Publications

  1. Liu Y, Jaquith JM, Mccarthy-Fruin K, Zhu X, Zhou X, Li Y, Crowson C, Davis JM 3rd, Thanarajasingam U, Zeng H. Immune checkpoint inhibitor-induced inflammatory arthritis: a novel clinical entity with striking similarities to seronegative rheumatoid arthritis. Clin Rheumatol. 2020 May 30 [Epub ahead of print]
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  2. Du X, Zeng H, Liu S, Guy C, Dhungana Y, Neale G, Bergo MO, Chi H. Mevalonate metabolism-dependent protein geranylgeranylation regulates thymocyte egress. J Exp Med. 2020 Feb 3; 217 (2)
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  3. Saravia J, Zeng H, Dhungana Y, Bastardo Blanco D, Nguyen TM, Chapman NM, Wang Y, Kanneganti A, Liu S, Raynor JL, Vogel P, Neale G, Carmeliet P, Chi H. Homeostasis and transitional activation of regulatory T cells require c-Myc. Sci Adv. 2020 Jan; 6 (1):eaaw6443 Epub 2020 Jan 01
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  4. Zhang Z, Huang Z, Ong B, Sahu C, Zeng H, Ruan HB. Bone marrow adipose tissue-derived stem cell factor mediates metabolic regulation of hematopoiesis. Haematologica. 2019 Sep; 104 (9):1731-1743 Epub 2019 Feb 21
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  5. Jung J, Zeng H, Horng T. Metabolism as a guiding force for immunity. Nat Cell Biol. 2019 Jan; 21 (1):85-93 Epub 2019 Jan 02
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  6. Chapman NM, Zeng H, Nguyen TM, Wang Y, Vogel P, Dhungana Y, Liu X, Neale G, Locasale JW, Chi H. mTOR coordinates transcriptional programs and mitochondrial metabolism of activated Treg subsets to protect tissue homeostasis. Nat Commun. 2018 May 29; 9 (1):2095
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  7. Li Y, Bakke J, Finkelstein D, Zeng H, Wu J, Chen T. HNRNPH1 is required for rhabdomyosarcoma cell growth and survival. Oncogenesis. 2018 Jan 24; 7 (1):9
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  8. Zeng H, Yu M, Tan H, Li Y, Su W, Shi H, Dhungana Y, Guy C, Neale G, Cloer C, Peng J, Wang D, Chi H. Discrete roles and bifurcation of PTEN signaling and mTORC1-mediated anabolic metabolism underlie IL-7-driven B lymphopoiesis. Sci Adv. 2018 Jan; 4 (1):eaar5701 Epub 2018 Jan 31
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  9. Yu M, Chen Y, Zeng H, Zheng Y, Fu G, Zhu W, Broeckel U, Aggarwal P, Turner A, Neale G, Guy C, Zhu N, Chi H, Wen R, Wang D. PLCgamma-dependent mTOR signalling controls IL-7-mediated early B cell development. Nat Commun. 2017 Nov 13; 8 (1):1457
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  10. Zeng H. mTOR signaling in immune cells and its implications for cancer immunotherapy. Cancer Lett. 2017 Nov 1; 408:182-189 Epub 2017 Sept 06
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  11. Zeng H, Chi H. mTOR signaling in the differentiation and function of regulatory and effector T cells Current opinion in immunology.2017;
  12. Lewis Zhichang Shi, Jordy Saravia, Hu Zeng, Nishan S. Kalupahana, Clifford S. Guy, Geoffrey Neale, and Hongbo Chi.. Gfi1-Foxo1 axis controls the fidelity of effector gene expression and developmental maturation of thymocytes PNAS.2017;
  13. Zeng H, Cohen S, Rathmell JC, Chi H. mTORC1 and mTORC2 kinase signaling and glucose metabolism drive follicular helper T cell differentiation Immunity. 2016.
