Microenvironment Modification and Anti-PD1 Immunotherapy of Lymphoma

Growing evidence suggests that the development of a robust anti-tumor immune response can be enhanced by modifying the tumor microenvironment in a manner that enhances the release, uptake and presentation of tumor antigens to T cells.

This research project in the University of Iowa/Mayo Clinic Lymphoma SPORE is exploring two distinct strategies of tumor microenvironment modulation combined with a checkpoint inhibitor to enhance anti-lymphoma response:

• Intratumoral injection of autologous dendritic cells into a cryoablated tumor
• Injection of a tumor with a virus-like particle containing immunostimulatory DNA