Publications

1. Thake A, Caruso M, Fernandez-Bussy S, Sacco K. The dual role of leukotrienes in the tumor microenvironment: balancing pro-tumorigenic and anti-tumor immunity. Cancer Biol Ther. 2026 Dec 31; 27 (1):2692168 Epub 2026 June 23
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2. Thake A, Sacco K. Temporal dynamics of type I interferon signaling in checkpoint inhibitor response and resistance. Cytokine Growth Factor Rev. 2026 Jun 19; 90:80-87 Epub 2026 June 19
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3. Nahas A, Zammit Lupi D, Nunez Colao B, Sacco K. Circadian control of innate immunity: molecular mechanisms and implications for allergic disorders. Curr Opin Allergy Clin Immunol. 2026 Jun 9 Epub 2026 June 09
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4. Orange JS, Chinen J, Horner CC, Kobrynski LJ, Ballow M, Butte MJ, Chandrakasan S, Chinn IK, Satter LF, Freeman AF, Heimall JR, Knight V, Lawrence MG, Lehman HK, Maglione PJ, Perez EE, Risma KA, Walter JE, Abraham RS, Barmettler S, Broderick L, Chang CC, Chan AY, Chen K, Connelly J, Danziger-Isakov LA, De la Morena MT, DiGiacomo D, Dimitriades VR, Dorsey MJ, Dulek DE, Dutmer CM, Dvorak CC, Farmer JR, Frazer-Abel A, Joshi AY, Keller MD, Khan YW, Kitcharoensakkul M, Leiding JW, Myers KC, Nandakumar V, Platt CD, Pai SY, Patel NC, Pozos TC, Puck JM, Rider NL, Sacco KA, Williams KW, Lieberman JA, Rank MA, Shaker MS, Abrams EM, Bernstein JA, Chu DK, Ellis AK, Golden DBK, Greenhawt M, Ledford DK, Mosnaim G, Wang J. 2025 Inborn errors of immunity practice parameter: Guidance from the Joint Task Force on Practice Parameters, the American Academy of Allergy, Asthma & Immunology (AAAAI), the American College of Allergy, Asthma and Immunology (ACAAI) and the Clinical Immunology Society (CIS). Ann Allergy Asthma Immunol. 2026 Apr; 136 (4):426-493.e1
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5. Krase I, Varghese M, Bauer CS, Wadera S, Sacco K. Infantile Aggressive Systemic Mastocytosis Complicated by Liver Fibrosis Treated With Oral Midostaurin Italian Journal of Pediatric Allergy and Immunology. 2025; (3).
   
6. Bansal R, Lorenzo L, Iro M, Sacco K, Dorr A. Demographic and clinical variation in pediatric hereditary angioedema: a single center service evaluation Italian Journal of Pediatric Allergy and Immunology.. 2025; (2).
   
7. Wang C, LaBere BA, Chinga MML, Harris AJ, Rosen LB, Rivera AE, Le Run E, Sacco KA, Ballan W, Woodward JV, Ostdiek SA, Smith MW, Anderson VL, Daub JR, Palmer CL, Kluczynski LC, Oler AJ, Walkiewicz MA, Ghosh R, Similuk M, Donovan FM, Witt J, Barros N, Wheat LJ, Galgiani JN, Freeman AF, Hsu AP, Zerbe CS, Holland SM. Interferon-gamma therapy in patients with refractory disseminated coccidioidomycosis. Clin Infect Dis. 2025 May 29 [Epub ahead of print]
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8. Krase IZ, Rukasin CRF, Sacco K, Rank MA, Volcheck GW, Gonzalez-Estrada A. Incidence of and risk factors for paediatric perioperative anaphylaxis in the USA. Br J Anaesth. 2024 Sep; 133(3):584-590. Epub 2024 Jul 03.
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9. Sacco KA, Barmettler S. Managing Secondary Immunodeficiency in a Common Variable Immune Deficiency Patient With Autoimmune Encephalitis. J Allergy Clin Immunol Pract. 2024 Sep; 12 (9):2547-2548
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10. Wilson B, Basu A, Sacco K, Abraham R. Novel intronic variant in CYBB causing X-linked chronic granulomatous disease: Case report. Medical Reports. 2024; 5:100060.
    
11. Zhang S, LaBere B, Woodward J, Perry K, Sacco K. Prevalence of Allergic Disorders in Pediatric Coccidioidomycosis. Pediatr Infect Dis J. 2024; 43(7):e245-e247.
    
