Publications

  1. Gates KV, Panicker AJ, Biendarra-Tiegs SM, Vetr NG, Lopera Higuita M, Nelson TJ, Pereira NL, Griffiths LG. Shotgun Immunoproteomics for Identification of Nonhuman Leukocyte Antigens Associated With Cellular Dysfunction in Heart Transplant Rejection. Transplantation. 2022 Jul 1; 106 (7):1376-1389 Epub 2021 Dec 17
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  2. Wu J, Yuk H, Sarrafian TL, Guo CF, Griffiths LG, Nabzdyk CS, Zhao X. An off-the-shelf bioadhesive patch for sutureless repair of gastrointestinal defects. Sci Transl Med. 2022 Feb 2; 14 (630):eabh2857 Epub 2022 Feb 02
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  3. Vogl BJ, Niemi NR, Griffiths LG, Alkhouli MA, Hatoum H. Impact of calcific aortic valve disease on valve mechanics. Biomech Model Mechanobiol. 2022 Feb; 21 (1):55-77 Epub 2021 Oct 23
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  4. Fayyaz AU, Sabbah MS, Dasari S, Griffiths LG, DuBrock HM, Wang Y, Charlesworth MC, Borlaug BA, Jenkins SM, Edwards WD, Redfield MM. Histologic and proteomic remodeling of the pulmonary veins and arteries in a porcine model of chronic pulmonary venous hypertension. Cardiovasc Res. 2022 Jan 12 [Epub ahead of print]
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  5. Lopera Higuita M, Lopera Giraldo JF, Sarrafian TL, Griffiths LG. Tissue engineered bovine saphenous vein extracellular matrix scaffolds produced via antigen removal achieve high in vivo patency rates. Acta Biomater. 2021 Oct 15; 134:144-159 Epub 2021 June 27
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  6. Yuk H, Wu J, Sarrafian TL, Mao X, Varela CE, Roche ET, Griffiths LG, Nabzdyk CS, Zhao X. Rapid and coagulation-independent haemostatic sealing by a paste inspired by barnacle glue. Nat Biomed Eng. 2021 Oct; 5 (10):1131-1142 Epub 2021 Aug 09
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  7. Xing Q, Parvizi M, Lopera Higuita M, Griffiths LG. Basement membrane proteins modulate cell migration on bovine pericardium extracellular matrix scaffold. Sci Rep. 2021 Feb 25; 11 (1):4607
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  8. Shaik TA, Alfonso-Garcia A, Zhou X, Arnold KM, Haudenschild AK, Krafft C, Griffiths LG, Popp J, Marcu L. FLIm-Guided Raman Imaging to Study Cross-Linking and Calcification of Bovine Pericardium. Anal Chem. 2020 Aug 4; 92 (15):10659-10667 Epub 2020 July 14
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  9. Lopera Higuita M, Griffiths LG. Antigen removal process preserves function of small diameter venous valved conduits, whereas SDS-decellularization results in significant valvular insufficiency. Acta Biomater. 2020 Apr 15; 107:115-128 Epub 2020 Mar 07
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  10. Lopera Higuita M, Griffiths LG. Small Diameter Xenogeneic Extracellular Matrix Scaffolds for Vascular Applications. Tissue Eng Part B Rev. 2020 Feb; 26 (1):26-45 Epub 2019 Nov 27
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  11. Shklover J, McMasters J, Alfonso-Garcia A, Higuita ML, Panitch A, Marcu L, Griffiths L. Bovine pericardial extracellular matrix niche modulates human aortic endothelial cell phenotype and function. Sci Rep. 2019 Nov 13; 9 (1):16688
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  12. Li C, Alfonso-Garcia A, McMasters J, Bec J, Weyers B, Uyesaka L, Griffiths L, Panitch A, Marcu L. Simultaneous intraluminal imaging of tissue autofluorescence and eGFP-labeled cells in engineered vascular grafts inside a bioreactor. Methods Appl Fluoresc. 2019 Sep 20; 7 (4):044003 Epub 2019 Sept 20
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  13. Gates KV, Xing Q, Griffiths LG. Immunoproteomic Identification of Noncarbohydrate Antigens Eliciting Graft-Specific Adaptive Immune Responses in Patients with Bovine Pericardial Bioprosthetic Heart Valves. Proteomics Clin Appl. 2019 Jul; 13 (4):e1800129 Epub 2018 Dec 19
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  14. Dalgliesh AJ, Parvizi M, Noble C, Griffiths LG. Effect of cyclic deformation on xenogeneic heart valve biomaterials. PLoS One. 2019; 14 (6):e0214656 Epub 2019 June 13
