Publications

  1. Zarrugh E, Girardo ME, Ryu E, Bielinski S, Moreno Garzon G, Hernandez V, Singh D, Levey S, Gonzalez C, Pompa DB, Meagher K, Sharp RR, Shaibi GQ, Mandarino L, Thibodeau S, Cerhan JR, Olson JE, De Filippis E. Sangre Por Salud (SPS) Biobank: cohort profile. BMJ Open. 2025 Feb 11; 15 (2):e093445
    View PubMed
  2. Zarrugh E, Girardo ME, Ryu E, Bielinski S, Moreno Garzon G, Hernandez V, Singh D, Levey S, Gonzalez C, Pompa DB, Meagher K, Sharp RR, Shaibi GQ, Mandarino L, Thibodeau S, Cerhan JR, Olson JE, De Filippis E. Sangre Por Salud (SPS) Biobank: cohort profile. BMJ Open. 2025 Feb 11; 15 (2):e093445
    View PubMed
  3. Arora A, Jack K, Kumar AV, Borad M, Girardo ME, De Filippis E, Yang P, Dinu V. Genome-Wide Association Study of Gallstone Disease Identifies Novel Candidate Genomic Variants in a Latino Community of Southwest USA. J Racial Ethn Health Disparities. 2025 Feb; 12 (1):234-240 Epub 2023 Nov 28
    View PubMed
  4. Arora A, Jack K, Kumar AV, Borad M, Girardo ME, De Filippis E, Yang P, Dinu V. Genome-Wide Association Study of Gallstone Disease Identifies Novel Candidate Genomic Variants in a Latino Community of Southwest USA. J Racial Ethn Health Disparities. 2025 Feb; 12 (1):234-240 Epub 2023 Nov 28
    View PubMed
  5. Arguinchona J, Mahajan A, Gonzalez-Estrada A, De Filippis E. Methimazole Desensitization in a Patient Experiencing a Thionamide-induced Hypersensitivity Reaction. JCEM Case Rep. 2024 Jun; 2 (6):luae066 Epub 2024 May 27
    View PubMed
  6. Arguinchona J, Mahajan A, Gonzalez-Estrada A, De Filippis E. Methimazole Desensitization in a Patient Experiencing a Thionamide-induced Hypersensitivity Reaction. JCEM Case Rep. 2024 Jun; 2 (6):luae066 Epub 2024 May 27
    View PubMed
  7. Hernandez JD, Li T, Ghannam H, Rau CM, Masuda MY, Madura JA 2nd, Jacobsen EA, De Filippis E. Linking adipose tissue eosinophils, IL-4, and leptin in human obesity and insulin resistance. JCI Insight. 2024 Feb 8; 9 (3) Epub 2024 Feb 08
    View PubMed
  8. Hernandez JD, Li T, Ghannam H, Rau CM, Masuda MY, Madura JA 2nd, Jacobsen EA, De Filippis E. Linking adipose tissue eosinophils, IL-4, and leptin in human obesity and insulin resistance. JCI Insight. 2024 Feb 8; 9 (3) Epub 2024 Feb 08
    View PubMed
  9. Freitas EDS, Kras KA, Roust LR, De Filippis EA, Kimball SR, Buras M, Katsanos CS. Lower muscle protein synthesis in humans with obesity concurrent with lower expression of muscle IGF1 splice variants. Obesity (Silver Spring). 2023 Nov; 31 (11):2689-2698 Epub 2023 Oct 16
    View PubMed
  10. Freitas EDS, Kras KA, Roust LR, De Filippis EA, Kimball SR, Buras M, Katsanos CS. Lower muscle protein synthesis in humans with obesity concurrent with lower expression of muscle IGF1 splice variants. Obesity (Silver Spring). 2023 Nov; 31 (11):2689-2698 Epub 2023 Oct 16
    View PubMed
  11. Bielinski SJ, Yanes Cardozo LL, Takahashi PY, Larson NB, Castillo A, Podwika A, De Filippis E, Hernandez V, Mahajan GJ, Gonzalez C, Shubhangi Shubhangi, Decker PA, Killian JM, Olson JE, St Sauver JL, Shah P, Vella A, Ryu E, Liu H, Marshall GD, Cerhan JR, Singh D, Summers RL. Predictors of Metformin Failure: Repurposing Electronic Health Record Data to Identify High-Risk Patients. J Clin Endocrinol Metab. 2023 Jun 16; 108 (7):1740-1746
    View PubMed
  12. Bielinski SJ, Yanes Cardozo LL, Takahashi PY, Larson NB, Castillo A, Podwika A, De Filippis E, Hernandez V, Mahajan GJ, Gonzalez C, Shubhangi Shubhangi, Decker PA, Killian JM, Olson JE, St Sauver JL, Shah P, Vella A, Ryu E, Liu H, Marshall GD, Cerhan JR, Singh D, Summers RL. Predictors of Metformin Failure: Repurposing Electronic Health Record Data to Identify High-Risk Patients. J Clin Endocrinol Metab. 2023 Jun 16; 108 (7):1740-1746
    View PubMed
  13. Miola A, De Filippis E, Veldic M, Ho AM, Winham SJ, Mendoza M, Romo-Nava F, Nunez NA, Gardea Resendez M, Prieto ML, McElroy SL, Biernacka JM, Frye MA, Cuellar-Barboza AB. The genetics of bipolar disorder with obesity and type 2 diabetes. J Affect Disord. 2022 Sep 15; 313:222-231 Epub 2022 June 30
