Publications

  1. Qin C, Chen M, Dong MH, Yang S, Zhang H, You YF, Zhou LQ, Chu YH, Tang Y, Pang XW, Wu LJ, Tian DS, Wang W. Soluble TREM2 triggers microglial dysfunction in neuromyelitis optica spectrum disorders. Brain. 2023 Sep 22 Epub 2023 Sept 22
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  2. Weilinger NL, Yang K, Choi HB, Groten CJ, Wendt S, Murugan M, Wicki-Stordeur LE, Bernier LP, Velayudhan PS, Zheng J, LeDue JM, Rungta RL, Tyson JR, Snutch TP, Wu LJ, MacVicar BA. Pannexin-1 opening in neuronal edema causes cell death but also leads to protection via increased microglia contacts. Cell Rep. 2023 Sep 22; 42 (10):113128 Epub 2023 Sept 22
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  3. Liu X, Lei Z, Gilhooly D, He J, Li Y, Ritzel RM, Li H, Wu LJ, Liu S, Wu J. Traumatic brain injury-induced inflammatory changes in the olfactory bulb disrupt neuronal networks leading to olfactory dysfunction. Brain Behav Immun. 2023 Aug 7; 114:22-45 Epub 2023 Aug 07
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  4. Ayasoufi K, Wolf DM, Namen SL, Jin F, Tritz ZP, Pfaller CK, Zheng J, Goddery EN, Fain CE, Gulbicki LR, Borchers AL, Reesman RA, Yokanovich LT, Maynes MA, Bamkole MA, Khadka RH, Hansen MJ, Wu LJ, Johnson AJ. Brain resident memory T cells rapidly expand and initiate neuroinflammatory responses following CNS viral infection. Brain Behav Immun. 2023 Aug; 112:51-76 Epub 2023 May 24
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  5. Zhao S, Zheng J, Wang L, Umpierre AD, Parusel S, Xie M, Dheer A, Ayasoufi K, Johnson AJ, Richardson JR, Wu LJ. Chemogenetic manipulation of CX3CR1(+) cells transiently induces hypolocomotion independent of microglia. Mol Psychiatry. 2023 Jun 26 Epub 2023 June 26
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  6. Qi F, Zuo Z, Hu K, Wang R, Wu T, Liu H, Tang J, Wang Q, Xie Y, Tan L, Yang Y, Zhang X, Zheng J, Xu J, Yao Z, Wang S, Wu LJ, Guo K. VEGF-A in serum protects against memory impairment in APP/PS1 transgenic mice by blocking neutrophil infiltration. Mol Psychiatry. 2023 Jun 6 Epub 2023 June 06
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  7. Qin C, Yang S, Chen M, Dong MH, Zhou LQ, Chu YH, Shen ZX, Bosco DB, Wu LJ, Tian DS, Wang W. Modulation of microglial metabolism facilitates regeneration in demyelination. iScience. 2023 May 19; 26 (5):106588 Epub 2023 Apr 11
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  8. Meneses AD, Koga S, Li Z, O'Leary J, Li F, Chen K, Murakami A, Qiao W, Kurti A, Heckman MG, White L, Xie M, Chen Y, Finch NA, Lim MJ, Delenclos M, DeTure MA, Linares C, Martin NB, Ikezu TC, van Blitterswijk MM, Wu LJ, McLean PJ, Rademakers R, Ross OA, Dickson DW, Bu G, Zhao N. APOE2 Exacerbates TDP-43 Related Toxicity in the Absence of Alzheimer Pathology. Ann Neurol. 2023 Apr; 93 (4):830-843 Epub 2023 Jan 10
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  9. Parusel S, Yi MH, Hunt CL, Wu LJ. Chemogenetic and Optogenetic Manipulations of Microglia in Chronic Pain. Neurosci Bull. 2023 Mar; 39 (3):368-378 Epub 2022 Aug 17
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  10. Shi Z, Yu P, Lin WJ, Chen S, Hu X, Chen S, Cheng J, Liu Q, Yang Y, Li S, Zhang Z, Xie J, Jiang J, He B, Li Y, Li H, Xu Y, Zeng J, Huang J, Mei J, Cai J, Chen J, Wu LJ, Ko H, Tang Y. Microglia drive transient insult-induced brain injury by chemotactic recruitment of CD8(+) T lymphocytes. Neuron. 2023 Mar 1; 111 (5):696-710.e9 Epub 2023 Jan 04
