Intra-Articular Dexamethasone to Prevent Post-Traumatic Osteoarthritis: A Pilot Study


About this study

The primary aim of the study is to see if a single wrist injection (intra-articular) of dexamethasone at the time of treatment will reduce the incidence of early-onset of post traumatic osteoarthritis.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Unstable distal radius fracture.
  • Fracture type AO B1, B2, B3, C1, or C2 or C3.
  • 18-65 years old.
  • Understand and read English.
  • Community dwelling (not in assisted living or NH).

Exclusion Criteria:

  • Open or bilateral DRF.
  • Associated upper extremity fracture or ligament injuries requiring casting or surgical repair at the time of DRF fixation.
  • Multitrauma pts.
  • Greater than 2 weeks post injury.
  • Neurologic disorders affecting the hand, wrist or arm.
  • History of dementia, Alzheimers or other neurologic dx.
  • Substance abuse.
  • Pathologic fractures.
  • Known pregnancy.
  • Radiocarpal joint arthritis.


Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status

Rochester, Minn.

Mayo Clinic principal investigator

Sanjeev Kakar, M.D.

Closed for enrollment

More information


Publications are currently not available

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