    View PubMed
  14. Miola A, De Filippis E, Veldic M, Ho AM, Winham SJ, Mendoza M, Romo-Nava F, Nunez NA, Gardea Resendez M, Prieto ML, McElroy SL, Biernacka JM, Frye MA, Cuellar-Barboza AB. The genetics of bipolar disorder with obesity and type 2 diabetes. J Affect Disord. 2022 Sep 15; 313:222-231 Epub 2022 June 30
    View PubMed
  15. Gardea-Resendez M, Winham SJ, Romo-Nava F, Cuellar-Barboza A, Clark MM, Andreazza AC, Cabello-Arreola A, Veldic M, Bond DJ, Singh B, Prieto ML, Nunez NA, Betcher H, Moore KM, Blom T, Colby C, Pendegraft RS, Kelpin SS, Ozerdem A, Miola A, De Filippis E, Biernacka JM, McElroy SL, Frye MA. Quantification of diet quality utilizing the rapid eating assessment for participants-shortened version in bipolar disorder: Implications for prospective depression and cardiometabolic studies. J Affect Disord. 2022 Aug 1; 310:150-155 Epub 2022 May 08
    View PubMed
  16. Gardea-Resendez M, Winham SJ, Romo-Nava F, Cuellar-Barboza A, Clark MM, Andreazza AC, Cabello-Arreola A, Veldic M, Bond DJ, Singh B, Prieto ML, Nunez NA, Betcher H, Moore KM, Blom T, Colby C, Pendegraft RS, Kelpin SS, Ozerdem A, Miola A, De Filippis E, Biernacka JM, McElroy SL, Frye MA. Quantification of diet quality utilizing the rapid eating assessment for participants-shortened version in bipolar disorder: Implications for prospective depression and cardiometabolic studies. J Affect Disord. 2022 Aug 1; 310:150-155 Epub 2022 May 08
    View PubMed
  17. Emont MP, Jacobs C, Essene AL, Pant D, Tenen D, Colleluori G, Di Vincenzo A, Jorgensen AM, Dashti H, Stefek A, McGonagle E, Strobel S, Laber S, Agrawal S, Westcott GP, Kar A, Veregge ML, Gulko A, Srinivasan H, Kramer Z, De Filippis E, Merkel E, Ducie J, Boyd CG, Gourash W, Courcoulas A, Lin SJ, Lee BT, Morris D, Tobias A, Khera AV, Claussnitzer M, Pers TH, Giordano A, Ashenberg O, Regev A, Tsai LT, Rosen ED. A single-cell atlas of human and mouse white adipose tissue. Nature. 2022 Mar; 603 (7903):926-933 Epub 2022 Mar 16
    View PubMed
  18. Emont MP, Jacobs C, Essene AL, Pant D, Tenen D, Colleluori G, Di Vincenzo A, Jorgensen AM, Dashti H, Stefek A, McGonagle E, Strobel S, Laber S, Agrawal S, Westcott GP, Kar A, Veregge ML, Gulko A, Srinivasan H, Kramer Z, De Filippis E, Merkel E, Ducie J, Boyd CG, Gourash W, Courcoulas A, Lin SJ, Lee BT, Morris D, Tobias A, Khera AV, Claussnitzer M, Pers TH, Giordano A, Ashenberg O, Regev A, Tsai LT, Rosen ED. A single-cell atlas of human and mouse white adipose tissue. Nature. 2022 Mar; 603 (7903):926-933 Epub 2022 Mar 16
    View PubMed
  19. Hernandez JD, Li T, Rau CM, LeSuer WE, Wang P, Coletta DK, Madura JA 2nd, Jacobsen EA, De Filippis E. omega-3PUFA supplementation ameliorates adipose tissue inflammation and insulin-stimulated glucose disposal in subjects with obesity: a potential role for apolipoprotein E. Int J Obes (Lond). 2021 Jun; 45 (6):1331-1341 Epub 2021 Mar 22
    View PubMed
  20. Hernandez JD, Li T, Rau CM, LeSuer WE, Wang P, Coletta DK, Madura JA 2nd, Jacobsen EA, De Filippis E. omega-3PUFA supplementation ameliorates adipose tissue inflammation and insulin-stimulated glucose disposal in subjects with obesity: a potential role for apolipoprotein E. Int J Obes (Lond). 2021 Jun; 45 (6):1331-1341 Epub 2021 Mar 22
    View PubMed
  21. Garcia LA, Day SE, Coletta RL, Campos B, Benjamin TR, De Filippis E, Madura JA 2nd, Mandarino LJ, Roust LR, Coletta DK. Weight loss after Roux-En-Y gastric bypass surgery reveals skeletal muscle DNA methylation changes. Clin Epigenetics. 2021 May 1; 13 (1):100 Epub 2021 May 01
    View PubMed
  22. Garcia LA, Day SE, Coletta RL, Campos B, Benjamin TR, De Filippis E, Madura JA 2nd, Mandarino LJ, Roust LR, Coletta DK. Weight loss after Roux-En-Y gastric bypass surgery reveals skeletal muscle DNA methylation changes. Clin Epigenetics. 2021 May 1; 13 (1):100 Epub 2021 May 01
    View PubMed
