Publications

1. Firdaus Z, Khanal S, Washington AM, Solverson JK, Doskey LC, Xiao Y, Yaqubi M, Pereyra D, Heimbach J, Taner T, Krueger EW, Huang CL, Shah VH, Starlinger PP, Razidlo GL, Schellenberg MJ, Kostallari E. With no lysine kinase 1 in hepatic stellate cells promotes mouse and human liver fibrosis through glycolytic triosephosphate isomerase 1. Hepatology. 2026 Aug 6 Epub 2026 Aug 06
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2. Martini H, Birch J, Marques FDM, Victorelli S, Lagnado AB, Pirius N, Franco AC, Lee G, Han Y, Rowsey JL, Ismail WM, Mazzone A, Espe TM, Hitosugi T, Li Y, Washington AM, Havas A, Murad R, Lei X, Porritt RA, Maddocks ODK, Machado Espindola-Netto J, Saul D, Khosla S, Jurk D, Kostallari E, Gaspar-Maia A, Adams PD, Passos JF. Mitochondrial metabolism and epigenetic crosstalk drive SASP. Nature. 2026 Aug; 656 (8129):980-992 Epub 2026 July 29
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3. Sano A, Guo Q, Warasnhe K, Meroueh C, Satthawiwat N, Hamdi A, Hmaydoosh G, Dai X, Yaqoob U, Pavelko KD, Miciano C, Kisseleva T, Firdaus Z, Starlinger PP, Pereyra D, Kostallari E, Hirsova P, Povero D, Ibrahim SH. Endothelial cell glycogen synthase kinase 3beta promotes lipotoxic endotheliopathy and liver inflammation in MASH. JCI Insight. 2026 Jun 22; 11 (12) Epub 2026 May 05
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4. Valenzuela-Perez L, Kim Lee HS, Bayer RL, Manna DF, Mishra SK, Washington AM, Hassan AA, Sidahmed MM, Ssali E, Dinc EJ, Manwana BK, Ibrahim A, Guo Q, Herman A, Graham RP, Pavelko KD, Gores GJ, Starlinger P, Revelo XS, Ibrahim SH, Kostallari E, Bamidele AO, Hirsova P. CD4+ T cells promote fibrosis during metabolic dysfunction-associated steatohepatitis. Hepatology. 2026 Apr 30 [Epub ahead of print]
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5. Guo Q, Satthawiwat N, Sano A, Meroueh C, Hamdi A, Dai X, Warasnhe K, Washington AM, Starlinger PP, Krivonos A, Cao S, Kostallari E, Jonker JW, van de Sluis B, Hamdan FH, Ibrahim SH. Toxic lipid-induced epigenetic activation of ICAM1 in liver sinusoidal endothelium regulates myeloid-driven fibro-inflammatory response in MASH. Hepatology. 2026 Apr 15 [Epub ahead of print]
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6. Jerez S, Cooper SA, Yaqoob U, Kalaiger MF, Anwar AA, Wong M, Arif B, Doskey LC, Hernandez-Tejero M, Sherman WA, De Boeck R, Li Y, Hilscher MB, Kostallari E, Jalan-Sakrikar N, Cao S, Shah VH. Macrophages expressing macrophage receptor with collagen structure attenuate liver fibrosis through a tissue restoration phenotype. JCI Insight. 2026 Mar 23; 11 (6)
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7. Scholtz CR, Doskey LC, Kandanur SGS, Vail NR, Roderick ER, Peterson EJ, Hoell ZJ, Shi K, Aihara H, Kostallari E, Shah VH, Malhi H, Pomerantz WCK. Development of cell-active BRD4-D1 selective inhibitors to decode the role of BET proteins in LPS-mediated liver inflammation. Eur J Med Chem. 2026 Feb 15; 304:118519 Epub 2025 Dec 20
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8. Kostallari E, Schwabe RF, Guillot A. Inflammation and immunity in liver homeostasis and disease: a nexus of hepatocytes, nonparenchymal cells and immune cells. Cell Mol Immunol. 2025 Oct; 22 (10):1205-1225 Epub 2025 July 01
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9. Washington AM, Kostallari E. Extracellular Vesicles and Micro-RNAs in Liver Disease. Semin Liver Dis. 2025 Jun; 45 (2):167-179 Epub 2024 Dec 03
