Publications

1. Robichaud JH, Zhang Y, Chen C, He K, Huang Y, Zhang X, Sun X, Ma X, Hardiman G, Morrison CG, Dong Z, LeBrasseur NK, Ling K, Hu J. Author Correction: Transiently formed nucleus-to-cilium microtubule arrays mediate senescence initiation in a KIFC3-dependent manner. Nat Commun. 2024 Oct 29; 15 (1):9331
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2. Gomez PT, Carver CM, Rodriguez SL, Wang L, Zhang X, Schafer MJ. Aging and senescent fates of oligodendrocyte precursor cells in the mouse brain. NPJ Aging. 2024 Oct 22; 10 (1):47
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3. Robichaud JH, Zhang Y, Chen C, He K, Huang Y, Zhang X, Sun X, Ma X, Hardiman G, Morrison CG, Dong Z, LeBrasseur NK, Ling K, Hu J. Transiently formed nucleus-to-cilium microtubule arrays mediate senescence initiation in a KIFC3-dependent manner. Nat Commun. 2024 Sep 12; 15 (1):7977 Epub 2024 Sept 12
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4. Zhang X, Ng YE, Chini LCS, Heeren AA, White TA, Li H, Huang H, Doolittle ML, Khosla S, LeBrasseur NK. Senescent skeletal muscle fibroadipogenic progenitors recruit and promote M2 polarization of macrophages. Aging Cell. 2024 Mar; 23 (3):e14069 Epub 2023 Dec 19
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5. Aversa Z, White TA, Heeren AA, Hulshizer CA, Saul D, Zhang X, Molina AJA, Redman LM, Martin CK, Racette SB, Huffman KM, Bhapkar M, Khosla S, Das SK, Fielding RA, Atkinson EJ, LeBrasseur NK. Calorie restriction reduces biomarkers of cellular senescence in humans. Aging Cell. 2024 Feb; 23 (2):e14038 Epub 2023 Nov 14
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6. Liu GY, Yu D, Fan MM, Zhang X, Jin ZY, Tang C, Liu XF. Antimicrobial resistance crisis: could artificial intelligence be the solution? Mil Med Res. 2024 Jan 23; 11 (1):7
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7. Englund DA, Jolliffe AM, Hanson GJ, Aversa Z, Zhang X, Jiang X, White TA, Zhang L, Monroe DG, Robbins PD, Niedernhofer LJ, Kamenecka TM, Khosla S, LeBrasseur NK. Senotherapeutic drug treatment ameliorates chemotherapy-induced cachexia. JCI Insight. 2024 Jan 23; 9 (2)
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8. Yang L, Ng YE, Sun H, Li Y, Chini LCS, LeBrasseur NK, Chen J, Zhang X. Single-cell Mayo Map (scMayoMap): an easy-to-use tool for cell type annotation in single-cell RNA-sequencing data analysis. BMC Biol. 2023 Oct 20; 21 (1):223
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9. Zhang X, Tyrrell DJ, Alliston T, Schilling B, Yousefzadeh MJ, Schafer MJ. Senescence and Inflammation: Summary of a Gerontological Society of America and National Institute on Aging-Sponsored Symposium. J Gerontol A Biol Sci Med Sci. 2023 Oct 9; 78 (10):1733-1739
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10. Zhang X, Suda M, Zhu Y. Senolytics combat COVID-19 in aging. Nat Aging 2023 Jul; 3 (7):762-763
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11. Aversa Z, Atkinson EJ, Carmona EM, White TA, Heeren AA, Jachim SK, Zhang X, Cummings SR, Chiarella SE, Limper AH, LeBrasseur NK. Biomarkers of cellular senescence in idiopathic pulmonary fibrosis. Respir Res. 2023 Apr 07; 24(1):101.