  23. Dugani SB, Girardo ME, De Filippis E, Mielke MM, Vella A. Risk Factors and Wellness Measures Associated with Prediabetes and Newly Diagnosed Type 2 Diabetes Mellitus in Hispanic Adults. Metab Syndr Relat Disord. 2021 Apr; 19 (3):180-189 Epub 2021 Jan 15
    View PubMed
  24. Dugani SB, Girardo ME, De Filippis E, Mielke MM, Vella A. Risk Factors and Wellness Measures Associated with Prediabetes and Newly Diagnosed Type 2 Diabetes Mellitus in Hispanic Adults. Metab Syndr Relat Disord. 2021 Apr; 19 (3):180-189 Epub 2021 Jan 15
    View PubMed
  25. Cuellar-Barboza AB, Cabello-Arreola A, Winham SJ, Colby C, Romo-Nava F, Nunez NA, Morgan RJ, Gupta R, Bublitz JT, Prieto ML, De Filippis EA, Lopez-Jimenez F, McElroy SL, Biernacka JM, Frye MA, Veldic M. Body mass index and blood pressure in bipolar patients: Target cardiometabolic markers for clinical practice. J Affect Disord. 2021 Mar 1; 282:637-643 Epub 2020 Dec 29
    View PubMed
  26. Cuellar-Barboza AB, Cabello-Arreola A, Winham SJ, Colby C, Romo-Nava F, Nunez NA, Morgan RJ, Gupta R, Bublitz JT, Prieto ML, De Filippis EA, Lopez-Jimenez F, McElroy SL, Biernacka JM, Frye MA, Veldic M. Body mass index and blood pressure in bipolar patients: Target cardiometabolic markers for clinical practice. J Affect Disord. 2021 Mar 1; 282:637-643 Epub 2020 Dec 29
    View PubMed
  27. Serrano N, Tran L, Hoffman N, Roust L, De Filippis EA, Carroll CC, Patel SH, Kras KA, Buras M, Katsanos CS. Lack of Increase in Muscle Mitochondrial Protein Synthesis During the Course of Aerobic Exercise and Its Recovery in the Fasting State Irrespective of Obesity. Front Physiol. 2021; 12:702742 Epub 2021 Aug 02
    View PubMed
  28. Zapata-Bustos R, Finlayson J, Langlais PR, Coletta DK, Luo M, Grandjean D, De Filippis EA, Mandarino L. Altered Transcription Factor Expression Responses to Exercise in Insulin Resistance. Front Physiol. 2021; 12:649461 Epub 2021 Apr 07
    View PubMed
  29. Serrano N, Tran L, Hoffman N, Roust L, De Filippis EA, Carroll CC, Patel SH, Kras KA, Buras M, Katsanos CS. Lack of Increase in Muscle Mitochondrial Protein Synthesis During the Course of Aerobic Exercise and Its Recovery in the Fasting State Irrespective of Obesity. Front Physiol. 2021; 12:702742 Epub 2021 Aug 02
    View PubMed
  30. Zapata-Bustos R, Finlayson J, Langlais PR, Coletta DK, Luo M, Grandjean D, De Filippis EA, Mandarino L. Altered Transcription Factor Expression Responses to Exercise in Insulin Resistance. Front Physiol. 2021; 12:649461 Epub 2021 Apr 07
    View PubMed
  31. Coletta DK, Hlusko LJ, Scott GR, Garcia LA, Vachon CM, Norman AD, Funk JL, Shaibi GQ, Hernandez V, De Filippis E, Mandarino LJ. Association of EDARV370A with breast density and metabolic syndrome in Latinos. PLoS One. 2021; 16 (10):e0258212 Epub 2021 Oct 07
    View PubMed
  32. Coletta DK, Hlusko LJ, Scott GR, Garcia LA, Vachon CM, Norman AD, Funk JL, Shaibi GQ, Hernandez V, De Filippis E, Mandarino LJ. Association of EDARV370A with breast density and metabolic syndrome in Latinos. PLoS One. 2021; 16 (10):e0258212 Epub 2021 Oct 07
    View PubMed
  33. Shaibi GQ, Kullo IJ, Singh DP, Hernandez V, Sharp RR, Cuellar I, De Filippis E, Levey S, Breitkopf CR, Mandarino LJ, Yang P, Thibodeau SN, Lindor NM. Returning genomic results in a Federally Qualified Health Center: the intersection of precision medicine and social determinants of health. Genet Med. 2020 Sep; 22 (9):1552-1559 Epub 2020 May 06
    View PubMed
  34. Shaibi GQ, Kullo IJ, Singh DP, Hernandez V, Sharp RR, Cuellar I, De Filippis E, Levey S, Breitkopf CR, Mandarino LJ, Yang P, Thibodeau SN, Lindor NM. Returning genomic results in a Federally Qualified Health Center: the intersection of precision medicine and social determinants of health. Genet Med. 2020 Sep; 22 (9):1552-1559 Epub 2020 May 06
    View PubMed
  35. Hernandez JD, Tew BY, Li T, Gooden GC, Ghannam H, Masuda M, Madura J 2nd, Salhia B, Jacobsen EA, De Filippis E. A FACS-based approach to obtain viable eosinophils from human adipose tissue. Sci Rep. 2020 Aug 6; 10 (1):13210 Epub 2020 Aug 06