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  15. Li C, Shklover J, Parvizi M, Sherlock BE, Alfonso Garcia A, Haudenschild AK, Griffiths LG, Marcu L. Label-Free Assessment of Collagenase Digestion on Bovine Pericardium Properties by Fluorescence Lifetime Imaging. Ann Biomed Eng. 2018 Nov; 46 (11):1870-1881 Epub 2018 July 12
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  16. Dalgliesh AJ, Parvizi M, Lopera-Higuita M, Shklover J, Griffiths LG. Graft-specific immune tolerance is determined by residual antigenicity of xenogeneic extracellular matrix scaffolds. Acta Biomater. 2018 Oct 1; 79:253-264 Epub 2018 Aug 18
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  17. Alfonso-Garcia A, Shklover J, Sherlock BE, Panitch A, Griffiths LG, Marcu L. Fiber-based fluorescence lifetime imaging of recellularization processes on vascular tissue constructs. J Biophotonics. 2018 Sep; 11 (9):e201700391 Epub 2018 June 08
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  18. Gates KV, Griffiths LG. Chronic graft-specific cell-mediated immune response toward candidate xenogeneic biomaterial. Immunol Res. 2018 Apr; 66 (2):288-298
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  19. Hegyi B, Bossuyt J, Griffiths LG, Shimkunas R, Coulibaly Z, Jian Z, Grimsrud KN, Sondergaard CS, Ginsburg KS, Chiamvimonvat N, Belardinelli L, Varro A, Papp JG, Pollesello P, Levijoki J, Izu LT, Boyd WD, Banyasz T, Bers DM, Chen-Izu Y. Complex electrophysiological remodeling in postinfarction ischemic heart failure. Proc Natl Acad Sci U S A. 2018 Mar 27; 115 (13):E3036-E3044 Epub 2018 Mar 12
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  20. Dalgliesh AJ, Liu ZZ, Griffiths LG. Magnesium Presence Prevents Removal of Antigenic Nuclear-Associated Proteins from Bovine Pericardium for Heart Valve Engineering. Tissue Eng Part A. 2017 Jul; 23 (13-14):609-621 Epub 2017 Mar 10
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  21. Gates KV, Dalgliesh AJ, Griffiths LG. Antigenicity of Bovine Pericardium Determined by a Novel Immunoproteomic Approach. Sci Rep. 2017 May 26; 7 (1):2446
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  22. Lake-Bakaar GA, Griffiths LG, Kittleson MD. Balloon Valvuloplasty of Tricuspid Stenosis: A Retrospective Study of 5 Labrador Retriever Dogs. J Vet Intern Med. 2017 Mar; 31 (2):311-315 Epub 2017 Feb 21
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  23. Gates KV, Pereira NL, Griffiths LG. Cardiac Non-Human Leukocyte Antigen Identification: Techniques and Troubles. Front Immunol. 2017; 8:1332 Epub 2017 Oct 18
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  24. Liu ZZ, Wong ML, Griffiths LG. Effect of bovine pericardial extracellular matrix scaffold niche on seeded human mesenchymal stem cell function. Sci Rep. 2016 Nov 15; 6:37089.
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  25. Papalamprou A, Chang CW, Vapniarsky N, Clark A, Walker N, Griffiths LG. Xenogeneic cardiac extracellular matrix scaffolds with or without seeded mesenchymal stem cells exhibit distinct in vivo immunosuppressive and regenerative properties. Acta Biomater. 2016 Jul 18;
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  26. Wong ML, Wong JL, Horn RM, Sannajust KC, Rice DA, Griffiths LG. Effect of Urea and Thiourea on Generation of Xenogeneic Extracellular Matrix Scaffolds for Tissue Engineering. Tissue Eng Part C Methods. 2016 Jul; 22: (7)700-7.
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  27. Silverman S, Sanchez-Migallon Guzman D, Stern J, Gustavsen KA, Griffiths LG. Standardization of the two-dimensional transcoelomic echocardiographic examination in the central bearded dragon (Pogona vitticeps). J Vet Cardiol. 2016 Jun; 18: (2)168-78.
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  28. Wong ML, Wong JL, Vapniarsky N, Griffiths LG. In vivo xenogeneic scaffold fate is determined by residual antigenicity and extracellular matrix preservation. Biomaterials. 2016 Jun; 92:1-12.
