Product Development Pathways

The CCaTS Office of Translation to Practice has developed managed pathways for novel technology development. Structured product development opportunities include:

Mayo Clinic-Sanford Burnham Prebys Medical Discovery Institute (SBP Discovery) Collaboration for Drug Discovery

The Mayo Clinic-SBP Discovery Collaboration for Drug Discovery funds projects to accelerate the discovery of small-molecule therapeutics. Through the collaboration, teams are able to:

  • Access the expertise and infrastructure of SBP Discovery to configure scalable high-throughput screening (HTS)
  • Generate preliminary data for additional funds through R01 grants from the National Institutes of Health or via other sources
  • Generate small-molecule compounds to be commercialized in partnership with SBP Discovery

Awards do not provide any direct funds to the awardee, but rather fund access to SBP Discovery's world-class drug discovery expertise and infrastructure.

Goals

Selected projects in the Mayo Clinic-SBP Discovery Collaboration for Drug Discovery work toward one of two goals:

  • HTS platforms. The selected team develops and optimizes an HTS platform for a target provided by the investigator and performs a pilot screen to determine the platform's operating characteristics. The investigative team works directly with SBP Discovery to validate and optimize the screening approach, using SBP Discovery's chemical library collection — containing more than 950,000 compounds — and screening infrastructure.
  • Chemical optimization. The selected team carries out chemical optimization of screening hits or early drug leads identified from prior awards' HTS platforms. Alternatively, the team may propose chemical matter to optimize. The team works with the SBP Discovery medicinal chemistry group and drug metabolism and pharmacokinetics group.

Support

Project funding for the Mayo Clinic-SBP Discovery Collaboration for Drug Discovery is provided by the Mayo Clinic Research Committee and CCaTS.

Translational Product Development Fund

The Translational Product Development Fund provides:

  • State funds for individual $50,000 awards available to researchers in Minnesota
  • Access to an Office of Translation to Practice project development team

All funded projects have clearly established milestones. Investigators monitor milestone progression in collaboration with a project development and management team.

The fund does not cover principal investigator effort.

Goals

The award supports the advancement of projects that have the potential to be commercialized, such as projects to form a startup company or create a license agreement with an established commercial entity. Selected projects may advance clinical practice through product development or through practice initiatives.

Support

The CCaTS Office of Translation to Practice leveraged support from the state of Minnesota to establish the Translational Product Development Fund with the University of Minnesota Clinical and Translational Science Institute, in conjunction with the Minnesota Partnership for Biotechnology and Medical Genomics.

Advance the Practice Research Award (new in 2018)

The Advance the Practice Research Award provides:

  • Individual $50,000 awards available to investigators at all Mayo Clinic campuses
  • Access to an Office of Translation to Practice project development team

Goals

The goal of the Advance the Practice Research Award is to help recipients improve patient care through either product development or practice initiatives. Selected projects support activities to impact and address the unmet clinical needs of patients, including:

  • Development of novel therapeutics, devices, diagnostics or other health care-related products that have the potential to change patient care
  • Development and implementation of novel practice initiatives that have the potential to change patient care

Examples of projects within the scope of the award include, but are not limited to:

  • Medical device prototype design, development or manufacture
  • Manufacture of antibodies or drug candidates
  • Preclinical proof-of-concept testing of prototypes or validation of antibody or drug candidates
  • Utilization of preferred contract research organizations to carry out critical testing of drug candidates
  • Pilot projects to improve practice efficiency, workflow or testing of novel decision support tools

Support

The Advance the Practice Research Award is patterned after the highly successful Translational Product Development Fund. It is the result of a collaborative initiative between:

  • The Department of Medicine at Mayo Clinic's campus in Rochester, Minnesota
  • Mayo Clinic Ventures
  • Mayo Clinic's campus in Phoenix/Scottsdale Arizona
  • Mayo Clinic's campus in Jacksonville, Florida
  • Mayo Clinic Center for Connected Care
  • Mayo Clinic CCaTS Office of Translation to Practice