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  11. Neal ML, Beier EE, Hossain MM, Boyle A, Zheng J, Kim C, Mhatre-Winters I, Wu LJ, Richardson JR. Voltage-Gated Proton Channel Hv1 Regulates Neuroinflammation and Dopaminergic Neurodegeneration in Parkinson's Disease Models. Antioxidants (Basel). 2023 Feb 25; 12 (3)
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  12. Cheng J, Jiang J, He B, Lin WJ, Li Y, Duan J, Li H, Huang X, Cai J, Xie J, Zhang Z, Yang Y, Xu Y, Hu X, Wu M, Zhuo X, Liu Q, Shi Z, Yu P, Rong X, Ye X, Saw PE, Wu LJ, Simone CB 2nd, Chua MLK, Mai HQ, Tang Y. A phase 2 study of thalidomide for the treatment of radiation-induced blood-brain barrier injury. Sci Transl Med. 2023 Feb 22; 15 (684):eabm6543
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  13. Luo W, Xu H, Xu L, Jiang W, Chen C, Chang Y, Liu C, Tian Z, Qiu X, Xie C, Li X, Chen H, Lai S, Wu L, Cui Y, Tang C, Qiu W. Remyelination in neuromyelitis optica spectrum disorder is promoted by edaravone through mTORC1 signaling activation. Glia. 2023 Feb; 71 (2):284-304 Epub 2022 Sept 12
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  14. Zhou LQ, Dong MH, Hu ZW, Tang Y, Chu YH, Chen M, Yang S, Chen Z, Wu LJ, Wang W, Qin C, Tian DS. Staged suppression of microglial autophagy facilitates regeneration in CNS demyelination by enhancing the production of linoleic acid. Proc Natl Acad Sci U S A. 2023 Jan 3; 120 (1):e2209990120 Epub 2022 Dec 28
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  15. Zhao N, Qiao W, Li F, Ren Y, Zheng J, Martens YA, Wang X, Li L, Liu CC, Chen K, Zhu Y, Ikezu TC, Li Z, Meneses AD, Jin Y, Knight JA, Chen Y, Bastea L, Linares C, Sonustun B, Job L, Smith ML, Xie M, Liu YU, Umpierre AD, Haruwaka K, Quicksall ZS, Storz P, Asmann YW, Wu LJ, Bu G. Elevating microglia TREM2 reduces amyloid seeding and suppresses disease-associated microglia. J Exp Med. 2022 Dec 5; 219 (12) Epub 2022 Sept 15
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  16. Paolicelli RC, Sierra A, Stevens B, Tremblay ME, Aguzzi A, Ajami B, Amit I, Audinat E, Bechmann I, Bennett M, Bennett F, Bessis A, Biber K, Bilbo S, Blurton-Jones M, Boddeke E, Brites D, Brone B, Brown GC, Butovsky O, Carson MJ, Castellano B, Colonna M, Cowley SA, Cunningham C, Davalos D, De Jager PL, de Strooper B, Denes A, Eggen BJL, Eyo U, Galea E, Garel S, Ginhoux F, Glass CK, Gokce O, Gomez-Nicola D, Gonzalez B, Gordon S, Graeber MB, Greenhalgh AD, Gressens P, Greter M, Gutmann DH, Haass C, Heneka MT, Heppner FL, Hong S, Hume DA, Jung S, Kettenmann H, Kipnis J, Koyama R, Lemke G, Lynch M, Majewska A, Malcangio M, Malm T, Mancuso R, Masuda T, Matteoli M, McColl BW, Miron VE, Molofsky AV, Monje M, Mracsko E, Nadjar A, Neher JJ, Neniskyte U, Neumann H, Noda M, Peng B, Peri F, Perry VH, Popovich PG, Pridans C, Priller J, Prinz M, Ragozzino D, Ransohoff RM, Salter MW, Schaefer A, Schafer DP, Schwartz M, Simons M, Smith CJ, Streit WJ, Tay TL, Tsai LH, Verkhratsky A, von Bernhardi R, Wake H, Wittamer V, Wolf SA, Wu LJ, Wyss-Coray T. Microglia states and nomenclature: A field at its crossroads. Neuron. 2022 Nov 2; 110 (21):3458-3483
