Paired Marrow Aspirations to Assess Assays in Sensitized Renal Allograft Recipients


About this study

The aim of this study is to determine the validity of two tests on bone marrow of sensitized kidney transplant recipients in order to better understand why these patients with antibodies against their donors are at a greater risk of rejection of their transplanted organs.

Participation eligibility

Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. Guidelines differ from study to study, and identify who can or cannot participate. There is no guarantee that every individual who qualifies and wants to participate in a trial will be enrolled. Contact the study team to discuss study eligibility and potential participation.

Inclusion Criteria:

- Pre or post renal transplant recipients who are "sensitized", having allo antibodies
as evidenced by single antigen bead analysis).

- Renal transplant donors.

- Those who give voluntary written informed consent before performance of any
study-related procedures, which are not part of normal medical care, with the
understanding that consent may be withdrawn by the subject at any time without
prejudice to future medical care.

Exclusion Criteria:

- Any patient currently receiving systemic anticoagulation therapy with heparin or

- Patient has a platelet count of < 30 x 10^9/L within 14 days before enrollment.

- Patient has an absolute neutrophil count of ANC < 1.0 x 10^9/L within 14 days before

- Patient has received other investigational drugs within14 days before enrollment.

- Serious medical or psychiatric illness likely to interfere with participation in this
clinical study.

- Diagnosed or treated for malignancy within 5 years of enrollment, with the exception
of complete resection of basal cell carcinoma or squamous cell carcinoma of the skin,
an in situ malignancy, or low-risk prostate cancer after curative therapy.

- Contraindication to kidney transplantation or donation-active infection, comorbid
medical conditions, etc

Participating Mayo Clinic locations

Study statuses change often. Please contact the study team for the most up-to-date information regarding possible participation.

Mayo Clinic Location Status Contact

Rochester, Minn.

Mayo Clinic principal investigator

Mark Stegall, M.D.

Open for enrollment

Contact information:

Nong Braaten L.P.N.

More information


Publications are currently not available

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