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10. Doskey LC, Scholtz CR, Vail NR, Khanal S, Lee AL, Kandanur SGS, Hoell ZJ, Huehls AM, Issa MR, Kostallari E, Cao S, Reid JM, Shah VH, Malhi H, Pomerantz WCK. Efficacy and Toxicity Analysis of Selective BET Bromodomain Inhibitors in Models of Inflammatory Liver Disease. J Med Chem. 2025 Apr 24; 68 (8):8091-8105 Epub 2025 Apr 14
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11. Kostallari E. Blood, sweat, tears and fibrosis: when overtraining injures the liver. Extracell Vesicles Circ Nucl Acids. 2025; 6 (4):724-727 Epub 2025 Nov 10
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12. Gao J, Lan T, Kostallari E, Guo Y, Lai E, Guillot A, Ding B, Tacke F, Tang C, Shah VH. Angiocrine signaling in sinusoidal homeostasis and liver diseases. J Hepatol. 2024 Sep; 81 (3):543-561 Epub 2024 May 17
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13. Khanal S, Liu Y, Bamidele AO, Wixom AQ, Washington AM, Jalan-Sakrikar N, Cooper SA, Vuckovic I, Zhang S, Zhong J, Johnson KL, Charlesworth MC, Kim I, Yeon Y, Yoon S, Noh YK, Meroueh C, Timbilla AA, Yaqoob U, Gao J, Kim Y, Lucien F, Huebert RC, Hay N, Simons M, Shah VH, Kostallari E. Glycolysis in hepatic stellate cells coordinates fibrogenic extracellular vesicle release spatially to amplify liver fibrosis. Sci Adv. 2024 Jun 28; 10 (26):eadn5228 Epub 2024 June 28
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14. Gan C, Yaqoob U, Lu J, Xie M, Anwar A, Jalan-Sakrikar N, Jerez S, Sehrawat TS, Navarro-Corcuera A, Kostallari E, Habash NW, Cao S, Shah VH. Liver sinusoidal endothelial cells contribute to portal hypertension through collagen type IV-driven sinusoidal remodeling. JCI Insight. 2024 May 7; 9 (11) Epub 2024 May 07
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15. Cooper SA, Kostallari E, Shah VH. Angiocrine Signaling in Sinusoidal Health and Disease. Semin Liver Dis. 2023 Aug; 43 (3):245-257 Epub 2023 July 13
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16. McConnell MJ, Kostallari E, Ibrahim SH, Iwakiri Y. The evolving role of liver sinusoidal endothelial cells in liver health and disease. Hepatology. 2023 Aug 1; 78 (2):649-669 Epub 2023 Jan 03
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17. Parthasarathy G, Hirsova P, Kostallari E, Sidhu GS, Ibrahim SH, Malhi H. Extracellular Vesicles in Hepatobiliary Health and Disease. Compr Physiol. 2023 Jun 26; 13 (3):4631-4658 Epub 2023 June 26
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18. Xiao Y, Zhao C, Tai Y, Li B, Lan T, Lai E, Dai W, Guo Y, Gan C, Kostallari E, Tang C, Gao J. STING mediates hepatocyte pyroptosis in liver fibrosis by Epigenetically activating the NLRP3 inflammasome. Redox Biol. 2023 Jun; 62:102691 Epub 2023 Mar 29
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19. Samaddar P, Mishra AK, Gaddam S, Singh M, Modi VK, Gopalakrishnan K, Bayer RL, Igreja Sa IC, Khanal S, Hirsova P, Kostallari E, Dey S, Mitra D, Roy S, Arunachalam SP. Machine Learning-Based Classification of Abnormal Liver Tissues Using Relative Permittivity. Sensors (Basel). 2022 Dec 16; 22 (24)
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20. Greuter T, Yaqoob U, Gan C, Jalan-Sakrikar N, Kostallari E, Lu J, Gao J, Sun L, Liu M, Sehrawat TS, Ibrahim SH, Furuta K, Nozickova K, Huang BQ, Gao B, Simons M, Cao S, Shah VH. Mechanotransduction-induced glycolysis epigenetically regulates a CXCL1-dominant angiocrine signaling program in liver sinusoidal endothelial cells in vitro and in vivo. J Hepatol. 2022 Sep; 77 (3):723-734 Epub 2022 Apr 12