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  17. Gu N, Yi MH, Murugan M, Xie M, Parusel S, Peng J, Eyo UB, Hunt CL, Dong H, Wu LJ. Spinal microglia contribute to sustained inflammatory pain via amplifying neuronal activity. Mol Brain. 2022 Oct 26; 15 (1):86
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  18. Kerezoudis P, Howe CL, Wu LJ, Lundstrom BN, Van Gompel JJ. Insula and the Immune System: More than mere Co-existence? Neurosci Bull. 2022 Oct; 38 (10):1271-1273 Epub 2022 June 28
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  19. Ma C, Fu Q, Diggs LP, McVey JC, McCallen J, Wabitsch S, Ruf B, Brown Z, Heinrich B, Zhang Q, Rosato U, Wang S, Cui L, Berzofsky JA, Kleiner DE, Bosco DB, Wu LJ, Lai CW, Rotman Y, Xie C, Korangy F, Greten TF. Platelets control liver tumor growth through P2Y12-dependent CD40L release in NAFLD. Cancer Cell. 2022 Sep 12; 40 (9):986-998.e5 Epub 2022 Sept 01
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  20. Jiang BC, Ding TY, Guo CY, Bai XH, Cao DL, Wu XB, Sha WL, Jiang M, Wu LJ, Gao YJ. NFAT1 Orchestrates Spinal Microglial Transcription and Promotes Microglial Proliferation via c-MYC Contributing to Nerve Injury-Induced Neuropathic Pain. Adv Sci (Weinh). 2022 Sep; 9 (27):e2201300 Epub 2022 July 27
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  21. Li EC, Zheng Y, Cai MT, Lai QL, Fang GL, Du BQ, Shen CH, Zhang YX, Wu LJ, Ding MP. Seizures and epilepsy in multiple sclerosis, aquaporin 4 antibody-positive neuromyelitis optica spectrum disorder, and myelin oligodendrocyte glycoprotein antibody-associated disease. Epilepsia. 2022 Sep; 63 (9):2173-2191 Epub 2022 July 10
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  22. Umpierre AD, Haruwaka K, Wu LJ. Getting a Sense of ATP in Real Time. Neurosci Bull. 2022 Jul; 38 (7):834-836 Epub 2022 Mar 30
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  23. Zheng J, Murugan M, Wang L, Wu LJ. Microglial voltage-gated proton channel Hv1 in spinal cord injury. Neural Regen Res. 2022 Jun; 17 (6):1183-1189
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  24. Tan Z, Lin ZJ, Wu LJ, Zhou LJ. The Macrophage IL-23/IL-17A Pathway: A New Neuro-Immune Mechanism in Female Mechanical Pain. Neurosci Bull. 2022 Apr; 38 (4):453-455 Epub 2021 Dec 15
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  25. Tian DS, Qin C, Zhou LQ, Yang S, Chen M, Xiao J, Shang K, Bosco DB, Wu LJ, Wang W. FSAP aggravated endothelial dysfunction and neurological deficits in acute ischemic stroke due to large vessel occlusion. Signal Transduct Target Ther. 2022 Jan 7; 7 (1):6 Epub 2022 Jan 07
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  26. Xie M, Zhao S, Bosco DB, Nguyen A, Wu LJ. Microglial TREM2 in amyotrophic lateral sclerosis. Dev Neurobiol. 2022 Jan; 82 (1):125-137 Epub 2021 Dec 18
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  27. Xie M, Liu YU, Zhao S, Zhang L, Bosco DB, Pang YP, Zhong J, Sheth U, Martens YA, Zhao N, Liu CC, Zhuang Y, Wang L, Dickson DW, Mattson MP, Bu G, Wu LJ. TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration. Nat Neurosci. 2022 Jan; 25 (1):26-38 Epub 2021 Dec 16
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  28. Yu HH, Ma XT, Ma X, Chen M, Chu YH, Wu LJ, Wang W, Qin C, Tian DS. Remote Limb Ischemic Postconditioning Protects Against Ischemic Stroke by Promoting Regulatory T Cells Thriving. J Am Heart Assoc. 2021 Nov 16; 10 (22):e023077 Epub 2021 Nov 02
