The mission of the Center for Immunology and Immune Therapies is to enable investigators from across Mayo Clinic to join forces with others they might not otherwise have the opportunity or incentive to work with. Collaborative projects unite researchers from different fields in unique teams to make innovative connections and use existing resources and knowledge in new ways.
This multidisciplinary problem-solving produces new knowledge about immunological diseases, with the goal of translating emerging insights into improved care to address patients' unmet needs. Recent successes facilitated by the center include short-term projects and ongoing efforts — all of which pave the way for future advances. Early endeavors have resulted in some remarkable journeys. The dialogue has been stimulating, the ideas have been inspiring, and the new discoveries are amazing.
Collaborative projects in the Center for Immunology and Immune Therapies include research on:
- Autoimmune cytopenias. In autoimmune cytopenias, the immune system targets the body's blood cells. Researchers are studying the biology of autoantibody-producing plasma cells to better treat these diseases. Learn more about research on autoimmune cytopenias.
- CAR-T cell therapy. CAR-T cell therapy engineers patients' own T cells to recognize and fight blood cancer. Researchers are finding ways to generate CAR-T cells in vivo, making the therapy more efficient. Learn more about CAR-T cell therapy research.
- Immune checkpoint blockade therapy. Patients with cancer can have great success with immune checkpoint blockade therapy, but then may get autoimmune disease. Research aims to remove this obstacle to successful cancer treatment. Learn more about immune checkpoint blockade therapy.
- Mass cytometry (CyTOF). Novel CyTOF technology allows researchers to study cancer cells and the immune system at the same time to advance the understanding of non-Hodgkin's lymphoma and other diseases. Learn more about applying CyTOF technology in research.
- Molecular control points. Researchers use state-of-the-art biochemical and genetic laboratory approaches to identify molecular control points (signaling pathways) that may help control autoimmunity. Learn more about research on molecular control points.
- Sjogren's syndrome. Researchers from Mayo Clinic and Brest University are studying the epidemiology of Sjogren's syndrome and the role of specialized immune cells in this disease. Learn more about Sjogren's syndrome research.