Genetic Mutations and Environmental Exposure in Young Patients With Retinoblastoma and in Their Parents and Young Healthy Unrelated Volunteers


About this study

This laboratory study is looking at genetic mutations and environmental exposure in young patients with retinoblastoma and in their parents and young healthy unrelated volunteers. Gathering information about gene mutations and environmental exposure may help doctors learn more about the causes of retinoblastoma in young patients.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Cases must meet the following criteria:
    • Diagnosed with sporadic retinoblastoma (RB) on or after 07/01/2006
      • No familial retinoblastoma
    • Have permission of physician to contact the parents
    • Diagnosed and/or treated at a Children's Oncology Group (COG) institution or *Wills Eye Hospital
  • Controls must meet 1 of the following criteria:
    • Mother of a child with unilateral RB
    • Father of a child with bilateral RB
    • Age-matched non-blood-related child if possible
  • Must reside in the U.S. or Canada
  • Must have telephone in the home
  • Biological parent speaks English or Spanish
  • Concurrent treatment on a therapeutic trial is NOT required

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Carola Arndt, M.D.

Closed for enrollment

Contact information:

Cancer Center Clinical Trials Referral Office

(855) 776-0015

More information


Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available


Mayo Clinic Footer