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  29. Ma X, Qin C, Chen M, Yu HH, Chu YH, Chen TJ, Bosco DB, Wu LJ, Bu BT, Wang W, Tian DS. Regulatory T cells protect against brain damage by alleviating inflammatory response in neuromyelitis optica spectrum disorder. J Neuroinflammation. 2021 Sep 15; 18 (1):201 Epub 2021 Sept 15
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  30. Umpierre AD, Wu LJ. How microglia sense and regulate neuronal activity. Glia. 2021 Jul; 69 (7):1637-1653 Epub 2020 Dec 28
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  31. Peng J, Yi MH, Jeong H, McEwan PP, Zheng J, Wu G, Ganatra S, Ren Y, Richardson JR, Oh SB, Wu LJ. The voltage-gated proton channel Hv1 promotes microglia-astrocyte communication and neuropathic pain after peripheral nerve injury. Mol Brain. 2021 Jun 28; 14 (1):99 Epub 2021 June 28
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  32. Eyo UB, Haruwaka K, Mo M, Campos-Salazar AB, Wang L, Speros XS 4th, Sabu S, Xu P, Wu LJ. Microglia provide structural resolution to injured dendrites after severe seizures. Cell Rep. 2021 May 4; 35 (5):109080
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  33. Yang S, Qin C, Hu ZW, Zhou LQ, Yu HH, Chen M, Bosco DB, Wang W, Wu LJ, Tian DS. Microglia reprogram metabolic profiles for phenotype and function changes in central nervous system. Neurobiol Dis. 2021 May; 152:105290 Epub 2021 Feb 05
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  34. Wei Y, Chen T, Bosco DB, Xie M, Zheng J, Dheer A, Ying Y, Wu Q, Lennon VA, Wu LJ. The complement C3-C3aR pathway mediates microglia-astrocyte interaction following status epilepticus. Glia. 2021 May; 69(5):1155-1169. Epub 2020 Dec 14.
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  35. Hu ZW, Zhou LQ, Yang S, Chen M, Yu HH, Tao R, Wu LJ, Wang W, Zhang Q, Qin C, Tian DS. FTY720 Modulates Microglia Toward Anti-inflammatory Phenotype by Suppressing Autophagy via STAT1 Pathway. Cell Mol Neurobiol. 2021 Mar; 41 (2):353-364 Epub 2020 Apr 27
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  36. Yi MH, Liu YU, Umpierre AD, Chen T, Ying Y, Zheng J, Dheer A, Bosco DB, Dong H, Wu LJ. Optogenetic activation of spinal microglia triggers chronic pain in mice. PLoS Biol. 2021 Mar; 19 (3):e3001154 Epub 2021 Mar 19
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  37. Ritzel RM, He J, Li Y, Cao T, Khan N, Shim B, Sabirzhanov B, Aubrecht T, Stoica BA, Faden AI, Wu LJ, Wu J. Proton extrusion during oxidative burst in microglia exacerbates pathological acidosis following traumatic brain injury. Glia. 2021 Mar; 69 (3):746-764 Epub 2020 Oct 22
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  38. Yi MH, Liu YU, Liu K, Chen T, Bosco DB, Zheng J, Xie M, Zhou L, Qu W, Wu LJ. Chemogenetic manipulation of microglia inhibits neuroinflammation and neuropathic pain in mice. Brain Behav Immun. 2021 Feb; 92:78-89 Epub 2020 Nov 20
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  39. Mai CL, Tan Z, Xu YN, Zhang JJ, Huang ZH, Wang D, Zhang H, Gui WS, Zhang J, Lin ZJ, Meng YT, Wei X, Jie YT, Grace PM, Wu LJ, Zhou LJ, Liu XG. CXCL12-mediated monocyte transmigration into brain perivascular space leads to neuroinflammation and memory deficit in neuropathic pain. Theranostics. 2021; 11 (3):1059-1078 Epub 2021 Jan 01
