Microenvironment Modification and Anti-PD1 Immunotherapy of Lymphoma

Growing evidence suggests that the development of a robust anti-tumor immune response can be enhanced by modifying the tumor microenvironment in a manner that enhances the release, uptake and presentation of tumor antigens to T cells.

This research project in the University of Iowa/Mayo Clinic Lymphoma SPORE is exploring two distinct strategies of tumor microenvironment modulation combined with a checkpoint inhibitor to enhance anti-lymphoma response:

  • Intratumoral injection of autologous dendritic cells into a cryoablated tumor
  • Injection of a tumor with a virus-like particle containing immunostimulatory DNA

Project investigators

The project co-leaders are:

  • Yi Lin, M.D., Ph.D., of Mayo Clinic
  • George J. Weiner, M.D., of University of Iowa

The co-investigators are:

  • Haidong Dong, M.D., Ph.D., of Mayo Clinic
  • Umar Farooq, M.D., of the University of Iowa
  • Jon Houtman, Ph.D., of the University of Iowa
  • Brian K. Link, M.D., of the University of Iowa