About the Program

A portion of the heart dies after a heart attack. Without advances in novel regenerative technologies, damaged cardiac tissue cannot heal or regenerate itself, leading to progressive organ failure and ultimately death. Irreversible heart disease is responsible for 20 million deaths worldwide each year.

The Mayo Clinic Van Cleve Cardiac Regenerative Medicine Program offers new hope. Through stem cell and cell-free therapies, the program's researchers are discovering methods to halt or even reverse damage to cardiac tissue. The results mean better quality of life for people with heart disease — matching patient health span with life span.

Strategic focus

The Mayo Clinic Van Cleve Cardiac Regenerative Medicine Program creates novel, affordable and accessible cardiac regenerative therapies to restore the health of patients with heart disease. The program's long-term goal is to accelerate the discovery, translation and application of innovative regenerative products for heart disease that will offer the greatest impact for the largest number of people.


Contemporary regenerative medicine is underpinned by the recognition that true regeneration restores the human as a whole. Fostering the Mayo Clinic regenerative care model, the program is working toward not only reversing chronic disease but restoring health to individuals and their communities.


The mission of the Mayo Clinic Van Cleve Cardiac Regenerative Medicine Program is to position Mayo Clinic as the premier regenerative medicine center of the world, leading in the discovery of novel cell-therapy platforms for cardiac pathology, the advancement of off-the-shelf cell-free therapies from the bench toward clinical cardiovascular practice and the establishment of cardiac tissue engineering.