Location

Rochester, Minnesota

Contact

Wigle.Dennis@mayo.edu

Summary

Research in our laboratory is directed along two main project lines:

  • Thoracic Oncology: We have a number of basic and translational interests in thoracic malignancies. The application of gene expression biomarkers for the molecular staging of non-small cell lung cancer (NSCLC) is an emerging field with the promise of clinical translation. At a more basic level, we are interested in the molecular steps transforming a normal bronchial epithelial cell through dysplasia to malignancy. A number of modern genomic, proteomic, and mouse transgenic technologies are used in these studies.
  • Lung organogenesis: Understanding of the molecular mechanisms involved in growth and development of the normal lung are fundamental to harnessing these processes for clinical tissue regeneration. We use the mouse as a model for this work, and are interested in the potential utility of lung stem cells for regenerative strategies.

Recent Publications

See my publications

Professional Details

Primary Appointment

  1. Thoracic Surgery

Academic Rank

  1. Associate Professor of Surgery

Education

  1. Postdoctoral Research Fellowship - Molecular and Medical Genetics Samuel Lunenfeld Research Institute, Mount Sinai Hospital
  2. MD - Faculty of Medicine University of Toronto
  3. PhD Department of Anatomy and Cell Biology, Queen's University
  4. MSc Department of Anatomy and Cell Biology, Queen's University
  5. BSc - Faculty of Science University of Waterloo
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BIO-00095401

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