Faculty

Lea Grinberg, M.D., Ph.D.

Publications

de Bruin H, Groot C, Barthel H, Bischof GN, Blazhenets G, Boellaard R, Boon BDC, Brendel M, Cash DM, Coath W, Day GS, Dickerson BC, Doering E, Drzezga A, van Dyck CH, van Eimeren T, van der Flier WM, Fredericks CA, Fryer TD, van de Giessen E, Gordon BA, Graff-Radford J, Grinberg LT, Hansson O, Hobbs DA, Hoenig MC, Hoglinger G, Irwin DJ, Jones PS, Josephs KA, Katsumi Y, La Joie R, Lee EB, Levin J, Malpetti M, McGinnis SM, Mecca AP, Mohanty R, Nasrallah IM, O'Brien JT, O'Dell RS, Palleis C, Perneczky R, Phillips JS, Putcha D, Rabinovici GD, Rahmouni N, Rosa-Neto P, Rowe JB, Rullmann M, Sabri O, Saur D, Schildan A, Schott JM, Schroeter ML, Seeley WW, Servaes S, Sintini I, Smith R, Spina S, Stevenson J, Stomrud E, Strandberg O, Therriault J, Tideman P, Touroutoglou A, Trainer AE, Visser D, Wekselman F, Weston PSJ, Whitwell JL, Wolk DA, Yong K, Pijnenburg YAL, Franzmeier N, Ossenkoppele R. Connectivity as a universal predictor of tau progression in atypical Alzheimer's disease. Brain. 2025 Aug 14 [Epub ahead of print]
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Alidadiani S, Faura J, Wynants S, Peeters N, Van den Broeck M, De Witte L, Policarpo R, Cheung S, Pottier C, Ghayal NB, Mol MO, van Blitterswijk M, Udine E, DeJesus-Hernandez M, Baker M, Finch NA, Asmann YW, van Rooij JGJ, Nguyen AT, Ross Reichard R, Nana AL, Lopez OL, Boxer AL, Rosen HJ, Spina S, Herms J, Josephs KA, Petersen RC, Rissman RA, Hiniker A, Ang LC, Grinberg LT, Halliday GM, Boeve BF, Graff-Radford NR, Seelaar H, Neumann M, Kofler J, White CL 3rd, Seeley WW, van Swieten JC, Dickson DW, Mackenzie IRA, De Coster W, Rademakers R. Brain transcriptomics highlight abundant gene expression and splicing alterations in non-neuronal cells in aFTLD-U. Acta Neuropathol. 2025 Aug 10; 150 (1):17
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Murray ME, Smith C, Menon V, Keene CD, Lein E, Hawrylycz M, Aguzzi A, Benedetti B, Brose K, Caetano-Anolles K, Sillero MIC, Crary JF, De Jager PL, Faustin A, Flanagan ME, Gokce O, Grant SGN, Grinberg LT, Gutman DA, Hillman EMC, Huang Z, Irwin DJ, Jones DT, Kapasi A, Karch CM, Kukull WT, Lashley T, Lee EB, Lehner T, Parkkinen L, Pedersen M, Pritchett D, Rutledge MH, Schneider JA, Seeley WW, Shepherd CE, Spires-Jones TL, Steen JA, Sutherland M, Vickovic S, Zhang B, Stewart DJ, Keiser MJ, Vogel JW, Dugger BN, Phatnani H. Accelerating biomedical discoveries in brain health through transformative neuropathology of aging and neurodegeneration. Neuron. 2025 Jul 15 Epub 2025 July 15
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Moscoso A, Heeman F, Raghavan S, Costoya-Sanchez A, van Essen M, Mainta I, Camacho V, Rodriguez-Fonseca O, Silva-Rodriguez J, Perissinotti A, Gu Y, Yun J, Peretti D, Ribaldi F, Coomans EM, Brum WS, Grothe MJ, Aguiar P, Bischof GN, Drzezga A, Seo SW, Villeneuve S, Malpetti M, O'Brien JT, Rowe JB, van de Giessen EM, Ossenkoppele R, Jagust WJ, Smith R, Hansson O, Frisoni GB, Garibotto V, Soleimani-Meigooni DN, Carrillo M, Dickerson BC, La Joie R, Rabinovici GD, Apostolova LG, LaMontagne PJ, Pontecorvo MJ, Johnson KA, Sperling RA, Weiner MW, Petersen RC, Jack CR Jr, Vemuri P, Scholl M, PREVENT-AD Research Group, the Harvard Aging Brain Study, the LEADS Consortium, and the Alzheimer's Disease Neuroimaging Initiative. Frequency and Clinical Outcomes Associated With Tau Positron Emission Tomography Positivity. JAMA. 2025 Jul 15; 334 (3):229-242
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Saloner R, Staffaroni AM, Dammer EB, Johnson ECB, Paolillo EW, Wise A, Heuer HW, Forsberg LK, Lario-Lago A, Webb JD, Vogel JW, Santillo AF, Hansson O, Kramer JH, Miller BL, Li J, Loureiro J, Sivasankaran R, Worringer KA, Seyfried NT, Yokoyama JS, Spina S, Grinberg LT, Seeley WW, VandeVrede L, Ljubenkov PA, Bayram E, Bozoki A, Brushaber D, Considine CM, Day GS, Dickerson BC, Domoto-Reilly K, Faber K, Galasko DR, Gendron T, Geschwind DH, Ghoshal N, Graff-Radford N, Hales CM, Honig LS, Hsiung GR, Huey ED, Kornak J, Kremers W, Lapid MI, Lee SE, Litvan I, McMillan CT, Mendez MF, Miyagawa T, Pantelyat A, Pascual B, Masdeu J, Paulson HL, Petrucelli L, Pressman P, Rademakers R, Ramos EM, Rascovsky K, Roberson ED, Savica R, Snyder A, Sullivan AC, Tartaglia MC, Vandebergh M, Boeve BF, Rosen HJ, Rojas JC, Boxer AL, Casaletto KB, ALLFTD Consortium. Author Correction: Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration. Nat Aging. 2025 Jul; 5 (7):1372
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Saloner R, Staffaroni AM, Dammer EB, Johnson ECB, Paolillo EW, Wise A, Heuer HW, Forsberg LK, Lario-Lago A, Webb JD, Vogel JW, Santillo AF, Hansson O, Kramer JH, Miller BL, Li J, Loureiro J, Sivasankaran R, Worringer KA, Seyfried NT, Yokoyama JS, Spina S, Grinberg LT, Seeley WW, VandeVrede L, Ljubenkov PA, Bayram E, Bozoki A, Brushaber D, Considine CM, Day GS, Dickerson BC, Domoto-Reilly K, Faber K, Galasko DR, Gendron T, Geschwind DH, Ghoshal N, Graff-Radford N, Hales CM, Honig LS, Hsiung GR, Huey ED, Kornak J, Kremers W, Lapid MI, Lee SE, Litvan I, McMillan CT, Mendez MF, Miyagawa T, Pantelyat A, Pascual B, Masdeu J, Paulson HL, Petrucelli L, Pressman P, Rademakers R, Ramos EM, Rascovsky K, Roberson ED, Savica R, Snyder A, Sullivan AC, Tartaglia MC, Vandebergh M, Boeve BF, Rosen HJ, Rojas JC, Boxer AL, Casaletto KB, ALLFTD Consortium. Large-scale network analysis of the cerebrospinal fluid proteome identifies molecular signatures of frontotemporal lobar degeneration. Nat Aging. 2025 Jun; 5 (6):1143-1158 Epub 2025 May 16
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Pottier C, Kucukali F, Baker M, Batzler A, Jenkins GD, van Blitterswijk M, Vicente CT, De Coster W, Wynants S, Van de Walle P, Ross OA, Murray ME, Faura J, Haggarty SJ, van Rooij JG, Mol MO, Hsiung GR, Graff C, Oijerstedt L, Neumann M, Asmann Y, McDonnell SK, Baheti S, Josephs KA, Whitwell JL, Bieniek KF, Forsberg L, Heuer H, Lago AL, Geier EG, Yokoyama JS, Oddi AP, Flanagan M, Mao Q, Hodges JR, Kwok JB, Domoto-Reilly K, Synofzik M, Wilke C, Onyike C, Dickerson BC, Evers BM, Dugger BN, Munoz DG, Keith J, Zinman L, Rogaeva E, Suh E, Gefen T, Geula C, Weintraub S, Diehl-Schmid J, Farlow MR, Edbauer D, Woodruff BK, Caselli RJ, Donker Kaat LL, Huey ED, Reiman EM, Mead S, King A, Roeber S, Nana AL, Ertekin-Taner N, Knopman DS, Petersen RC, Petrucelli L, Uitti RJ, Wszolek ZK, Ramos EM, Grinberg LT, Tempini MLG, Rosen HJ, Spina S, Piguet O, Grossman M, Trojanowski JQ, Keene CD, Jin LW, Prudlo J, Geschwind DH, Rissman RA, Cruchaga C, Ghetti B, Halliday GM, Beach TG, Serrano GE, Arzberger T, Herms J, Boxer AL, Honig LS, Vonsattel JP, Lopez OL, Kofler J, White CL 3rd, Gearing M, Glass J, Rohrer JD, Irwin DJ, Lee EB, Van Deerlin V, Castellani R, Mesulam MM, Tartaglia MC, Finger EC, Troakes C, Al-Sarraj S, Dalgard CL, Miller BL, Seelaar H, Graff-Radford NR, Boeve BF, Mackenzie IR, van Swieten JC, Seeley WW, Sleegers K, Dickson DW, Biernacka JM, Rademakers R. Deciphering distinct genetic risk factors for FTLD-TDP pathological subtypes via whole-genome sequencing. Nat Commun. 2025 Apr 25; 16 (1):3914
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Putcha D, Katsumi Y, Touroutoglou A, Eloyan A, Taurone A, Thangarajah M, Aisen P, Dage JL, Foroud T, Jack CR Jr, Kramer JH, Nudelman KNH, Raman R, Vemuri P, Atri A, Day GS, Duara R, Graff-Radford NR, Grant IM, Honig LS, Johnson ECB, Jones DT, Masdeu JC, Mendez MF, Musiek E, Onyike CU, Riddle M, Rogalski E, Salloway S, Sha S, Turner RS, Wingo TS, Wolk DA, Womack K, Carrillo MC, Rabinovici GD, Dickerson BC, Apostolova LG, Hammers DB, LEADS Consortium. Heterogeneous clinical phenotypes of sporadic early-onset Alzheimer's disease: a neuropsychological data-driven approach. Alzheimers Res Ther. 2025 Feb 6; 17 (1):38 Epub 2025 Feb 06
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Kovacs GG, Grinberg LT, Halliday G, Alafuzoff I, Dugger BN, Murayama S, Forrest SL, Martinez-Valbuena I, Tanaka H, Kon T, Yoshida K, Jaunmuktane Z, Spina S, Nelson PT, Gentleman S, Alegre-Abarrategui J, Serrano GE, Paes VR, Takao M, Wakabayashi K, Uchihara T, Yoshida M, Saito Y, Kofler J, Rodriguez RD, Gelpi E, Attems J, Crary JF, Seeley WW, Duda JE, Keene CD, Woulfe J, Munoz D, Smith C, Lee EB, Neumann M, White CL 3rd, McKee AC, Thal DR, Jellinger K, Ghetti B, Mackenzie IRA, Dickson DW, Beach TG. Biomarker-Based Approach to alpha-Synucleinopathies: Lessons from Neuropathology. Mov Disord. 2024 Dec; 39 (12):2173-2179 Epub 2024 Oct 03
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Wise A, Li J, Yamakawa M, Loureiro J, Peterson B, Worringer K, Sivasankaran R, Palma JA, Mitic L, Heuer HW, Lario-Lago A, Staffaroni AM, Clark A, Taylor J, Ljubenkov PA, Vandevrede L, Grinberg LT, Spina S, Seeley WW, Miller BL, Boeve BF, Dickerson BC, Grossman M, Litvan I, Pantelyat A, Tartaglia MC, Zhang Z, Wills AA, Rexach J, Rojas JC, Boxer AL, as the 4-Repeat Tauopathy Neuroimaging Initiative. CSF Proteomics in Patients With Progressive Supranuclear Palsy. Neurology. 2024 Aug 13; 103 (3):e209585 Epub 2024 July 03
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Valentino RR, Scotton WJ, Roemer SF, Lashley T, Heckman MG, Shoai M, Martinez-Carrasco A, Tamvaka N, Walton RL, Baker MC, Macpherson HL, Real R, Soto-Beasley AI, Mok K, Revesz T, Christopher EA, DeTure M, Seeley WW, Lee EB, Frosch MP, Molina-Porcel L, Gefen T, Redding-Ochoa J, Ghetti B, Robinson AC, Kobylecki C, Rowe JB, Beach TG, Teich AF, Keith JL, Bodi I, Halliday GM, Gearing M, Arzberger T, Morris CM, White CL 3rd, Mechawar N, Boluda S, MacKenzie IR, McLean C, Cykowski MD, Wang SJ, Graff C, Nagra RM, Kovacs GG, Giaccone G, Neumann M, Ang LC, Carvalho A, Morris HR, Rademakers R, Hardy JA, Dickson DW, Rohrer JD, Ross OA, Pick's disease International Consortium. MAPT H2 haplotype and risk of Pick's disease in the Pick's disease International Consortium: a genetic association study. Lancet Neurol. 2024 May; 23 (5):487-499
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Samudra N, Fischer DL, Lenio S, Lario Lago A, Ljubenkov PA, Rojas JC, Seeley WW, Spina S, Staffaroni AM, Tablante J, Wekselman F, Lamoureux J, Concha-Marambio L, Grinberg LT, Boxer AL, VandeVrede L. Clinicopathological correlation of cerebrospinal fluid alpha-synuclein seed amplification assay in a behavioral neurology autopsy cohort. Alzheimers Dement. 2024 May; 20 (5):3334-3341 Epub 2024 Mar 27
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Nascimento C, Villela Nunes P, Paraizo Leite RE, Grinberg LT, Suemoto CK, Lafer B. The relationship of neuropsychiatric symptoms with inflammatory markers in the hippocampus and cingulate cortex of bipolar disorder subjects: A post-mortem study. J Psychiatr Res. 2024 May; 173:25-33 Epub 2024 Mar 02
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Asken BM, Tanner JA, Vandevrede L, Apple A, Chapleau M, Gaynor LS, Lane-Donovan C, Lenio S, Yadollahikhales G, Lee S, Gontrum E, Knudtson M, Iaccarino L, La Joie R, Cobigo Y, Staffaroni AM, Casaletto KB, Gardner RC, Grinberg LT, Gorno-Tempini ML, Rosen HJ, Seeley WW, Miller BL, Kramer J, Rabinovici GD. Linking Type and Extent of Head Trauma to Cavum Septum Pellucidum in Older Adults With and Without Alzheimer Disease and Related Dementias. Neurology. 2024 Apr 9; 102 (7):e209183 Epub 2024 Mar 15
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Illan-Gala I, Lorca-Puls DL, Tee BL, Ezzes Z, de Leon J, Miller ZA, Rubio-Guerra S, Santos-Santos M, Gomez-Andres D, Grinberg LT, Spina S, Kramer JH, Wauters LD, Henry ML, Boxer AL, Rosen HJ, Miller BL, Seeley WW, Mandelli ML, Gorno-Tempini ML. Clinical dimensions along the non-fluent variant primary progressive aphasia spectrum. Brain. 2024 Apr 4; 147 (4):1511-1525
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Van Egroo M, van Someren EJW, Grinberg LT, Bennett DA, Jacobs HIL. Associations of 24-Hour Rest-Activity Rhythm Fragmentation, Cognitive Decline, and Postmortem Locus Coeruleus Hypopigmentation in Alzheimer's Disease. Ann Neurol. 2024 Apr; 95 (4):653-664 Epub 2024 Feb 26
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Korczyn AD, Grinberg LT. Is Alzheimer disease a disease? Nat Rev Neurol. 2024 Apr; 20 (4):245-251 Epub 2024 Feb 29
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Diehl Rodriguez R, Tavares MCH, Brucki SMD, Takada LT, Otaduy MCG, da Graca Morais Martin M, Kimie Suemoto C, Grinberg LT, Leite CC, Tomaz C, Nitrini R. Bearded capuchin monkeys as a model for Alzheimer's disease. Sci Rep. 2024 Mar 15; 14 (1):6287
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Gaynor LS, Yadollahikhales G, Tsoy E, Hall M, Boxer AL, Miller BL, Grinberg LT. C9orf72 Repeat Expansion Initially Presenting as Late-Onset Bipolar Disorder With Psychosis. Neurologist. 2024 Mar 1; 29 (2):109-112 Epub 2024 Mar 01
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Chen Y, Spina S, Callahan P, Grinberg LT, Seeley WW, Rosen HJ, Kramer JH, Miller BL, Rankin KP. Pathology-specific patterns of cerebellar atrophy in neurodegenerative disorders. Alzheimers Dement. 2024 Mar; 20 (3):1771-1783 Epub 2023 Dec 18
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Nie X, Ruan J, Otaduy MCG, Grinberg LT, Ringman J, Shi Y. Surface-Based Probabilistic Fiber Tracking in Superficial White Matter. IEEE Trans Med Imaging. 2024 Mar; 43 (3):1113-1124 Epub 2024 Mar 05
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Rizzi L, Grinberg LT. Exploring the significance of caspase-cleaved tau in tauopathies and as a complementary pathology to phospho-tau in Alzheimer's disease: implications for biomarker development and therapeutic targeting. Acta Neuropathol Commun. 2024 Feb 28; 12 (1):36
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Chapleau M, La Joie R, Yong K, Agosta F, Allen IE, Apostolova L, Best J, Boon BDC, Crutch S, Filippi M, Fumagalli GG, Galimberti D, Graff-Radford J, Grinberg LT, Irwin DJ, Josephs KA, Mendez MF, Mendez PC, Migliaccio R, Miller ZA, Montembeault M, Murray ME, Nemes S, Pelak V, Perani D, Phillips J, Pijnenburg Y, Rogalski E, Schott JM, Seeley W, Sullivan AC, Spina S, Tanner J, Walker J, Whitwell JL, Wolk DA, Ossenkoppele R, Rabinovici GD, PCA International Work Group. Demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy: an international cohort study and individual participant data meta-analysis. Lancet Neurol. 2024 Feb; 23 (2):168-177
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Kauwe G, Pareja-Navarro KA, Yao L, Chen JH, Wong I, Saloner R, Cifuentes H, Nana AL, Shah S, Li Y, Le D, Spina S, Grinberg LT, Seeley WW, Kramer JH, Sacktor TC, Schilling B, Gan L, Casaletto KB, Tracy TE. KIBRA repairs synaptic plasticity and promotes resilience to tauopathy-related memory loss. J Clin Invest. 2024 Feb 1; 134 (3) Epub 2024 Feb 01
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Samudra N, Lerner H, Yack L, Walsh CM, Kirsch HE, Kudo K, Yballa C, La Joie R, Gorno-Tempini ML, Spina S, Seeley WW, Neylan TC, Miller BL, Rabinovici GD, Boxer A, Grinberg LT, Rankin KP, Nagarajan SS, Ranasinghe KG. Spatiotemporal characteristics of neurophysiological changes in patients with four-repeat tauopathies. Ann Clin Transl Neurol. 2024 Feb; 11 (2):525-535 Epub 2024 Jan 16
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Lorca-Puls DL, Gajardo-Vidal A, Mandelli ML, Illan-Gala I, Ezzes Z, Wauters LD, Battistella G, Bogley R, Ratnasiri B, Licata AE, Battista P, Garcia AM, Tee BL, Lukic S, Boxer AL, Rosen HJ, Seeley WW, Grinberg LT, Spina S, Miller BL, Miller ZA, Henry ML, Dronkers NF, Gorno-Tempini ML. Neural basis of speech and grammar symptoms in non-fluent variant primary progressive aphasia spectrum. Brain. 2024 Feb 1; 147 (2):607-626
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Son G, Neylan TC, Grinberg LT. Neuronal and glial vulnerability of the suprachiasmatic nucleus in tauopathies: evidence from human studies and animal models. Mol Neurodegener. 2024 Jan 10; 19 (1):4
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Paradela RS, Justo AFO, Paes VR, Leite REP, Pasqualucci CA, Grinberg LT, Naslavsky MS, Zatz M, Nitrini R, Jacob-Filho W, Suemoto CK. Association between APOE-epsilon4 allele and cognitive function is mediated by Alzheimer's disease pathology: a population-based autopsy study in an admixed sample. Acta Neuropathol Commun. 2023 Dec 19; 11 (1):205
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Bodart-Santos V, Pinheiro LS, da Silva-Junior AJ, Froza RL, Ahrens R, Gonçalves RA, Andrade MM, Chen Y, Alcantara CL, Grinberg LT, Leite REP, Ferreira ST, Fraser PE, De Felice FG. Alzheimer's disease brain-derived extracellular vesicles reveal altered synapse-related proteome and induce cognitive impairment in mice. Alzheimers Dement. 2023 Dec; 19(12):5418-5436. Epub 2023 May 19.