12. Zhang S, LaBere B, Woodward JV, Ballan W, Perry KW, Sacco K. PREVALENCE OF ATOPIC DISORDERS AMONG PEDIATRIC PATIENTS WITH PULMONARY AND DISSEMINATED COCCIDIOIDOMYCOSIS. Pediatr Infect Dis J. 2024 Mar 22 [Epub ahead of print]
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13. Manchikalapati R, Schening J, Farias AJ, Sacco KA. CLINICAL UTILITY OF INTERLEUKIN-1 INHIBITORS IN PEDIATRIC SEPSIS. Shock. 2024 Mar 1; 61 (3):340-345 Epub 2023 Sept 05
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14. Alzahrani F, Miller HK, Sacco K, Dupuy E. Severe eczema in Wiskott-Aldrich syndrome-related disorder successfully treated with dupilumab. Pediatr Dermatol. 2024 Jan-Feb; 41 (1):143-144 Epub 2023 July 19
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15. FitzPatrick AM, Chin AT, Nirenberg S, Cunningham-Rundles C, Sacco K, Perlmutter J, Dasso JF, Tsalatsanis A, Maru J, Creech J, Walter JE, Hartog N, Izadi N, Palmucci M, Butte MJ, Loewy K, Relan A, Rider NL. Piloting an automated query and scoring system to facilitate APDS patient identification from health systems. Front Immunol. 2024; 15:1508780 Epub 2025 Jan 21
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16. Cunningham L, Merguerian M, Calvo KR, Davis J, Deuitch NT, Dulau-Florea A, Patel N, Yu K, Sacco K, Bhattacharya S, Passi M, Ozkaya N, De Leon S, Chong S, Craft K, Diemer J, Bresciani E, O'Brien K, Andrews EJ, Park N, Hathaway L, Cowen EW, Heller T, Ryan K, Barochia A, Nghiem K, Niemela J, Rosenzweig S, Young DJ, Frischmeyer-Guerrerio PA, Braylan R, Liu PP. Natural history study of patients with familial platelet disorder with associated myeloid malignancy. Blood. 2023 Dec 21; 142 (25):2146-2158
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17. Mesbah Z, Tiwari N, Sacco K. Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy-Associated Hepatitis. ACG Case Rep J. 2023 Dec; 10 (12):e01235 Epub 2023 Dec 16
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18. Wilson BE, Stechelman PV, Mariani R, Goswami N, Sidebottom N, Bauer CS, Sacco KA. Dominant-negative CARD11 loss-of-function variant presenting with hypereosinophilic syndrome. Pediatr Allergy Immunol. 2023 Nov; 34 (11):e14041
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19. Rao A, Piwoz J, Newby K, Sidebottom N, Sacco K. An Infant with Cervical Lymphadenitis Secondary to Nontuberculous Mycobacteria Refractory to Conventional Treatment, Responsive to Interferon-Gamma. Pediatr Infect Dis J 2023 Oct 1; 42 (10):e389-e390 Epub 2023 June 20
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20. Tiano R, Krase IZ, Sacco K. Updates in diagnosis and management of paediatric mastocytosis. Curr Opin Allergy Clin Immunol. 2023 Apr 1; 23 (2):158-163 Epub 2022 Nov 02
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21. Sacco KA, Notarangelo LD, Delmonte OM. When to suspect inborn errors of immunity in Epstein-Barr virus-related lymphoproliferative disorders. Clin Microbiol Infect. 2023 Apr; 29 (4):457-462 Epub 2022 Oct 06
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22. Redmond CJ, Kitakule MM, Son A, Sylvester M, Sacco K, Delmonte O, Licciardi F, Castagnoli R, Poli MC, Espinoza Y, Astudillo C, Weber SE, Montealegre Sanchez GA, Barron KS, Magliocco M, Dobbs K, Zhang Y, Matthews H, Oguz C, Su HC, Notarangelo LD, Frischmeyer-Guerrerio P, Schwartz DM. Deep immune profiling uncovers novel associations with clinical phenotypes of multisystem inflammatory syndrome in children (MIS-C). Ann Rheum Dis. 2023 Mar; 82 (3):442-445 Epub 2022 Nov 24
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23. Sacco K, Kuehn HS, Kawai T, Alsaati N, Smith L, Davila B, Bundy V, Kuhns DB, Dobbs K, Delmonte O, Notarangelo LD, Rosenzweig SD, Keller MD. A Heterozygous Gain-of-Function Variant in IKBKB Associated with Autoimmunity and Autoinflammation. J Clin Immunol. 2023 Feb; 43 (2):512-520 Epub 2022 Nov 15
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24. Sacco KA, Gazzin A, Notarangelo LD, Delmonte OM. Granulomatous inflammation in inborn errors of immunity. Front Pediatr. 2023; 11:1110115 Epub 2023 Feb 20
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25. Krase IZ, Woodward J, Bauer CS, Miller H, Sacco K. Seronegative Mediastinal Coccidioidomycosis as a Novel Presentation of CTPS1 Combined Immunodeficiency. Open Forum Infect Dis. 2022 Aug; 9 (8):ofac403 Epub 2022 Aug 04
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26. Donko A, Kuhns DB, Cousin MA, Smith MJ, Sacco KA, Klee EW, Joshi AY, Gavrilova RH, Holland SM, Leto TL, Abraham RS. Interpretation of Dihydrorhodamine-1,2,3 Flow Cytometry in Chronic Granulomatous Disease: an Atypical Exemplar. J Clin Immunol. 2022 Jul; 42 (5):986-999 Epub 2022 Mar 28
