Research Projects

Investigators in the Evidence-Based Practice Research Program have conducted hundreds of systematic reviews and meta-analyses to support decision-making and clinical practice guidelines by numerous agencies, foundations and professional societies.

These entities include:

  • AABB
  • American Association for the Study of Liver Diseases
  • American College of Chest Physicians
  • American Society of Hematology
  • American Urological Association
  • Centers for Disease Control and Prevention
  • Centers for Medicare and Medicaid Services
  • Endocrine Society
  • National Heart, Lung, and Blood Institute
  • Pediatric Endocrine Society
  • Society for Vascular Surgery
  • Undersea and Hyperbaric Medical Society
  • World Health Organization

Treatments of migraine

Migraine is a common and debilitating type of headache associated with significant morbidity. Our team conducted a systematic review to evaluate the benefits and harms associated with the various available treatments to facilitate decision-making and choice of therapy. The results of this systematic review were published in JAMA in 2021. Read our review.

Home ventilators

Chronic obstructive pulmonary disease (COPD) is a common respiratory illness associated with increased risk of mortality, morbidity and health care use. Patients may require devices to help them breathe. Our research team conducted a systematic review to compare various modes of ventilation to assist patients and clinicians in treatment decisions. The results of this systematic review were published in JAMA in 2020. Read our review.

Clinical practice guidelines

Our program has supported the development of numerous national and international guidelines through the years. One example is the guideline from the Society for Vascular Surgery on the management of carotid artery disease, published in the Journal of Vascular Surgery in 2021. Read our review.

Tools to support decision-making

Evidence summarized in systematic reviews requires tools to facilitate implementation. The Evidence-Based Practice Research Program developed two tools to improve the care of children with anxiety and to translate the results of the systematic review.

A decision aid (for patients and clinicians) and a health system aid (to provide guidance on resources, costs and logistics of the different treatments) were developed. These aids have been implemented in mental health clinics at Mayo Clinic and are freely available for nationwide use.