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Ribeiro FC, Cozachenco D, Heimfarth L, Fortuna JTS, de Freitas GB, de Sousa JM, Alves-Leon SV, Leite REP, Suemoto CK, Grinberg LT, De Felice FG, Lourenco MV, Ferreira ST. Synaptic proteasome is inhibited in Alzheimer's disease models and associates with memory impairment in mice. Commun Biol. 2023 Nov 7; 6 (1):1127 Epub 2023 Nov 07
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Dage JL, Eloyan A, Thangarajah M, Hammers DB, Fagan AM, Gray JD, Schindler SE, Snoddy C, Nudelman KNH, Faber KM, Foroud T, Aisen P, Griffin P, Grinberg LT, Iaccarino L, Kirby K, Kramer J, Koeppe R, Kukull WA, La Joie R, Mundada NS, Murray ME, Rumbaugh M, Soleimani-Meigooni DN, Toga AW, Touroutoglou A, Vemuri P, Atri A, Beckett LA, Day GS, Graff-Radford NR, Duara R, Honig LS, Jones DT, Masdeu JC, Mendez MF, Musiek E, Onyike CU, Riddle M, Rogalski E, Salloway S, Sha SJ, Turner RS, Wingo TS, Wolk DA, Womack KB, Carrillo MC, Dickerson BC, Rabinovici GD, Apostolova LG, LEADS Consortium. Cerebrospinal fluid biomarkers in the Longitudinal Early-onset Alzheimer's Disease Study. Alzheimers Dement. 2023 Nov; 19 Suppl 9 (Suppl 9):S115-S125 Epub 2023 July 25
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Nemes S, Logan PE, Manchella MK, Mundada NS, La Joie R, Polsinelli AJ, Hammers DB, Koeppe RA, Foroud TM, Nudelman KN, Eloyan A, Iaccarino L, Dorsant-Ardon V, Taurone A, Thangarajah M, Dage JL, Aisen P, Grinberg LT, Jack CR Jr, Kramer J, Kukull WA, Murray ME, Rumbaugh M, Soleimani-Meigooni DN, Toga A, Touroutoglou A, Vemuri P, Atri A, Day GS, Duara R, Graff-Radford NR, Honig LS, Jones DT, Masdeu J, Mendez MF, Musiek E, Onyike CU, Riddle M, Rogalski E, Salloway S, Sha SJ, Turner RS, Wingo TS, Womack KB, Wolk DA, Rabinovici GD, Carrillo MC, Dickerson BC, Apostolova LG, LEADS Consortium. Sex and APOE epsilon4 carrier effects on atrophy, amyloid PET, and tau PET burden in early-onset Alzheimer's disease. Alzheimers Dement. 2023 Nov; 19 Suppl 9 (Suppl 9):S49-S63 Epub 2023 July 26
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Bushnell J, Hammers DB, Aisen P, Dage JL, Eloyan A, Foroud T, Grinberg LT, Iaccarino L, Jack CR Jr, Kirby K, Kramer J, Koeppe R, Kukull WA, La Joie R, Mundada NS, Murray ME, Nudelman K, Rumbaugh M, Soleimani-Meigooni DN, Toga A, Touroutoglou A, Vemuri P, Atri A, Day GS, Duara R, Graff-Radford NR, Honig LS, Jones DT, Masdeu J, Mendez M, Musiek E, Onyike CU, Riddle M, Rogalski E, Salloway S, Sha S, Turner RS, Wingo TS, Wolk DA, Carrillo MC, Dickerson BC, Rabinovici GD, Apostolova LG, Clark DG, LEADS Consortium. Influence of amyloid and diagnostic syndrome on non-traditional memory scores in early-onset Alzheimer's disease. Alzheimers Dement. 2023 Nov; 19 Suppl 9(Suppl 9):S29-S41. Epub 2023 Aug 31.
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Cho H, Mundada NS, Apostolova LG, Carrillo MC, Shankar R, Amuiri AN, Zeltzer E, Windon CC, Soleimani-Meigooni DN, Tanner JA, Heath CL, Lesman-Segev OH, Aisen P, Eloyan A, Lee HS, Hammers DB, Kirby K, Dage JL, Fagan A, Foroud T, Grinberg LT, Jack CR, Kramer J, Kukull WA, Murray ME, Nudelman K, Toga A, Vemuri P, Atri A, Day GS, Duara R, Graff-Radford NR, Honig LS, Jones DT, Masdeu J, Mendez M, Musiek E, Onyike CU, Riddle M, Rogalski EJ, Salloway S, Sha S, Turner RS, Wingo TS, Wolk DA, Koeppe R, Iaccarino L, Dickerson BC, La Joie R, Rabinovici GD, LEADS Consortium. Amyloid and tau-PET in early-onset AD: Baseline data from the Longitudinal Early-onset Alzheimer's Disease Study (LEADS). Alzheimers Dement. 2023 Nov; 19 Suppl 9(Suppl 9):S98-S114. Epub 2023 Sep 10.
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Hammers DB, Eloyan A, Taurone A, Thangarajah M, Beckett L, Gao S, Kirby K, Aisen P, Dage JL, Foroud T, Griffin P, Grinberg LT, Jack CR Jr, Kramer J, Koeppe R, Kukull WA, Mundada NS, La Joie R, Soleimani-Meigooni DN, Iaccarino L, Murray ME, Nudelman K, Polsinelli AJ, Rumbaugh M, Toga A, Touroutoglou A, Vemuri P, Atri A, Day GS, Duara R, Graff-Radford NR, Honig LS, Jones DT, Masdeu J, Mendez MF, Womack K, Musiek E, Onyike CU, Riddle M, Rogalski E, Salloway S, Sha SJ, Turner RS, Wingo TS, Wolk DA, Carrillo MC, Dickerson BC, Rabinovici GD, Apostolova LG, LEADS Consortium. Profiling baseline performance on the Longitudinal Early-Onset Alzheimer's Disease Study (LEADS) cohort near the midpoint of data collection. Alzheimers Dement. 2023 Nov; 19 Suppl 9(Suppl 9):S8-S18. Epub 2023 May 31.
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Bhagat R, Minaya MA, Renganathan A, Mehra M, Marsh J, Martinez R, Eteleeb AM, Nana AL, Spina S, Seeley WW, Grinberg LT, Karch CM. Long non-coding RNA SNHG8 drives stress granule formation in tauopathies. Mol Psychiatry. 2023 Nov; 28 (11):4889-4901 Epub 2023 Sept 21
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Bhagat R, Minaya MA, Renganathan A, Mehra M, Marsh J, Martinez R, Eteleeb AM, Nana AL, Spina S, Seeley WW, Grinberg LT, Karch CM. Mutant tau and stress lead to downregulation of long noncoding RNA, SNHG8. Mol Psychiatry. 2023 Nov; 28 (11):4489
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Pasquini L, Pereira FL, Seddighi S, Zeng Y, Wei Y, Illán-Gala I, Vatsavayai SC, Friedberg A, Lee AJ, Brown JA, Spina S, Grinberg LT, Sirkis DW, Bonham LW, Yokoyama JS, Boxer AL, Kramer JH, Rosen HJ, Humphrey J, Gitler AD, Miller BL, Pollard KS, Ward ME, Seeley WW. FTLD targets brain regions expressing recently evolved genes. medRxiv. 2023.
Sokolowski A, Roy ARK, Goh SM, Hardy EG, Datta S, Cobigo Y, Brown JA, Spina S, Grinberg L, Kramer J, Rankin KP, Seeley WW, Sturm VE, Rosen HJ, Miller BL, Perry DC. Neuropsychiatric symptoms and imbalance of atrophy in behavioral variant frontotemporal dementia. Hum Brain Mapp. 2023 Oct 15; 44 (15):5013-5029 Epub 2023 July 20
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Abskharon R, Pan H, Sawaya MR, Seidler PM, Olivares EJ, Chen Y, Murray KA, Zhang J, Lantz C, Bentzel M, Boyer DR, Cascio D, Nguyen BA, Hou K, Cheng X, Pardon E, Williams CK, Nana AL, Vinters HV, Spina S, Grinberg LT, Seeley WW, Steyaert J, Glabe CG, Ogorzalek Loo RR, Loo JA, Eisenberg DS. Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils. Proc Natl Acad Sci U S A. 2023 Oct 10; 120 (41):e2300258120 Epub 2023 Oct 06
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Rexach JE, Cheng Y, Chen L, Polioudakis D, Lin LC, Mitri V, Elkins A, Yin A, Calini D, Kawaguchi R, Ou J, Huang J, Williams C, Robinson J, Gaus SE, Spina S, Lee EB, Grinberg LT, Vinters H, Trojanowski JQ, Seeley WW, Malhotra D, Geschwind DH. Disease-specific selective vulnerability and neuroimmune pathways in dementia revealed by single cell genomics. bioRxiv. 2023.
Paradela RS, Farias-Itao DS, Leite REP, Pasqualucci CA, Grinberg LT, Naslavsky MS, Zatz M, Nitrini R, Jacob-Filho W, Suemoto CK. Apolipoprotein E epsilon2 allele is associated with lower risk of carotid artery obstruction in a population-based autopsy study. J Stroke Cerebrovasc Dis. 2023 Sep; 32 (9):107229 Epub 2023 July 31
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Falgas N, Walsh CM, Yack L, Simon AJ, Allen IE, Kramer JH, Rosen HJ, Joie R, Rabinovici G, Miller B, Spina S, Seeley WW, Ranasinghe K, Vossel K, Neylan TC, Grinberg LT. Alzheimer's disease phenotypes show different sleep architecture. Alzheimers Dement. 2023 Aug; 19 (8):3272-3282 Epub 2023 Feb 07
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Simon SS, Brucki SMD, Fonseca LM, Becker J, Cappi C, Marques AH, Heyn PC, Goncalves PD, Martins SS, Busatto G, Bertola L, Suemoto CK, Nitrini R, Caramelli P, Yassuda MS, Miotto EC, Grinberg LT, Arce Renteria M, Alegria M, Stern Y, Rivera-Mindt M. The (in)visible Brazilians: A perspective review on the need for brain health and dementia research with Brazilian immigrants in the United States. Alzheimers Dement (N Y). 2023 Jul-Sep; 9 (3):e12425 Epub 2023 Sept 23
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Castro-Fonseca E, Morais V, da Silva CG, Wollner J, Freitas J, Mello-Neto AF, Oliveira LE, de Oliveira VC, Leite REP, Alho AT, Rodriguez RD, Ferretti-Rebustini REL, Suemoto CK, Jacob-Filho W, Nitrini R, Pasqualucci CA, Grinberg LT, Tovar-Moll F, Lent R. The influence of age and sex on the absolute cell numbers of the human brain cerebral cortex. Cereb Cortex. 2023 Jun 20; 33 (13):8654-8666
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Resende EPF, Lara VP, Santiago ALC, Friedlaender CV, Rosen HJ, Brown JA, Cobigo Y, Silva LLG, de Souza LC, Rincon L, Grinberg LT, Maciel FIP, Caramelli P. Literacy, but not memory, is associated with hippocampal connectivity in illiterate adults. Res Sq. 2023.
Ehrenberg AJ, Kelberman MA, Liu KY, Dahl MJ, Weinshenker D, Falgas N, Dutt S, Mather M, Ludwig M, Betts MJ, Winer JR, Teipel S, Weigand AJ, Eschenko O, Hammerer D, Leiman M, Counts SE, Shine JM, Robertson IH, Levey AI, Lancini E, Son G, Schneider C, Egroo MV, Liguori C, Wang Q, Vazey EM, Rodriguez-Porcel F, Haag L, Bondi MW, Vanneste S, Freeze WM, Yi YJ, Maldinov M, Gatchel J, Satpati A, Babiloni C, Kremen WS, Howard R, Jacobs HIL, Grinberg LT. Priorities for research on neuromodulatory subcortical systems in Alzheimer's disease: Position paper from the NSS PIA of ISTAART. Alzheimers Dement. 2023 May; 19 (5):2182-2196 Epub 2023 Jan 15
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Davis SE, Cook AK, Hall JA, Voskobiynyk Y, Carullo NV, Boyle NR, Hakim AR, Anderson KM, Hobdy KP, Pugh DA, Murchison CF, McMeekin LJ, Simmons M, Margolies KA, Cowell RM, Nana AL, Spina S, Grinberg LT, Miller BL, Seeley WW, Arrant AE. Patients with sporadic FTLD exhibit similar increases in lysosomal proteins and storage material as patients with FTD due to GRN mutations. Acta Neuropathol Commun. 2023 Apr 28; 11 (1):70
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Friedberg A, Pasquini L, Diggs R, Glaubitz EA, Lopez L, Illan-Gala I, Iaccarino L, La Joie R, Mundada N, Knudtson M, Neylan K, Brown J, Allen IE, Rankin KP, Bonham LW, Yokoyama JS, Ramos EM, Geschwind DH, Spina S, Grinberg LT, Miller ZA, Kramer JH, Rosen H, Gorno-Tempini ML, Rabinovici G, Seeley WW, Miller BL. Prevalence, Timing, and Network Localization of Emergent Visual Creativity in Frontotemporal Dementia. JAMA Neurol. 2023 Apr 1; 80 (4):377-387
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Satpati A, Neylan T, Grinberg LT. Histaminergic neurotransmission in aging and Alzheimer's disease: A review of therapeutic opportunities and gaps. Alzheimers Dement (N Y). 2023 Apr-Jun; 9 (2):e12379 Epub 2023 Apr 25
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Gibson LL, Grinberg LT, Ffytche D, Leite REP, Rodriguez RD, Ferretti-Rebustini REL, Pasqualucci CA, Nitrini R, Jacob-Filho W, Aarsland D, Suemoto CK. Neuropathological correlates of neuropsychiatric symptoms in dementia. Alzheimers Dement. 2023 Apr; 19 (4):1372-1382 Epub 2022 Sept 23
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Toscano ECB, Vieira ELM, Grinberg LT, Rocha NP, Brant JAS, Paradela RS, Giannetti AV, Suemoto CK, Leite REP, Nitrini R, Rachid MA, Teixeira AL. Hyperphosphorylated Tau in Mesial Temporal Lobe Epilepsy: a Neuropathological and Cognitive Study. Mol Neurobiol. 2023 Apr; 60 (4):2174-2185 Epub 2023 Jan 09
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Marsan E, Velmeshev D, Ramsey A, Patel RK, Zhang J, Koontz M, Andrews MG, de Majo M, Mora C, Blumenfeld J, Li AN, Spina S, Grinberg LT, Seeley WW, Miller BL, Ullian EM, Krummel MF, Kriegstein AR, Huang EJ. Astroglial toxicity promotes synaptic degeneration in the thalamocortical circuit in frontotemporal dementia with GRN mutations. J Clin Invest. 2023 Mar 15; 133 (6)
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Maestre G, Carrillo M, Kalaria R, Acosta D, Adams L, Adoukonou T, Akinwande K, Akinyemi J, Akinyemi R, Akpa O, Alladi S, Allegri R, Arizaga R, Arshad F, Arulogun O, Babalola D, Baiyewu O, Bak T, Bellaj T, Boshe J, Brayne C, Brodie-Mends D, Brown R, Cahn J, Cyrille N, Damasceno A, de Silva R, de Silva R, Djibuti M, Dreyer AJ, Ellajosyula R, Farombi T, Fongang B, Forner S, Friedland R, Garza N, Gbessemehlan A, Georgiou EE, Gouider R, Govia I, Grinberg L, Guerchet M, Gugssa S, Gumikiriza-Onoria JL, Gustafson D, Hogervorst E, Hornberger M, Ibanez A, Ihara M, Ismail O, Issac T, Jonsson L, Kaputu C, Karanja W, Karungi J, Tshala-Katumbay D, Kunkle B, Lee JH, Leroi I, Lewis R, Livingston G, Lopera F, Lwere K, Manes F, Mbakile-Mahlanza L, Mena P, Miller B, Millogo A, Mohamed A, Musyimi C, Mutiso V, Nakasujja N, Ndetei D, Nightingale S, Njamnshi AK, Novotni G, Nyamayaro P, Nyame S, Ogeng'o J, Ogunniyi A, Okada De Oliveira M, Okubadejo N, Orrell M, Orunmuyi A, Owolabi M, Paddick S, A Pericak-Vance M, Pirtosek Z, Potocnik F, Preston B, Raman R, Ranchod K, Rizig M, Rosselli M, Deepa R, Roy U, Salokhiddinov M, Sano M, Sarfo F, Satizabal CL, Sepulveda-Falla D, Seshadri S, Sexton C, Skoog I, St George-Hyslop P, Suemoto C, Tanner J, Thapa P, Toure K, Ucheagwu V, Udeh-Momoh C, Valcour V, Vance J, Varghese M, Vera J, Walker R, Weidner W, Sebastian W, Whitehead Gay P, Zetterberg H, Zewde Y, African Dementia Consortium. The Nairobi Declaration-Reducing the burden of dementia in low- and middle-income countries (LMICs): Declaration of the 2022 Symposium on Dementia and Brain Aging in LMICs. Alzheimers Dement. 2023 Mar 11 [Epub ahead of print]
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Nelson PT, Lee EB, Cykowski MD, Alafuzoff I, Arfanakis K, Attems J, Brayne C, Corrada MM, Dugger BN, Flanagan ME, Ghetti B, Grinberg LT, Grossman M, Grothe MJ, Halliday GM, Hasegawa M, Hokkanen SRK, Hunter S, Jellinger K, Kawas CH, Keene CD, Kouri N, Kovacs GG, Leverenz JB, Latimer CS, Mackenzie IR, Mao Q, McAleese KE, Merrick R, Montine TJ, Murray ME, Myllykangas L, Nag S, Neltner JH, Newell KL, Rissman RA, Saito Y, Sajjadi SA, Schwetye KE, Teich AF, Thal DR, Tome SO, Troncoso JC, Wang SJ, White CL 3rd, Wisniewski T, Yang HS, Schneider JA, Dickson DW, Neumann M. LATE-NC staging in routine neuropathologic diagnosis: an update. Acta Neuropathol. 2023 Feb; 145 (2):159-173 Epub 2022 Dec 13
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de Morais VAC, de Oliveira-Pinto AV, Mello Neto AF, Freitas JS, da Silva MM, Suemoto CK, Leite RP, Grinberg LT, Jacob-Filho W, Pasqualucci C, Nitrini R, Caramelli P, Lent R. Resilience of Neural Cellularity to the Influence of Low Educational Level. Brain Sci. 2023 Jan 5; 13 (1) Epub 2023 Jan 05
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Paradela RS, Farias-Itao DS, Leite REP, Pasqualucci CA, Grinberg LT, Naslavsky MS, Zatz M, Nitrini R, Jacob-Filho W, Suemoto CK. Apolipoprotein E genotypes were not associated with intracranial atherosclerosis: a population-based autopsy study. Cardiovasc Pathol. 2023 Jan-Feb; 62:107479 Epub 2022 Sept 23
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Minaya MA, Mahali S, Iyer AK, Eteleeb AM, Martinez R, Huang G, Budde J, Temple S, Nana AL, Seeley WW, Spina S, Grinberg LT, Harari O, Karch CM. Conserved gene signatures shared among MAPT mutations reveal defects in calcium signaling. Front Mol Biosci. 2023; 10:1051494 Epub 2023 Feb 09
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Argouarch AR, Schultz N, Yang AC, Jang Y, Garcia K, Cosme CG, Corrales CI, Nana AL, Karydas AM, Spina S, Grinberg LT, Miller B, Wyss-Coray T, Abyzov A, Goodarzi H, Seeley WW, Kao AW. Postmortem Human Dura Mater Cells Exhibit Phenotypic, Transcriptomic and Genetic Abnormalities that Impact their Use for Disease Modeling. Stem Cell Rev Rep. 2022 Dec; 18(8):3050-3065. Epub 2022 Jul 09.
