Publications

    Review select publications related to our three translational research projects and the Biospecimen and Pathology Core


    Project 1: Developing a Diagnostic Test and Therapeutic Agents for Fibrolamellar Hepatocellular Carcinoma

    2024

    Increased protein kinase A activity induces fibrolamellar hepatocellular carcinoma features independent of DNAJB1

    Liver cancer multiomics reveals diverse protein kinase A disruptions convergently produce fibrolamellar hepatocellular carcinoma

    GalNAc-conjugated siRNA targeting the DNAJB1-PRKACA fusion junction in fibrolamellar hepatocellular carcinoma

    2023

    Fighting rare cancers: lessons from fibrolamellar hepatocellular carcinoma

    Disruption of proteome by an oncogenic fusion kinase alters metabolism in fibrolamellar hepatocellular carcinoma

    Oncogenic addiction of Fibrolamellar hepatocellular carcinoma to the fusion kinase DNAJB1-PRKACA

    Alternative lengthening of telomeres in primary hepatic neoplasms

    2022

    Clinical and demographic predictors of survival for fibrolamellar carcinoma patients-A patient community, registry-based study

    Clinical Outcomes in Fibrolamellar Hepatocellular Carcinoma Treated with Immune Checkpoint Inhibitors

    Targeting BCL-XL in fibrolamellar hepatocellular carcinoma

    Human liver organoids for disease modeling of fibrolamellar carcinoma

    2021

    Identification of Novel Therapeutic Targets for Fibrolamellar Carcinoma Using Patient¬Derived Xenografts and Direct-from-Patient Screening

    Morphologic and Molecular Findings in Myxoid Hepatic Adenomas

    Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A

    2020

    Structural analyses of the PKA Rllf3 holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma

    Stem cell-derived polarized hepatocytes

    A Human Organoid Model of Aggressive Hepatoblastoma for Disease Modeling and Drug Testing

    2019

    Structures of the PKA Ria Holoenzyme with the FLHCC Driver J-PKAca or Wild-Type PKAca

    2018

    Fibrolamellar carcinoma in the Carney complex: PRKAR1A loss instead of the classic DNAJB1-PRKACA fusion

    Sequencing the peripheral blood B and T cell repertoire - Quantifying robustness and limitations

    Non coding RNA analysis in fibrolamellar hepatocellular carcinoma

    Fibrolamellar Carcinoma: Recent Advances and Unresolved Questions on the Molecular Mechanisms

    Conformational Landscape of the PRKACA-DNAJB1 Chimeric Kinase, the Driver for Fibrolamellar Hepatocellular Carcinoma

    Intracranial metastasis in fibrolamellar hepatocellular carcinoma


    Project 2: Therapeutic Inhibition of Fibroblast Growth Factor and YAP Signaling in Cholangiocarcinoma


    Project 3: Development of a New Viral Immunotherapeutic Approach for Hepatocellular Carcinoma


    Biospecimen and Pathology Core


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