|Peter Amadio, M.D.
Tendon and Soft Tissue Biology Lab
|Researches injuries to tendons and soft tissues by studying orthopedics, biomechanics,
biochemistry, dynamic ultrasound, and molecular and cell biology.
|Daniel D. Billadeau, Ph.D.
||Researchers use wet lab technology to stain and visualize intracellular proteins and organelles using organelle-specific fluorescent proteins and fluorescent antibodies.
|Eduardo N. Chini, M.D., Ph.D.
Anesthesiology and Perioperative Medicine Research
|Researchers are studying anesthetic effects on subcellular function to reduce the need for perioperative transfusions, improve chronic pain management and the use of gene therapy to treat cardiovascular disease in the perioperative period.
|Doo-Sup Choi, Ph.D.
||PCR/ Western Blot / microscope observation
Neurobiology of Alcoholism and Drug
|Investigates, identifies and validates the roles of genetic components in alcoholism
and drug addiction.
|Peter J. Dyck, M.D.
||Neurology – peripheral nerve fibers
||Researchers are studying methodologies to discover the neuropathological basis of the various neuropathies, such as diabetic polyneuropathy, amyloid polyneuropathy, hereditary sensorimotor polyneuropathy and uremic neuropathies.
|Martin E. Fernandez-Zapico, M.D.
||Cancer cell cultures and epigenetic assays
Cell Biology Program
|Defines the molecular and cellular basis of neoplastic transformation, growth and
metastasis, and provides insights into normal and aberrant functions of genetic lesions.
|Michael P. Fautsch, Ph.D.
|Researchers seek to understand the physiology of intraocular pressure regulation related to the development of glaucoma to prevent and treat the disease by regulating pressure and preserving the function of the optic nerve.
|Martin E. Fernandez-Zapico
Gastrointestinal Cancer Program
|Focuses on the cellular and molecular characterization of epigenetic pathways regulating pancreatic carcinogenesis, studying the modulation of chromatin and nuclear dynamics by oncogenic cascades and its impact in gene expression regulation, a critical step during pancreatic neoplastic transformation.
|Evanthia Galanis, M.D.
|Researchers are developing and optimizing novel virotherapy approaches with special emphasis on paramyxoviruses ─ testing a number of different strategies, including use of therapeutic transgenes; trackable markers; combinations with small molecules, cytotoxic agents and radiation therapy; re-targeting of viral strains against tumor-specific antigens; development of novel viral delivery approaches; and exploration of immunomodulatory methods to modify humoral and innate immunity as a means of optimizing virotherapy efficacy.
|James F. Greenleaf, Ph.D.
Ultrasound Imaging Lab
|Advanced ultrasound and acoustic sciences with a primary focus on developing new
applications in medical and biological areas.
|Susan Hallbeck, Ph.D.
Renaldo C. Blocker, Ph.D.
Melissa (Missy) Morrow, Ph.D.
|Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery
Human Factors Engineering
|In human factors engineering and systems integration, scientists use ergonomics and organization science to identify and correct incompatibilities among people, technology and work environments. Research focuses on improving technologies and systems to be as effective as possible within the physical and psychological limitations of humans.
||Team scientists focus on the development and application of techniques to prevent and treat sports-related injuries by working to make scientific, data-supported advancements that lead to efficacious changes in practice relative to joint injury risk screening, injury risk prevention and post-injury rehabilitation.
|David R. Holmes, III, Ph.D.
Physiology and Biomedical Engineering
|Scientists, engineers and physicians work together to translate basic discoveries in medicine and engineering into enhanced patient care by studying how the body works normally, investigating processes that contribute to a variety of diseases and conditions, and developing approaches to cure them.
|Michael J. Joyner, M.D.
||Metabolic exercise testing
Human and Integrative Physiology and Clinical
|Studies how the peripheral circulation and autonomic reflexes adapt to physical
stresses, and how gender and age influence these factors.
|Jeong-Heon Lee, Ph.D.