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Younes K, Borghesani V, Montembeault M, Spina S, Mandelli ML, Welch AE, Weis E, Callahan P, Elahi FM, Hua AY, Perry DC, Karydas A, Geschwind D, Huang E, Grinberg LT, Kramer JH, Boxer AL, Rabinovici GD, Rosen HJ, Seeley WW, Miller ZA, Miller BL, Sturm VE, Rankin KP, Gorno-Tempini ML. Right temporal degeneration and socioemotional semantics: semantic behavioural variant frontotemporal dementia. Brain. 2022 Nov 21; 145 (11):4080-4096
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Naslavsky MS, Suemoto CK, Brito LA, Scliar MO, Ferretti-Rebustini RE, Rodriguez RD, Leite REP, Araujo NM, Borda V, Tarazona-Santos E, Jacob-Filho W, Pasqualucci C, Nitrini R, Yaffe K, Zatz M, Grinberg LT. Global and local ancestry modulate APOE association with Alzheimer's neuropathology and cognitive outcomes in an admixed sample. Mol Psychiatry. 2022 Nov; 27 (11):4800-4808 Epub 2022 Sept 07
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Suemoto CK, Bertola L, Grinberg LT, Leite REP, Rodriguez RD, Santana PH, Pasqualucci CA, Jacob-Filho W, Nitrini R. Education, but not occupation, is associated with cognitive impairment: The role of cognitive reserve in a sample from a low-to-middle-income country. Alzheimers Dement. 2022 Nov; 18 (11):2079-2087 Epub 2022 Jan 03
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Boland S, Swarup S, Ambaw YA, Malia PC, Richards RC, Fischer AW, Singh S, Aggarwal G, Spina S, Nana AL, Grinberg LT, Seeley WW, Surma MA, Klose C, Paulo JA, Nguyen AD, Harper JW, Walther TC, Farese RV Jr. Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis. Nat Commun. 2022 Oct 7; 13 (1):5924 Epub 2022 Oct 07
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Roemer SF, Grinberg LT, Crary JF, Seeley WW, McKee AC, Kovacs GG, Beach TG, Duyckaerts C, Ferrer IA, Gelpi E, Lee EB, Revesz T, White CL 3rd, Yoshida M, Pereira FL, Whitney K, Ghayal NB, Dickson DW. Rainwater Charitable Foundation criteria for the neuropathologic diagnosis of progressive supranuclear palsy. Acta Neuropathol. 2022 Oct; 144(4):603-614. Epub 2022 Aug 10.
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Hopfner F, Tietz AK, Ruf VC, Ross OA, Koga S, Dickson D, Aguzzi A, Attems J, Beach T, Beller A, Cheshire WP, van Deerlin V, Desplats P, Deuschl G, Duyckaerts C, Ellinghaus D, Evsyukov V, Flanagan ME, Franke A, Frosch MP, Gearing M, Gelpi E, van Gerpen JA, Ghetti B, Glass JD, Grinberg LT, Halliday G, Helbig I, Höllerhage M, Huitinga I, Irwin DJ, Keene DC, Kovacs GG, Lee EB, Levin J, Martí MJ, Mackenzie I, McKeith I, Mclean C, Mollenhauer B, Neumann M, Newell KL, Pantelyat A, Pendziwiat M, Peters A, Molina Porcel L, Rabano A, Matej R, Rajput A, Rajput A, Reimann R, Scott WK, Seeley W, Selvackadunco S, Simuni T, Stadelmann C, Svenningsson P, Thomas A, Trenkwalder C, Troakes C, Trojanowski JQ, Uitti RJ, White CL, Wszolek ZK, Xie T, Ximelis T, Yebenes J, Alzheimer's Disease Genetics Consortium, Müller U, Schellenberg GD, Herms J, Kuhlenbäumer G, Höglinger G. Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy. Mov Disord. 2022 Oct; 37(10):2110-2121. Epub 2022 Aug 23.
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Quiroz YT, Solis M, Aranda MP, Arbaje AI, Arroyo-Miranda M, Cabrera LY, Carrasquillo MM, Corrada MM, Crivelli L, Diminich ED, Dorsman KA, Gonzales M, González HM, Gonzalez-Seda AL, Grinberg LT, Guerrero LR, Hill CV, Jimenez-Velazquez IZ, Guerra JJL, Lopera F, Maestre G, Medina LD, O'Bryant S, Peñaloza C, Pinzon MM, Mavarez RVP, Pluim CF, Raman R, Rascovsky K, Rentz DM, Reyes Y, Rosselli M, Tansey MG, Vila-Castelar C, Zuelsdorff M, Carrillo M, Sexton C. Addressing the disparities in dementia risk, early detection and care in Latino populations: Highlights from the second Latinos & Alzheimer's Symposium. Alzheimers Dement. 2022 Sep; 18(9):1677-1686. Epub 2022 Feb 24.
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Nunes PV, Suemoto CK, Rodriguez RD, Paraizo Leite RE, Nascimento C, Pasqualucci CA, Nitrini R, Jacob-Filho W, Grinberg LT, Lafer B. Neuropathology of depression in non-demented older adults: A large postmortem study of 741 individuals. Neurobiol Aging. 2022 Sep; 117:107-116 Epub 2022 May 26
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Asken BM, Tanner JA, VandeVrede L, Casaletto KB, Staffaroni AM, Mundada N, Fonseca C, Iaccarino L, La Joie R, Tsuei T, Mladinov M, Grant H, Shankar R, Wang KKW, Xu H, Cobigo Y, Rosen H, Gardner RC, Perry DC, Miller BL, Spina S, Seeley WW, Kramer JH, Grinberg LT, Rabinovici GD. Multi-Modal Biomarkers of Repetitive Head Impacts and Traumatic Encephalopathy Syndrome: A Clinicopathological Case Series. J Neurotrauma. 2022 Sep; 39 (17-18):1195-1213 Epub 2022 June 06
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Asken BM, Tanner JA, VandeVrede L, Mantyh WG, Casaletto KB, Staffaroni AM, La Joie R, Iaccarino L, Soleimani-Meigooni D, Rojas JC, Gardner RC, Miller BL, Grinberg LT, Boxer AL, Kramer JH, Rabinovici GD. Plasma P-tau181 and P-tau217 in Patients With Traumatic Encephalopathy Syndrome With and Without Evidence of Alzheimer Disease Pathology. Neurology. 2022 Aug 9; 99 (6):e594-e604 Epub 2022 May 16
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Theofilas P, Piergies AMH, Oh I, Lee YB, Li SH, Pereira FL, Petersen C, Ehrenberg AJ, Eser RA, Ambrose AJ, Chin B, Yang T, Khan S, Ng R, Spina S, Seeley WW, Miller BL, Arkin MR, Grinberg LT. Caspase-6-cleaved tau is relevant in Alzheimer's disease and marginal in four-repeat tauopathies: Diagnostic and therapeutic implications. Neuropathol Appl Neurobiol. 2022 Aug; 48 (5):e12819 Epub 2022 June 02
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Nelson PT, Brayne C, Flanagan ME, Abner EL, Agrawal S, Attems J, Castellani RJ, Corrada MM, Cykowski MD, Di J, Dickson DW, Dugger BN, Ervin JF, Fleming J, Graff-Radford J, Grinberg LT, Hokkanen SRK, Hunter S, Kapasi A, Kawas CH, Keage HAD, Keene CD, Kero M, Knopman DS, Kouri N, Kovacs GG, Labuzan SA, Larson EB, Latimer CS, Leite REP, Matchett BJ, Matthews FE, Merrick R, Montine TJ, Murray ME, Myllykangas L, Nag S, Nelson RS, Neltner JH, Nguyen AT, Petersen RC, Polvikoski T, Reichard RR, Rodriguez RD, Suemoto CK, Wang SJ, Wharton SB, White L, Schneider JA. Frequency of LATE neuropathologic change across the spectrum of Alzheimer's disease neuropathology: combined data from 13 community-based or population-based autopsy cohorts. Acta Neuropathol. 2022 Jul; 144(1):27-44. Epub 2022 Jun 13.
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Correa-Velloso JC, Linardi AM, Glaser T, Velloso FJ, Rivas MP, Leite REP, Grinberg LT, Ulrich H, Akins MR, Chiavegatto S, Haddad LA. Fmr1 exon 14 skipping in late embryonic development of the rat forebrain. BMC Neurosci. 2022 May 31; 23 (1):32
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Oh JY, Walsh CM, Ranasinghe K, Mladinov M, Pereira FL, Petersen C, Falgas N, Yack L, Lamore T, Nasar R, Lew C, Li S, Metzler T, Coppola Q, Pandher N, Le M, Heuer HW, Heinsen H, Spina S, Seeley WW, Kramer J, Rabinovici GD, Boxer AL, Miller BL, Vossel K, Neylan TC, Grinberg LT. Subcortical Neuronal Correlates of Sleep in Neurodegenerative Diseases. JAMA Neurol. 2022 May 1; 79 (5):498-508
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Wang C, Fan L, Khawaja RR, Liu B, Zhan L, Kodama L, Chin M, Li Y, Le D, Zhou Y, Condello C, Grinberg LT, Seeley WW, Miller BL, Mok SA, Gestwicki JE, Cuervo AM, Luo W, Gan L. Microglial NF-kappaB drives tau spreading and toxicity in a mouse model of tauopathy. Nat Commun. 2022 Apr 12; 13 (1):1969
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Falgas N, Allen IE, Spina S, Grant H, Pina Escudero SD, Merrilees J, Gearhart R, Rosen HJ, Kramer JH, Seeley WW, Neylan TC, Miller BL, Rabinovici GD, Grinberg LT, Walsh CM. The severity of neuropsychiatric symptoms is higher in early-onset than late-onset Alzheimer's disease. Eur J Neurol. 2022 Apr; 29 (4):957-967 Epub 2021 Dec 20
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Illan-Gala I, Nigro S, VandeVrede L, Falgas N, Heuer HW, Painous C, Compta Y, Marti MJ, Montal V, Pagonabarraga J, Kulisevsky J, Lleo A, Fortea J, Logroscino G, Quattrone A, Quattrone A, Perry DC, Gorno-Tempini ML, Rosen HJ, Grinberg LT, Spina S, La Joie R, Rabinovici GD, Miller BL, Rojas JC, Seeley WW, Boxer AL. Diagnostic Accuracy of Magnetic Resonance Imaging Measures of Brain Atrophy Across the Spectrum of Progressive Supranuclear Palsy and Corticobasal Degeneration. JAMA Netw Open. 2022 Apr 1; 5 (4):e229588 Epub 2022 Apr 01
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Mattsson-Carlgren N, Grinberg LT, Boxer A, Ossenkoppele R, Jonsson M, Seeley W, Ehrenberg A, Spina S, Janelidze S, Rojas-Martinex J, Rosen H, La Joie R, Lesman-Segev O, Iaccarino L, Kollmorgen G, Ljubenkov P, Eichenlaub U, Gorno-Tempini ML, Miller B, Hansson O, Rabinovici GD. Cerebrospinal Fluid Biomarkers in Autopsy-Confirmed Alzheimer Disease and Frontotemporal Lobar Degeneration. Neurology. 2022 Mar 15; 98 (11):e1137-e1150 Epub 2022 Feb 16
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Ushizima D, Chen Y, Alegro M, Ovando D, Eser R, Lee W, Poon K, Shankar A, Kantamneni N, Satrawada S, Junior EA, Heinsen H, Tosun D, Grinberg LT. Deep learning for Alzheimer's disease: Mapping large-scale histological tau protein for neuroimaging biomarker validation. Neuroimage. 2022 Mar; 248:118790 Epub 2021 Dec 20
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Llibre-Guerra JJ, Li Y, Allen IE, Llibre-Guerra JC, Rodriguez Salgado AM, Penalver AI, Almirall Sanchez A, Yokoyama JS, Grinberg L, Valcour V, Miller BL, Llibre-Rodriguez JJ. Race, Genetic Admixture, and Cognitive Performance in the Cuban Population. J Gerontol A Biol Sci Med Sci. 2022 Feb 3; 77 (2):331-338
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Toller G, Zitser J, Sukhanov P, Grant H, Miller BL, Kramer JH, Rosen HJ, Rankin KP, Grinberg LT. Clinical, neuroimaging, and neuropathological characterization of a patient with Alzheimer's disease syndrome due to Pick's pathology. Neurocase. 2022 Feb; 28 (1):19-28 Epub 2021 Aug 17
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Singleton EH, Pijnenburg YAL, Gami-Patel P, Boon BDC, Bouwman F, Papma JM, Seelaar H, Scheltens P, Grinberg LT, Spina S, Nana AL, Rabinovici GD, Seeley WW, Ossenkoppele R, Dijkstra AA. The behavioral variant of Alzheimer's disease does not show a selective loss of Von Economo and phylogenetically related neurons in the anterior cingulate cortex. Alzheimers Res Ther. 2022 Jan 20; 14(1):11.
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Nowinski CJ, Bureau SC, Buckland ME, Curtis MA, Daneshvar DH, Faull RLM, Grinberg LT, Hill-Yardin EL, Murray HC, Pearce AJ, Suter CM, White AJ, Finkel AM, Cantu RC. Applying the Bradford Hill Criteria for Causation to Repetitive Head Impacts and Chronic Traumatic Encephalopathy. Front Neurol. 2022; 13:938163 Epub 2022 July 22
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Matias I, Diniz LP, Damico IV, Araujo APB, Neves LDS, Vargas G, Leite REP, Suemoto CK, Nitrini R, Jacob-Filho W, Grinberg LT, Hol EM, Middeldorp J, Gomes FCA. Loss of lamin-B1 and defective nuclear morphology are hallmarks of astrocyte senescence in vitro and in the aging human hippocampus. Aging Cell. 2022 Jan; 21 (1):e13521 Epub 2021 Dec 10
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Suemoto CK, Nunes PV, Leite REP, Ferretti-Rebustini REL, Pasqualucci CA, Nitrini R, Rodriguez RD, Grinberg LT, Jacob-Filho W. Neuropsychiatric symptoms in community-dwelling older Brazilians with mild cognitive impairment and dementia. Alzheimers Dement (Amst). 2022; 14 (1):e12343 Epub 2022 July 13
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Nascimento C, Nunes PV, Kim HK, Leite REP, Rodriguez RD, De Oliveira KC, Brentani HP, Jacob-Filho W, Nitrini R, Pasqualucci CA, Grinberg LT, Suemoto CK, Lafer B. Increased levels of TAR DNA-binding protein 43 in the hippocampus of subjects with bipolar disorder: a postmortem study. J Neural Transm (Vienna). 2022 Jan; 129 (1):95-103 Epub 2021 Dec 29
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de Paula Franca Resende E, Ketelle R, Karydas A, Allen I, Grinberg LT, Spina S, Seeley WW, Perry DC, Miller B, Naasan G. Late-Onset Alcohol Abuse as a Presenting Symptom of Neurodegenerative Diseases. J Alzheimers Dis. 2022; 86 (3):1073-1080
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Costa NRD, Mancine L, Salvini R, Teixeira JM, Rodriguez RD, Leite REP, Nascimento C, Pasqualucci CA, Nitrini R, Jacob-Filho W, Lafer B, Grinberg LT, Suemoto CK, Nunes PV. Microcephaly measurement in adults and its association with clinical variables. Rev Saude Publica. 2022; 56:38 Epub 2022 May 27
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Apostolova LG, Aisen P, Eloyan A, Fagan A, Fargo KN, Foroud T, Gatsonis C, Grinberg LT, Jack CR Jr, Kramer J, Koeppe R, Kukull WA, Murray ME, Nudelman K, Rumbaugh M, Toga A, Vemuri P, Trullinger A, Iaccarino L, Day GS, Graff-Radford NR, Honig LS, Jones DT, Masdeu J, Mendez M, Musiek E, Onyike CU, Rogalski E, Salloway S, Wolk DA, Wingo TS, Carrillo MC, Dickerson BC, Rabinovici GD, LEADS Consortium. The Longitudinal Early-onset Alzheimer's Disease Study (LEADS): Framework and methodology. Alzheimers Dement. 2021 Dec; 17(12):2043-2055. Epub 2021 May 21.
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Lew CH, Petersen C, Neylan TC, Grinberg LT. Tau-driven degeneration of sleep- and wake-regulating neurons in Alzheimer's disease. Sleep Med Rev. 2021 Dec; 60:101541 Epub 2021 Aug 16
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Ranasinghe KG, Petersen C, Kudo K, Mizuiri D, Rankin KP, Rabinovici GD, Gorno-Tempini ML, Seeley WW, Spina S, Miller BL, Vossel K, Grinberg LT, Nagarajan SS. Reduced synchrony in alpha oscillations during life predicts post mortem neurofibrillary tangle density in early-onset and atypical Alzheimer's disease. Alzheimers Dement. 2021 Dec; 17 (12):2009-2019 Epub 2021 Apr 21
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Rimal S, Li Y, Vartak R, Geng J, Tantray I, Li S, Huh S, Vogel H, Glabe C, Grinberg LT, Spina S, Seeley WW, Guo S, Lu B. Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer's disease. Acta Neuropathol Commun. 2021 Oct 18; 9 (1):169
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Thijssen EH, La Joie R, Strom A, Fonseca C, Iaccarino L, Wolf A, Spina S, Allen IE, Cobigo Y, Heuer H, VandeVrede L, Proctor NK, Lago AL, Baker S, Sivasankaran R, Kieloch A, Kinhikar A, Yu L, Valentin MA, Jeromin A, Zetterberg H, Hansson O, Mattsson-Carlgren N, Graham D, Blennow K, Kramer JH, Grinberg LT, Seeley WW, Rosen H, Boeve BF, Miller BL, Teunissen CE, Rabinovici GD, Rojas JC, Dage JL, Boxer AL, Advancing Research and Treatment for Frontotemporal Lobar Degeneration investigators. Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers in Alzheimer's disease and frontotemporal lobar degeneration: a retrospective diagnostic performance study. Lancet Neurol. 2021 Sep; 20(9):739-752.
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Spina S, La Joie R, Petersen C, Nolan AL, Cuevas D, Cosme C, Hepker M, Hwang JH, Miller ZA, Huang EJ, Karydas AM, Grant H, Boxer AL, Gorno-Tempini ML, Rosen HJ, Kramer JH, Miller BL, Seeley WW, Rabinovici GD, Grinberg LT. Comorbid neuropathological diagnoses in early versus late-onset Alzheimer's disease. Brain. 2021 Aug 17; 144 (7):2186-2198
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Illan-Gala I, Casaletto KB, Borrego-Ecija S, Arenaza-Urquijo EM, Wolf A, Cobigo Y, Goh SYM, Staffaroni AM, Alcolea D, Fortea J, Blesa R, Clarimon J, Iulita MF, Brugulat-Serrat A, Llado A, Grinberg LT, Possin K, Rankin KP, Kramer JH, Rabinovici GD, Boxer A, Seeley WW, Sturm VE, Gorno-Tempini ML, Miller BL, Sanchez-Valle R, Perry DC, Lleo A, Rosen HJ. Sex differences in the behavioral variant of frontotemporal dementia: A new window to executive and behavioral reserve. Alzheimers Dement. 2021 Aug; 17 (8):1329-1341 Epub 2021 Feb 16
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Falgas N, Walsh CM, Neylan TC, Grinberg LT. Deepen into sleep and wake patterns across Alzheimer's disease phenotypes. Alzheimers Dement. 2021 Aug; 17 (8):1403-1406 Epub 2021 Mar 12
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Matchett BJ, Grinberg LT, Theofilas P, Murray ME. The mechanistic link between selective vulnerability of the locus coeruleus and neurodegeneration in Alzheimer's disease. Acta Neuropathol. 2021 May; 141(5):631-650. Epub 2021 Jan 11.