    View PubMed
  36. Hernandez JD, Tew BY, Li T, Gooden GC, Ghannam H, Masuda M, Madura J 2nd, Salhia B, Jacobsen EA, De Filippis E. A FACS-based approach to obtain viable eosinophils from human adipose tissue. Sci Rep. 2020 Aug 6; 10 (1):13210 Epub 2020 Aug 06
    View PubMed
  37. Kras KA, Hoffman N, Roust LR, Benjamin TR, DE Filippis EA, Katsanos CS. Adenosine Triphosphate Production of Muscle Mitochondria after Acute Exercise in Lean and Obese Humans. Med Sci Sports Exerc. 2019 Mar; 51 (3):445-453
    View PubMed
  38. Fonseca-Portilla R, Krell-Roesch J, Shaibi GQ, Caselli RJ, Mandarino LJ, Zhang N, Hentz JG, Coletta DK, de Filippis EA, Dawit S, Geda YE. Brain-Derived Neurotrophic Factor and Its Associations with Metabolism and Physical Activity in a Latino Sample. Metab Syndr Relat Disord. 2019 Mar; 17 (2):75-80 Epub 2018 Nov 10
    View PubMed
  39. Kras KA, Hoffman N, Roust LR, Benjamin TR, DE Filippis EA, Katsanos CS. Adenosine Triphosphate Production of Muscle Mitochondria after Acute Exercise in Lean and Obese Humans. Med Sci Sports Exerc. 2019 Mar; 51 (3):445-453
    View PubMed
  40. Fonseca-Portilla R, Krell-Roesch J, Shaibi GQ, Caselli RJ, Mandarino LJ, Zhang N, Hentz JG, Coletta DK, de Filippis EA, Dawit S, Geda YE. Brain-Derived Neurotrophic Factor and Its Associations with Metabolism and Physical Activity in a Latino Sample. Metab Syndr Relat Disord. 2019 Mar; 17 (2):75-80 Epub 2018 Nov 10
    View PubMed
  41. Kras KA, Langlais PR, Hoffman N, Roust LR, Benjamin TR, De Filippis EA, Dinu V, Katsanos CS. Obesity modifies the stoichiometry of mitochondrial proteins in a way that is distinct to the subcellular localization of the mitochondria in skeletal muscle. Metabolism. 2018 Dec; 89:18-26 Epub 2018 Sept 22
    View PubMed
  42. Kras KA, Langlais PR, Hoffman N, Roust LR, Benjamin TR, De Filippis EA, Dinu V, Katsanos CS. Obesity modifies the stoichiometry of mitochondrial proteins in a way that is distinct to the subcellular localization of the mitochondria in skeletal muscle. Metabolism. 2018 Dec; 89:18-26 Epub 2018 Sept 22
    View PubMed
  43. Willis WT, Miranda-Grandjean D, Hudgens J, Willis EA, Finlayson J, De Filippis EA, Zapata Bustos R, Langlais PR, Mielke C, Mandarino LJ. Dominant and sensitive control of oxidative flux by the ATP-ADP carrier in human skeletal muscle mitochondria: Effect of lysine acetylation. Arch Biochem Biophys. 2018 Jun 1; 647:93-103 Epub 2018 Apr 10
    View PubMed
  44. Willis WT, Miranda-Grandjean D, Hudgens J, Willis EA, Finlayson J, De Filippis EA, Zapata Bustos R, Langlais PR, Mielke C, Mandarino LJ. Dominant and sensitive control of oxidative flux by the ATP-ADP carrier in human skeletal muscle mitochondria: Effect of lysine acetylation. Arch Biochem Biophys. 2018 Jun 1; 647:93-103 Epub 2018 Apr 10
    View PubMed
  45. Zhang X, Saarinen AM, Campbell LE, De Filippis EA, Liu J. Regulation of Lipolytic Response and Energy Balance by Melanocortin 2 Receptor Accessory Protein (MRAP) in Adipocytes. Diabetes. 2018 Feb; 67 (2):222-234 Epub 2017 Dec 07
    View PubMed
  46. Zhang X, Saarinen AM, Campbell LE, De Filippis EA, Liu J. Regulation of Lipolytic Response and Energy Balance by Melanocortin 2 Receptor Accessory Protein (MRAP) in Adipocytes. Diabetes. 2018 Feb; 67 (2):222-234 Epub 2017 Dec 07
    View PubMed
  47. De Filippis E, Li T, Rosen ED. Exposure of adipocytes to bisphenol-A in vitro interferes with insulin action without enhancing adipogenesis. PLoS One. 2018; 13 (8):e0201122 Epub 2018 Aug 22
    View PubMed
  48. De Filippis E, Li T, Rosen ED. Exposure of adipocytes to bisphenol-A in vitro interferes with insulin action without enhancing adipogenesis. PLoS One. 2018; 13 (8):e0201122 Epub 2018 Aug 22
    View PubMed
  49. Day SE, Coletta RL, Kim JY, Garcia LA, Campbell LE, Benjamin TR, Roust LR, De Filippis EA, Mandarino LJ, Coletta DK. Potential epigenetic biomarkers of obesity-related insulin resistance in human whole-blood. Epigenetics. 2017 Apr 3; 12 (4):254-263 Epub 2017 Jan 20