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27. Sacco K, Castagnoli R, Vakkilainen S, Liu C, Delmonte OM, Oguz C, Kaplan IM, Alehashemi S, Burbelo PD, Bhuyan F, de Jesus AA, Dobbs K, Rosen LB, Cheng A, Shaw E, Vakkilainen MS, Pala F, Lack J, Zhang Y, Fink DL, Oikonomou V, Snow AL, Dalgard CL, Chen J, Sellers BA, Montealegre Sanchez GA, Barron K, Rey-Jurado E, Vial C, Poli MC, Licari A, Montagna D, Marseglia GL, Licciardi F, Ramenghi U, Discepolo V, Lo Vecchio A, Guarino A, Eisenstein EM, Imberti L, Sottini A, Biondi A, Mato S, Gerstbacher D, Truong M, Stack MA, Magliocco M, Bosticardo M, Kawai T, Danielson JJ, Hulett T, Askenazi M, Hu S, Cohen JI, Su HC, Kuhns DB, Lionakis MS, Snyder TM, Holland SM, Goldbach-Mansky R, Tsang JS, Notarangelo LD, NIAID Immune Response to COVID Group//Chile MIS-C Group//Pavia Pediatric COVID-19 Group. Immunopathological signatures in multisystem inflammatory syndrome in children and pediatric COVID-19. Nat Med. 2022 Feb 17 [Epub ahead of print]
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28. Nunes-Santos CJ, Koh C, Rai A, Sacco K, Marciano BE, Kleiner DE, Marko J, Bergerson JRE, Stack M, Rivera MM, Constantine G, Strober W, Uzel G, Fuss IJ, Notarangelo LD, Holland SM, Rosenzweig SD, Heller T. Nodular regenerative hyperplasia in X-linked agammaglobulinemia: An underestimated and severe complication. J Allergy Clin Immunol. 2022 Jan; 149 (1):400-409.e3 Epub 2021 June 01
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29. Stack M, Sacco K, Castagnoli R, Livinski AA, Notarangelo LD, Lionakis MS. BTK inhibitors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): A systematic review. Clin Immunol. 2021 Sep; 230:108816 Epub 2021 Aug 02
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30. Park MA, Jenkins SM, Smith CY, Pyle RC, Sacco KA, Ryu E, Hagan JB, Joshi AY, Snyder MR, Abraham RS. Pneumococcal serotype-specific cut-offs based on antibody responses to pneumococcal polysaccharide vaccination in healthy adults. Vaccine. 2021 May 18; 39 (21):2850-2856 Epub 2021 Apr 22
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31. Shin JJ, Catanzaro J, Yonkof JR, Delmonte O, Sacco K, Shin MS, Reddy S, Whittington PJ, Soffer G, Mustillo PJ, Sullivan KE, Notarangelo LD, Abraham RS, Romberg N, Kang I. Infectious Complications Predict Premature CD8(+) T-cell Senescence in CD40 Ligand-Deficient Patients. J Clin Immunol. 2021 May; 41 (4):795-806 Epub 2021 Jan 26
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32. Sacco KA, Stack M, Notarangelo LD. Targeted pharmacologic immunomodulation for inborn errors of immunity. Br J Clin Pharmacol. 2020 Aug 1 Epub 2020 Aug 01
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33. Bojanini L, Sacco K, Maya Villamizar JJ, Wheeler JA, Ahmed NH, Gonzalez-Estrada A. Successful Rapid Oral Desensitization to Sulfasalazine: An 11-Step Protocol. J Clin Rheumatol. 2020 Feb 5 Epub 2020 Feb 05
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34. Sacco KA, Smith MJ, Bahna SL, Buchbinder D, Burkhardt J, Cooper MA, Hartog NL, Kobrynski L, Patel KP, Abraham RS. NAPDH Oxidase-Specific Flow Cytometry Allows for Rapid Genetic Triage and Classification of Novel Variants in Chronic Granulomatous Disease. J Clin Immunol. 2020 Jan; 40 (1):191-202 Epub 2019 Dec 08
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35. Sacco K, Khan TM, Passi M, Hernandez JM, Komarow H. Pancreatic neuroendocrine tumor presenting in indolent systemic mastocytosis: A case report. Int J Surg Case Rep. 2020; 77:397-402 Epub 2020 Nov 10
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36. Bryde RE, Ray JC, Sacco KA, Shapiro B, Cooper L. Eosinophillic Myocarditis Secondary to Metastatic Melanoma. Radiol Cardiothorac Imaging. 2019 Oct 31; 1 (4):e190076
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37. Bryde RE, Ray JC, Sacco KA, Shapiro B, Cooper L. Eosinophillic Myocarditis Secondary to Metastatic Melanoma. Radiol Cardiothorac Imaging. 2019 Oct 31; 1 (4):e190076
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38. Sacco KA, Milner JD. Gene-environment interactions in primary atopic disorders. Curr Opin Immunol. 2019 Oct; 60:148-155 Epub 2019 July 11
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39. Sacco KA, Cochran BP, Epps K, Parkulo M, Gonzalez-Estrada A. Inpatient beta-lactam test-dose protocol and antimicrobial stewardship in patients with a history of penicillin allergy. Ann Allergy Asthma Immunol. 2019 Feb; 122 (2):184-188 Epub 2018 Nov 20
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40. Heckman AJ, Agarwal A, Sacco KA, Hiroto BT, Guru PK. An ounce of caution: Superparamagnetic iron oxide nanoparticle based magnetic resonance imaging contrast-associated anaphylaxis. Ann Allergy Asthma Immunol 2019 Feb; 122 (2):210-211 Epub 2018 Nov 13
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41. Padmanabhan Menon D, Sacco K, Shalev JA, Narula T, Gonzalez-Estrada A. Safety of penicillin allergy skin testing in patients with low lung volumes before lung transplant. Ann Allergy Asthma Immunol 2019 Jan; 122 (1):122-123 Epub 2018 Sept 11
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42. Sacco K, Irvin M, Bates A, Hiroto B, Heckman A, Mareth K, Williams S, Parkulo MA. Evaluation of Medication List Accuracy from Hospital Discharge to first Outpatient Follow-up. Journal of Pharmacy Practice and Research. 2018; 48(5):437-441.
    