Epigenomics Development Laboratory in the Center for Individualized Medicine
|Researchers are deciphering epigenetic mechanisms in the etiology and progression of human diseases using next-generation sequencing (NGS)-based epigenetic technologies to identify disease-specific epigenetic features for early detection, prognosis and treatment stratification.
|Lilach O. Lerman, M.D., Ph.D.
||2D and 3D visualizations and renderings of kidneys
Renovascular Disease Lab
|Studies renal and cardiovascular physiology and pathophysiology to develop novel
diagnostic and therapeutic techniques.
|Hongfang Liu, Ph.D.
||Medical Informatics, natural language processing
Health Sciences Research
|The team collects, organizes and provides access to clinical information, using that information to develop and test hypotheses, validating those hypotheses against real-world health problems, and incorporating the outcomes of those tests back into the knowledge base.
|Louis (Jim) J. Maher III, Ph.D.
||Polymer chemistry/DNA structure
Nucleic Acid Structure and Recognition Lab
|Develops new approaches to study DNA flexibility in cells, novel DNA- and RNA-based
drug therapies, and rare cancers caused by errors in metabolism.
|Georges Mer, Ph.D.
||NMR and chromatography
Metabolomics Nuclear Magnetic Resonance Spectroscopy
|Provides an NMRS-based dynamic metabolomic platform for untargeted and targeted
quantification of metabolite levels and measurement of fluxes within metabolic networks in human and transgenic
|Sanjay Misra, M.D.
||Tour of mouse surgical area
Vascular and Interventional Radiology Translational Research
|Studies multiple different animal models in order to improve outcomes in patients with
end-stage renal disease by developing novel therapies that can be delivered by image-guided intervention.
|Tamas Ordog, M.D.
||Researchers are studying the molecular, cellular and translational biology of the gastrointestinal neuromuscular system, with particular focus on interstitial cells of Cajal (ICC).
|Kaylan S. Pasupathy, Ph.D.
Robert D. and Patricia E. Kern Center for the Science of Health Care Delivery
|Researchers are focused on increasing the understanding of complex systems at the intersection of people, processes and information to improve patient care experience and population health. The team leads clinical engineering learning laboratories and directs studies to improve quality of care delivery though operations research, informatics and human factors.
|Y.S. Prakash, M.D., Ph.D.
||Lung physiology and asthma
Pulmonary Cell Biology
|Researchers and clinicians from multiple disciplines (anesthesiology, physiology, pulmonary medicine and neonatology) study mechanisms that regulate the structure and function of airways and pulmonary arteries, focusing on mechanisms that trigger and regulate physiological and pathological processes in the lung.
|Stephen J. Riederer, Ph.D.
Magnetic Resonance Lab
|Development of new image acquisition methods based on MRI physics. Human studies are done in collaboration with radiologists and other medical specialists in the areas of cardiovascular, neurological and cancer imaging.
|Lindsey R. Sangaralingham, M.P.H.
|OptumLabs provides a research environment — including technology, tools, collaboration space and operating processes — and a translation network to assist in translating knowledge to changes in practice and policy. Core linked data assets include de-identified claims data for privately insured and Medicare Advantage enrollees and de-identified electronic health record (EHR) data from a nationwide network of provider groups.
|Gary C. Sieck, Ph.D.
||Confocal imaging and ventilation
Cell and Regenerative Physiology Lab
|Investigates the neural control and adaptation of breathing muscles. Focus areas
include research on the diaphragm muscle, aging and respiratory muscle sarcopenia, spinal cord injury, and airway
|Ravinder J. Singh, Ph.D.
||Dilution and pipetting
|Provides immunochemical, chemistry and immune testing at an affordable cost to clinical
and basic science researchers.
|David I. Smith, Ph.D.
||Next Gen. Seq. Facility Lab/DNA "necklace"
Medical Genome Facility
|Gives clinicians and researchers detailed information about the genetic makeup of their
samples, allowing them to identify and characterize the role of genetics in disease and treatment.
|George Vasmatzis, Ph.D.
Biomarker Discovery Program in the Center for Individualized Medicine
|Researchers are focused on discovery and translation of several biomarkers and developing evidence-based models to help clinicians stratify patients with cancer in order to provide each individual with the appropriate care. With the recent advances in next-generation sequencing technologies, researchers have become engaged in massive sequencing to scan the genome of cancer cells for abnormalities that can be used for clinical purposes such as diagnosis and stratification of patients for optimal treatment.
|Liewei Wang, M.D., Ph.D.
Pharmacogenomics and Drug Targets
|The team studies the role of inheritance in variation in drug response using various high-throughput "omics" tools, including genomics, transcriptomics and metabolomics, to identify biomarkers that can help predict clinical response. Researchers also use models, including cells, patient-derived xenografts and patient samples, to validate and understand the biology underlying these biomarkers.
|Anthony J. Windebank, M.D.
||Chemo-induced peripheral neuropathy
Regenerative Neurobiology Lab
|Research strives to understand the cellular mechanisms underlying injury and repair in
the nervous system.