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Ehrenberg AJ, Leng K, Letourneau KN, Hernandez I, Lew C, Seeley WW, Spina S, Miller B, Heinsen H, Kampmann M, Kosik KS, Grinberg LT. Patterns of neuronal Rhes as a novel hallmark of tauopathies. Acta Neuropathol. 2021 May; 141 (5):651-666 Epub 2021 Mar 07
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Llibre-Guerra JJ, Lee SE, Suemoto CK, Ehrenberg AJ, Kovacs GG, Karydas A, Staffaroni A, Franca Resende EP, Kim EJ, Hwang JH, Ramos EM, Wojta KJ, Pasquini L, Pang SY, Spina S, Allen IE, Kramer J, Miller BL, Seeley WW, Grinberg LT. A novel temporal-predominant neuro-astroglial tauopathy associated with TMEM106B gene polymorphism in FTLD/ALS-TDP. Brain Pathol. 2021 Mar; 31 (2):267-282 Epub 2021 Feb 11
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Illan-Gala I, Falgas N, Friedberg A, Castro-Suarez S, Keret O, Rogers N, Oz D, Nigro S, Quattrone A, Quattrone A, Wolf A, Younes K, Santos-Santos M, Borrego-Ecija S, Cobigo Y, Dols-Icardo O, Llado A, Sanchez-Valle R, Clarimon J, Blesa R, Alcolea D, Fortea J, Lleo A, Grinberg LT, Spina S, Kramer JH, Rabinovici GD, Boxer A, Gorno Tempini ML, Miller BL, Seeley WW, Rosen HJ, Perry DC. Diagnostic Utility of Measuring Cerebral Atrophy in the Behavioral Variant of Frontotemporal Dementia and Association With Clinical Deterioration. JAMA Netw Open. 2021 Mar 1; 4 (3):e211290 Epub 2021 Mar 01
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Illan-Gala I, Lleo A, Karydas A, Staffaroni AM, Zetterberg H, Sivasankaran R, Grinberg LT, Spina S, Kramer JH, Ramos EM, Coppola G, La Joie R, Rabinovici GD, Perry DC, Gorno-Tempini ML, Seeley WW, Miller BL, Rosen HJ, Blennow K, Boxer AL, Rojas JC. Plasma Tau and Neurofilament Light in Frontotemporal Lobar Degeneration and Alzheimer Disease. Neurology. 2021 Feb 2; 96 (5):e671-e683 Epub 2020 Nov 16
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Parra MA, Baez S, Sedeno L, Gonzalez Campo C, Santamaria-Garcia H, Aprahamian I, Bertolucci PH, Bustin J, Camargos Bicalho MA, Cano-Gutierrez C, Caramelli P, Chaves MLF, Cogram P, Beber BC, Court FA, de Souza LC, Custodio N, Damian A, de la Cruz M, Diehl Rodriguez R, Brucki SMD, Fajersztajn L, Farias GA, De Felice FG, Ferrari R, de Oliveira FF, Ferreira ST, Ferretti C, Figueredo Balthazar ML, Ferreira Frota NA, Fuentes P, Garcia AM, Garcia PJ, de Gobbi Porto FH, Duque Penailillo L, Engler HW, Maier I, Mata IF, Gonzalez-Billault C, Lopez OL, Morelli L, Nitrini R, Quiroz YT, Guerrero Barragan A, Huepe D, Pio FJ, Suemoto CK, Kochhann R, Kochen S, Kumfor F, Lanata S, Miller B, Mansur LL, Hosogi ML, Lillo P, Llibre Guerra J, Lira D, Lopera F, Comas A, Avila-Funes JA, Sosa AL, Ramos C, Resende EPF, Snyder HM, Tarnanas I, Yokoyama J, Llibre J, Cardona JF, Possin K, Kosik KS, Montesinos R, Moguilner S, Solis PCL, Ferretti-Rebustini REL, Ramirez JM, Matallana D, Mbakile-Mahlanza L, Marques Ton AM, Tavares RM, Miotto EC, Muniz-Terrera G, Munoz-Nevarez LA, Orozco D, Okada de Oliveira M, Piguet O, Pintado Caipa M, Pina Escudero SD, Schilling LP, Rodrigues Palmeira AL, Yassuda MS, Santacruz-Escudero JM, Serafim RB, Smid J, Slachevsky A, Serrano C, Soto-Anari M, Takada LT, Grinberg LT, Teixeira AL, Barbosa MT, Trepel D, Ibanez A. Dementia in Latin America: Paving the way toward a regional action plan. Alzheimers Dement. 2021 Feb; 17 (2):295-313 Epub 2020 Nov 20
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Lesman-Segev OH, La Joie R, Iaccarino L, Lobach I, Rosen HJ, Seo SW, Janabi M, Baker SL, Edwards L, Pham J, Olichney J, Boxer A, Huang E, Gorno-Tempini M, DeCarli C, Hepker M, Hwang JL, Miller BL, Spina S, Grinberg LT, Seeley WW, Jagust WJ, Rabinovici GD. Diagnostic Accuracy of Amyloid versus (18) F-Fluorodeoxyglucose Positron Emission Tomography in Autopsy-Confirmed Dementia. Ann Neurol. 2021 Feb; 89 (2):389-401 Epub 2020 Dec 07
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Attems J, Toledo JB, Walker L, Gelpi E, Gentleman S, Halliday G, Hortobagyi T, Jellinger K, Kovacs GG, Lee EB, Love S, McAleese KE, Nelson PT, Neumann M, Parkkinen L, Polvikoski T, Sikorska B, Smith C, Grinberg LT, Thal DR, Trojanowski JQ, McKeith IG. Neuropathological consensus criteria for the evaluation of Lewy pathology in post-mortem brains: a multi-centre study. Acta Neuropathol. 2021 Feb; 141 (2):159-172 Epub 2021 Jan 05
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Leng K, Li E, Eser R, Piergies A, Sit R, Tan M, Neff N, Li SH, Rodriguez RD, Suemoto CK, Leite REP, Ehrenberg AJ, Pasqualucci CA, Seeley WW, Spina S, Heinsen H, Grinberg LT, Kampmann M. Molecular characterization of selectively vulnerable neurons in Alzheimer's disease. Nat Neurosci. 2021 Feb; 24 (2):276-287 Epub 2021 Jan 11
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Tahira A, Marques F, Lisboa B, Feltrin A, Barbosa A, de Oliveira KC, de Braganca Pereira CA, Leite R, Grinberg L, Suemoto C, de Lucena Ferretti-Rebustini RE, Pasqualucci CA, Jacob-Filho W, Brentani H, Palha JA. Are the 50's, the transition decade, in choroid plexus aging? Geroscience. 2021 Feb; 43 (1):225-237 Epub 2021 Feb 12
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Blevins BL, Vinters HV, Love S, Wilcock DM, Grinberg LT, Schneider JA, Kalaria RN, Katsumata Y, Gold BT, Wang DJJ, Ma SJ, Shade LMP, Fardo DW, Hartz AMS, Jicha GA, Nelson KB, Magaki SD, Schmitt FA, Teylan MA, Ighodaro ET, Phe P, Abner EL, Cykowski MD, Van Eldik LJ, Nelson PT. Brain arteriolosclerosis. Acta Neuropathol. 2021 Jan; 141(1):1-24. Epub 2020 Oct 24.
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Berry K, Farias-Itao DS, Grinberg LT, Plowey ED, Schneider JA, Rodriguez RD, Suemoto CK, Buckwalter MS. B and T Lymphocyte Densities Remain Stable With Age in Human Cortex. ASN Neuro. 2021 Jan-Dec; 13:17590914211018117
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Saldanha NM, Suemoto CK, Rodriguez RD, Leite REP, Nascimento C, Ferreti-Rebustini R, da Silva MM, Pasqualucci CA, Nitrini R, Jacob-Filho W, Lafer B, Grinberg LT, Nunes PV. beta-amyloid pathology is not associated with depression in a large community sample autopsy study. J Affect Disord. 2021 Jan 1; 278:372-381 Epub 2020 Sept 15
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Ciciliati AMM, Adriazola IO, Souza Farias-Itao D, Pasqualucci CA, Leite REP, Nitrini R, Grinberg LT, Jacob-Filho W, Suemoto CK. Severe Dementia Predicts Weight Loss by the Time of Death. Front Neurol. 2021; 12:610302 Epub 2021 May 14
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Real CC, Suemoto CK, Binda KH, Grinberg LT, Pasqualucci CA, Jacob W, Ferretti-Rebustini REL, Nitrini R, Leite REP, de Britto LR. Active lifestyle enhances protein expression profile in subjects with Lewy body pathology. Dement Neuropsychol. 2021 Jan-Mar; 15 (1):41-50
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Falgas N, Illan-Gala I, Allen IE, Mumford P, Essanaa YM, Le MM, You M, Grinberg LT, Rosen HJ, Neylan TC, Kramer JH, Walsh CM. Specific cortical and subcortical grey matter regions are associated with insomnia severity. PLoS One. 2021; 16 (5):e0252076 Epub 2021 May 26
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Wesseling H, Mair W, Kumar M, Schlaffner CN, Tang S, Beerepoot P, Fatou B, Guise AJ, Cheng L, Takeda S, Muntel J, Rotunno MS, Dujardin S, Davies P, Kosik KS, Miller BL, Berretta S, Hedreen JC, Grinberg LT, Seeley WW, Hyman BT, Steen H, Steen JA. Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer's Disease. Cell. 2020 Dec 10; 183 (6):1699-1713.e13 Epub 2020 Nov 13
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Soleimani-Meigooni DN, Iaccarino L, La Joie R, Baker S, Bourakova V, Boxer AL, Edwards L, Eser R, Gorno-Tempini ML, Jagust WJ, Janabi M, Kramer JH, Lesman-Segev OH, Mellinger T, Miller BL, Pham J, Rosen HJ, Spina S, Seeley WW, Strom A, Grinberg LT, Rabinovici GD. 18F-flortaucipir PET to autopsy comparisons in Alzheimer's disease and other neurodegenerative diseases. Brain. 2020 Dec 5; 143 (11):3477-3494
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Plum S, Eggers B, Helling S, Stepath M, Theiss C, Leite REP, Molina M, Grinberg LT, Riederer P, Gerlach M, May C, Marcus K. Proteomic Characterization of Synaptosomes from Human Substantia Nigra Indicates Altered Mitochondrial Translation in Parkinson's Disease. Cells. 2020 Dec 2; 9 (12) Epub 2020 Dec 02
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Arrant AE, Davis SE, Vollmer RM, Murchison CF, Mobley JA, Nana AL, Spina S, Grinberg LT, Karydas AM, Miller BL, Seeley WW, Roberson ED. Elevated levels of extracellular vesicles in progranulin-deficient mice and FTD-GRN Patients. Ann Clin Transl Neurol. 2020 Dec; 7 (12):2433-2449 Epub 2020 Nov 16
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Nascimento C, Nunes PV, Suemoto CK, Rodriguez RD, Leite REP, Grinberg LT, Pasqualucci CA, Nitrini R, Jacob-Filho W, Brentani HP, Lafer B. Differential levels of inflammatory and neuroendocrine markers in the hippocampus and anterior cingulate cortex of bipolar disorder subjects: A post-mortem study. Brain Behav Immun. 2020 Nov; 90:286-293 Epub 2020 Sept 16
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Pasquini L, Nana AL, Toller G, Brown JA, Deng J, Staffaroni A, Kim EJ, Hwang JL, Li L, Park Y, Gaus SE, Allen I, Sturm VE, Spina S, Grinberg LT, Rankin KP, Kramer JH, Rosen HJ, Miller BL, Seeley WW. Salience Network Atrophy Links Neuron Type-Specific Pathobiology to Loss of Empathy in Frontotemporal Dementia. Cereb Cortex. 2020 Sep 3; 30 (10):5387-5399
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Dos Santos SE, Medeiros M, Porfirio J, Tavares W, Pessoa L, Grinberg L, Leite REP, Ferretti-Rebustini REL, Suemoto CK, Filho WJ, Noctor SC, Sherwood CC, Kaas JH, Manger PR, Herculano-Houzel S. Similar Microglial Cell Densities across Brain Structures and Mammalian Species: Implications for Brain Tissue Function. J Neurosci. 2020 Jun 10; 40 (24):4622-4643 Epub 2020 Apr 06
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Ehrenberg AJ, Khatun A, Coomans E, Betts MJ, Capraro F, Thijssen EH, Senkevich K, Bharucha T, Jafarpour M, Young PNE, Jagust W, Carter SF, Lashley T, Grinberg LT, Pereira JB, Mattsson-Carlgren N, Ashton NJ, Hanrieder J, Zetterberg H, Scholl M, Paterson RW. Correction to: Relevance of biomarkers across different neurodegenerative diseases. Alzheimers Res Ther. 2020 Jun 9; 12 (1):71 Epub 2020 June 09
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Ehrenberg AJ, Morales DO, Piergies AMH, Li SH, Tejedor JS, Mladinov M, Mulder J, Grinberg LT. A manual multiplex immunofluorescence method for investigating neurodegenerative diseases. J Neurosci Methods. 2020 Jun 1; 339:108708 Epub 2020 Mar 31
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Ehrenberg AJ, Khatun A, Coomans E, Betts MJ, Capraro F, Thijssen EH, Senkevich K, Bharucha T, Jafarpour M, Young PNE, Jagust W, Carter SF, Lashley T, Grinberg LT, Pereira JB, Mattsson-Carlgren N, Ashton NJ, Hanrieder J, Zetterberg H, Scholl M, Paterson RW. Relevance of biomarkers across different neurodegenerative diseases. Alzheimers Res Ther. 2020 May 13; 12 (1):56
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Mantyh WG, Spina S, Lee A, Iaccarino L, Soleimani-Meigooni D, Tsoy E, Mellinger TJ, Grant H, Vandevrede L, La Joie R, Lesman-Segev O, Gaus S, Possin KL, Grinberg LT, Miller BL, Seeley WW, Rabinovici GD. Tau Positron Emission Tomographic Findings in a Former US Football Player With Pathologically Confirmed Chronic Traumatic Encephalopathy. JAMA Neurol. 2020 Apr 1; 77 (4):517-521
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Caso F, Agosta F, Magnani G, Cardamone R, Borghesani V, Miller Z, Riva N, La Joie R, Coppola G, Grinberg LT, Seeley WW, Miller BL, Gorno-Tempini ML, Filippi M. Temporal variant of frontotemporal dementia in C9orf72 repeat expansion carriers: two case studies. Brain Imaging Behav. 2020 Apr; 14 (2):336-345
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Resende EPF, Nolan AL, Petersen C, Ehrenberg AJ, Spina S, Allen IE, Rosen HJ, Kramer J, Miller BL, Seeley WW, Gorno-Tempini ML, Miller Z, Grinberg LT. Language and spatial dysfunction in Alzheimer disease with white matter thorn-shaped astrocytes. Neurology. 2020 Mar 31; 94 (13):e1353-e1364 Epub 2020 Jan 30
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Thijssen EH, La Joie R, Wolf A, Strom A, Wang P, Iaccarino L, Bourakova V, Cobigo Y, Heuer H, Spina S, VandeVrede L, Chai X, Proctor NK, Airey DC, Shcherbinin S, Duggan Evans C, Sims JR, Zetterberg H, Blennow K, Karydas AM, Teunissen CE, Kramer JH, Grinberg LT, Seeley WW, Rosen H, Boeve BF, Miller BL, Rabinovici GD, Dage JL, Rojas JC, Boxer AL, Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL) investigators. Diagnostic value of plasma phosphorylated tau181 in Alzheimer's disease and frontotemporal lobar degeneration. Nat Med. 2020 Mar; 26 (3):387-397 Epub 2020 Mar 02
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Selles MC, Fortuna JTS, Zappa-Villar MF, de Faria YPR, Souza AS, Suemoto CK, Leite REP, Rodriguez RD, Grinberg LT, Reggiani PC, Ferreira ST. Adenovirus-Mediated Transduction of Insulin-Like Growth Factor 1 Protects Hippocampal Neurons from the Toxicity of Abeta Oligomers and Prevents Memory Loss in an Alzheimer Mouse Model. Mol Neurobiol. 2020 Mar; 57 (3):1473-1483 Epub 2019 Nov 23
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Saijo E, Metrick MA 2nd, Koga S, Parchi P, Litvan I, Spina S, Boxer A, Rojas JC, Galasko D, Kraus A, Rossi M, Newell K, Zanusso G, Grinberg LT, Seeley WW, Ghetti B, Dickson DW, Caughey B. Correction to: 4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration. Acta Neuropathol. 2020 Jan; 139 (1):79-81
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Saijo E, Metrick MA 2nd, Koga S, Parchi P, Litvan I, Spina S, Boxer A, Rojas JC, Galasko D, Kraus A, Rossi M, Newell K, Zanusso G, Grinberg LT, Seeley WW, Ghetti B, Dickson DW, Caughey B. 4-Repeat tau seeds and templating subtypes as brain and CSF biomarkers of frontotemporal lobar degeneration. Acta Neuropathol. 2020 Jan; 139 (1):63-77 Epub 2019 Oct 16
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Kim EJ, Hwang JL, Gaus SE, Nana AL, Deng J, Brown JA, Spina S, Lee MJ, Ramos EM, Grinberg LT, Kramer JH, Boxer AL, Gorno-Tempini ML, Rosen HJ, Miller BL, Seeley WW. Evidence of corticofugal tau spreading in patients with frontotemporal dementia. Acta Neuropathol. 2020 Jan; 139 (1):27-43 Epub 2019 Sept 21
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Borghesani V, Battistella G, Mandelli ML, Welch A, Weis E, Younes K, Neuhaus J, Grinberg LT, Seeley WM, Spina S, Miller B, Miller Z, Gorno-Tempini ML. Regional and hemispheric susceptibility of the temporal lobe to FTLD-TDP type C pathology. Neuroimage Clin. 2020; 28:102369 Epub 2020 Aug 06
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Arrant AE, Roth JR, Boyle NR, Kashyap SN, Hoffmann MQ, Murchison CF, Ramos EM, Nana AL, Spina S, Grinberg LT, Miller BL, Seeley WW, Roberson ED. Impaired beta-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations. Acta Neuropathol Commun. 2019 Dec 23; 7 (1):218
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Farias-Itao DS, Pasqualucci CA, Nishizawa A, da Silva LFF, Campos FM, Bittencourt MS, da Silva KCS, Leite REP, Grinberg LT, Ferretti-Rebustini REL, Jacob-Filho W, Suemoto CK. B Lymphocytes and Macrophages in the Perivascular Adipose Tissue Are Associated With Coronary Atherosclerosis: An Autopsy Study. J Am Heart Assoc. 2019 Dec 17; 8 (24):e013793 Epub 2019 Dec 10
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Chen JJ, Nathaniel DL, Raghavan P, Nelson M, Tian R, Tse E, Hong JY, See SK, Mok SA, Hein MY, Southworth DR, Grinberg LT, Gestwicki JE, Leonetti MD, Kampmann M. Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation. J Biol Chem. 2019 Dec 13; 294 (50):18952-18966 Epub 2019 Oct 02
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Brown JA, Deng J, Neuhaus J, Sible IJ, Sias AC, Lee SE, Kornak J, Marx GA, Karydas AM, Spina S, Grinberg LT, Coppola G, Geschwind DH, Kramer JH, Gorno-Tempini ML, Miller BL, Rosen HJ, Seeley WW. Patient-Tailored, Connectivity-Based Forecasts of Spreading Brain Atrophy. Neuron. 2019 Dec 4; 104 (5):856-868.e5 Epub 2019 Oct 14
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Nolan A, De Paula Franca Resende E, Petersen C, Neylan K, Spina S, Huang E, Seeley W, Miller Z, Grinberg LT. Astrocytic Tau Deposition Is Frequent in Typical and Atypical Alzheimer Disease Presentations. J Neuropathol Exp Neurol. 2019 Dec 1; 78 (12):1112-1123
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Karch CM, Kao AW, Karydas A, Onanuga K, Martinez R, Argouarch A, Wang C, Huang C, Sohn PD, Bowles KR, Spina S, Silva MC, Marsh JA, Hsu S, Pugh DA, Ghoshal N, Norton J, Huang Y, Lee SE, Seeley WW, Theofilas P, Grinberg LT, Moreno F, McIlroy K, Boeve BF, Cairns NJ, Crary JF, Haggarty SJ, Ichida JK, Kosik KS, Miller BL, Gan L, Goate AM, Temple S, Tau Consortium Stem Cell Group. A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies. Stem Cell Reports. 2019 Nov 12; 13(5):939-955. Epub 2019 Oct 17.