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12. Ma X, Zhang Y, Zhang Y, Zhang X, Huang Y, He K, Chen C, Hao J, Zhao D, LeBrasseur NK, Kirkland JL, Chini EN, Wei Q, Ling K, Hu J. A stress-induced cilium-to-PML-NB route drives senescence initiation. Nat Commun. 2023 Apr 3; 14 (1):1840 Epub 2023 Apr 03
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13. Englund DA, Jolliffe A, Aversa Z, Zhang X, Sturmlechner I, Sakamoto AE, Zeidler JD, Warner GM, McNinch C, White TA, Chini EN, Baker DJ, van Deursen JM, LeBrasseur NK. p21 induces a senescence program and skeletal muscle dysfunction. Mol Metab. 2023 Jan; 67:101652 Epub 2022 Dec 09
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14. Li LX, Zhang X, Zhang H, Agborbesong E, Zhou JX, Calvet JP, Li X. Single-Cell and CellChat Resolution Identifies Collecting Duct Cell Subsets and Their Communications with Adjacent Cells in PKD Kidneys. Cells. 2022 Dec 22; 12 (1)
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15. Zhang X, Englund DA, Aversa Z, Jachim SK, White TA, LeBrasseur NK. Exercise Counters the Age-Related Accumulation of Senescent Cells. Exerc Sport Sci Rev. 2022 Oct 1; 50 (4):213-221 Epub 2022 July 01
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16. Zhang X, Pearsall VM, Carver CM, Atkinson EJ, Clarkson BDS, Grund EM, Baez-Faria M, Pavelko KD, Kachergus JM, White TA, Johnson RK, Malo CS, Gonzalez-Suarez AM, Ayasoufi K, Johnson KO, Tritz ZP, Fain CE, Khadka RH, Ogrodnik M, Jurk D, Zhu Y, Tchkonia T, Revzin A, Kirkland JL, Johnson AJ, Howe CL, Thompson EA, LeBrasseur NK, Schafer MJ. Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance. Nat Commun. 2022 Sep 27; 13 (1):5671 Epub 2022 Sept 27
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17. Saul D, Kosinsky RL, Atkinson EJ, Doolittle ML, Zhang X, LeBrasseur NK, Pignolo RJ, Robbins PD, Niedernhofer LJ, Ikeno Y, Jurk D, Passos JF, Hickson LJ, Xue A, Monroe DG, Tchkonia T, Kirkland JL, Farr JN, Khosla S. A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues. Nat Commun. 2022 Aug 16; 13 (1):4827
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18. Zhang X, Habiballa L, Aversa Z, Ng YE, Sakamoto AE, Englund DA, Pearsall VM, White TA, Robinson MM, Rivas DA, Dasari S, Hruby AJ, Lagnado AB, Jachim SK, Granic A, Sayer AA, Jurk D, Lanza IR, Khosla S, Fielding RA, Nair KS, Schafer MJ, Passos JF, LeBrasseur NK. Characterization of cellular senescence in aging skeletal muscle. Nat Aging. 2022 Jul; 2 (7):601-615 Epub 2022 July 15
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19. Englund DA, Zhang X, Aversa Z, LeBrasseur NK. Skeletal muscle aging, cellular senescence, and senotherapeutics: Current knowledge and future directions. Mech Ageing Dev. 2021 Dec; 200:111595 Epub 2021 Nov 03
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20. Englund DA, Sakamoto AE, Fritsche CM, Heeren AA, Zhang X, Kotajarvi BR, Lecy DR, Yousefzadeh MJ, Schafer MJ, White TA, Atkinson EJ, LeBrasseur NK. Exercise reduces circulating biomarkers of cellular senescence in humans. Aging Cell. 2021 Jul; 20 (7):e13415 Epub 2021 June 08
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21. Jachim SK, Sakamoto AE, Zhang X, Pearsall VM, Schafer MJ, LeBrasseur NK. Harnessing the effects of endurance exercise to optimize cognitive health: Fundamental insights from Dr. Mark P. Mattson. Ageing Res Rev. 2020 Dec; 64:101147 Epub 2020 Aug 16
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22. Schafer MJ, Zhang X, Kumar A, Atkinson EJ, Zhu Y, Jachim S, Mazula DL, Brown AK, Berning M, Aversa Z, Kotajarvi B, Bruce CJ, Greason KL, Suri RM, Tracy RP, Cummings SR, White TA, LeBrasseur NK. The senescence-associated secretome as an indicator of age and medical risk. JCI Insight. 2020 Jun 18; 5 (12) Epub 2020 June 18