    View PubMed
  50. Day SE, Coletta RL, Kim JY, Garcia LA, Campbell LE, Benjamin TR, Roust LR, De Filippis EA, Mandarino LJ, Coletta DK. Potential epigenetic biomarkers of obesity-related insulin resistance in human whole-blood. Epigenetics. 2017 Apr 3; 12 (4):254-263 Epub 2017 Jan 20
    View PubMed
  51. Day SE, Garcia LA, Coletta RL, Campbell LE, Benjamin TR, De Filippis EA, Madura JA 2nd, Mandarino LJ, Roust LR, Coletta DK. Alterations of sorbin and SH3 domain containing 3 (SORBS3) in human skeletal muscle following Roux-en-Y gastric bypass surgery. Clin Epigenetics. 2017; 9:96 Epub 2017 Sept 02
    View PubMed
  52. Day SE, Garcia LA, Coletta RL, Campbell LE, Benjamin TR, De Filippis EA, Madura JA 2nd, Mandarino LJ, Roust LR, Coletta DK. Alterations of sorbin and SH3 domain containing 3 (SORBS3) in human skeletal muscle following Roux-en-Y gastric bypass surgery. Clin Epigenetics. 2017; 9:96 Epub 2017 Sept 02
    View PubMed
  53. Campbell LE, Langlais PR, Day SE, Coletta RL, Benjamin TR, De Filippis EA, Madura JA 2nd, Mandarino LJ, Roust LR, Coletta DK. Identification of Novel Changes in Human Skeletal Muscle Proteome After Roux-en-Y Gastric Bypass Surgery. Diabetes. 2016 Sep; 65 (9):2724-31 Epub 2016 May 10
    View PubMed
  54. Campbell LE, Langlais PR, Day SE, Coletta RL, Benjamin TR, De Filippis EA, Madura JA 2nd, Mandarino LJ, Roust LR, Coletta DK. Identification of Novel Changes in Human Skeletal Muscle Proteome After Roux-en-Y Gastric Bypass Surgery. Diabetes. 2016 Sep; 65 (9):2724-31 Epub 2016 May 10
    View PubMed
  55. Shaibi G, Singh D, De Filippis EA, Hernandez V, Rosenfeld B, Otu E, Montes de Oca G, Levey S, Radecki Breitkopf C, Sharp R, Olson J, Cerhan J, Thibodeau S, Winkler E, Mandarino L. The Sangre Por Salud Biobank: Facilitating Genetic Research in an Underrepresented Latino Community. Public Health Genomics. 2016 Jul 5;
    View PubMed
  56. Shaibi G, Singh D, De Filippis EA, Hernandez V, Rosenfeld B, Otu E, Montes de Oca G, Levey S, Radecki Breitkopf C, Sharp R, Olson J, Cerhan J, Thibodeau S, Winkler E, Mandarino L. The Sangre Por Salud Biobank: Facilitating Genetic Research in an Underrepresented Latino Community. Public Health Genomics. 2016 Jul 5;
    View PubMed
  57. Day SE, Coletta RL, Kim JY, Campbell LE, Benjamin TR, Roust LR, De Filippis EA, Dinu V, Shaibi GQ, Mandarino LJ, Coletta DK. Next-generation sequencing methylation profiling of subjects with obesity identifies novel gene changes. Clin Epigenetics. 2016; 8:77 Epub 2016 July 18
    View PubMed
  58. Tran L, Hanavan PD, Campbell LE, De Filippis E, Lake DF, Coletta DK, Roust LR, Mandarino LJ, Carroll CC, Katsanos CS. Prolonged Exposure of Primary Human Muscle Cells to Plasma Fatty Acids Associated with Obese Phenotype Induces Persistent Suppression of Muscle Mitochondrial ATP Synthase beta Subunit. PLoS One. 2016; 11 (8):e0160057 Epub 2016 Aug 17
    View PubMed
  59. Day SE, Coletta RL, Kim JY, Campbell LE, Benjamin TR, Roust LR, De Filippis EA, Dinu V, Shaibi GQ, Mandarino LJ, Coletta DK. Next-generation sequencing methylation profiling of subjects with obesity identifies novel gene changes. Clin Epigenetics. 2016; 8:77 Epub 2016 July 18
    View PubMed
  60. Tran L, Hanavan PD, Campbell LE, De Filippis E, Lake DF, Coletta DK, Roust LR, Mandarino LJ, Carroll CC, Katsanos CS. Prolonged Exposure of Primary Human Muscle Cells to Plasma Fatty Acids Associated with Obese Phenotype Induces Persistent Suppression of Muscle Mitochondrial ATP Synthase beta Subunit. PLoS One. 2016; 11 (8):e0160057 Epub 2016 Aug 17
    View PubMed
  61. De Filippis EA, Sabet A, Sun MR, Garber JR. Pemberton's sign: explained nearly 70 years later. J Clin Endocrinol Metab. 2014 Jun; 99(6):1949-54. Epub 2014 Mar 19.
    View PubMed
  62. De Filippis EA, Sabet A, Sun MR, Garber JR. Pemberton's sign: explained nearly 70 years later. J Clin Endocrinol Metab. 2014 Jun; 99(6):1949-54. Epub 2014 Mar 19.