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  40. Li Y, Ritzel RM, He J, Cao T, Sabirzhanov B, Li H, Liu S, Wu LJ, Wu J. The voltage-gated proton channel Hv1 plays a detrimental role in contusion spinal cord injury via extracellular acidosis-mediated neuroinflammation. Brain Behav Immun. 2021 Jan; 91:267-283 Epub 2020 Oct 08
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  41. Chen T, Bosco DB, Ying Y, Tian DS, Wu LJ. The Emerging Role of Microglia in Neuromyelitis Optica. Front Immunol. 2021; 12:616301 Epub 2021 Feb 19
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  42. Chen M, Yang LL, Hu ZW, Qin C, Zhou LQ, Duan YL, Bosco DB, Wu LJ, Zhan KB, Xu SB, Tian DS. Deficiency of microglial Hv1 channel is associated with activation of autophagic pathway and ROS production in LPC-induced demyelination mouse model. J Neuroinflammation. 2020 Nov 6; 17 (1):333 Epub 2020 Nov 06
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  43. Bosco DB, Tian DS, Wu LJ. Neuroimmune interaction in seizures and epilepsy: focusing on monocyte infiltration. FEBS J. 2020 Nov; 287 (22):4822-4837 Epub 2020 June 15
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  44. Tao R, Qin C, Chen M, Yu HH, Wu LJ, Bu BT, Tian DS. Unilateral cerebral cortical encephalitis with epilepsy: a possible special phenotype of MOG antibody-associated disorders. Int J Neurosci. 2020 Nov; 130 (11):1161-1165 Epub 2020 Feb 09
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  45. Murugan M, Zheng J, Wu G, Mogilevsky R, Zheng X, Hu P, Wu J, Wu LJ. The voltage-gated proton channel Hv1 contributes to neuronal injury and motor deficits in a mouse model of spinal cord injury. Mol Brain. 2020 Oct 20; 13 (1):143
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  46. Wu W, Li Y, Wei Y, Bosco DB, Xie M, Zhao MG, Richardson JR, Wu LJ. Microglial depletion aggravates the severity of acute and chronic seizures in mice. Brain Behav Immun. 2020 Oct; 89:245-255 Epub 2020 July 02
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  47. Chen T, Lennon VA, Liu YU, Bosco DB, Li Y, Yi MH, Zhu J, Wei S, Wu LJ. Astrocyte-microglia interaction drives evolving neuromyelitis optica lesion. J Clin Invest. 2020 Aug 3; 130 (8):4025-4038
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  48. Umpierre AD, Bystrom LL, Ying Y, Liu YU, Worrell G, Wu LJ. Microglial calcium signaling is attuned to neuronal activity in awake mice. Elife. 2020 Jul 27; 9 Epub 2020 July 27
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  49. Sharma K, Wu LJ, Eyo UB. Calming Neurons with a Microglial Touch. Trends Neurosci. 2020 Apr; 43 (4):197-199 Epub 2020 Feb 15
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  50. Umpierre AD, Wu LJ. Microglia Research in the 100th Year Since Its Discovery. Neurosci Bull. 2020 Mar; 36 (3):303-306 Epub 2020 Feb 26
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  51. Xu M, Bennett DLH, Querol LA, Wu LJ, Irani SR, Watson JC, Pittock SJ, Klein CJ. Pain and the immune system: emerging concepts of IgG-mediated autoimmune pain and immunotherapies. J Neurol Neurosurg Psychiatry. 2020 Feb; 91(2):177-188. Epub 2018 Sep 17.