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  29. Papalamprou A, Griffiths LG. Cardiac Extracellular Matrix Scaffold Generated Using Sarcomeric Disassembly and Antigen Removal. Ann Biomed Eng. 2016 Apr; 44: (4)1047-60.
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  30. Chang CW, Dalgliesh AJ, Lopez JE, Griffiths LG. Cardiac extracellular matrix proteomics: Challenges, techniques, and clinical implications. Proteomics Clin Appl. 2016 Jan; 10: (1)39-50.
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  31. Bozorgmanesh R, Magdesian KG, Estell KE, Stern JA, Swain EA, Griffiths LG. Atrial Fibrillation in Eight New World Camelids. J Vet Intern Med. 2016 Jan-Feb; 30: (1)335-8.
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  32. Chang CW, Petrie T, Clark A, Lin X, Sondergaard CS, Griffiths LG. Mesenchymal Stem Cell Seeding of Porcine Small Intestinal Submucosal Extracellular Matrix for Cardiovascular Applications. PLoS One. 2016; 11: (4)e0153412.
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  33. Jung SW, Sun W, Griffiths LG, Kittleson MD. Atrial Fibrillation as a Prognostic Indicator in Medium to Large-Sized Dogs with Myxomatous Mitral Valvular Degeneration and Congestive Heart Failure. J Vet Intern Med. 2016 Jan-Feb; 30: (1)51-7.
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  34. Kol A, Arzi B, Athanasiou KA, Farmer DL, Nolta JA, Rebhun RB, Chen X, Griffiths LG, Verstraete FJ, Murphy CJ, Borjesson DL. Companion animals: Translational scientist's new best friends. Sci Transl Med. 2015 Oct 7; 7: (308)308ps21.
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  35. Lake-Bakaar GA, Singh MK, Kass PH, Griffiths LG. Effect of pimobendan on the incidence of arrhythmias in small breed dogs with myxomatous mitral valve degeneration. J Vet Cardiol. 2015 Jun; 17: (2)120-8.
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  36. Hanes DW, Wong ML, Jenny Chang CW, Humphrey S, Grayson JK, Boyd WD, Griffiths LG. Embolization of the first diagonal branch of the left anterior descending coronary artery as a porcine model of chronic trans-mural myocardial infarction. J Transl Med. 2015; 13:187.
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  37. Soicher MA, Christiansen BA, Stover SM, Leach JK, Yellowley CE, Griffiths LG, Fyhrie DP. Remineralized bone matrix as a scaffold for bone tissue engineering. J Biomed Mater Res A. 2014 Dec; 102: (12)4480-90.
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  38. Fatakdawala H, Griffiths LG, Humphrey S, Marcu L. Time-resolved fluorescence spectroscopy and ultrasound backscatter microscopy for nondestructive evaluation of vascular grafts. J Biomed Opt. 2014 Aug; 19: (8)080503.
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  39. Cissell DD, Hu JC, Griffiths LG, Athanasiou KA. Antigen removal for the production of biomechanically functional, xenogeneic tissue grafts. J Biomech. 2014 Jun 27; 47: (9)1987-96.
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  40. Wong ML, Griffiths LG. Immunogenicity in xenogeneic scaffold generation: antigen removal vs. decellularization. Acta Biomater. 2014 May; 10: (5)1806-16.
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  41. Wong ML, Wong JL, Athanasiou KA, Griffiths LG. Stepwise solubilization-based antigen removal for xenogeneic scaffold generation in tissue engineering. Acta Biomater. 2013 May; 9: (5)6492-501.
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  42. Lake-Bakaar GA, Johnson EG, Griffiths LG. Aortic thrombosis in dogs: 31 cases (2000-2010). J Am Vet Med Assoc. 2012 Oct 1; 241: (7)910-5.
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  43. Singh MK, Kittleson MD, Kass PH, Griffiths LG. Occlusion devices and approaches in canine patent ductus arteriosus: comparison of outcomes. J Vet Intern Med. 2012 Jan-Feb; 26: (1)85-92.
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  44. Jung S, Orvalho J, Griffiths LG. Aortopulmonary window characterized with two- and three-dimensional echocardiogram in a dog. J Vet Cardiol. 2012; 14: (2)371-5.