    View PubMed
  63. Langlais P, Yi Z, Finlayson J, Luo M, Mapes R, De Filippis E, Meyer C, Plummer E, Tongchinsub P, Mattern M, Mandarino LJ. Global IRS-1 phosphorylation analysis in insulin resistance. Diabetologia. 2011 Nov; 54(11):2878-89. Epub 2011 Aug 18.
    View PubMed
  64. Langlais P, Yi Z, Finlayson J, Luo M, Mapes R, De Filippis E, Meyer C, Plummer E, Tongchinsub P, Mattern M, Mandarino LJ. Global IRS-1 phosphorylation analysis in insulin resistance. Diabetologia. 2011 Nov; 54(11):2878-89. Epub 2011 Aug 18.
    View PubMed
  65. Holmes RM, Yi Z, De Filippis E, Berria R, Shahani S, Sathyanarayana P, Sherman V, Fujiwara K, Meyer C, Christ-Roberts C, Hwang H, Finlayson J, Dong LQ, Mandarino LJ, Bajaj M. Increased abundance of the adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif (APPL1) in patients with obesity and type 2 diabetes: evidence for altered adiponectin signalling. Diabetologia. 2011 Aug; 54(8):2122-31. Epub 2011 May 12.
    View PubMed
  66. Holmes RM, Yi Z, De Filippis E, Berria R, Shahani S, Sathyanarayana P, Sherman V, Fujiwara K, Meyer C, Christ-Roberts C, Hwang H, Finlayson J, Dong LQ, Mandarino LJ, Bajaj M. Increased abundance of the adaptor protein containing pleckstrin homology domain, phosphotyrosine binding domain and leucine zipper motif (APPL1) in patients with obesity and type 2 diabetes: evidence for altered adiponectin signalling. Diabetologia. 2011 Aug; 54(8):2122-31. Epub 2011 May 12.
    View PubMed
  67. Lefort N, Glancy B, Bowen B, Willis WT, Bailowitz Z, De Filippis EA, Brophy C, Meyer C, Hojlund K, Yi Z, Mandarino LJ. Increased reactive oxygen species production and lower abundance of complex I subunits and carnitine palmitoyltransferase 1B protein despite normal mitochondrial respiration in insulin-resistant human skeletal muscle. Diabetes. 2010 Oct; 59(10):2444-52. Epub 2010 Aug 03.
    View PubMed
  68. Lefort N, Glancy B, Bowen B, Willis WT, Bailowitz Z, De Filippis EA, Brophy C, Meyer C, Hojlund K, Yi Z, Mandarino LJ. Increased reactive oxygen species production and lower abundance of complex I subunits and carnitine palmitoyltransferase 1B protein despite normal mitochondrial respiration in insulin-resistant human skeletal muscle. Diabetes. 2010 Oct; 59(10):2444-52. Epub 2010 Aug 03.
    View PubMed
  69. Hwang H, Bowen BP, Lefort N, Flynn CR, De Filippis EA, Roberts C, Smoke CC, Meyer C, Hojlund K, Yi Z, Mandarino LJ. Proteomics analysis of human skeletal muscle reveals novel abnormalities in obesity and type 2 diabetes. Diabetes. 2010 Jan; 59(1):33-42. Epub 2009 Oct 15.
    View PubMed
  70. Hwang H, Bowen BP, Lefort N, Flynn CR, De Filippis EA, Roberts C, Smoke CC, Meyer C, Hojlund K, Yi Z, Mandarino LJ. Proteomics analysis of human skeletal muscle reveals novel abnormalities in obesity and type 2 diabetes. Diabetes. 2010 Jan; 59(1):33-42. Epub 2009 Oct 15.
    View PubMed
  71. Lefort N, Yi Z, Bowen B, Glancy B, De Filippis EA, Mapes R, Hwang H, Flynn CR, Willis WT, Civitarese A, Hojlund K, Mandarino LJ. Proteome profile of functional mitochondria from human skeletal muscle using one-dimensional gel electrophoresis and HPLC-ESI-MS/MS. J Proteomics. 2009 Aug 20; 72(6):1046-60. Epub 2009 Jun 28.
    View PubMed
  72. Lefort N, Yi Z, Bowen B, Glancy B, De Filippis EA, Mapes R, Hwang H, Flynn CR, Willis WT, Civitarese A, Hojlund K, Mandarino LJ. Proteome profile of functional mitochondria from human skeletal muscle using one-dimensional gel electrophoresis and HPLC-ESI-MS/MS. J Proteomics. 2009 Aug 20; 72(6):1046-60. Epub 2009 Jun 28.
    View PubMed
  73. Yi Z, Bowen BP, Hwang H, Jenkinson CP, Coletta DK, Lefort N, Bajaj M, Kashyap S, Berria R, De Filippis EA, Mandarino LJ. Global relationship between the proteome and transcriptome of human skeletal muscle. J Proteome Res. 2008 Aug; 7(8):3230-41. Epub 2008 Jul 10.
    View PubMed
  74. Yi Z, Bowen BP, Hwang H, Jenkinson CP, Coletta DK, Lefort N, Bajaj M, Kashyap S, Berria R, De Filippis EA, Mandarino LJ. Global relationship between the proteome and transcriptome of human skeletal muscle. J Proteome Res. 2008 Aug; 7(8):3230-41. Epub 2008 Jul 10.