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23. Aversa Z, Zhang X, Fielding RA, Lanza I, LeBrasseur NK. The clinical impact and biological mechanisms of skeletal muscle aging. Bone. 2019 Oct; 127:26-36 Epub 2019 May 22
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24. Zhang YJ, Gendron TF, Ebbert MTW, O'Raw AD, Yue M, Jansen-West K, Zhang X, Prudencio M, Chew J, Cook CN, Daughrity LM, Tong J, Song Y, Pickles SR, Castanedes-Casey M, Kurti A, Rademakers R, Oskarsson B, Dickson DW, Hu W, Gitler AD, Fryer JD, Petrucelli L. Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis. Nat Med. 2018 Aug; 24 (8):1136-1142 Epub 2018 June 25
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25. Zhang X, Chen X, Liu Q, Zhang S, Hu W. Translation repression via modulation of the cytoplasmic poly(A)-binding protein in the inflammatory response. Elife. 2017 Jun 21; 6 Epub 2017 June 21
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26. Alvarez-Dominguez JR, Zhang X, Hu W. Widespread and dynamic translational control of red blood cell development. Blood. 2017 Feb 2; 129 (5):619-629 Epub 2016 Nov 29
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27. Zhang X, Hu W. Long noncoding RNAs in hematopoiesis. F1000Res. 2016; 5 Epub 2016 July 20
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28. Zhang S, Ma R, Liu X, Zhang X, Sun B. Modulation of ccrAB Expression and SCCmec Excision by an Inverted Repeat Element and SarS in Methicillin-Resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2015 Oct; 59 (10):6223-32 Epub 2015 July 27
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29. Zhu Y, Wu B, Zhang X, Fan X, Niu L, Li X, Wang J, Teng M. Structural and biochemical studies reveal UbiG/Coq3 as a class of novel membrane-binding proteins. Biochem J. 2015 Aug 15; 470 (1):105-14 Epub 2015 June 18
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30. Chen C, Zhang X, Shang F, Sun H, Sun B, Xue T. The Staphylococcus aureus protein-coding gene gdpS modulates sarS expression via mRNA-mRNA interaction. Infect Immun. 2015 Aug; 83 (8):3302-10 Epub 2015 June 08
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31. Fan X, Zhang X, Zhu Y, Niu L, Teng M, Sun B, Li X. Structure of the DNA-binding domain of the response regulator SaeR from Staphylococcus aureus. Acta Crystallogr D Biol Crystallogr. 2015 Aug; 71 (Pt 8):1768-76 Epub 2015 July 31
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32. Zhang X, Zhu Q, Tian T, Zhao C, Zang J, Xue T, Sun B. Identification of RNAIII-binding proteins in Staphylococcus aureus using tethered RNAs and streptavidin aptamers based pull-down assay. BMC Microbiol. 2015 May 15; 15:102
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33. Bao Y, Zhang X, Jiang Q, Xue T, Sun B. Pfs promotes autolysis-dependent release of eDNA and biofilm formation in Staphylococcus aureus. Med Microbiol Immunol. 2015 Apr; 204 (2):215-26 Epub 2014 Sept 04
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34. Hu J, Zhang X, Liu X, Chen C, Sun B. Mechanism of reduced vancomycin susceptibility conferred by walK mutation in community-acquired methicillin-resistant Staphylococcus aureus strain MW2. Antimicrob Agents Chemother. 2015 Feb; 59 (2):1352-5 Epub 2014 Dec 01
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35. Zhu Y, Fan X, Zhang X, Jiang X, Niu L, Teng M, Li X. Structure of Rot, a global regulator of virulence genes in Staphylococcus aureus. Acta Crystallogr D Biol Crystallogr. 2014 Sep; 70 (Pt 9):2467-76 Epub 2014 Aug 29
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36. Xue T, Zhang X, Sun H, Sun B. ArtR, a novel sRNA of Staphylococcus aureus, regulates alpha-toxin expression by targeting the 5' UTR of sarT mRNA. Med Microbiol Immunol. 2014 Feb; 203 (1):1-12 Epub 2013 Aug 18
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