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  52. Chen B, Qin C, Tao R, Dong YJ, Ma X, Chen M, Wu LJ, Bu BT, Tian DS. The clinical value of the albumin quotient in patients with neuromyelitis optica spectrum disorder. Mult Scler Relat Disord. 2020 Feb; 38:101880 Epub 2019 Dec 02
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  53. Neal ML, Fleming SM, Budge KM, Boyle AM, Kim C, Alam G, Beier EE, Wu LJ, Richardson JR. Pharmacological inhibition of CSF1R by GW2580 reduces microglial proliferation and is protective against neuroinflammation and dopaminergic neurodegeneration. FASEB J. 2020 Jan; 34 (1):1679-1694 Epub 2019 Dec 04
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  54. Shang K, He J, Zou J, Qin C, Lin L, Zhou LQ, Yang LL, Wu LJ, Wang W, Zhan KB, Tian DS. Fingolimod promotes angiogenesis and attenuates ischemic brain damage via modulating microglial polarization. Brain Res. 2020 Jan 1; 1726:146509 Epub 2019 Oct 15
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  55. Qin C, Tao R, Zhang SQ, Chen B, Chen M, Yu HH, Chu YH, Shang K, Wu LJ, Bu BT, Tian DS. Predictive Factors of Resistance to High-Dose Steroids Therapy in Acute Attacks of Neuromyelitis Optica Spectrum Disorder. Front Neurol. 2020; 11:585471 Epub 2020 Nov 12
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  56. Mo M, Eyo UB, Xie M, Peng J, Bosco DB, Umpierre AD, Zhu X, Tian DS, Xu P, Wu LJ. Microglial P2Y12 Receptor Regulates Seizure-Induced Neurogenesis and Immature Neuronal Projections. J Neurosci. 2019 Nov 20; 39 (47):9453-9464 Epub 2019 Oct 09
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  57. Liu YU, Ying Y, Li Y, Eyo UB, Chen T, Zheng J, Umpierre AD, Zhu J, Bosco DB, Dong H, Wu LJ. Neuronal network activity controls microglial process surveillance in awake mice via norepinephrine signaling. Nat Neurosci. 2019 Nov; 22 (11):1771-1781 Epub 2019 Oct 21
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  58. Qin C, Zhou LQ, Ma XT, Hu ZW, Yang S, Chen M, Bosco DB, Wu LJ, Tian DS. Dual Functions of Microglia in Ischemic Stroke. Neurosci Bull. 2019 Oct; 35 (5):921-933 Epub 2019 May 06
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  59. Qin C, Chen B, Tao R, Chen M, Ma X, Shang K, Wu LJ, Wang W, Bu BT, Tian DS. The clinical value of complement proteins in differentiating AQP4-IgG-positive from MOG-IgG-positive neuromyelitis optica spectrum disorders. Mult Scler Relat Disord. 2019 Oct; 35:1-4 Epub 2019 June 29
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  60. Peng J, Liu Y, Umpierre AD, Xie M, Tian DS, Richardson JR, Wu LJ. Microglial P2Y12 receptor regulates ventral hippocampal CA1 neuronal excitability and innate fear in mice. Mol Brain. 2019 Aug 19; 12 (1):71
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  61. Eyo UB, Wu LJ. Microglia: Lifelong patrolling immune cells of the brain. Prog Neurobiol. 2019 Aug; 179:101614 Epub 2019 May 07
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  62. Feng L, Murugan M, Bosco DB, Liu Y, Peng J, Worrell GA, Wang HL, Ta LE, Richardson JR, Shen Y, Wu LJ. Microglial proliferation and monocyte infiltration contribute to microgliosis following status epilepticus. Glia. 2019 Aug; 67 (8):1434-1448 Epub 2019 Apr 05
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  63. Younger D, Murugan M, Rama Rao KV, Wu LJ, Chandra N. Microglia Receptors in Animal Models of Traumatic Brain Injury. Mol Neurobiol. 2019 Jul; 56 (7):5202-5228 Epub 2018 Dec 16
