Paired Marrow Aspirations to Assess Assays in Sensitized Renal Allograft Recipients

Overview

About this study

The aim of this study is to determine the validity of two tests on bone marrow of sensitized kidney transplant recipients in order to better understand why these patients with antibodies against their donors are at a greater risk of rejection of their transplanted organs.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

  • Pre or post renal transplant recipients.
  • Kidney donors or recipients undergoing a surgery other than transplant, or at the time of their transplant.
  • Those who give voluntary written informed consent before performance of any study-related procedures, which are not part of normal medical care, with the understanding that consent may be withdrawn by the subject at any time without prejudice to future medical care.

Exclusion Criteria:

  • Any patient currently receiving systemic anticoagulation therapy with heparin or Coumadin.
  • Patient has a platelet count of < 30x 10^9/L within 14 days before enrollment.
  • Patient has an absolute neutrophil count of ANC < 1.0 x 10^9/L within 14 days before enrollment.
  • Patient has received other investigational drugs within 14 days before enrollment.
  • Serious medical or psychiatric illness likely to interfere with participation in this clinical study.
  • Diagnosed or treated for malignancy within 5 years of enrollment, with the exception of complete resection of basal cell carcinoma or squamous cell carcinoma of the skin, an in situ malignancy, or low-risk prostate cancer after curative therapy.
  • Contraindication to kidney transplantation - active infection, comorbid medical conditions, etc.

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Mark Stegall, M.D.

Open for enrollment

Contact information:

Leah Majerus B.S.

Majerus.Leah@mayo.edu

More information

Publications

Publications are currently not available

Study Results Summary

Not yet available

Supplemental Study Information

Not yet available

.
CLS-20126677

Mayo Clinic Footer