  14. Chaohong Liu, Nicole Chapman, Peer Karmaus, Zeng Hu, Hongbo Chi. mTOR and metabolic regulation of conventional and regulatory T cells. Journal of Leukocyte Biology.2015;
  15. Hu Zeng , Hongbo Chi. Metabolic control of regulatory T cell development and function. Trends in Immunology.2015;
  16. Zeng H, Chi H. mTOR signaling and transcriptional regulation in T lymphocytes Transcription.2014;
  17. Kai Yang, Sharad Shrestha, Hu Zeng, Peer W. F. Karmaus, Geoffrey Neale, Peter Vogel, David A. Guertin, Richard F. Lamb, Hongbo Chi.. T cell exit from quiescence and differentiation into Th2 cells depend on raptor-mTORC1-mediated metabolic reprogramming. Immunity.2013;
  18. Zeng H, Chi H. The interplay between regulatory T cells and metabolic signals in immune regulation Oncoimmunology.2013;
  19. Yanyan Wang, Guanghua Huang, Hu Zeng, Kai Yang, Richard F. Lamb, Hongbo Chi. Tuberous sclerosis 1 (Tsc1)-dependent metabolic checkpoint controls development of dendritic cells PNAS.2013;
  20. Hu Zeng , Kai Yang, Caryn Cloer, Geoffrey Neale, Peter Vogel, Hongbo Chi. mTORC1 couples immune signals and metabolic programming to establish Treg cell function. Nature.2013;
  21. Zeng H, Chi H. mTOR and lymphocyte metabolism Current opinion in immunology.2013;
  22. Wuerzberger-Davis SM, Chen Y, Yang DT, Kearns JD, Bates PW, Lynch C, Ladell NC, Yu M, Podd A, Zeng H, Huang T, Wen R, Hoffman A, Wang D. Nuclear Export of the NF-kB Inhibitor IkBa Is Required for Proper B Cell and Secondary Lymphoid Tissue Formation Immunity.2011;
  23. Yokosuka T, Kobayashi W, Takamatsu M, Sakata-Sogawa K, Zeng H, Hashimoto-Tane A, Yagita H, Tokunaga M, Saito T. Spatiotemporal Basis of CTLA-4 Costimulatory Molecule-Mediated Negative Regulation of T Cell Activation Immunity.2010;
  24. Hu Zeng , Yuhong Chen, Mei Yu, Liquan Xue, Xiang Gao, Stephan W. Morris, Demin Wang, and Renren Wen. TCR-mediated activation of CD4+CD44hi T cells bypasses Bcl10---An implication of differential NF-?B dependence of naïve and memory T cells during TCR-mediated responses Journal of Biological Chemistry.2008;
  25. Malarkannan S, Regunathan J, Chu H, Kutlesa S, Chen Y, Zeng H, Wen R, Wang D. Bcl10 Plays a Divergent Role in NK Cell-Mediated Cytotoxicity and Cytokine Generation Journal of Immunology.2007;
  26. Zeng H, Di L, Fu G, Chen Y, Gao X, Xu L, Lin X, Wen R. Phosphorylation of Bcl10 Negatively Regulates T-cell- receptor Mediated NF-?B Activation Molecular and Cellular Biology.2007;
  27. Chen Y, Pappu BP, Zeng H, Xue L, Morris SW, Lin X, Wen R, Wang D. B Cell Lymphoma 10 Is Essential for FcR-Mediated Degranulation and IL-6 Production in Mast Cells Journal of Immunology.2007;
  28. Wen R, Chen Y, Bai L, Fu G, Schuman J, Dai X, Zeng H, Yang C, Stephan RP, Cleveland JL, Wang D. Essential Role of Phospholipase C?? in Early B-Cell Development and Myc-Mediated Lymphomagenesis Molecular and Cellular Biology.2006;
  29. Yu M, Sha H, Gao Y, Zeng H, Zhu M, Gao X. Alternative 3’UTR polyadenylation of Bzw1 transcripts display differential translation efficiency and tissue-specific expression Biochemical and Biophysical Research Communications.2006;
  30. Wu X, Zeng H, Zhang X, Zhao Y, Sha H, Ge X, Zhang M, Gao X, Xu Q. Phosphatase of Regenerating Liver-3 Promotes Motility and Metastasis of Mouse Melanoma Cells American Journal of Pathology.2004;