Noninvasive Characterization of Renal Stones

The long-term goal of our research project on noninvasive characterization of renal stones is to use advanced CT methodologies to characterize urinary calculi to help direct clinical treatment and facilitate clinical investigation.

Based on our extensive work in this field, we already know that dual energy CT can discriminate between uric acid and non-uric acid urinary stones. Led by principal investigator Cynthia H. McCollough, Ph.D., the research project team's objectives are to:

  • Expand the number of stone types that can be differentiated
  • Provide accurate quantification of stone morphology (for example, shape, volume, surface and interior structure)
  • Develop a comprehensive, low-dose, stone-characterization exam using commercially available dual energy CT technology
  • Detect stone precursor lesions in specimens using a prototype CT system equipped with energy-resolving detectors

Our research findings are expected to greatly improve the ability to conduct noninvasive clinical research protocols and to accurately diagnose and monitor patients.