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21. Kostallari E, Wei B, Sicard D, Li J, Cooper SA, Gao J, Dehankar M, Li Y, Cao S, Yin M, Tschumperlin DJ, Shah VH. Stiffness is associated with hepatic stellate cell heterogeneity during liver fibrosis. Am J Physiol Gastrointest Liver Physiol. 2022 Feb 1; 322 (2):G234-G246 Epub 2021 Dec 23
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22. Samaddar P, Samadder P, Baraskar B, Anvekar P, Khanal S, Gaddam S, Roy S, Mitra D, Kostallari E, Arunachalam SP. Machine learning models to classify normal and fibrotic mouse liver model using dielectric properties. Proceedings - 2022 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2022. 2022; 2696-703
    
23. Kousar A, Damani S, Anvekar P, Rajotia A, Gopalakrishnan K, Baraskar B, Modi VK, Aedma K, Agarwal J, Voruganti HV, Singh M, Kostallari E, Arunachalam SP. Deep learning based classification of normal and hepatic fibrosis mouse model using digital pathology images. Proceedings - 2022 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2022. 2022; 2308-13
    
24. Guo Q, Furuta K, Islam S, Caporarello N, Kostallari E, Dielis K, Tschumperlin DJ, Hirsova P, Ibrahim SH. Liver sinusoidal endothelial cell expressed vascular cell adhesion molecule 1 promotes liver fibrosis. Front Immunol. 2022; 13:983255 Epub 2022 Aug 25
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25. Kostallari E, Valainathan S, Biquard L, Shah VH, Rautou PE. Role of extracellular vesicles in liver diseases and their therapeutic potential. Adv Drug Deliv Rev. 2021 Aug; 175:113816 Epub 2021 June 02
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26. Gao J, Wei B, Liu M, Hirsova P, Sehrawat TS, Cao S, Hu X, Xue F, Yaqoob U, Kang N, Cui H, Pomerantz WCK, Kostallari E, Shah VH. Endothelial p300 Promotes Portal Hypertension and Hepatic Fibrosis Through C-C Motif Chemokine Ligand 2-Mediated Angiocrine Signaling. Hepatology. 2021 Jun; 73 (6):2468-2483 Epub 2021 Apr 19
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27. Gao J, Wei B, de Assuncao TM, Liu Z, Hu X, Ibrahim S, Cooper SA, Cao S, Shah VH, Kostallari E. Hepatic stellate cell autophagy inhibits extracellular vesicle release to attenuate liver fibrosis. J Hepatol. 2020 Nov; 73 (5):1144-1154 Epub 2020 May 08
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28. Azad AI, Krishnan A, Troop L, Li Y, Katsumi T, Pavelko K, Kostallari E, Guicciardi ME, Gores GJ. Targeted Apoptosis of Ductular Reactive Cells Reduces Hepatic Fibrosis in a Mouse Model of Cholestasis. Hepatology. 2020 Sep; 72 (3):1013-1028
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29. Arab JP, Cabrera D, Sehrawat TS, Jalan-Sakrikar N, Verma VK, Simonetto D, Cao S, Yaqoob U, Leon J, Freire M, Vargas JI, De Assuncao TM, Kwon JH, Guo Y, Kostallari E, Cai Q, Kisseleva T, Oh Y, Arrese M, Huebert RC, Shah VH. Hepatic stellate cell activation promotes alcohol-induced steatohepatitis through Igfbp3 and SerpinA12. J Hepatol. 2020 Jul; 73 (1):149-160 Epub 2020 Feb 20
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30. Yaqoob U, Luo F, Greuter T, Jalan Sakrikar N, Sehrawat TS, Lu J, Hu X, Gao J, Kostallari E, Chen J, Arab JP, Martin-Mateos R, Cao S, Shah VH. GIPC-Regulated IGFBP-3 Promotes HSC Migration In Vitro and Portal Hypertension In Vivo Through a beta1-Integrin Pathway. Cell Mol Gastroenterol Hepatol. 2020; 10 (3):545-559 Epub 2020 May 22