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  64. Qin C, Zhao XL, Ma XT, Zhou LQ, Wu LJ, Shang K, Wang W, Tian DS. Proteomic profiling of plasma biomarkers in acute ischemic stroke due to large vessel occlusion. J Transl Med. 2019 Jul 1; 17 (1):214 Epub 2019 July 01
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  65. Zhou LJ, Peng J, Xu YN, Zeng WJ, Zhang J, Wei X, Mai CL, Lin ZJ, Liu Y, Murugan M, Eyo UB, Umpierre AD, Xin WJ, Chen T, Li M, Wang H, Richardson JR, Tan Z, Liu XG, Wu LJ. Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain. Cell Rep. 2019 Jun 25; 27 (13):3844-3859.e6
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  66. Hu Y, Nie H, Yu HH, Qin C, Wu LJ, Tang ZP, Tian DS. Efficacy and safety of rituximab for relapsing-remitting multiple sclerosis: A systematic review and meta-analysis. Autoimmun Rev. 2019 May; 18 (5):542-548 Epub 2019 Mar 04
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  67. Liu Y, Cheng A, Li YJ, Yang Y, Kishimoto Y, Zhang S, Wang Y, Wan R, Raefsky SM, Lu D, Saito T, Saido T, Zhu J, Wu LJ, Mattson MP. SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice. Nat Commun. 2019 Apr 23; 10 (1):1886
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  68. Hossain MM, Weig B, Reuhl K, Gearing M, Wu LJ, Richardson JR. The anti-parkinsonian drug zonisamide reduces neuroinflammation: Role of microglial Nav 1.6. Exp Neurol. 2018 Oct; 308:111-119 Epub 2018 July 12
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  69. Bosco DB, Zheng J, Xu Z, Peng J, Eyo UB, Tang K, Yan C, Huang J, Feng L, Wu G, Richardson JR, Wang H, Wu LJ. RNAseq analysis of hippocampal microglia after kainic acid-induced seizures. Mol Brain. 2018 Jun 20; 11 (1):34 Epub 2018 June 20
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  70. Zhao X, Eyo UB, Murugan M, Wu LJ. Microglial interactions with the neurovascular system in physiology and pathology. Dev Neurobiol. 2018 Jun; 78 (6):604-617 Epub 2018 Feb 01
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  71. Eyo UB, Mo M, Yi MH, Murugan M, Liu J, Yarlagadda R, Margolis DJ, Xu P, Wu LJ. P2Y12R-Dependent Translocation Mechanisms Gate the Changing Microglial Landscape. Cell Rep. 2018 Apr 24; 23 (4):959-966
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  72. Eyo UB, Bispo A, Liu J, Sabu S, Wu R, DiBona VL, Zheng J, Murugan M, Zhang H, Tang Y, Wu LJ. The GluN2A Subunit Regulates Neuronal NMDA receptor-Induced Microglia-Neuron Physical Interactions. Sci Rep. 2018 Jan 16; 8 (1):828
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  73. Qin C, Liu Q, Hu ZW, Zhou LQ, Shang K, Bosco DB, Wu LJ, Tian DS, Wang W. Microglial TLR4-dependent autophagy induces ischemic white matter damage via STAT1/6 pathway. Theranostics. 2018; 8 (19):5434-5451 Epub 2018 Oct 29
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  74. Qin C, Fan WH, Liu Q, Shang K, Murugan M, Wu LJ, Wang W, Tian DS. Fingolimod Protects Against Ischemic White Matter Damage by Modulating Microglia Toward M2 Polarization via STAT3 Pathway. Stroke. 2017 Dec; 48 (12):3336-3346 Epub 2017 Nov 07
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  75. Beier EE, Neal M, Alam G, Edler M, Wu LJ, Richardson JR. Alternative microglial activation is associated with cessation of progressive dopamine neuron loss in mice systemically administered lipopolysaccharide. Neurobiol Dis. 2017 Dec; 108:115-127 Epub 2017 Aug 18
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  76. Tian DS, Peng J, Murugan M, Feng LJ, Liu JL, Eyo UB, Zhou LJ, Mogilevsky R, Wang W, Wu LJ. Chemokine CCL2-CCR2 Signaling Induces Neuronal Cell Death via STAT3 Activation and IL-1beta Production after Status Epilepticus. J Neurosci. 2017 Aug 16; 37 (33):7878-7892 Epub 2017 July 17
