The PEARL study is a multicenter clinical trial, including Mayo Clinic, to evaluate the safety and effectiveness of coronary angiography performed early after hospital arrival in a population of post-cardiac arrest patients without ST segment elevation on their electrocardiograms (ECGs).
The PEARL study stands for a Pilot Randomized Clinical Trial of Early Coronary Angiography Versus No Early Coronary Angiography for Post-Cardiac Arrest Patients Without ECG ST Segment Elevation (NCT02387398).
The principal investigator for the PEARL study at Mayo Clinic is Jacob C. Jentzer, M.D., a consultant in cardiovascular diseases and pulmonary and critical care medicine at Mayo Clinic, Rochester, Minnesota.
PEARL study overview
Cardiac arrest is a common and potentially lethal condition in which the heart suddenly can't pump enough blood to the brain and body. Cardiac arrest is often caused by a heart attack, which usually is diagnosed by the presence of ST elevation on an ECG.
Coronary angiography (also known as heart catheterization, or heart cath) is typically performed for patients with cardiac arrest due to a heart attack with ST elevation on their ECGs. Some cardiac arrest patients without ST elevation on their ECGs may be having a heart attack, but uncertainty remains about the best approach for their care.
The PEARL study will help answer the question, "Does an early heart cath improve survival and prevent heart muscle damage after a cardiac arrest without ST segment elevation on the ECG?"
Adult patients who are resuscitated from cardiac arrest outside the hospital will be enrolled in the PEARL study if they meet all the eligibility criteria.
The PEARL study is being conducted using a process called exception from informed consent (EFIC), which allows patients to be enrolled in emergency research trials without their direct consent. Review the PEARL Q & A information sheet to learn more about the EFIC process.
Patients enrolled in the PEARL study will be randomized into one of two groups: either to receive immediate coronary angiography (within 120 minutes of hospital arrival) or to receive initial medical stabilization in the intensive care unit prior to delayed coronary angiography (more than six hours after hospital arrival). Both groups will otherwise receive the same high-quality post-arrest care.
Patients who don't want to be enrolled in this research study if they have a cardiac arrest can opt out of participation in advance by requesting an opt-out wristband to wear.
To request an opt-out wristband or for more information about opting out of the Mayo Clinic PEARL study, email the research team or call 507-538-7178.
Review these documents to learn more about the PEARL study at Mayo Clinic:
One of the most important aspects of performing the PEARL study under the EFIC process is to engage community members in order to understand and address any concerns.
You can provide feedback to the Mayo Clinic study team by completing a short survey about the PEARL study:
To request an opt-out wristband or for more information about the PEARL study at Mayo Clinic, email the research team or call 507-538-7178.