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Suemoto CK, Leite REP, Ferretti-Rebustini REL, Rodriguez RD, Nitrini R, Pasqualucci CA, Jacob-Filho W, Grinberg LT. Neuropathological lesions in the very old: results from a large Brazilian autopsy study. Brain Pathol. 2019 Nov; 29 (6):771-781 Epub 2019 Apr 10
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Lin LC, Nana AL, Hepker M, Hwang JL, Gaus SE, Spina S, Cosme CG, Gan L, Grinberg LT, Geschwind DH, Coppola G, Rosen HJ, Miller BL, Seeley WW. Preferential tau aggregation in von Economo neurons and fork cells in frontotemporal lobar degeneration with specific MAPT variants. Acta Neuropathol Commun. 2019 Oct 22; 7 (1):159
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Oh J, Eser RA, Ehrenberg AJ, Morales D, Petersen C, Kudlacek J, Dunlop SR, Theofilas P, Resende EDPF, Cosme C, Alho EJL, Spina S, Walsh CM, Miller BL, Seeley WW, Bittencourt JC, Neylan TC, Heinsen H, Grinberg LT. Profound degeneration of wake-promoting neurons in Alzheimer's disease. Alzheimers Dement. 2019 Oct; 15(10):1253-1263. Epub 2019 Aug 12.
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Petersen C, Nolan AL, de Paula Franca Resende E, Miller Z, Ehrenberg AJ, Gorno-Tempini ML, Rosen HJ, Kramer JH, Spina S, Rabinovici GD, Miller BL, Seeley WW, Heinsen H, Grinberg LT. Alzheimer's disease clinical variants show distinct regional patterns of neurofibrillary tangle accumulation. Acta Neuropathol. 2019 Oct; 138 (4):597-612 Epub 2019 June 27
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Oh J, Petersen C, Walsh CM, Bittencourt JC, Neylan TC, Grinberg LT. The role of co-neurotransmitters in sleep and wake regulation. Mol Psychiatry. 2019 Sep; 24 (9):1284-1295 Epub 2018 Oct 30
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Betts MJ, Kirilina E, Otaduy MCG, Ivanov D, Acosta-Cabronero J, Callaghan MF, Lambert C, Cardenas-Blanco A, Pine K, Passamonti L, Loane C, Keuken MC, Trujillo P, Lusebrink F, Mattern H, Liu KY, Priovoulos N, Fliessbach K, Dahl MJ, Maass A, Madelung CF, Meder D, Ehrenberg AJ, Speck O, Weiskopf N, Dolan R, Inglis B, Tosun D, Morawski M, Zucca FA, Siebner HR, Mather M, Uludag K, Heinsen H, Poser BA, Howard R, Zecca L, Rowe JB, Grinberg LT, Jacobs HIL, Duzel E, Hammerer D. Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases. Brain. 2019 Sep 1; 142 (9):2558-2571
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Ravalin M, Theofilas P, Basu K, Opoku-Nsiah KA, Assimon VA, Medina-Cleghorn D, Chen YF, Bohn MF, Arkin M, Grinberg LT, Craik CS, Gestwicki JE. Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases. Nat Chem Biol. 2019 Aug; 15 (8):786-794 Epub 2019 July 18
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Nascimento C, Nunes VP, Diehl Rodriguez R, Takada L, Suemoto CK, Grinberg LT, Nitrini R, Lafer B. A review on shared clinical and molecular mechanisms between bipolar disorder and frontotemporal dementia. Prog Neuropsychopharmacol Biol Psychiatry. 2019 Jul 13; 93:269-283 Epub 2019 Apr 20
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Spina S, Brown JA, Deng J, Gardner RC, Nana AL, Hwang JL, Gaus SE, Huang EJ, Kramer JH, Rosen HJ, Kornak J, Neuhaus J, Miller BL, Grinberg LT, Boxer AL, Seeley WW. Neuropathological correlates of structural and functional imaging biomarkers in 4-repeat tauopathies. Brain. 2019 Jul 1; 142 (7):2068-2081
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Pottier C, Ren Y, Perkerson RB 3rd, Baker M, Jenkins GD, van Blitterswijk M, DeJesus-Hernandez M, van Rooij JGJ, Murray ME, Christopher E, McDonnell SK, Fogarty Z, Batzler A, Tian S, Vicente CT, Matchett B, Karydas AM, Hsiung GR, Seelaar H, Mol MO, Finger EC, Graff C, Öijerstedt L, Neumann M, Heutink P, Synofzik M, Wilke C, Prudlo J, Rizzu P, Simon-Sanchez J, Edbauer D, Roeber S, Diehl-Schmid J, Evers BM, King A, Mesulam MM, Weintraub S, Geula C, Bieniek KF, Petrucelli L, Ahern GL, Reiman EM, Woodruff BK, Caselli RJ, Huey ED, Farlow MR, Grafman J, Mead S, Grinberg LT, Spina S, Grossman M, Irwin DJ, Lee EB, Suh E, Snowden J, Mann D, Ertekin-Taner N, Uitti RJ, Wszolek ZK, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Hodges JR, Piguet O, Geier EG, Yokoyama JS, Rissman RA, Rogaeva E, Keith J, Zinman L, Tartaglia MC, Cairns NJ, Cruchaga C, Ghetti B, Kofler J, Lopez OL, Beach TG, Arzberger T, Herms J, Honig LS, Vonsattel JP, Halliday GM, Kwok JB, White CL 3rd, Gearing M, Glass J, Rollinson S, Pickering-Brown S, Rohrer JD, Trojanowski JQ, Van Deerlin V, Bigio EH, Troakes C, Al-Sarraj S, Asmann Y, Miller BL, Graff-Radford NR, Boeve BF, Seeley WW, Mackenzie IRA, van Swieten JC, Dickson DW, Biernacka JM, Rademakers R. Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD. Acta Neuropathol. 2019 Jun; 137(6):879-899. Epub 2019 Feb 09.
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Vinceti G, Olney N, Mandelli ML, Spina S, Hubbard HI, Santos-Santos MA, Watson C, Miller ZA, Lomen-Hoerth C, Nichelli P, Miller BL, Grinberg LT, Seeley WW, Gorno-Tempini ML. Primary progressive aphasia and the FTD-MND spectrum disorders: clinical, pathological, and neuroimaging correlates. Amyotroph Lateral Scler Frontotemporal Degener. 2019 May; 20 (3-4):146-158 Epub 2019 Jan 22
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Liu J, Heinsen H, Grinberg LT, Alho E, Amaro E Jr, Pasqualucci CA, Rub U, Seidel K, den Dunnen W, Arzberger T, Schmitz C, Kiessling MC, Bader B, Danek A. Pathoarchitectonics of the cerebral cortex in chorea-acanthocytosis and Huntington's disease. Neuropathol Appl Neurobiol. 2019 Apr; 45 (3):230-243 Epub 2018 June 10
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O'Sullivan S, Heinsen H, Grinberg LT, Chimelli L, Amaro E Jr, do Nascimento Saldiva PH, Jeanquartier F, Jean-Quartier C, da Graca Morais Martin M, Sajid MI, Holzinger A. The role of artificial intelligence and machine learning in harmonization of high-resolution post-mortem MRI (virtopsy) with respect to brain microstructure. Brain Inform. 2019 Mar 7; 6 (1):3 Epub 2019 Mar 07
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Godoy MDCL, Fornazieri MA, Doty RL, Pinna FR, Farfel JM, Santos GBD, Molina M, Ferretti-Rebustini REL, Leite REP, Suemoto CK, Grinberg LT, Pasqualucci CAG, Voegels RL, Nitrini R, Jacob Filho W. Is Olfactory Epithelium Biopsy Useful for Confirming Alzheimer's Disease? Ann Otol Rhinol Laryngol. 2019 Mar; 128 (3):184-192 Epub 2018 Dec 02
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Woerman AL, Oehler A, Kazmi SA, Lee J, Halliday GM, Middleton LT, Gentleman SM, Mordes DA, Spina S, Grinberg LT, Olson SH, Prusiner SB. Multiple system atrophy prions retain strain specificity after serial propagation in two different Tg(SNCA*A53T) mouse lines. Acta Neuropathol. 2019 Mar; 137 (3):437-454 Epub 2019 Jan 28
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Lisboa BCG, Oliveira KC, Tahira AC, Barbosa AR, Feltrin AS, Gouveia G, Lima L, Feio Dos Santos AC, Martins DC Jr, Puga RD, Moretto AC, De Braganca Pereira CA, Lafer B, Leite REP, Ferretti-Rebustini REL, Farfel JM, Grinberg LT, Jacob-Filho W, Miguel EC, Hoexter MQ, Brentani H. Initial findings of striatum tripartite model in OCD brain samples based on transcriptome analysis. Sci Rep. 2019 Feb 28; 9 (1):3086
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Staffaroni AM, Ljubenkov PA, Kornak J, Cobigo Y, Datta S, Marx G, Walters SM, Chiang K, Olney N, Elahi FM, Knopman DS, Dickerson BC, Boeve BF, Gorno-Tempini ML, Spina S, Grinberg LT, Seeley WW, Miller BL, Kramer JH, Boxer AL, Rosen HJ. Longitudinal multimodal imaging and clinical endpoints for frontotemporal dementia clinical trials. Brain. 2019 Feb 01; 142(2):443-459.
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La Joie R, Ayakta N, Seeley WW, Borys E, Boxer AL, DeCarli C, Doré V, Grinberg LT, Huang E, Hwang JH, Ikonomovic MD, Jack C Jr, Jagust WJ, Jin LW, Klunk WE, Kofler J, Lesman-Segev OH, Lockhart SN, Lowe VJ, Masters CL, Mathis CA, McLean CL, Miller BL, Mungas D, O'Neil JP, Olichney JM, Parisi JE, Petersen RC, Rosen HJ, Rowe CC, Spina S, Vemuri P, Villemagne VL, Murray ME, Rabinovici GD. Multisite study of the relationships between antemortem [11C]PIB-PET Centiloid values and postmortem measures of Alzheimer's disease neuropathology. Alzheimers Dement. 2019 Feb; 15(2):205-216. Epub 2018 Oct 19.
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De Leon J, Mandelli ML, Nolan A, Miller ZA, Mead C, Watson C, Welch AE, Henry ML, Bourakova V, La Joie R, Bajorek LP, Grinberg L, Rabinovici G, Miller BL, Gorno-Tempini ML. Atypical clinical features associated with mixed pathology in a case of non-fluent variant primary progressive aphasia. Neurocase. 2019 Feb-Apr; 25 (1-2):39-47 Epub 2019 Apr 29
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Tsai RM, Bejanin A, Lesman-Segev O, LaJoie R, Visani A, Bourakova V, O'Neil JP, Janabi M, Baker S, Lee SE, Perry DC, Bajorek L, Karydas A, Spina S, Grinberg LT, Seeley WW, Ramos EM, Coppola G, Gorno-Tempini ML, Miller BL, Rosen HJ, Jagust W, Boxer AL, Rabinovici GD. (18)F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes. Alzheimers Res Ther. 2019 Jan 31; 11 (1):13
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Geier EG, Bourdenx M, Storm NJ, Cochran JN, Sirkis DW, Hwang JH, Bonham LW, Ramos EM, Diaz A, Van Berlo V, Dokuru D, Nana AL, Karydas A, Balestra ME, Huang Y, Russo SP, Spina S, Grinberg LT, Seeley WW, Myers RM, Miller BL, Coppola G, Lee SE, Cuervo AM, Yokoyama JS. Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia. Acta Neuropathol. 2019 Jan; 137 (1):71-88 Epub 2018 Oct 31
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Soltys DT, Pereira CPM, Rowies FT, Farfel JM, Grinberg LT, Suemoto CK, Leite REP, Rodriguez RD, Ericson NG, Bielas JH, Souza-Pinto NC. Lower mitochondrial DNA content but not increased mutagenesis associates with decreased base excision repair activity in brains of AD subjects. Neurobiol Aging. 2019 Jan; 73:161-170 Epub 2018 Sept 22
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de Oliveira KC, Grinberg LT, Hoexter MQ, Brentani H, Suemoto CK, Nery FG, Lima LC, Alho ATDL, Farfel JM, Ferretti-Rebustini REL, Leite REP, Moretto AC, da Silva AV, Lafer B, Miguel EC, Nitrini R, Jacob-Filho W, Heinsen H, Pasqualucci CA. Layer-specific reduced neuronal density in the orbitofrontal cortex of older adults with obsessive-compulsive disorder. Brain Struct Funct. 2019 Jan; 224 (1):191-203 Epub 2018 Oct 08
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Nana AL, Sidhu M, Gaus SE, Hwang JL, Li L, Park Y, Kim EJ, Pasquini L, Allen IE, Rankin KP, Toller G, Kramer JH, Geschwind DH, Coppola G, Huang EJ, Grinberg LT, Miller BL, Seeley WW. Neurons selectively targeted in frontotemporal dementia reveal early stage TDP-43 pathobiology. Acta Neuropathol. 2019 Jan; 137 (1):27-46 Epub 2018 Dec 03
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Miller ZA, Spina S, Pakvasa M, Rosenberg L, Watson C, Mandelli ML, Paredes MF, Joie R, Rabinovici GD, Rosen HJ, Grinberg LT, Huang EJ, Miller BL, Seeley WW, Gorno-Tempini ML. Cortical developmental abnormalities in logopenic variant primary progressive aphasia with dyslexia. Brain Commun. 2019; 1 (1):fcz027 Epub 2019 Oct 23
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Nunes PV, Schwarzer MC, Leite REP, Ferretti-Rebustini REL, Pasqualucci CA, Nitrini R, Rodriguez RD, Nascimento CF, Oliveira KC, Grinberg LT, Jacob-Filho W, Lafer B, Suemoto CK. Neuropsychiatric Inventory in Community-Dwelling Older Adults with Mild Cognitive Impairment and Dementia. J Alzheimers Dis. 2019; 68 (2):669-678
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Nishizawa A, Cuelho A, de Farias-Itao DS, Campos FM, Leite REP, Ferretti-Rebustini REL, Grinberg LT, Nitrini R, Jacob-Filho W, Pasqualucci CA, Suemoto CK. Direct Measurements of Abdominal Visceral Fat and Cognitive Impairment in Late Life: Findings From an Autopsy Study. Front Aging Neurosci. 2019; 11:109 Epub 2019 May 07
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Nunes PV, Nascimento CF, Kim HK, Andreazza AC, Brentani HP, Suemoto CK, Leite REP, Ferretti-Rebustini REL, Pasqualucci CA, Nitrini R, Grinberg LT, Yong LT, Jacob-Filho W, Lafer B. Low brain-derived neurotrophic factor levels in post-mortem brains of older adults with depression and dementia in a large clinicopathological sample. J Affect Disord. 2018 Dec 1; 241:176-181 Epub 2018 Aug 09
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Kim EJ, Brown JA, Deng J, Hwang JL, Spina S, Miller ZA, DeMay MG, Valcour V, Karydas A, Ramos EM, Coppola G, Miller BL, Rosen HJ, Seeley WW, Grinberg LT. Mixed TDP-43 proteinopathy and tauopathy in frontotemporal lobar degeneration: nine case series. J Neurol. 2018 Dec; 265 (12):2960-2971 Epub 2018 Oct 15
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Ljubenkov PA, Staffaroni AM, Rojas JC, Allen IE, Wang P, Heuer H, Karydas A, Kornak J, Cobigo Y, Seeley WW, Grinberg LT, Spina S, Fagan AM, Jerome G, Knopman D, Boeve BF, Dickerson BC, Kramer J, Miller B, Boxer AL, Rosen HJ. Cerebrospinal fluid biomarkers predict frontotemporal dementia trajectory. Ann Clin Transl Neurol. 2018 Oct; 5(10):1250-1263. Epub 2018 Sep 20.
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de Souza RKM, Grinberg LT, Josviak ND, de Almeida DB, Ramina R, Kowacs PA, Caramelli P. A patient with posterior cortical atrophy due to Alzheimer's disease. Dement Neuropsychol. 2018 Jul-Sep; 12 (3):326-328
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Pottier C, Zhou X, Perkerson RB 3rd, Baker M, Jenkins GD, Serie DJ, Ghidoni R, Benussi L, Binetti G, López de Munain A, Zulaica M, Moreno F, Le Ber I, Pasquier F, Hannequin D, Sánchez-Valle R, Antonell A, Lladó A, Parsons TM, Finch NA, Finger EC, Lippa CF, Huey ED, Neumann M, Heutink P, Synofzik M, Wilke C, Rissman RA, Slawek J, Sitek E, Johannsen P, Nielsen JE, Ren Y, van Blitterswijk M, DeJesus-Hernandez M, Christopher E, Murray ME, Bieniek KF, Evers BM, Ferrari C, Rollinson S, Richardson A, Scarpini E, Fumagalli GG, Padovani A, Hardy J, Momeni P, Ferrari R, Frangipane F, Maletta R, Anfossi M, Gallo M, Petrucelli L, Suh E, Lopez OL, Wong TH, van Rooij JGJ, Seelaar H, Mead S, Caselli RJ, Reiman EM, Noel Sabbagh M, Kjolby M, Nykjaer A, Karydas AM, Boxer AL, Grinberg LT, Grafman J, Spina S, Oblak A, Mesulam MM, Weintraub S, Geula C, Hodges JR, Piguet O, Brooks WS, Irwin DJ, Trojanowski JQ, Lee EB, Josephs KA, Parisi JE, Ertekin-Taner N, Knopman DS, Nacmias B, Piaceri I, Bagnoli S, Sorbi S, Gearing M, Glass J, Beach TG, Black SE, Masellis M, Rogaeva E, Vonsattel JP, Honig LS, Kofler J, Bruni AC, Snowden J, Mann D, Pickering-Brown S, Diehl-Schmid J, Winkelmann J, Galimberti D, Graff C, Öijerstedt L, Troakes C, Al-Sarraj S, Cruchaga C, Cairns NJ, Rohrer JD, Halliday GM, Kwok JB, van Swieten JC, White CL 3rd, Ghetti B, Murell JR, Mackenzie IRA, Hsiung GR, Borroni B, Rossi G, Tagliavini F, Wszolek ZK, Petersen RC, Bigio EH, Grossman M, Van Deerlin VM, Seeley WW, Miller BL, Graff-Radford NR, Boeve BF, Dickson DW, Biernacka JM, Rademakers R. Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study. Lancet Neurol. 2018 Jun; 17(6):548-558. Epub 2018 Apr 30.
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Miller ZA, Rosenberg L, Santos-Santos MA, Stephens M, Allen IE, Hubbard HI, Cantwell A, Mandelli ML, Grinberg LT, Seeley WW, Miller BL, Rabinovici GD, Gorno-Tempini ML. Prevalence of Mathematical and Visuospatial Learning Disabilities in Patients With Posterior Cortical Atrophy. JAMA Neurol. 2018 Jun 1; 75 (6):728-737
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Nascimento C, Di Lorenzo Alho AT, Bazan Conceicao Amaral C, Leite REP, Nitrini R, Jacob-Filho W, Pasqualucci CA, Hokkanen SRK, Hunter S, Keage H, Kovacs GG, Grinberg LT, Suemoto CK. Prevalence of transactive response DNA-binding protein 43 (TDP-43) proteinopathy in cognitively normal older adults: systematic review and meta-analysis. Neuropathol Appl Neurobiol. 2018 Apr; 44 (3):286-297 Epub 2017 Sept 20
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Caplan A, Marx G, Elofson J, Lis C, Grinberg L, Miller B, Rosen H. A case of semantic variant primary progressive aphasia with Pick's pathology. Neurocase. 2018 Apr; 24 (2):90-94 Epub 2018 Mar 06
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Alho EJL, Alho ATDL, Grinberg L, Amaro E Jr, Dos Santos GAB, da Silva RE, Neves RC, Alegro M, Coelho DB, Teixeira MJ, Fonoff ET, Heinsen H. High thickness histological sections as alternative to study the three-dimensional microscopic human sub-cortical neuroanatomy. Brain Struct Funct. 2018 Apr; 223 (3):1121-1132 Epub 2017 Nov 01
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Liu J, Heinsen H, Grinberg LT, Alho E, Amaro E Jr, Pasqualucci CA, Rub U, den Dunnen W, Arzberger T, Schmitz C, Kiessling M, Bader B, Danek A. Subcortical neurodegeneration in chorea: Similarities and differences between chorea-acanthocytosis and Huntington's disease. Parkinsonism Relat Disord. 2018 Apr; 49:54-59 Epub 2018 Jan 10
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Seo SW, Thibodeau MP, Perry DC, Hua A, Sidhu M, Sible I, Vargas JNS, Gaus SE, Rabinovici GD, Rankin KD, Boxer AL, Kramer JH, Rosen HJ, Gorno-Tempini ML, Grinberg LT, Huang EJ, DeArmond SJ, Trojanowski JQ, Miller BL, Seeley WW. Early vs late age at onset frontotemporal dementia and frontotemporal lobar degeneration. Neurology. 2018 Mar 20; 90 (12):e1047-e1056 Epub 2018 Feb 16
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Santos-Santos MA, Rabinovici GD, Iaccarino L, Ayakta N, Tammewar G, Lobach I, Henry ML, Hubbard I, Mandelli ML, Spinelli E, Miller ZA, Pressman PS, O'Neil JP, Ghosh P, Lazaris A, Meyer M, Watson C, Yoon SJ, Rosen HJ, Grinberg L, Seeley WW, Miller BL, Jagust WJ, Gorno-Tempini ML. Rates of Amyloid Imaging Positivity in Patients With Primary Progressive Aphasia. JAMA Neurol. 2018 Mar 1; 75 (3):342-352
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Suemoto CK, Grinberg LT, Leite REP, Ferretti-Rebustini REL, Jacob-Filho W, Yaffe K, Nitrini R, Pasqualucci CA. Morphometric measurements of extracranial and intracranial atherosclerotic disease: A population-based autopsy study. Atherosclerosis. 2018 Mar; 270:218-223 Epub 2017 Dec 09
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Eser RA, Ehrenberg AJ, Petersen C, Dunlop S, Mejia MB, Suemoto CK, Walsh CM, Rajana H, Oh J, Theofilas P, Seeley WW, Miller BL, Neylan TC, Heinsen H, Grinberg LT. Selective Vulnerability of Brainstem Nuclei in Distinct Tauopathies: A Postmortem Study. J Neuropathol Exp Neurol. 2018 Feb 01; 77(2):149-161.
