Paige C. Arneson

Doctoral thesis research: Metabolic regulation of muscle stem cells

Research focus

Paige C. Arneson is pursuing her doctoral degree in biomedical sciences at Mayo Clinic Graduate School of Biomedical Sciences, specializing in biochemistry and molecular biology and regenerative medical science.

After earning her Bachelor of Science in biology and chemistry from the University of Wisconsin in Superior, Wisconsin, Paige was recruited to Mayo Clinic's Ph.D. program in 2016. She is completing her thesis research in the Skeletal Muscle Wasting and Progenitor Cell Biology Laboratory of Jason D. Doles, Ph.D., in the Department of Biochemistry and Molecular Biology at Mayo Clinic's campus in Rochester, Minnesota.

Paige's doctoral thesis research focuses on understanding how to solve the problem of cachexia, a form of muscle wasting implicated in many pathologies, including advanced cancer. Her research also has the potential to impact other forms of muscle wasting, such as wasting associated with normal aging (sarcopenia) and muscular dystrophy.

Background

Paige began doing biomedical research as an undergraduate student, working both at her undergraduate college and at Mayo Clinic as a summer undergraduate research fellow. In her work with Roberto Cattaneo, Ph.D., at Mayo Clinic, Paige utilized super-resolution microscopy to characterize the organization of viral proteins on the surfaces of cells infected by the measles virus.

Paige's undergraduate research results helped scientists develop a better understanding of how the measles virus infects human cells. This knowledge can now be applied to engineering measles viruses for use in regenerative medical therapies.