Rochester, Minnesota


Wigle.Dennis@mayo.edu Clinical Profile


Research in our laboratory is directed along two main project lines:

  • Thoracic Oncology: We have a number of basic and translational interests in thoracic malignancies. The application of gene expression biomarkers for the molecular staging of non-small cell lung cancer (NSCLC) is an emerging field with the promise of clinical translation. At a more basic level, we are interested in the molecular steps transforming a normal bronchial epithelial cell through dysplasia to malignancy. A number of modern genomic, proteomic, and mouse transgenic technologies are used in these studies.
  • Lung organogenesis: Understanding of the molecular mechanisms involved in growth and development of the normal lung are fundamental to harnessing these processes for clinical tissue regeneration. We use the mouse as a model for this work, and are interested in the potential utility of lung stem cells for regenerative strategies.


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Academic Rank

  1. Associate Professor of Surgery


  1. Postdoctoral Research Fellowship - Molecular and Medical Genetics Samuel Lunenfeld Research Institute, Mount Sinai Hospital
  2. MD - Faculty of Medicine University of Toronto
  3. PhD Department of Anatomy and Cell Biology, Queen's University
  4. MSc Department of Anatomy and Cell Biology, Queen's University
  5. BSc - Faculty of Science University of Waterloo

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