PEARL study at Mayo Clinic

The PEARL study is a multicenter clinical trial, including Mayo Clinic, to evaluate the safety and effectiveness of coronary angiography performed early after hospital arrival in a population of post-cardiac arrest patients without ST segment elevation on their electrocardiograms (ECGs).

The PEARL study stands for a Pilot Randomized Clinical Trial of Early Coronary Angiography Versus No Early Coronary Angiography for Post-Cardiac Arrest Patients Without ECG ST Segment Elevation (NCT02387398).

The principal investigator for the PEARL study at Mayo Clinic is Jacob C. Jentzer, M.D., a critical care specialist and echocardiographer at Mayo Clinic in Rochester, Minnesota.

PEARL study overview

Cardiac arrest is a common and potentially lethal condition in which the heart suddenly can't pump enough blood to the brain and body. Cardiac arrest is often caused by a heart attack, which usually is diagnosed by the presence of ST elevation on an ECG.

Coronary angiography (also known as heart catheterization, or heart cath) is typically performed for patients with cardiac arrest due to a heart attack with ST elevation on their ECGs. Some cardiac arrest patients without ST elevation on their ECGs may be having a heart attack, but uncertainty remains about the best approach for their care.

The PEARL study will help answer the question, "Does an early heart cath improve survival and prevent heart muscle damage after a cardiac arrest without ST segment elevation on the ECG?"

Study eligibility

The PEARL study is currently closed to new enrollment.

More information

Review these documents to learn more about the PEARL study at Mayo Clinic:

Contact information

For more information about the PEARL study at Mayo Clinic, email the research team or call 507-538-7178.