Rachel M. Hurley

Thesis lab

Research project

Ovarian cancer is the deadliest of women's cancers, with a 70 percent case fatality rate and poor survival when the cancer recurs after treatment with platinum compounds, the current standard of care.

The goal of my thesis work is twofold: to investigate novel therapies for platinum resistant ovarian cancer and to identify DNA repair pathway alterations that are predictive of response.

Toward that end, I am performing both drug sensitivity testing and biochemical analyses, including DNA repair assays, whole-exome sequencing and transcriptional profiling, in tissue culture cell lines and unique patient-derived ovarian tumor grafts to understand mechanisms of drug sensitivity or resistance.

Email: hurley.rachel@mayo.edu

Nov. 12, 2015