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  45. Wong ML, Leach JK, Athanasiou KA, Griffiths LG. The role of protein solubilization in antigen removal from xenogeneic tissue for heart valve tissue engineering. Biomaterials. 2011 Nov; 32: (32)8129-38.
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  46. Arai S, Griffiths LG, Mama K, Hackett TB, Monnet E, Boon JA, Carter L, Orton EC. Bioprosthesis valve replacement in dogs with congenital tricuspid valve dysplasia: technique and outcome. J Vet Cardiol. 2011 Jun; 13: (2)91-9.
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  47. Griffiths LG, Fransioli JR, Chigerwe M. Echocardiographic assessment of interventricular and intraventricular mechanical synchrony in normal dogs. J Vet Cardiol. 2011 Jun; 13: (2)115-26.
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  48. Jung S, Griffiths LG. ECG of the Month. Atrial fibrillation. J Am Vet Med Assoc. 2011 May 15; 238: (10)1258-60.
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  49. Blossom JE, Bright JM, Griffiths LG. Transvenous occlusion of patent ductus arteriosus in 56 consecutive dogs. J Vet Cardiol. 2010 Aug; 12: (2)75-84.
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  50. Griffiths LG. Surgery for cardiac disease in small animals: current techniques. Vet Clin North Am Small Anim Pract. 2010 Jul; 40: (4)605-22.
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  51. Griffiths LG, Choe L, Lee KH, Reardon KF, Orton EC. Protein extraction and 2-DE of water- and lipid-soluble proteins from bovine pericardium, a low-cellularity tissue. Electrophoresis. 2008 Nov; 29: (22)4508-15.
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  52. Griffiths LG, Choe LH, Reardon KF, Dow SW, Christopher Orton E. Immunoproteomic identification of bovine pericardium xenoantigens. Biomaterials. 2008 Sep; 29: (26)3514-20.
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  53. Griffiths LG, Bright JM, Chan KC. Transcatheter intravascular stent placement to relieve supravalvular pulmonic stenosis. J Vet Cardiol. 2006 Nov; 8: (2)145-55.
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  54. Goncalves AC, Griffiths LG, Anthony RV, Orton EC. Decellularization of bovine pericardium for tissue-engineering by targeted removal of xenoantigens. J Heart Valve Dis. 2005 Mar; 14: (2)212-7.
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  55. Griffiths LG, Orton EC, Boon JA. Evaluation of techniques and outcomes of mitral valve repair in dogs. J Am Vet Med Assoc. 2004 Jun 15; 224: (12)1941-5.
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  56. Griffiths LG, Sullivan M, O'Neill T, Reid SW. Ultrasonography versus radiography for detection of fluid in the canine tympanic bulla. Vet Radiol Ultrasound. 2003 Mar-Apr; 44: (2)210-3.
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  57. Doust R, Griffiths LG, Sullivan M. Evaluation of once daily treatment with cyclosporine for anal furunculosis in dogs. Vet Rec. 2003 Feb 22; 152: (8)225-9.
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  58. Griffiths LG, Sullivan M, Reid SW. A comparison of the effects of unilateral thyroarytenoid lateralization versus cricoarytenoid laryngoplasty on the area of the rima glottidis and clinical outcome in dogs with laryngeal paralysis. Vet Surg. 2001 Jul-Aug; 30: (4)359-65.
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  59. Griffiths LG, Sullivan M. Bilateral overlapping mucosal single-pedicle flaps for correction of soft palate defects. J Am Anim Hosp Assoc. 2001 Mar-Apr; 37: (2)183-6.
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  60. Ridyard AE, Corcoran BM, Tasker S, Willis R, Welsh EM, Demetriou JL, Griffiths LG. Spontaneous laryngeal paralysis in four white-coated German shepherd dogs. J Small Anim Pract. 2000 Dec; 41: (12)558-61.
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  61. Griffiths LG, Tiruneh R, Sullivan M, Reid SW. Oropharyngeal penetrating injuries in 50 dogs: a retrospective study. Vet Surg. 2000 Sep-Oct; 29: (5)383-8.
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  62. Griffiths LG, Sullivan M, Borland WW. Cyclosporin as the sole treatment for anal furunculosis: preliminary results. J Small Anim Pract. 1999 Dec; 40: (12)569-72.
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  63. Griffiths LG, Sullivan M, Lerche P. Intrathoracic tracheal avulsion and pseudodiverticulum following pneumomediastinum in a cat. Vet Rec. 1998 Jun 20; 142: (25)693-6.
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