43. Sacco KA, Stancampiano FF. Metastatic Carcinoid Taken to Heart. Mayo Clin Proc. 2018 Aug; 93 (8):1152
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44. Sacco KA, Abraham RS. Consequences of B-cell-depleting therapy: hypogammaglobulinemia and impaired B-cell reconstitution. Immunotherapy. 2018 Jun; 10 (8):713-728 Epub 2018 Mar 23
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45. Sacco KA, Chirila R, Libertin C, Hiroto B, Bhasin A, Johnson MM, Pongdee T, Burton MC. Utilization and timeliness of an inpatient penicillin allergy evaluation. Allergy Asthma Proc. 2018 May 1; 39 (3):245-251
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46. Sacco K, Gonzalez-Estrada A. An Update on the Management of Anaphylaxis. Current Treatment Options in Allergy. 2018; 5:212-220.
    
47. Sacco KA, Pongdee T. 52-Year-Old Man With Hyposmia, Rhinorrhea, and Wheezing. Mayo Clin Proc. 2018 Apr; 93 (4):518-522 Epub 2018 Feb 01
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48. Sacco KA, Pongdee T, Binnicker MJ, Espy M, Pardi D, Khanna S, Joshi AY. Presence of immune deficiency increases the risk of hospitalization in patients with norovirus infection. Diagn Microbiol Infect Dis. 2018 Apr; 90 (4):300-306 Epub 2017 Dec 05
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49. Libertin CR, Sacco KA, Peterson JH. Education and coaching to optimise blood culture volumes: continuous quality improvement in microbiology. BMJ Open Qual. 2018; 7 (3):e000228 Epub 2018 July 21
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50. Cornell LF, Sacco KA, Chirila RM. 60-Year-Old Woman With Headache and Fatigue. Mayo Clin Proc. 2017 Sep; 92 (9):e121-e125 Epub 2017 July 08
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51. Sacco KA, Mousa OY, Wang MH. Chronic Abdominal Pain and Cutaneous Swelling. Gastroenterology. 2017 Sep; 153 (3):651-652 Epub 2017 Aug 03
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52. Sacco KA, Bates A, Brigham TJ, Imam JS, Burton MC. Clinical outcomes following inpatient penicillin allergy testing: A systematic review and meta-analysis. Allergy. 2017 Sep; 72 (9):1288-1296 Epub 2017 Apr 26
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53. Greenway MRF, Sacco KA, Burton MC. In Deep: Cerebral Toxoplasmosis. Am J Med. 2017 Jul; 130 (7):802-804 Epub 2017 Apr 08
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54. Sacco KA, Cowdell JC, Burton MC. A non-travel related rash in a traveler. IDCases 2017; 7:32-33 Epub 2016 Dec 16
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55. Sacco KA, Burton MC. Persistent immune thrombocytopenia heralds the diagnosis of Mycobacterium chimaera prosthetic valve endocarditis. IDCases 2017; 7:1-3 Epub 2016 Nov 11
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56. Sacco K, Muhammad A, Saleem W, Alshaker H, Monzon L, Islam MR, Pchejetski D. Leptomeningeal carcinomatosis as the primary presentation of relapse in breast cancer. Oncol Lett. 2016 Aug; 12 (2):779-782 Epub 2016 June 16
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57. Pchejetski D, Alfraidi A, Sacco K, Alshaker H, Muhammad A, Monzon L. Histone deacetylases as new therapy targets for platinum-resistant epithelial ovarian cancer. J Cancer Res Clin Oncol. 2016 Aug; 142: (8)1659-71.
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58. Azzopardi N, Sacco K, Grech G. The Influence of Innate and Adaptive Immunity on Crohn’s Disease Severity. Journal of Clinical & Cellular Immunology. 2016; 5(3):219.
    
