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Centers and Programs

Mayo Clinic Hepatobiliary SPORE

  • Overview
  • Research
    • Translational Research Projects Overview
    • Project 1: Developing a Diagnostic Test and Therapeutic Agents for Fibrolamellar Hepatocellular Carcinoma
    • Project 2: Therapeutic Inhibition of Fibroblast Growth Factor and YAP Signaling in Cholangiocarcinoma
    • Project 3: Inhibition of SCD1 As a Therapeutic Strategy for Hepatocellular Carcinoma
    • Project 4: Development of a New Viral Immunotherapeutic Approach for Hepatocellular Carcinoma
  • Cores
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    • Biospecimen and Pathology Core
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  • Cancer Center
  • Photograph showing two masked and gowned Mayo Clinic doctors in an operating room

    Specimen donations are crucial to our mission

  • An image showing an electron micrograph of an autophagic structure in a hepatocellular carcinoma cell

    An electron micrograph of an autophagic structure in a hepatocellular carcinoma cell

  • An image showing a scanning electron micrograph of a round hepatocellular carcinoma cell undergoing division

    A scanning electron micrograph of a round hepatocellular carcinoma cell undergoing division

  • An image showing vesicular stomatitis virions used for oncolytic therapies

    Vesicular stomatitis virions used for oncolytic therapies

  • An image showing a histological image of cholangiocarcinoma

    A histological image of a bile duct cancer (cholangiocarcinoma)

  • An image showing immune cells surrounding bile duct tumors

    Immune cells surrounding bile duct tumors

Overview

As the first SPORE of its kind in the United States, the Mayo Clinic Hepatobiliary SPORE is devoted to improving the diagnosis and treatment of liver cancer (hepatocellular carcinoma) and bile duct cancer (cholangiocarcinoma), which are grouped together as hepatobiliary cancers.

Tackling an urgent need to treat a lethal cancer

New treatment options for hepatobiliary cancers (hepatobiliary carcinomas) are urgently needed. Five-year survival rates are low, and the death rate is on the rise.

Research in the Hepatobiliary SPORE is driving new discoveries that are providing important insights about the biology of hepatobiliary cancers. Investigators are working on new diagnostic tests, screening treatment compounds, launching new clinical trials, identifying biomarkers and harnessing the power of oncolytic viruses to attack cancer. Research advances in the SPORE can change the trajectory of liver cancer and bile duct cancer, offering optimism for patients facing a sometimes grim prognosis.

The Mayo Clinic Hepatobiliary SPORE builds on significant contributions our investigators have already made to research on liver cancer and bile duct cancer.

  • Understanding hepatobiliary cancer biology
  • Improving liver cancer diagnostics
  • Identifying new liver cancer therapeutics
  • Harnessing the power of viral and immune therapies

Clinical Trials

Learn about ongoing and upcoming clinical trials, including a study of MTI-301 in patients with advanced malignancy.

Translational Research Projects

Building on significant contributions to science, the SPORE has four translational research projects that focus on hepatobiliary cancer.

Pilot Projects

Both the Developmental Research Program and the Career Enhancement Program encourage promising investigators by funding pilot projects that advance hepatobiliary cancer research.

Cores

The SPORE receives vital support from its Administrative Core, its Biostatistics and Bioinformatics Core, and its Biospecimen and Pathology Core.

Publications

Review select publications related to our research in the Mayo Clinic Hepatobiliary SPORE.

Contact

Contact us about research projects or to learn about our funding awards and training opportunities for qualified women, people of color, people with disabilities and other promising researchers.

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ORG-20449557

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