria:

• Written informed consent.
• At least 18 years of age.
• HBsAg-positive and either:
  • Pregnant;
  • Anti-HDV positive;
  • Diagnosed with acute HBV infection or experiencing a hepatitis flare;
  • Immune tolerant or immune active phenotype;
  • Potentially eligible for the Immune Regulation and Costimulation in Natural History of Chronic Hepatitis B ancillary study;
• OR completed the HBRN Adult Immune Active trial (regardless of HBsAg status).

Exclusion Criteria:

• History of hepatic decompensation based on clinical or laboratory criteria.
• Hepatocellular carcinoma (HCC).
• History of solid organ transplantation or bone marrow transplantation.
• Current hepatitis B antiviral treatment (except pregnant women, and patients who are anti-HDV positive, and participants who completed the HBRN Adult Immune Active trial).
• Chronic immunosuppression therapy.
• Known HIV co-infection (patients with HDV or HCV co-infection are not excluded).
• Medical or social condition which, in the opinion of the investigator, would make the patient unsuitable for the study or interfere with or prevent follow up per protocol.
• Unable or unwilling to return for follow-up visits.