Bioinformatics and Genomics

From the study of molecular processes to the analysis of population patterns, research methods are constantly evolving. CCaTS' online bioinformatics and genetics courses introduce novel methods for engaging in research along the full translational continuum.

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'The Promise of Epigenomics in Medical Research and Future Practice' (502E00CMA130040)

Epigenomics is the study of all the changes in gene function that occur without a change in the sequence of the DNA, known as epigenetic changes. Upon completion of this module, learners will be able to:

  • Define and explain the history of epigenetics and epigenomics
  • Identify how epigenetic mechanisms underlie the regulation of gene expression
  • Describe how DNA modification occurs — for example, the role of chromatin dynamics
  • Explain how epigenetics and epigenomics contribute to inheritance and human diseases
  • Discuss the use of epigenetics and epigenomics in diagnostics and therapeutics

Presenter: Raul A. Urrutia, M.D.

'Essentials of Microarray Technology' (502E00CMF120031)

High-throughput microarray technologies enable researchers to study gene expression, exon composition of transcripts, protein-binding sites, single-nucleotide polymorphisms (SNPs), gene copy number variations and other molecular events on the genome-wide scale. There are numerous platforms, but each follows a similar basic concept that must be understood to allow researchers to design quality experiments.