59. Grech G, Baldacchino S, Saliba C, Sacco K, Yee B, Scerri C. Molecular Classification of Breast Cancer Patients using Formalin-Fixed Paraffin-Embedded derived RNA Samples. Journal of Molecular Biomarkers & Diagnosis. 2016; S8:016.
    
60. Sacco KA, Chirila RM. Postchikungunya Chronic Inflammatory Rheumatism. Case Rep Rheumatol. 2016; 2016:7068901. Epub 2016 Dec 28.
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61. Alshaker H, Sacco K, Alfraidi A, Muhammad A, Winkler M, Pchejetski D. Leptin signalling, obesity and prostate cancer: molecular and clinical perspective on the old dilemma. Oncotarget. 2015 Nov 03; 6: (34)35556-63.
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62. Sacco K, Grech G. Actionable pharmacogenetic markers for prediction and prognosis in breast cancer. EPMA J. 2015; 6: (1)15.
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63. Grech G, Pollacco J, Portelli M, Sacco K, Baldacchino S, Grixti J, Saliba C. Expression of different functional isoforms in haematopoiesis. Int J Hematol. 2014 Jan; 99: (1)4-11.
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64. Pollacco J, Sacco K, Portelli M, Schembri-Wismayer P, Calleja-Agius J. Molecular links between endometriosis and cancer. Gynecol Endocrinol. 2012 Aug; 28: (8)577-81.
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65. Sacco K, Portelli M, Pollacco J, Schembri-Wismayer P, Calleja-Agius J. The role of prostaglandin E2 in endometriosis. Gynecol Endocrinol. 2012 Feb; 28: (2)134-8.
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66. Portelli M, Pollacco J, Sacco K, Schembri-Wismayer P, Calleja-Agius J. Endometrial seedlings. A survival instinct? Immunomodulation and its role in the pathophysiology of endometriosis. Minerva Ginecol. 2011 Dec; 63 (6):563-70
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67. Adam MP, Bick S, Mirzaa GM, Pagon RA, Wallace SE, Amemiya A, Sacco K, Uzel G. Activated PI3K Delta Syndrome Seattle (WA): University of Washington, Seattle. 1993.
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