    View PubMed
  75. Formoso G, De Filippis EA, Michetti N, Di Fulvio P, Pandolfi A, Bucciarelli T, Ciabattoni G, Nicolucci A, Davi G, Consoli A. Decreased in vivo oxidative stress and decreased platelet activation following metformin treatment in newly diagnosed type 2 diabetic subjects. Diabetes Metab Res Rev. 2008 Mar-Apr; 24: (3)231-7.
    View PubMed
  76. Formoso G, De Filippis EA, Michetti N, Di Fulvio P, Pandolfi A, Bucciarelli T, Ciabattoni G, Nicolucci A, Davi G, Consoli A. Decreased in vivo oxidative stress and decreased platelet activation following metformin treatment in newly diagnosed type 2 diabetic subjects. Diabetes Metab Res Rev. 2008 Mar-Apr; 24: (3)231-7.
    View PubMed
  77. De Filippis E, Alvarez G, Berria R, Cusi K, Everman S, Meyer C, Mandarino LJ. Insulin-resistant muscle is exercise resistant: evidence for reduced response of nuclear-encoded mitochondrial genes to exercise. Am J Physiol Endocrinol Metab. 2008 Mar; 294(3):E607-14. Epub 2008 Jan 08.
    View PubMed
  78. De Filippis E, Alvarez G, Berria R, Cusi K, Everman S, Meyer C, Mandarino LJ. Insulin-resistant muscle is exercise resistant: evidence for reduced response of nuclear-encoded mitochondrial genes to exercise. Am J Physiol Endocrinol Metab. 2008 Mar; 294(3):E607-14. Epub 2008 Jan 08.
    View PubMed
  79. Pandolfi A, De Filippis EA. Chronic hyperglicemia and nitric oxide bioavailability play a pivotal role in pro-atherogenic vascular modifications. Genes Nutr. 2007 Nov; 2(2):195-208. Epub 2007 Oct 17.
    View PubMed
  80. Pandolfi A, De Filippis EA. Chronic hyperglicemia and nitric oxide bioavailability play a pivotal role in pro-atherogenic vascular modifications. Genes Nutr. 2007 Nov; 2(2):195-208. Epub 2007 Oct 17.
    View PubMed
  81. Luo M, Langlais P, Yi Z, Lefort N, De Filippis EA, Hwang H, Christ-Roberts CY, Mandarino LJ. Phosphorylation of human insulin receptor substrate-1 at Serine 629 plays a positive role in insulin signaling. Endocrinology. 2007 Oct; 148(10):4895-905. Epub 2007 Jul 19.
    View PubMed
  82. Luo M, Langlais P, Yi Z, Lefort N, De Filippis EA, Hwang H, Christ-Roberts CY, Mandarino LJ. Phosphorylation of human insulin receptor substrate-1 at Serine 629 plays a positive role in insulin signaling. Endocrinology. 2007 Oct; 148(10):4895-905. Epub 2007 Jul 19.
    View PubMed
  83. Berria R, Glass L, Mahankali A, Miyazaki Y, Monroy A, De Filippis E, Cusi K, Cersosimo E, Defronzo RA, Gastaldelli A. Reduction in hematocrit and hemoglobin following pioglitazone treatment is not hemodilutional in Type II diabetes mellitus. Clin Pharmacol Ther. 2007 Sep; 82: (3)275-81.
    View PubMed
  84. Berria R, Glass L, Mahankali A, Miyazaki Y, Monroy A, De Filippis E, Cusi K, Cersosimo E, Defronzo RA, Gastaldelli A. Reduction in hematocrit and hemoglobin following pioglitazone treatment is not hemodilutional in Type II diabetes mellitus. Clin Pharmacol Ther. 2007 Sep; 82: (3)275-81.
    View PubMed
  85. Yi Z, Langlais P, De Filippis EA, Luo M, Flynn CR, Schroeder S, Weintraub ST, Mapes R, Mandarino LJ. Global assessment of regulation of phosphorylation of insulin receptor substrate-1 by insulin in vivo in human muscle. Diabetes. 2007 Jun; 56(6):1508-16. Epub 2007 Mar 14.
    View PubMed
  86. Yi Z, Langlais P, De Filippis EA, Luo M, Flynn CR, Schroeder S, Weintraub ST, Mapes R, Mandarino LJ. Global assessment of regulation of phosphorylation of insulin receptor substrate-1 by insulin in vivo in human muscle. Diabetes. 2007 Jun; 56(6):1508-16. Epub 2007 Mar 14.
    View PubMed
  87. De Filippis E, Cusi K, Ocampo G, Berria R, Buck S, Consoli A, Mandarino LJ. Exercise-induced improvement in vasodilatory function accompanies increased insulin sensitivity in obesity and type 2 diabetes mellitus. J Clin Endocrinol Metab. 2006 Dec; 91(12):4903-10. Epub 2006 Oct 03.
    View PubMed
  88. De Filippis E, Cusi K, Ocampo G, Berria R, Buck S, Consoli A, Mandarino LJ. Exercise-induced improvement in vasodilatory function accompanies increased insulin sensitivity in obesity and type 2 diabetes mellitus. J Clin Endocrinol Metab. 2006 Dec; 91(12):4903-10. Epub 2006 Oct 03.