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31. Haak AJ, Kostallari E, Sicard D, Ligresti G, Choi KM, Caporarello N, Jones DL, Tan Q, Meridew J, Diaz Espinosa AM, Aravamudhan A, Maiers JL, Britt RD Jr, Roden AC, Pabelick CM, Prakash YS, Nouraie SM, Li X, Zhang Y, Kass DJ, Lagares D, Tager AM, Varelas X, Shah VH, Tschumperlin DJ. Selective YAP/TAZ inhibition in fibroblasts via dopamine receptor D1 agonism reverses fibrosis. Sci Transl Med. 2019 Oct 30; 11 (516)
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32. Hilscher MB, Sehrawat T, Arab Verdugo JP, Arab JP, Zeng Z, Gao J, Liu M, Kostallari E, Gao Y, Simonetto DA, Yaqoob U, Cao S, Revzin A, Beyder A, Wang RA, Kamath PS, Kubes P, Shah VH. Mechanical Stretch Increases Expression of CXCL1 in Liver Sinusoidal Endothelial Cells to Recruit Neutrophils, Generate Sinusoidal Microthombi, and Promote Portal Hypertension. Gastroenterology. 2019 Jul; 157 (1):193-209.e9 Epub 2019 Mar 11
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33. Eguchi A, Kostallari E, Feldstein AE, Shah VH. Extracellular vesicles, the liquid biopsy of the future. J Hepatol. 2019 Jun; 70 (6):1292-1294 Epub 2019 Apr 12
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34. Kostallari E, Hirsova P, Prasnicka A, Verma VK, Yaqoob U, Wongjarupong N, Roberts LR, Shah VH. Hepatic stellate cell-derived platelet-derived growth factor receptor-alpha-enriched extracellular vesicles promote liver fibrosis in mice through SHP2. Hepatology. 2018 Jul; 68 (1):333-348 Epub 2018 May 10
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35. Drinane MC, Yaqoob U, Yu H, Luo F, Greuter T, Arab JP, Kostallari E, Verma VK, Maiers J, De Assuncao TM, Simons M, Mukhopadhyay D, Kisseleva T, Brenner DA, Urrutia R, Lomberk G, Gao Y, Ligresti G, Tschumperlin DJ, Revzin A, Cao S, Shah VH. Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms. JCI Insight. 2017 Dec 21; 2 (24)
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36. El-Sayed IY, Daher A, Destouches D, Firlej V, Kostallari E, Maille P, Huet E, Haidar-Ahmad N, Jenster G, de la Taille A, Abou Merhi R, Terry S, Vacherot F. Extracellular vesicles released by mesenchymal-like prostate carcinoma cells modulate EMT state of recipient epithelial-like carcinoma cells through regulation of AR signaling. Cancer Lett. 2017 Dec 1; 410:100-111 Epub 2017 Sept 19
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37. Maiers JL, Kostallari E, Mushref M, deAssuncao TM, Li H, Jalan-Sakrikar N, Huebert RC, Cao S, Malhi H, Shah VH. The unfolded protein response mediates fibrogenesis and collagen I secretion through regulating TANGO1 in mice. Hepatology. 2017 Mar; 65 (3):983-998 Epub 2016 Dec 31
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38. Kostallari E, Shah VH. Angiocrine signaling in the hepatic sinusoids in health and disease. Am J Physiol Gastrointest Liver Physiol. 2016 Aug 1; 311 (2):G246-51 Epub 2016 June 10
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39. Kostallari E, Baba-Amer Y, Alonso-Martin S, Ngoh P, Relaix F, Lafuste P, Gherardi RK. Pericytes in the myovascular niche promote post-natal myofiber growth and satellite cell quiescence. Development. 2015 Apr 1; 142 (7):1242-53 Epub 2015 Mar 05
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40. Gitiaux C, Kostallari E, Lafuste P, Authier FJ, Christov C, Gherardi RK. Whole microvascular unit deletions in dermatomyositis. Ann Rheum Dis. 2013 Mar; 72 (3):445-52 Epub 2012 Sept 08
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