Mayo Clinic is designated by the Agency for Healthcare Research and Quality (AHRQ) as an Evidence-Based Practice Center. These designated centers, which undertake projects assigned by AHRQ, produce evidence summaries to improve the quality of health care and make it safer, more accessible, equitable and affordable.

Leadership of the Evidence-Based Practice Research Program:

  1. Director M. Hassan Murad, M.D.
  2. Associate Director Victor M. Montori, M.D.
  3. Associate Director Zhen Wang, Ph.D.

Evidence synthesis research, such as that conducted by the Evidence-Based Practice Research Program at Mayo Clinic, involves "studying studies." In health care, evidence requires synthesis because a single study rarely provides all the information needed to make a decision. A stand-alone study can be biased and often is limited.

The Evidence-Based Practice Research Program focuses on evaluating and summarizing all available evidence on a particular topic through comprehensive literature searches and advanced qualitative and quantitative synthesis methods. The process includes conducting systematic reviews, meta-analysis, meta-regression, meta-narrative synthesis, clinical practice guidelines and methodology research.

The goals of evidence synthesis are to:

  • Provide the least biased and most precise and applicable results
  • Lead to evidence-based practice and policy decisions
  • Ensure that resources are not wasted pursuing questions that have already been answered
  • Create future research agendas by identifying gaps in knowledge

Before Mayo Clinic became an AHRQ-designated Evidence-Based Practice Center, the investigators of this program conducted more than 300 systematic reviews and meta-analyses to support decision-making and clinical practice guidelines by numerous organizations, including the:

  • Centers for Disease Control and Prevention
  • National Heart, Lung, and Blood Institute
  • World Health Organization
  • Society for Vascular Surgery
  • Endocrine Society
  • Pediatric Endocrine Society
  • AABB
  • American Urological Association
  • American College of Chest Physicians
  • Undersea and Hyperbaric Medical Society
  • American Association for the Study of Liver Diseases