    View PubMed
  89. Triplitt C, Glass L, Miyazaki Y, Wajcberg E, Gastaldelli A, De Filippis E, Cersosimo E, DeFronzo RA. Comparison of glargine insulin versus rosiglitazone addition in poorly controlled type 2 diabetic patients on metformin plus sulfonylurea. Diabetes Care. 2006 Nov; 29: (11)2371-7.
    View PubMed
  90. Triplitt C, Glass L, Miyazaki Y, Wajcberg E, Gastaldelli A, De Filippis E, Cersosimo E, DeFronzo RA. Comparison of glargine insulin versus rosiglitazone addition in poorly controlled type 2 diabetic patients on metformin plus sulfonylurea. Diabetes Care. 2006 Nov; 29: (11)2371-7.
    View PubMed
  91. Berria R, Gastaldelli A, Lucidi S, Belfort R, De Filippis E, Easton C, Brytzki R, Cusi K, Jovanovic L, DeFronzo R. Reduction in hematocrit level after pioglitazone treatment is correlated with decreased plasma free testosterone level, not hemodilution, in women with polycystic ovary syndrome. Clin Pharmacol Ther. 2006 Aug; 80: (2)105-14.
    View PubMed
  92. Berria R, Gastaldelli A, Lucidi S, Belfort R, De Filippis E, Easton C, Brytzki R, Cusi K, Jovanovic L, DeFronzo R. Reduction in hematocrit level after pioglitazone treatment is correlated with decreased plasma free testosterone level, not hemodilution, in women with polycystic ovary syndrome. Clin Pharmacol Ther. 2006 Aug; 80: (2)105-14.
    View PubMed
  93. Maddux BA, Chan A, De Filippis EA, Mandarino LJ, Goldfine ID. IGF-binding protein-1 levels are related to insulin-mediated glucose disposal and are a potential serum marker of insulin resistance. Diabetes Care. 2006 Jul; 29(7):1535-7.
    View PubMed
  94. Maddux BA, Chan A, De Filippis EA, Mandarino LJ, Goldfine ID. IGF-binding protein-1 levels are related to insulin-mediated glucose disposal and are a potential serum marker of insulin resistance. Diabetes Care. 2006 Jul; 29(7):1535-7.
    View PubMed
  95. Berria R, Wang L, Richardson DK, Finlayson J, Belfort R, Pratipanawatr T, De Filippis EA, Kashyap S, Mandarino LJ. Increased collagen content in insulin-resistant skeletal muscle. Am J Physiol Endocrinol Metab. 2006 Mar; 290(3):E560-5. Epub 2005 Oct 25.
    View PubMed
  96. Berria R, Wang L, Richardson DK, Finlayson J, Belfort R, Pratipanawatr T, De Filippis EA, Kashyap S, Mandarino LJ. Increased collagen content in insulin-resistant skeletal muscle. Am J Physiol Endocrinol Metab. 2006 Mar; 290(3):E560-5. Epub 2005 Oct 25.
    View PubMed
  97. Miyazaki Y, De Filippis E, Wajcberg E, Glass L, Triplitt C, Cersosimo E, Mandarino LJ, DeFronzo R. Predictors of improved glycemic control with thiazolidinediones therapy in type 2 diabetic patients: a practical approach for the primary care physician. British J of Diabetes and Cardiovasc Disease. 2005; 5(1):28-35.
  98. Miyazaki Y, De Filippis E, Wajcberg E, Glass L, Triplitt C, Cersosimo E, Mandarino LJ, DeFronzo R. Predictors of improved glycemic control with thiazolidinediones therapy in type 2 diabetic patients: a practical approach for the primary care physician. British J of Diabetes and Cardiovasc Disease. 2005; 5(1):28-35.
  99. Federici M, Pandolfi A, De Filippis EA, Pellegrini G, Menghini R, Lauro D, Cardellini M, Romano M, Sesti G, Lauro R, Consoli A. G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells. Circulation. 2004 Jan 27; 109: (3)399-405.
    View PubMed
  100. Federici M, Pandolfi A, De Filippis EA, Pellegrini G, Menghini R, Lauro D, Cardellini M, Romano M, Sesti G, Lauro R, Consoli A. G972R IRS-1 variant impairs insulin regulation of endothelial nitric oxide synthase in cultured human endothelial cells. Circulation. 2004 Jan 27; 109: (3)399-405.
    View PubMed
  101. Pandolfi A, Giaccari A, Cilli C, Alberta MM, Morviducci L, De Filippis EA, Buongiorno A, Pellegrini G, Capani F, Consoli A. Acute hyperglycemia and acute hyperinsulinemia decrease plasma fibrinolytic activity and increase plasminogen activator inhibitor type 1 in the rat. Acta Diabetol. 2001; 38: (2)71-6.
    View PubMed
  102. Pandolfi A, Giaccari A, Cilli C, Alberta MM, Morviducci L, De Filippis EA, Buongiorno A, Pellegrini G, Capani F, Consoli A. Acute hyperglycemia and acute hyperinsulinemia decrease plasma fibrinolytic activity and increase plasminogen activator inhibitor type 1 in the rat. Acta Diabetol. 2001; 38: (2)71-6.
    View PubMed