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  77. Wu R, Li X, Xu P, Huang L, Cheng J, Huang X, Jiang J, Wu LJ, Tang Y. TREM2 protects against cerebral ischemia/reperfusion injury. Mol Brain. 2017 Jun 7; 10 (1):20 Epub 2017 June 07
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  78. Liu Y, Zhou LJ, Wang J, Li D, Ren WJ, Peng J, Wei X, Xu T, Xin WJ, Pang RP, Li YY, Qin ZH, Murugan M, Mattson MP, Wu LJ, Liu XG. TNF-alpha Differentially Regulates Synaptic Plasticity in the Hippocampus and Spinal Cord by Microglia-Dependent Mechanisms after Peripheral Nerve Injury. J Neurosci. 2017 Jan 25; 37 (4):871-881
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  79. Eyo UB, Murugan M, Wu LJ. Microglia-Neuron Communication in Epilepsy. Glia. 2017 Jan; 65: (1)5-18.
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  80. Eyo UB, Peng J, Murugan M, Mo M, Lalani A, Xie P, Xu P, Margolis DJ, Wu LJ. Regulation of Physical Microglia-Neuron Interactions by Fractalkine Signaling after Status Epilepticus. eNeuro. 2016 Nov-Dec; 3 (6) Epub 2017 Jan 16
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  81. Tian DS, Li CY, Qin C, Murugan M, Wu LJ, Liu JL. Deficiency in the voltage-gated proton channel Hv1 increases M2 polarization of microglia and attenuates brain damage from photothrombotic ischemic stroke. J Neurochem. 2016 Oct; 139: (1)96-105.
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  82. Gu N, Peng J, Murugan M, Wang X, Eyo UB, Sun D, Ren Y, DiCicco-Bloom E, Young W, Dong H, Wu LJ. Spinal Microgliosis Due to Resident Microglial Proliferation Is Required for Pain Hypersensitivity after Peripheral Nerve Injury. Cell Rep. 2016 Jul 19; 16: (3)605-14.
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  83. Gu N, Eyo UB, Murugan M, Peng J, Matta S, Dong H, Wu LJ. Microglial P2Y12 receptors regulate microglial activation and surveillance during neuropathic pain. Brain Behav Immun. 2016 Jul; 55:82-92.
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  84. Peng J, Gu N, Zhou L, B Eyo U, Murugan M, Gan WB, Wu LJ. Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury. Nat Commun. 2016 Jun 28; 7:12029.
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  85. Jeong H, Na YJ, Lee K, Kim YH, Lee Y, Kang M, Jiang BC, Yeom YI, Wu LJ, Gao YJ, Kim J, Oh SB. High-resolution transcriptome analysis reveals neuropathic pain gene-expression signatures in spinal microglia after nerve injury. Pain. 2016 Apr; 157: (4)964-76.
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  86. Swiatkowski P, Murugan M, Eyo UB, Wang Y, Rangaraju S, Oh SB, Wu LJ. Activation of microglial P2Y12 receptor is required for outward potassium currents in response to neuronal injury. Neuroscience. 2016 Mar 24; 318:22-33 Epub 2016 Jan 12
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  87. Gui WS, Wei X, Mai CL, Murugan M, Wu LJ, Xin WJ, Zhou LJ, Liu XG. Interleukin-1beta overproduction is a common cause for neuropathic pain, memory deficit, and depression following peripheral nerve injury in rodents. Mol Pain. 2016; 12:
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  88. Xu P, Xu Y, Hu B, Wang J, Pan R, Murugan M, Wu LJ, Tang Y. Extracellular ATP enhances radiation-induced brain injury through microglial activation and paracrine signaling via P2X7 receptor. Brain Behav Immun. 2015 Nov; 50:87-100.
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