Children's Research Center

Below are current clinical trials.

229 studies in Children's Research Center
(all studies, either open or closed).

Filter this list of studies by location, status and more.

1. Will Making the HPV Vaccine Available at Mayo Clinic Express Care with Use of Electronic Point of Care Reminder Improve Overall Vaccination Rates Among an Empaneled Adolescent Population?

   Rochester, Minn.

   The purpose of this study is to determine if a medical record prompt at the time of a medical consult will help to address lapses in routine immunizations, including the HPV vaccine.

    

    

2. A Study of the Effectiveness of Daily Vitamin D3 Supplementation in Normal Weight Adolescents

   Rochester, Minn.

   The purpose of this study is to measure the blood level of vitamin D in normal weight adolescents following a 12-week supplementation with Vitamin D3 2000 IU/day.

3. A Study of Markers in the Blood and/or Stored Kidney Biopsy Tissue in Patients with a History of Childhood Onset of Membranous Nephropathy

   Rochester, Minn.

   The study is being done to look for markers in the blood and/or stored kidney biopsy tissue, in patients with a history of childhood onset Membranous Nephropathy. By collecting health information and laboratory samples, our goal is to learn more about membranous nephropathy.

4. Study to Explore the Therapeutic Effect of Eluxadoline in Treating Irritable Bowel Syndrome With Diarrhea in Children

   Rochester, Minn.

   The primary objectives of this study are to explore the therapeutic effect of eluxadoline in treating IBS-D in pediatric patients 12-17 years of age, to evaluate the pharmacokinetics of eluxadoline in pediatric patients with IBS-D, and to evaluate the safety and tolerability of eluxadoline in pediatric patients with IBS-D.

    

    

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5. A Study of Characteristics and Post-surgical Outcomes of Pediatric Patients Diagnosed with Lipoblastoma

   Rochester, Minn.

   The purose of this study is to examine the characteristics and post-surgical outcomes of pediatric patients diagnosed with lipoblastoma.

6. A Study of Environmental Effects on the Intestine Bacteria Commonly Present in Children and Adolescents with Multiple Sclerosis

   Rochester, Minn.

   The purpose of this study is to better understand multiple sclerosis in children and adolescents, see how it is different from adult MS, and learn if genes, the environment, or both put them at increased risk of getting MS.

7. Low-Dose or High-Dose Lenalidomide in Treating Children with Recurrent, Refractory, or Progressive Pilocytic Astrocytoma or Optic Pathway Glioma

   Rochester, Minn.

   This randomized phase II trial studies how well low-dose lenalidomide works compared with high-dose lenalidomide in treating children with juvenile pilocytic astrocytomas or optic nerve pathway gliomas that have come back (recurrent), have not responded to treatment (refractory), or are growing, spreading, or getting worse (progressive). Lenalidomide may stop the growth of tumor cells by blocking blood flow to the tumor. It is not yet known whether low-dose lenalidomide is more or less effective than high-dose lenalidomide in treating patients with juvenile pilocytic astrocytomas or optic nerve pathway gliomas.

8. Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations

   Rochester, Minn.

   This randomized phase III trial studies how well combination chemotherapy works in treating young patients with newly diagnosed B acute lymphoblastic leukemia that is likely to come back or spread, and in patients with Philadelphia chromosome (Ph)-like tyrosine kinase inhibitor (TKI) sensitive mutations. Drugs used in chemotherapy work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving more than one drug (combination chemotherapy) and giving the drugs in different doses and in different combinations may kill more cancer cells.

9. Evaluation of Autonomic Function in Individuals With Cornelia de Lange Syndrome (CdLS)

   Rochester, Minn.

   Based on survey data, individuals with Cornelia de Lange Syndrome (CdLS) often experience symptoms of autonomic dysfunction however there are no reported studies in which these patients have had objective testing of the autonomic nervous system. This is a pilot study in which patients with CdLS will undergo the standard clinical testing for autonomic dysfunction with a autonomic reflex screen and thermoregulatory sweat test.

10. A Study of Neurophysiological and Inflammatory Biomarkers of Seizures and Brain Injury in Children

    Rochester, Minn.

    The purpose of this study is to connect brain inflammation measured by biomarkers, with data from advanced EEG technology, and clinical outcomes to provide new predictive information about seizure activity in children with critical brain injuries and epilepsy.