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Theofilas P, Ehrenberg AJ, Nguy A, Thackrey JM, Dunlop S, Mejia MB, Alho AT, Paraizo Leite RE, Rodriguez RD, Suemoto CK, Nascimento CF, Chin M, Medina-Cleghorn D, Cuervo AM, Arkin M, Seeley WW, Miller BL, Nitrini R, Pasqualucci CA, Filho WJ, Rueb U, Neuhaus J, Heinsen H, Grinberg LT. Probing the correlation of neuronal loss, neurofibrillary tangles, and cell death markers across the Alzheimer's disease Braak stages: a quantitative study in humans. Neurobiol Aging. 2018 Jan; 61:1-12. Epub 2017 Sep 20.
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Villela D, Suemoto CK, Leite R, Pasqualucci CA, Grinberg LT, Pearson P, Rosenberg C. Increased DNA Copy Number Variation Mosaicism in Elderly Human Brain. Neural Plast. 2018; 2018:2406170 Epub 2018 June 28
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Nunes PV, Suemoto CK, Leite REP, Ferretti-Rebustini REL, Pasqualucci CA, Nitrini R, Farfel JM, de Oliveira KC, Grinberg LT, da Costa NR, Nascimento CF, Salmasi F, Kim HK, Young LT, Jacob-Filho W, Lafer B. Factors associated with brain volume in major depression in older adults without dementia: results from a large autopsy study. Int J Geriatr Psychiatry. 2018 Jan; 33 (1):14-20 Epub 2017 Jan 05
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Ehrenberg AJ, Suemoto CK, Franca Resende EP, Petersen C, Leite REP, Rodriguez RD, Ferretti-Rebustini REL, You M, Oh J, Nitrini R, Pasqualucci CA, Jacob-Filho W, Kramer JH, Gatchel JR, Grinberg LT. Neuropathologic Correlates of Psychiatric Symptoms in Alzheimer's Disease. J Alzheimers Dis. 2018; 66 (1):115-126
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Resende EPF, Rosen HJ, Chiang K, Staffaroni AM, Allen I, Grinberg LT, Carmona KC, Guimaraes HC, Carvalho VA, Barbosa MT, de Souza LC, Caramelli P. Primary School Education May Be Sufficient to Moderate a Memory-Hippocampal Relationship. Front Aging Neurosci. 2018; 10:381 Epub 2018 Nov 20
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Perry DC, Brown JA, Possin KL, Datta S, Trujillo A, Radke A, Karydas A, Kornak J, Sias AC, Rabinovici GD, Gorno-Tempini ML, Boxer AL, De May M, Rankin KP, Sturm VE, Lee SE, Matthews BR, Kao AW, Vossel KA, Tartaglia MC, Miller ZA, Seo SW, Sidhu M, Gaus SE, Nana AL, Vargas JNS, Hwang JL, Ossenkoppele R, Brown AB, Huang EJ, Coppola G, Rosen HJ, Geschwind D, Trojanowski JQ, Grinberg LT, Kramer JH, Miller BL, Seeley WW. Clinicopathological correlations in behavioural variant frontotemporal dementia. Brain. 2017 Dec 1; 140 (12):3329-3345
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Walsh CM, Ruoff L, Walker K, Emery A, Varbel J, Karageorgiou E, Luong PN, Mance I, Heuer HW, Boxer AL, Grinberg LT, Kramer JH, Miller BL, Neylan TC. Sleepless Night and Day, the Plight of Progressive Supranuclear Palsy. Sleep. 2017 Nov 1; 40 (11)
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Karageorgiou E, Naasan G, Pleasure SJ, Alexandrescu S, Gelfand JM, Tammewar G, Miller BL, Rabinovici GD, Grinberg LT. Focal cerebral beta-amyloid angiopathy: A distinct clinicopathologic presentation. Neurol Clin Pract. 2017 Oct; 7 (5):444-448
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Matioli MNPDS, Suemoto CK, Rodriguez RD, Farias DS, da Silva MM, Leite REP, Ferretti-Rebustini REL, Pasqualucci CA, Jacob Filho, Grinberg LT, Nitrini R. Association between diabetes and causes of dementia: Evidence from a clinicopathological study. Dement Neuropsychol. 2017 Oct-Dec; 11 (4):406-412
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Schonhaut DR, McMillan CT, Spina S, Dickerson BC, Siderowf A, Devous MD Sr, Tsai R, Winer J, Russell DS, Litvan I, Roberson ED, Seeley WW, Grinberg LT, Kramer JH, Miller BL, Pressman P, Nasrallah I, Baker SL, Gomperts SN, Johnson KA, Grossman M, Jagust WJ, Boxer AL, Rabinovici GD. (18) F-flortaucipir tau positron emission tomography distinguishes established progressive supranuclear palsy from controls and Parkinson disease: A multicenter study. Ann Neurol. 2017 Oct; 82 (4):622-634
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Shi Y, Yamada K, Liddelow SA, Smith ST, Zhao L, Luo W, Tsai RM, Spina S, Grinberg LT, Rojas JC, Gallardo G, Wang K, Roh J, Robinson G, Finn MB, Jiang H, Sullivan PM, Baufeld C, Wood MW, Sutphen C, McCue L, Xiong C, Del-Aguila JL, Morris JC, Cruchaga C, Fagan AM, Miller BL, Boxer AL, Seeley WW, Butovsky O, Barres BA, Paul SM, Holtzman DM, Alzheimer's Disease Neuroimaging Initiative. ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy. Nature. 2017 Sep 28; 549 (7673):523-527 Epub 2017 Sept 20
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Ehrenberg AJ, Nguy AK, Theofilas P, Dunlop S, Suemoto CK, Di Lorenzo Alho AT, Leite RP, Diehl Rodriguez R, Mejia MB, Rub U, Farfel JM, de Lucena Ferretti-Rebustini RE, Nascimento CF, Nitrini R, Pasquallucci CA, Jacob-Filho W, Miller B, Seeley WW, Heinsen H, Grinberg LT. Quantifying the accretion of hyperphosphorylated tau in the locus coeruleus and dorsal raphe nucleus: the pathological building blocks of early Alzheimer's disease. Neuropathol Appl Neurobiol. 2017 Aug; 43 (5):393-408 Epub 2017 Mar 31
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Alho ATDL, Hamani C, Alho EJL, da Silva RE, Santos GAB, Neves RC, Carreira LL, Araujo CMM, Magalhaes G, Coelho DB, Alegro MC, Martin MGM, Grinberg LT, Pasqualucci CA, Heinsen H, Fonoff ET, Amaro E Jr. Magnetic resonance diffusion tensor imaging for the pedunculopontine nucleus: proof of concept and histological correlation. Brain Struct Funct. 2017 Aug; 222 (6):2547-2558 Epub 2017 Mar 10
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Kovacs GG, Xie SX, Lee EB, Robinson JL, Caswell C, Irwin DJ, Toledo JB, Johnson VE, Smith DH, Alafuzoff I, Attems J, Bencze J, Bieniek KF, Bigio EH, Bodi I, Budka H, Dickson DW, Dugger BN, Duyckaerts C, Ferrer I, Forrest SL, Gelpi E, Gentleman SM, Giaccone G, Grinberg LT, Halliday GM, Hatanpaa KJ, Hof PR, Hofer M, Hortobágyi T, Ironside JW, King A, Kofler J, Kövari E, Kril JJ, Love S, Mackenzie IR, Mao Q, Matej R, McLean C, Munoz DG, Murray ME, Neltner J, Nelson PT, Ritchie D, Rodriguez RD, Rohan Z, Rozemuller A, Sakai K, Schultz C, Seilhean D, Smith V, Tacik P, Takahashi H, Takao M, Rudolf Thal D, Weis S, Wharton SB, White CL 3rd, Woulfe JM, Yamada M, Trojanowski JQ. Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG). J Neuropathol Exp Neurol. 2017 Jul 01; 76(7):605-619.
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Fernandez-Fournier M, Perry DC, Tartaglia MC, de May M, Boxer A, Coppola G, Christine CW, Huang EJ, Seeley WW, Miller BL, DeArmond SJ, Grinberg LT, Geschwind MD. Precipitous Deterioration of Motor Function, Cognition, and Behavior. JAMA Neurol. 2017 May 1; 74 (5):591-596
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Alegro M, Theofilas P, Nguy A, Castruita PA, Seeley W, Heinsen H, Ushizima DM, Grinberg LT. Automating cell detection and classification in human brain fluorescent microscopy images using dictionary learning and sparse coding. J Neurosci Methods. 2017 Apr 15; 282:20-33 Epub 2017 Mar 04
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Theofilas P, Ehrenberg AJ, Dunlop S, Di Lorenzo Alho AT, Nguy A, Leite REP, Rodriguez RD, Mejia MB, Suemoto CK, Ferretti-Rebustini REL, Polichiso L, Nascimento CF, Seeley WW, Nitrini R, Pasqualucci CA, Jacob Filho W, Rueb U, Neuhaus J, Heinsen H, Grinberg LT. Locus coeruleus volume and cell population changes during Alzheimer's disease progression: A stereological study in human postmortem brains with potential implication for early-stage biomarker discovery. Alzheimers Dement. 2017 Mar; 13(3):236-246. Epub 2016 Aug 08.
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Spinelli EG, Mandelli ML, Miller ZA, Santos-Santos MA, Wilson SM, Agosta F, Grinberg LT, Huang EJ, Trojanowski JQ, Meyer M, Henry ML, Comi G, Rabinovici G, Rosen HJ, Filippi M, Miller BL, Seeley WW, Gorno-Tempini ML. Typical and atypical pathology in primary progressive aphasia variants. Ann Neurol. 2017 Mar; 81 (3):430-443 Epub 2017 Mar 20
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Suemoto CK, Ferretti-Rebustini RE, Rodriguez RD, Leite RE, Soterio L, Brucki SM, Spera RR, Cippiciani TM, Farfel JM, Chiavegatto Filho A, Naslavsky MS, Zatz M, Pasqualucci CA, Jacob-Filho W, Nitrini R, Grinberg LT. Neuropathological diagnoses and clinical correlates in older adults in Brazil: A cross-sectional study. PLoS Med. 2017 Mar; 14 (3):e1002267 Epub 2017 Mar 28
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Dos Santos Matioli MNP, Suemoto CK, Rodriguez RD, Farias DS, da Silva MM, Leite REP, Ferretti-Rebustini REL, Farfel JM, Pasqualucci CA, Jacob Filho W, Arvanitakis Z, Naslavsky MS, Zatz M, Grinberg LT, Nitrini R. Diabetes is Not Associated with Alzheimer's Disease Neuropathology. J Alzheimers Dis. 2017; 60 (3):1035-1043
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Seo SW, Ayakta N, Grinberg LT, Villeneuve S, Lehmann M, Reed B, DeCarli C, Miller BL, Rosen HJ, Boxer AL, O'Neil JP, Jin LW, Seeley WW, Jagust WJ, Rabinovici GD. Regional correlations between [(11)C]PIB PET and post-mortem burden of amyloid-beta pathology in a diverse neuropathological cohort. Neuroimage Clin. 2017; 13:130-137 Epub 2016 Nov 11
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Nishizawa A, Suemoto CK, Farias-Itao DS, Campos FM, Silva KCS, Bittencourt MS, Grinberg LT, Leite REP, Ferretti-Rebustini REL, Farfel JM, Jacob-Filho W, Pasqualucci CA. Morphometric measurements of systemic atherosclerosis and visceral fat: Evidence from an autopsy study. PLoS One. 2017; 12 (10):e0186630 Epub 2017 Oct 16
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Woerman AL, Aoyagi A, Patel S, Kazmi SA, Lobach I, Grinberg LT, McKee AC, Seeley WW, Olson SH, Prusiner SB. Tau prions from Alzheimer's disease and chronic traumatic encephalopathy patients propagate in cultured cells. Proc Natl Acad Sci U S A. 2016 Dec 13; 113 (50):E8187-E8196 Epub 2016 Nov 28
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Miller ZA, Sturm VE, Camsari GB, Karydas A, Yokoyama JS, Grinberg LT, Boxer AL, Rosen HJ, Rankin KP, Gorno-Tempini ML, Coppola G, Geschwind DH, Rademakers R, Seeley WW, Graff-Radford NR, Miller BL. Increased prevalence of autoimmune disease within C9 and FTD/MND cohorts: Completing the picture. Neurol Neuroimmunol Neuroinflamm. 2016 Dec; 3(6):e301. Epub 2016 Oct 28.
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Farias-Itao DS, Pasqualucci CA, Nishizawa A, Silva LF, Campos FM, Silva KC, Leite RE, Grinberg LT, Ferretti-Rebustini RE, Jacob Filho W, Suemoto CK. Perivascular Adipose Tissue Inflammation and Coronary Artery Disease: An Autopsy Study Protocol. JMIR Res Protoc. 2016 Nov 18; 5 (4):e211
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Takada LT, Bahia VS, Guimaraes HC, Costa TV, Vale TC, Rodriguez RD, Porto FH, Machado JC, Beato RG, Cesar KG, Smid J, Nascimento CF, Grinberg LT, Brucki SM, Maximino JR, Camargos ST, Chadi G, Caramelli P, Nitrini R. GRN and MAPT Mutations in 2 Frontotemporal Dementia Research Centers in Brazil. Alzheimer Dis Assoc Disord. 2016 Oct-Dec; 30 (4):310-317
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Oliveira-Pinto AV, Andrade-Moraes CH, Oliveira LM, Parente-Bruno DR, Santos RM, Coutinho RA, Alho AT, Leite RE, Suemoto CK, Grinberg LT, Pasqualucci CA, Jacob-Filho W, Lent R. Do age and sex impact on the absolute cell numbers of human brain regions? Brain Struct Funct. 2016 Sep; 221 (7):3547-59 Epub 2015 Sept 28
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Ranasinghe KG, Rankin KP, Pressman PS, Perry DC, Lobach IV, Seeley WW, Coppola G, Karydas AM, Grinberg LT, Shany-Ur T, Lee SE, Rabinovici GD, Rosen HJ, Gorno-Tempini ML, Boxer AL, Miller ZA, Chiong W, DeMay M, Kramer JH, Possin KL, Sturm VE, Bettcher BM, Neylan M, Zackey DD, Nguyen LA, Ketelle R, Block N, Wu TQ, Dallich A, Russek N, Caplan A, Geschwind DH, Vossel KA, Miller BL. Distinct Subtypes of Behavioral Variant Frontotemporal Dementia Based on Patterns of Network Degeneration. JAMA Neurol. 2016 Sep 1; 73 (9):1078-88
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Di Lorenzo Alho AT, Suemoto CK, Polichiso L, Tampellini E, de Oliveira KC, Molina M, Santos GA, Nascimento C, Leite RE, de Lucena Ferreti-Rebustini RE, da Silva AV, Nitrini R, Pasqualucci CA, Jacob-Filho W, Heinsen H, Grinberg LT. Three-dimensional and stereological characterization of the human substantia nigra during aging. Brain Struct Funct. 2016 Sep; 221 (7):3393-403 Epub 2015 Sept 19
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McAleese KE, Alafuzoff I, Charidimou A, De Reuck J, Grinberg LT, Hainsworth AH, Hortobagyi T, Ince P, Jellinger K, Gao J, Kalaria RN, Kovacs GG, Kovari E, Love S, Popovic M, Skrobot O, Taipa R, Thal DR, Werring D, Wharton SB, Attems J. Post-mortem assessment in vascular dementia: advances and aspirations. BMC Med. 2016 Aug 26; 14 (1):129
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Grinberg LT, Anghinah R, Nascimento CF, Amaro E, Leite RP, Martin G, Naslavsky MS, Takada LT, Filho WJ, Pasqualucci CA, Nitrini R. Chronic Traumatic Encephalopathy Presenting as Alzheimer's Disease in a Retired Soccer Player. J Alzheimers Dis. 2016 Jul 29; 54 (1):169-74
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Rodriguez RD, Suemoto CK, Molina M, Nascimento CF, Leite RE, de Lucena Ferretti-Rebustini RE, Farfel JM, Heinsen H, Nitrini R, Ueda K, Pasqualucci CA, Jacob-Filho W, Yaffe K, Grinberg LT. Argyrophilic Grain Disease: Demographics, Clinical, and Neuropathological Features From a Large Autopsy Study. J Neuropathol Exp Neurol. 2016 Jul; 75 (7):628-35 Epub 2016 June 09
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Sohn PD, Tracy TE, Son HI, Zhou Y, Leite RE, Miller BL, Seeley WW, Grinberg LT, Gan L. Acetylated tau destabilizes the cytoskeleton in the axon initial segment and is mislocalized to the somatodendritic compartment. Mol Neurodegener. 2016 Jun 29; 11 (1):47 Epub 2016 June 29
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Grothe MJ, Heinsen H, Amaro E Jr, Grinberg LT, Teipel SJ. Cognitive Correlates of Basal Forebrain Atrophy and Associated Cortical Hypometabolism in Mild Cognitive Impairment. Cereb Cortex. 2016 Jun; 26 (6):2411-2426 Epub 2015 Apr 02
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Walsh CM, Ruoff L, Varbel J, Walker K, Grinberg LT, Boxer AL, Kramer JH, Miller BL, Neylan TC. Rest-activity rhythm disruption in progressive supranuclear palsy. Sleep Med. 2016 Jun; 22:50-56 Epub 2016 June 21
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Santos-Santos MA, Mandelli ML, Binney RJ, Ogar J, Wilson SM, Henry ML, Hubbard HI, Meese M, Attygalle S, Rosenberg L, Pakvasa M, Trojanowski JQ, Grinberg LT, Rosen H, Boxer AL, Miller BL, Seeley WW, Gorno-Tempini ML. Features of Patients With Nonfluent/Agrammatic Primary Progressive Aphasia With Underlying Progressive Supranuclear Palsy Pathology or Corticobasal Degeneration. JAMA Neurol. 2016 Jun 1; 73 (6):733-42
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Stratmann K, Heinsen H, Korf HW, Del Turco D, Ghebremedhin E, Seidel K, Bouzrou M, Grinberg LT, Bohl J, Wharton SB, den Dunnen W, Rub U. Precortical Phase of Alzheimer's Disease (AD)-Related Tau Cytoskeletal Pathology. Brain Pathol. 2016 May; 26 (3):371-86 Epub 2015 Aug 24
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Schrotter A, Park YM, Marcus K, Martins-de-Souza D, Nilsson P, Magraoui FE, Meyer HE, Grinberg LT. Key players in neurodegenerative disorders in focus-New insights into the proteomic profile of Alzheimer's disease, schizophrenia, ALS, and multiple sclerosis-24th HUPO BPP Workshop: September 29, 2015, Vancouver, Canada. Proteomics. 2016 Apr; 16 (7):1047-50
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Nascimento C, Suemoto CK, Rodriguez RD, Alho AT, Leite RP, Farfel JM, Pasqualucci CA, Jacob-Filho W, Grinberg LT. Higher Prevalence of TDP-43 Proteinopathy in Cognitively Normal Asians: A Clinicopathological Study on a Multiethnic Sample. Brain Pathol. 2016 Mar; 26 (2):177-85 Epub 2015 Sept 17
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Kovacs GG, Ferrer I, Grinberg LT, Alafuzoff I, Attems J, Budka H, Cairns NJ, Crary JF, Duyckaerts C, Ghetti B, Halliday GM, Ironside JW, Love S, Mackenzie IR, Munoz DG, Murray ME, Nelson PT, Takahashi H, Trojanowski JQ, Ansorge O, Arzberger T, Baborie A, Beach TG, Bieniek KF, Bigio EH, Bodi I, Dugger BN, Feany M, Gelpi E, Gentleman SM, Giaccone G, Hatanpaa KJ, Heale R, Hof PR, Hofer M, Hortobágyi T, Jellinger K, Jicha GA, Ince P, Kofler J, Kövari E, Kril JJ, Mann DM, Matej R, McKee AC, McLean C, Milenkovic I, Montine TJ, Murayama S, Lee EB, Rahimi J, Rodriguez RD, Rozemüller A, Schneider JA, Schultz C, Seeley W, Seilhean D, Smith C, Tagliavini F, Takao M, Thal DR, Toledo JB, Tolnay M, Troncoso JC, Vinters HV, Weis S, Wharton SB, White CL 3rd, Wisniewski T, Woulfe JM, Yamada M, Dickson DW. Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy. Acta Neuropathol. 2016 Jan; 131(1):87-102. Epub 2015 Dec 10.
