Graph showing renal function with PKD over time

In the past two decades, researchers at Mayo Clinic and around the world have made great progress in understanding the fundamental genetic and biological mechanisms that contribute to the etiology and pathogenesis of polycystic kidney disease (PKD).

The Translational Polycystic Kidney Disease Center at Mayo Clinic, which builds on Mayo's strong history of PKD research, focuses on translating these basic findings into new and better treatments that improve the care of patients with PKD.

Translational PKD Center research, as well as the center's core services, concentrates on the common, adult form of the disease, autosomal dominant PKD (ADPKD). The services provided focus on understanding the genetic basis of disease, more accurately monitoring disease progression and improving prognostics, and employing model systems to explore pathogenesis and conduct preclinical testing.