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Rosenberg GA, Wallin A, Wardlaw JM, Markus HS, Montaner J, Wolfson L, Iadecola C, Zlokovic BV, Joutel A, Dichgans M, Duering M, Schmidt R, Korczyn AD, Grinberg LT, Chui HC, Hachinski V. Consensus statement for diagnosis of subcortical small vessel disease. J Cereb Blood Flow Metab. 2016 Jan; 36 (1):6-25
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Naasan G, Rabinovici GD, Ghosh P, Elofson JD, Miller BL, Coppola G, Karydas A, Fong J, Perry D, Lee SE, Yokoyama JS, Seeley WW, Kramer JH, Weiner MW, Schuff N, Jagust WJ, Grinberg LT, Pribadi M, Yang Z, Sears R, Klein E, Wojta K, Rosen HJ. Amyloid in dementia associated with familial FTLD: not an innocent bystander. Neurocase. 2016; 22 (1):76-83 Epub 2015 June 04
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Nishizawa A, Suemoto CK, Farias DS, Campos FM, da Silva KC, Cuelho A, Leite RE, Ferretti-Rebustini RE, Grinberg LT, Farfel JM, Jacob-Filho W, Pasqualucci CA. Association between adiposity and systemic atherosclerosis: a protocol of a cross-sectional autopsy study. Open Heart. 2016; 3 (2):e000433 Epub 2016 Aug 23
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Villela D, Ramalho RF, Silva AR, Brentani H, Suemoto CK, Pasqualucci CA, Grinberg LT, Krepischi AC, Rosenberg C. Differential DNA Methylation of MicroRNA Genes in Temporal Cortex from Alzheimer's Disease Individuals. Neural Plast. 2016; 2016:2584940 Epub 2016 Apr 26
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Villela D, Suemoto CK, Pasqualucci CA, Grinberg LT, Rosenberg C. Do Copy Number Changes in CACNA2D2, CACNA2D3, and CACNA1D Constitute a Predisposing Risk Factor for Alzheimer's Disease? Front Genet. 2016; 7:107 Epub 2016 June 14
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Ferretti-Rebustini RE, Balbinotti MA, Jacob-Filho W, Rebustini F, Suemoto CK, Pasqualucci CA, Farfel JM, Leite RE, Grinberg LT, Nitrini R. Validity of the Katz Index to assess activities of daily living by informants in neuropathological studies. Rev Esc Enferm USP. 2015 Dec; 49 (6):946-52
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Fredericks CA, Koestler M, Seeley W, Miller B, Boxer A, Grinberg LT. Primary chronic traumatic encephalopathy in an older patient with late-onset AD phenotype. Neurol Clin Pract. 2015 Dec; 5 (6):475-479
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Paraizo Leite RE, Tenenholz Grinberg L. Closing the gap between brain banks and proteomics to advance the study of neurodegenerative diseases. Proteomics Clin Appl. 2015 Oct; 9 (9-10):832-7 Epub 2015 Sept 08
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Prusiner SB, Woerman AL, Mordes DA, Watts JC, Rampersaud R, Berry DB, Patel S, Oehler A, Lowe JK, Kravitz SN, Geschwind DH, Glidden DV, Halliday GM, Middleton LT, Gentleman SM, Grinberg LT, Giles K. Evidence for alpha-synuclein prions causing multiple system atrophy in humans with parkinsonism. Proc Natl Acad Sci U S A. 2015 Sep 22; 112 (38):E5308-17 Epub 2015 Aug 31
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Magraoui FE, Schrotter A, Heinsen H, Leite R, Park YM, Meyer HE, Grinberg LT. A Long Journey from Childhood to Senility: The 23rd HUPO BPP Workshop: 16-17 April 2015, Sao Paulo, Brazil. Proteomics. 2015 Sep; 15 (17):2895-7
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Ossenkoppele R, Pijnenburg YA, Perry DC, Cohn-Sheehy BI, Scheltens NM, Vogel JW, Kramer JH, van der Vlies AE, La Joie R, Rosen HJ, van der Flier WM, Grinberg LT, Rozemuller AJ, Huang EJ, van Berckel BN, Miller BL, Barkhof F, Jagust WJ, Scheltens P, Seeley WW, Rabinovici GD. The behavioural/dysexecutive variant of Alzheimer's disease: clinical, neuroimaging and pathological features. Brain. 2015 Sep; 138 (Pt 9):2732-49 Epub 2015 July 02
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Gardner RC, Possin KL, Hess CP, Huang EJ, Grinberg LT, Nolan AL, Cohn-Sheehy BI, Ghosh PM, Lanata S, Merrilees J, Kramer JH, Berger MS, Miller BL, Yaffe K, Rabinovici GD. Evaluating and treating neurobehavioral symptoms in professional American football players: Lessons from a case series. Neurol Clin Pract. 2015 Aug; 5 (4):285-295
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Engelhardt E, Grinberg LT. Alzheimer and vascular brain diseases: Focal and diffuse subforms. Dement Neuropsychol. 2015 Jul-Sep; 9 (3):306-310
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Villeneuve S, Rabinovici GD, Cohn-Sheehy BI, Madison C, Ayakta N, Ghosh PM, La Joie R, Arthur-Bentil SK, Vogel JW, Marks SM, Lehmann M, Rosen HJ, Reed B, Olichney J, Boxer AL, Miller BL, Borys E, Jin LW, Huang EJ, Grinberg LT, DeCarli C, Seeley WW, Jagust W. Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation. Brain. 2015 Jul; 138 (Pt 7):2020-33 Epub 2015 May 06
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Molina M, Steinbach S, Park YM, Yun SY, Di Lorenzo Alho AT, Heinsen H, Grinberg LT, Marcus K, Leite RE, May C. Enrichment of single neurons and defined brain regions from human brain tissue samples for subsequent proteome analysis. J Neural Transm (Vienna). 2015 Jul; 122 (7):993-1005 Epub 2015 June 30
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Nascimento C, Kim HK, Young LT, Mendonca KM, Grinberg LT, Lafer B, Andreazza AC. Glutathione-mediated effects of lithium in decreasing protein oxidation induced by mitochondrial complex I dysfunction. J Neural Transm (Vienna). 2015 Jun; 122 (6):741-6 Epub 2014 Sept 27
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Shinagawa S, Naasan G, Karydas AM, Coppola G, Pribadi M, Seeley WW, Trojanowski JQ, Miller BL, Grinberg LT. Clinicopathological Study of Patients With C9ORF72-Associated Frontotemporal Dementia Presenting With Delusions. J Geriatr Psychiatry Neurol. 2015 Jun; 28 (2):99-107 Epub 2014 Oct 23
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Madeira C, Lourenco MV, Vargas-Lopes C, Suemoto CK, Brandao CO, Reis T, Leite RE, Laks J, Jacob-Filho W, Pasqualucci CA, Grinberg LT, Ferreira ST, Panizzutti R. d-serine levels in Alzheimer's disease: implications for novel biomarker development. Transl Psychiatry. 2015 May 5; 5 (5):e561 Epub 2015 May 05
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Moreno F, Rabinovici GD, Karydas A, Miller Z, Hsu SC, Legati A, Fong J, Schonhaut D, Esselmann H, Watson C, Stephens ML, Kramer J, Wiltfang J, Seeley WW, Miller BL, Coppola G, Grinberg LT. A novel mutation P112H in the TARDBP gene associated with frontotemporal lobar degeneration without motor neuron disease and abundant neuritic amyloid plaques. Acta Neuropathol Commun. 2015 Apr 3; 3:19 Epub 2015 Apr 03
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Ferretti-Rebustini REL, Jacob-Filho W, Suemoto CK, Farfel JM, Leite REP, Grinberg LT, Pasqualucci CA, Nitrini R. Factors associated with morphometric brain changes in cognitively normal aging. Dement Neuropsychol. 2015 Apr-Jun; 9 (2):103-109
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Engelhardt E, Grinberg LT. Alzheimer and vascular brain disease: Senile dementia. Dement Neuropsychol. 2015 Apr-Jun; 9 (2):184-188
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Seidel K, Mahlke J, Siswanto S, Kruger R, Heinsen H, Auburger G, Bouzrou M, Grinberg LT, Wicht H, Korf HW, den Dunnen W, Rub U. The brainstem pathologies of Parkinson's disease and dementia with Lewy bodies. Brain Pathol. 2015 Mar; 25 (2):121-35 Epub 2014 Sept 12
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Liljegren M, Naasan G, Temlett J, Perry DC, Rankin KP, Merrilees J, Grinberg LT, Seeley WW, Englund E, Miller BL. Criminal behavior in frontotemporal dementia and Alzheimer disease. JAMA Neurol. 2015 Mar; 72 (3):295-300
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Schrotter A, Magraoui FE, Marcus K, Park YM, Meyer HE, Grinberg LT. New milestones in the development of characterization tools for neurodegenerative diseases in proteomics: 22nd HUPO BPP Workshop 7 October 2014, Madrid, Spain. Proteomics. 2015 Feb; 15 (4):627-9
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Sha SJ, Ghosh PM, Lee SE, Corbetta-Rastelli C, Jagust WJ, Kornak J, Rankin KP, Grinberg LT, Vinters HV, Mendez MF, Dickson DW, Seeley WW, Gorno-Tempini M, Kramer J, Miller BL, Boxer AL, Rabinovici GD. Predicting amyloid status in corticobasal syndrome using modified clinical criteria, magnetic resonance imaging and fluorodeoxyglucose positron emission tomography. Alzheimers Res Ther. 2015; 7(1):8. Epub 2015 Mar 02.
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Theofilas P, Dunlop S, Heinsen H, Grinberg LT. Turning on the Light Within: Subcortical Nuclei of the Isodentritic Core and their Role in Alzheimer's Disease Pathogenesis. J Alzheimers Dis. 2015; 46(1):17-34.
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Rodriguez RD, Grinberg LT. Argyrophilic grain disease: An underestimated tauopathy. Dement Neuropsychol. 2015 Jan-Mar; 9 (1):2-8
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Engelhardt E, Grinberg LT. Alois Alzheimer and vascular brain disease: Arteriosclerotic atrophy of the brain. Dement Neuropsychol. 2015 Jan-Mar; 9 (1):81-84
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Crary JF, Trojanowski JQ, Schneider JA, Abisambra JF, Abner EL, Alafuzoff I, Arnold SE, Attems J, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Gearing M, Grinberg LT, Hof PR, Hyman BT, Jellinger K, Jicha GA, Kovacs GG, Knopman DS, Kofler J, Kukull WA, Mackenzie IR, Masliah E, McKee A, Montine TJ, Murray ME, Neltner JH, Santa-Maria I, Seeley WW, Serrano-Pozo A, Shelanski ML, Stein T, Takao M, Thal DR, Toledo JB, Troncoso JC, Vonsattel JP, White CL 3rd, Wisniewski T, Woltjer RL, Yamada M, Nelson PT. Primary age-related tauopathy (PART): a common pathology associated with human aging. Acta Neuropathol. 2014 Dec; 128(6):755-66. Epub 2014 Oct 28.
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van Blitterswijk M, Mullen B, Heckman MG, Baker MC, DeJesus-Hernandez M, Brown PH, Murray ME, Hsiung GY, Stewart H, Karydas AM, Finger E, Kertesz A, Bigio EH, Weintraub S, Mesulam M, Hatanpaa KJ, White CL 3rd, Neumann M, Strong MJ, Beach TG, Wszolek ZK, Lippa C, Caselli R, Petrucelli L, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Mackenzie IR, Seeley WW, Grinberg LT, Miller BL, Boylan KB, Graff-Radford NR, Boeve BF, Dickson DW, Rademakers R. Ataxin-2 as potential disease modifier in C9ORF72 expansion carriers. Neurobiol Aging. 2014 Oct; 35(10):2421.e13-7. Epub 2014 May 02.
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van Blitterswijk M, Mullen B, Wojtas A, Heckman MG, Diehl NN, Baker MC, DeJesus-Hernandez M, Brown PH, Murray ME, Hsiung GY, Stewart H, Karydas AM, Finger E, Kertesz A, Bigio EH, Weintraub S, Mesulam M, Hatanpaa KJ, White CL 3rd, Neumann M, Strong MJ, Beach TG, Wszolek ZK, Lippa C, Caselli R, Petrucelli L, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Mackenzie IR, Seeley WW, Grinberg LT, Miller BL, Boylan KB, Graff-Radford NR, Boeve BF, Dickson DW, Rademakers R. Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene. Mol Neurodegener. 2014 Sep 20; 9:38.
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Villela D, Schlesinger D, Suemoto CK, Grinberg LT, Rosenberg C. A microdeletion in Alzheimer's disease disrupts NAMPT gene. J Genet. 2014 Aug; 93 (2):535-7
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Sanders DW, Kaufman SK, DeVos SL, Sharma AM, Mirbaha H, Li A, Barker SJ, Foley AC, Thorpe JR, Serpell LC, Miller TM, Grinberg LT, Seeley WW, Diamond MI. Distinct tau prion strains propagate in cells and mice and define different tauopathies. Neuron. 2014 Jun 18; 82 (6):1271-88 Epub 2014 May 22
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El Magraoui F, Eisenacher M, Schrotter A, Kuhlmann K, Heinsen H, Andren P, Nilsson P, Haggmark A, Schmitz G, Verhaert P, Borchers C, Yoo JS, Lee BH, Meyer HE, Grinberg LT. Developing new methods to answer old and new questions in neurodegenerative diseases: 21(st) Workshop of the HUPO Brain Proteome Project (HBPP) 23-24 January 2014, Honolulu, Hawaii. Proteomics. 2014 Jun; 14 (11):1308-10 Epub 2014 Apr 22
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Schrotter A, El Magraoui F, Grottrup B, Heinsen H, Marcus K, Meyer HE, Park YM, Grinberg LT. Frontiers in neurodegeneration--new insights and prospects--20th HUPO BPP Workshop: 15 September 2013, Yokohama, Japan. Proteomics. 2014 Jun; 14 (11):1305-7
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Theofilas P, Polichiso L, Wang X, Lima LC, Alho ATL, Leite REP, Suemoto CK, Pasqualucci CA, Jacob-Filho W, Heinsen H, Grinberg LT, Brazilian Aging Brain Study Group. A novel approach for integrative studies on neurodegenerative diseases in human brains. J Neurosci Methods. 2014 Apr 15; 226:171-183 Epub 2014 Feb 03
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Teipel SJ, Flatz W, Ackl N, Grothe M, Kilimann I, Bokde AL, Grinberg L, Amaro E Jr, Kljajevic V, Alho E, Knels C, Ebert A, Heinsen H, Danek A. Brain atrophy in primary progressive aphasia involves the cholinergic basal forebrain and Ayala's nucleus. Psychiatry Res. 2014 Mar 30; 221 (3):187-94 Epub 2013 Dec 06
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van Blitterswijk M, Mullen B, Nicholson AM, Bieniek KF, Heckman MG, Baker MC, DeJesus-Hernandez M, Finch NA, Brown PH, Murray ME, Hsiung GY, Stewart H, Karydas AM, Finger E, Kertesz A, Bigio EH, Weintraub S, Mesulam M, Hatanpaa KJ, White CL 3rd, Strong MJ, Beach TG, Wszolek ZK, Lippa C, Caselli R, Petrucelli L, Josephs KA, Parisi JE, Knopman DS, Petersen RC, Mackenzie IR, Seeley WW, Grinberg LT, Miller BL, Boylan KB, Graff-Radford NR, Boeve BF, Dickson DW, Rademakers R. TMEM106B protects C9ORF72 expansion carriers against frontotemporal dementia. Acta Neuropathol. 2014 Mar; 127(3):397-406. Epub 2014 Jan 03.
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Teipel S, Heinsen H, Amaro E Jr, Grinberg LT, Krause B, Grothe M, Alzheimer's Disease Neuroimaging Initiative. Cholinergic basal forebrain atrophy predicts amyloid burden in Alzheimer's disease. Neurobiol Aging. 2014 Mar; 35 (3):482-91 Epub 2013 Oct 28
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Caso F, Mandelli ML, Henry M, Gesierich B, Bettcher BM, Ogar J, Filippi M, Comi G, Magnani G, Sidhu M, Trojanowski JQ, Huang EJ, Grinberg LT, Miller BL, Dronkers N, Seeley WW, Gorno-Tempini ML. In vivo signatures of nonfluent/agrammatic primary progressive aphasia caused by FTLD pathology. Neurology. 2014 Jan 21; 82 (3):239-47 Epub 2013 Dec 18
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Sanchez-Juan P, Ghosh PM, Hagen J, Gesierich B, Henry M, Grinberg LT, O'Neil JP, Janabi M, Huang EJ, Trojanowski JQ, Vinters HV, Gorno-Tempini M, Seeley WW, Boxer AL, Rosen HJ, Kramer JH, Miller BL, Jagust WJ, Rabinovici GD. Practical utility of amyloid and FDG-PET in an academic dementia center. Neurology. 2014 Jan 21; 82 (3):230-8 Epub 2013 Dec 18
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Kilimann I, Grothe M, Heinsen H, Alho EJ, Grinberg L, Amaro E Jr, Dos Santos GA, da Silva RE, Mitchell AJ, Frisoni GB, Bokde AL, Fellgiebel A, Filippi M, Hampel H, Kloppel S, Teipel SJ. Subregional basal forebrain atrophy in Alzheimer's disease: a multicenter study. J Alzheimers Dis. 2014; 40 (3):687-700
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Scherling CS, Hall T, Berisha F, Klepac K, Karydas A, Coppola G, Kramer JH, Rabinovici G, Ahlijanian M, Miller BL, Seeley W, Grinberg LT, Rosen H, Meredith J Jr, Boxer AL. Cerebrospinal fluid neurofilament concentration reflects disease severity in frontotemporal degeneration. Ann Neurol. 2014 Jan; 75 (1):116-26 Epub 2014 Jan 02
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Silva AR, Santos AC, Farfel JM, Grinberg LT, Ferretti RE, Campos AH, Cunha IW, Begnami MD, Rocha RM, Carraro DM, de Braganca Pereira CA, Jacob-Filho W, Brentani H. Repair of oxidative DNA damage, cell-cycle regulation and neuronal death may influence the clinical manifestation of Alzheimer's disease. PLoS One. 2014; 9 (6):e99897 Epub 2014 June 17
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Oliveira-Pinto AV, Santos RM, Coutinho RA, Oliveira LM, Santos GB, Alho AT, Leite RE, Farfel JM, Suemoto CK, Grinberg LT, Pasqualucci CA, Jacob-Filho W, Lent R. Sexual dimorphism in the human olfactory bulb: females have more neurons and glial cells than males. PLoS One. 2014; 9 (11):e111733 Epub 2014 Nov 05
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Corradini BR, Iamashita P, Tampellini E, Farfel JM, Grinberg LT, Moreira-Filho CA. Complex network-driven view of genomic mechanisms underlying Parkinson's disease: analyses in dorsal motor vagal nucleus, locus coeruleus, and substantia nigra. Biomed Res Int. 2014; 2014:543673 Epub 2014 Nov 26
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Plum S, Helling S, Theiss C, Leite REP, May C, Jacob-Filho W, Eisenacher M, Kuhlmann K, Meyer HE, Riederer P, Grinberg LT, Gerlach M, Marcus K. Combined enrichment of neuromelanin granules and synaptosomes from human substantia nigra pars compacta tissue for proteomic analysis. J Proteomics. 2013 Dec 6; 94:202-206 Epub 2013 Aug 03
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Andrade-Moraes CH, Oliveira-Pinto AV, Castro-Fonseca E, da Silva CG, Guimaraes DM, Szczupak D, Parente-Bruno DR, Carvalho LR, Polichiso L, Gomes BV, Oliveira LM, Rodriguez RD, Leite RE, Ferretti-Rebustini RE, Jacob-Filho W, Pasqualucci CA, Grinberg LT, Lent R. Cell number changes in Alzheimer's disease relate to dementia, not to plaques and tangles. Brain. 2013 Dec; 136 (Pt 12):3738-52 Epub 2013 Oct 17
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Villela D, Kimura L, Schlesinger D, Goncalves A, Pearson PL, Suemoto CK, Pasqualucci C, Krepischi AC, Grinberg LT, Rosenberg C. Germline DNA copy number variation in individuals with Argyrophilic grain disease reveals CTNS as a plausible candidate gene. Genet Mol Biol. 2013 Dec; 36 (4):498-501 Epub 2013 Nov 08
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Schrotter A, Magraoui FE, Grottrup B, Wiltfang J, Heinsen H, Marcus K, Meyer HE, Grinberg LT, Park YM. Early diagnosis of neurodegenerative diseases - the long awaited Holy Grail and bottleneck of modern brain research - 19th HUPO BPP workshop: May 22-24, 2013, Dortmund, Germany. Proteomics. 2013 Oct; 13 (20):2938-41
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Miller ZA, Rankin KP, Graff-Radford NR, Takada LT, Sturm VE, Cleveland CM, Criswell LA, Jaeger PA, Stan T, Heggeli KA, Hsu SC, Karydas A, Khan BK, Grinberg LT, Gorno-Tempini ML, Boxer AL, Rosen HJ, Kramer JH, Coppola G, Geschwind DH, Rademakers R, Seeley WW, Wyss-Coray T, Miller BL. TDP-43 frontotemporal lobar degeneration and autoimmune disease. J Neurol Neurosurg Psychiatry. 2013 Sep; 84(9):956-62. Epub 2013 Mar 30.
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Farfel JM, Nitrini R, Suemoto CK, Grinberg LT, Ferretti RE, Leite RE, Tampellini E, Lima L, Farias DS, Neves RC, Rodriguez RD, Menezes PR, Fregni F, Bennett DA, Pasqualucci CA, Jacob Filho W, Brazilian Aging Brain Study Group. Very low levels of education and cognitive reserve: a clinicopathologic study. Neurology. 2013 Aug 13; 81 (7):650-7 Epub 2013 July 19
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Perry DC, Lehmann M, Yokoyama JS, Karydas A, Lee JJ, Coppola G, Grinberg LT, Geschwind D, Seeley WW, Miller BL, Rosen H, Rabinovici G. Progranulin mutations as risk factors for Alzheimer disease. JAMA Neurol. 2013 Jun; 70 (6):774-8
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Suemoto CK, Damico MV, Ferretti RE, Grinberg LT, Farfel JM, Leite RE, Nitrini R, Lafer B, Jacob-Filho W, Pasqualucci CA, Brazilian Aging Brain Study Group. Depression and cardiovascular risk factors: evidence from a large postmortem sample. Int J Geriatr Psychiatry. 2013 May; 28 (5):487-93 Epub 2012 June 29
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Grinberg LT, Wang X, Wang C, Sohn PD, Theofilas P, Sidhu M, Arevalo JB, Heinsen H, Huang EJ, Rosen H, Miller BL, Gan L, Seeley WW. Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation. Acta Neuropathol. 2013 Apr; 125 (4):581-93 Epub 2013 Jan 31
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Schlesinger D, Grinberg LT, Alba JG, Naslavsky MS, Licinio L, Farfel JM, Suemoto CK, de Lucena Ferretti RE, Leite RE, de Andrade MP, dos Santos AC, Brentani H, Pasqualucci CA, Nitrini R, Jacob-Filho W, Zatz M, Brazilian Aging Brain Study Group. African ancestry protects against Alzheimer's disease-related neuropathology. Mol Psychiatry. 2013 Jan; 18 (1):79-85 Epub 2011 Nov 08
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Grottrup B, Esselmann H, May C, Schrotter A, Woitalla D, Heinsen H, Marcus K, Wiltfang J, Meyer HE, Grinberg LT, Park YM. Challenges in modern biomarker discovery--17th HUPO BPP workshop: May 24-25, 2012, Sao Paulo, Brazil. Proteomics. 2013 Jan; 13 (2):210-6
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Grinberg LT, Nitrini R, Suemoto CK, Lucena Ferretti-Rebustini RE, Leite RE, Farfel JM, Santos E, Andrade MP, Alho AT, Lima C, Oliveira KC, Tampellini E, Polichiso L, Santos GB, Rodriguez RD, Ueda K, Pasqualucci CA, Jacob-Filho W. Prevalence of dementia subtypes in a developing country: a clinicopathological study. Clinics (Sao Paulo). 2013; 68 (8):1140-5
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Grottrup B, May C, Meyer HE, Grinberg LT, Park YM. Progresses in neuroproteomics of neurodegenerative diseases--18th HUPO BPP workshop: September 12, 2012, Boston, USA. Proteomics. 2013 Jan; 13 (2):217-8
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Ribeiro PF, Ventura-Antunes L, Gabi M, Mota B, Grinberg LT, Farfel JM, Ferretti-Rebustini RE, Leite RE, Filho WJ, Herculano-Houzel S. The human cerebral cortex is neither one nor many: neuronal distribution reveals two quantitatively different zones in the gray matter, three in the white matter, and explains local variations in cortical folding. Front Neuroanat. 2013; 7:28 Epub 2013 Sept 02
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Korczyn AD, Vakhapova V, Grinberg LT. Vascular dementia. J Neurol Sci. 2012 Nov 15; 322 (1-2):2-10 Epub 2012 May 08
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Thal DR, Grinberg LT, Attems J. Vascular dementia: different forms of vessel disorders contribute to the development of dementia in the elderly brain. Exp Gerontol. 2012 Nov; 47 (11):816-24 Epub 2012 June 13
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Grinberg LT, Korczyn AD, Heinsen H. Cerebral amyloid angiopathy impact on endothelium. Exp Gerontol. 2012 Nov; 47 (11):838-42 Epub 2012 Aug 28
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Grinberg LT. Vascular dementia: Current concepts and nomenclature harmonization. Dement Neuropsychol. 2012 Jul-Sep; 6 (3):122-126
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Laforce R Jr, Kerchner GA, Rabinovici GD, Fong JC, Miller BL, Seeley WW, Grinberg LT. A 44-year-old man with profound behavioural changes. Can J Neurol Sci. 2012 Jul; 39 (4):527-30
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de Oliveira KC, Nery FG, Ferreti RE, Lima MC, Cappi C, Machado-Lima A, Polichiso L, Carreira LL, Avila C, Alho AT, Brentani HP, Miguel EC, Heinsen H, Jacob-Filho W, Pasqualucci CA, Lafer B, Grinberg LT. Brazilian psychiatric brain bank: a new contribution tool to network studies. Cell Tissue Bank. 2012 Jun; 13 (2):315-26 Epub 2011 May 12
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Grottrup B, Bockmann M, Stephan C, Marcus K, Grinberg LT, Meyer HE, Park YM. Translational proteomics in neurodegenerative diseases--16th HUPO BPP workshop September 5, 2011 Geneva, Switzerland. Proteomics. 2012 Feb; 12 (3):356-8
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Silva AR, Grinberg LT, Farfel JM, Diniz BS, Lima LA, Silva PJ, Ferretti RE, Rocha RM, Filho WJ, Carraro DM, Brentani H. Transcriptional alterations related to neuropathology and clinical manifestation of Alzheimer's disease. PLoS One. 2012; 7 (11):e48751 Epub 2012 Nov 07
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Rabinovici GD, Rosen HJ, Alkalay A, Kornak J, Furst AJ, Agarwal N, Mormino EC, O'Neil JP, Janabi M, Karydas A, Growdon ME, Jang JY, Huang EJ, Dearmond SJ, Trojanowski JQ, Grinberg LT, Gorno-Tempini ML, Seeley WW, Miller BL, Jagust WJ. Amyloid vs FDG-PET in the differential diagnosis of AD and FTLD. Neurology. 2011 Dec 6; 77 (23):2034-42 Epub 2011 Nov 30
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Moreira MS, Velasco IT, Ferreira LS, Ariga SK, Abatepaulo F, Grinberg LT, Marques MM. Effect of laser phototherapy on wound healing following cerebral ischemia by cryogenic injury. J Photochem Photobiol B. 2011 Dec 2; 105 (3):207-15 Epub 2011 Oct 04
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Ewers M, Frisoni GB, Teipel SJ, Grinberg LT, Amaro E Jr, Heinsen H, Thompson PM, Hampel H. Staging Alzheimer's disease progression with multimodality neuroimaging. Prog Neurobiol. 2011 Dec; 95 (4):535-46 Epub 2011 June 22
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Suemoto CK, Nitrini R, Grinberg LT, Ferretti RE, Farfel JM, Leite RE, Menezes PR, Fregni F, Jacob-Filho W, Pasqualucci CA, Brazilian Aging Brain Study Group. Atherosclerosis and dementia: a cross-sectional study with pathological analysis of the carotid arteries. Stroke. 2011 Dec; 42 (12):3614-5 Epub 2011 Sept 22
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Middleton LE, Grinberg LT, Miller B, Kawas C, Yaffe K. Neuropathologic features associated with Alzheimer disease diagnosis: age matters. Neurology. 2011 Nov 8; 77 (19):1737-44 Epub 2011 Oct 26
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Grottrup B, Bockmann M, Marcus K, Wiltfang J, Grinberg LT, Meyer HE, Park YM. Clinical aspects of neurodegenerative diseases - 15th HUPO BPP Workshop April 8-9, 2011, Bochum, Germany. Proteomics. 2011 Nov; 11 (22):4279-83
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Teipel SJ, Meindl T, Grinberg L, Grothe M, Cantero JL, Reiser MF, Moller HJ, Heinsen H, Hampel H. The cholinergic system in mild cognitive impairment and Alzheimer's disease: an in vivo MRI and DTI study. Hum Brain Mapp. 2011 Sep; 32 (9):1349-62 Epub 2010 July 29
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Gigante AD, Young LT, Yatham LN, Andreazza AC, Nery FG, Grinberg LT, Heinsen H, Lafer B. Morphometric post-mortem studies in bipolar disorder: possible association with oxidative stress and apoptosis. Int J Neuropsychopharmacol. 2011 Sep; 14 (8):1075-89 Epub 2010 Dec 23
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Grottrup B, Marcus K, Grinberg LT, Lee SK, Meyer HE, Park YM. Creating a human brain proteome atlas--14th HUPO BPP workshop September 20-21, 2010, Sydney, Australia. Proteomics. 2011 Aug; 11 (16):3269-72
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Grottrup B, Stephan C, Marcus K, Grinberg LT, Wiltfang J, Lee SK, Kim YH, Meyer HE, Park YM. Creating a human brain proteome atlas--13th HUPO BPP Workshop March 30-31, 2010, Ochang, Korea. Proteomics. 2011 Jul; 11 (14):2759-62
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Grinberg LT, Rueb U, Heinsen H. Brainstem: neglected locus in neurodegenerative diseases. Front Neurol. 2011; 2:42 Epub 2011 July 11
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Grinberg LT, Heinsen H. Toward a pathological definition of vascular dementia. J Neurol Sci. 2010 Dec 15; 299 (1-2):136-8
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Ferretti REL, Jacob-Filho W, Grinberg LT, Leite REP, Farfel JM, Suemoto CK, Saldiva PHN, Rosemberg S, Pasqualucci CA, Nitrini R. Morphometric brain changes during aging: Results from a Brazilian necropsy sample. Dement Neuropsychol. 2010 Oct-Dec; 4 (4):332-337
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Ferretti REL, Damin AE, Brucki SMD, Morillo LS, Perroco TR, Campora F, Moreira EG, Balbino ES, Lima MDCA, Battela C, Ruiz L, Grinberg LT, Farfel JM, Leite REP, Suemoto CK, Pasqualucci CA, Rosemberg S, Saldiva PHN, Jacob-Filho W, Nitrini R. Post-Mortem diagnosis of dementia by informant interview. Dement Neuropsychol. 2010 Apr-Jun; 4 (2):138-144
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Grinberg LT, Thal DR. Vascular pathology in the aged human brain. Acta Neuropathol. 2010 Mar; 119 (3):277-90 Epub 2010 Feb 14
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Grinberg LT, Rueb U, Alho AT, Heinsen H. Brainstem pathology and non-motor symptoms in PD. J Neurol Sci. 2010 Feb 15; 289 (1-2):81-8 Epub 2009 Sept 15
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Takada LT, Camiz P, Grinberg LT, Leite CDC. Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case study. Dement Neuropsychol. 2009 Oct-Dec; 3 (4):352-357
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Suemoto CK, Ferretti RE, Grinberg LT, de Oliveira KC, Farfel JM, Leite REP, Nitrini R, Jacob Filho W, Pasqualucci CA, Brazilian Aging Brain Study Group. Association between cardiovascular disease and dementia. Dement Neuropsychol. 2009 Oct-Dec; 3 (4):308-314
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Kim YH, Marcus K, Grinberg LT, Goehler H, Wiltfang J, Stephan C, Eisenacher M, Hardt T, Martens L, J Dunn M, Park YM, Meyer HE. Toward a Successful Clinical Neuroproteomics The 11th HUPO Brain Proteome Project Workshop 3 March, 2009, Kolymbari, Greece. Proteomics Clin Appl. 2009 Sep; 3 (9):1012-6 Epub 2009 Aug 04
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Grinberg LT, Amaro Junior E, da Silva AV, da Silva RE, Sato JR, dos Santos DD, de Paula Pacheco S, de Lucena Ferretti RE, Paraizo Leite RE, Pasqualucci CA, Teipel SJ, Flatz WH, Heinsen H, Brazilian Aging Brain Study Group. Improved detection of incipient vascular changes by a biotechnological platform combining post mortem MRI in situ with neuropathology. J Neurol Sci. 2009 Aug 15; 283 (1-2):2-8 Epub 2009 Mar 16
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Grinberg LT, Rub U, Ferretti RE, Nitrini R, Farfel JM, Polichiso L, Gierga K, Jacob-Filho W, Heinsen H, Brazilian Brain Bank Study Group. The dorsal raphe nucleus shows phospho-tau neurofibrillary changes before the transentorhinal region in Alzheimer's disease. A precocious onset? Neuropathol Appl Neurobiol. 2009 Aug; 35 (4):406-16
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Paula-Lima AC, Tricerri MA, Brito-Moreira J, Bomfim TR, Oliveira FF, Magdesian MH, Grinberg LT, Panizzutti R, Ferreira ST. Human apolipoprotein A-I binds amyloid-beta and prevents Abeta-induced neurotoxicity. Int J Biochem Cell Biol. 2009 Jun; 41 (6):1361-70 Epub 2008 Dec 14
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Azevedo FA, Carvalho LR, Grinberg LT, Farfel JM, Ferretti RE, Leite RE, Jacob Filho W, Lent R, Herculano-Houzel S. Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain. J Comp Neurol. 2009 Apr 10; 513 (5):532-41
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Grinberg LT, Heinsen H. Argyrophilic grain disease: an update about a frequent cause of dementia. Dement Neuropsychol. 2009 Jan-Mar; 3 (1):2-7
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Grinberg LT, Amaro E Jr, Teipel S, dos Santos DD, Pasqualucci CA, Leite RE, Camargo CR, Goncalves JA, Sanches AG, Santana M, Ferretti RE, Jacob-Filho W, Nitrini R, Heinsen H, Brazilian Aging Brain Study Group. Assessment of factors that confound MRI and neuropathological correlation of human postmortem brain tissue. Cell Tissue Bank. 2008 Sep; 9 (3):195-203 Epub 2008 June 12
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Liscic RM, Grinberg LT, Zidar J, Gitcho MA, Cairns NJ. ALS and FTLD: two faces of TDP-43 proteinopathy. Eur J Neurol. 2008 Aug; 15 (8):772-80
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Teipel SJ, Meindl T, Grinberg L, Heinsen H, Hampel H. Novel MRI techniques in the assessment of dementia. Eur J Nucl Med Mol Imaging. 2008 Mar; 35 Suppl 1:S58-69
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Leite REP; Jacob Filho W, Saiki M, Grinberg LT, Ferretti REL. Determination of trace elements in human brain tissues using neutron activation analysis. J Radioanal Nucl Chem. 2008; (278):581-584.
Grinberg LT, Ferraz da Silva LF, Galtarossa Xavier AC, Nascimento Saldiva PH, Mauad T. Clinico-pathological discrepancies in the diagnoses of solid malignancies. Pathol Res Pract. 2008; 204 (12):867-73 Epub 2008 Aug 27
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Grinberg LT, Ferretti REL, Leite REP, Farfel JM, Pacheco SP, Alho ATDL, Grisoli RP, Matos HTM, Moreira EG, Balbino ES, Oliveira KC, Rosemberg S, Carvalho HB, Pasquallucci CAG, Saldiva PHN, Jacob-Filho W, Nitrini R. Clinicopathological correlates of Alzheimer's disease in a general autopsy series from Brazil. Dement Neuropsychol. 2007 Oct-Dec; 1 (4):356-360
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Grinberg LT, Heinsen H. Computer-assisted 3D reconstruction of the human basal forebrain complex. Dement Neuropsychol. 2007 Apr-Jun; 1 (2):140-146
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Behrens MI, Mukherjee O, Tu PH, Liscic RM, Grinberg LT, Carter D, Paulsmeyer K, Taylor-Reinwald L, Gitcho M, Norton JB, Chakraverty S, Goate AM, Morris JC, Cairns NJ. Neuropathologic heterogeneity in HDDD1: a familial frontotemporal lobar degeneration with ubiquitin-positive inclusions and progranulin mutation. Alzheimer Dis Assoc Disord. 2007 Jan-Mar; 21 (1):1-7
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Grinberg LT, Ferretti RE, Farfel JM, Leite R, Pasqualucci CA, Rosemberg S, Nitrini R, Saldiva PH, Filho WJ, Brazilian Aging Brain Study Group. Brain bank of the Brazilian aging brain study group - a milestone reached and more than 1,600 collected brains. Cell Tissue Bank. 2007; 8 (2):151-62 Epub 2006 Oct 31
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Mukherjee O, Pastor P, Cairns NJ, Chakraverty S, Kauwe JS, Shears S, Behrens MI, Budde J, Hinrichs AL, Norton J, Levitch D, Taylor-Reinwald L, Gitcho M, Tu PH, Tenenholz Grinberg L, Liscic RM, Armendariz J, Morris JC, Goate AM. HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin. Ann Neurol. 2006 Sep; 60 (3):314-22
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Mauad T, Silva LF, Santos MA, Grinberg L, Bernardi FD, Martins MA, Saldiva PH, Dolhnikoff M. Abnormal alveolar attachments with decreased elastic fiber content in distal lung in fatal asthma. Am J Respir Crit Care Med. 2004 Oct 15; 170 (8):857-62 Epub 2004 May 19
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Lea Grinberg, M.D., Ph.D.

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