Publications

  1. Peng DH, Kundu ST, Fradette JJ, Diao L, Tong P, Byers LA, Wang J, Canales JR, Villalobos PA, Mino B, Yang Y, Minelli R, Peoples MD, Bristow CA, Heffernan TP, Carugo A, Wistuba II, Gibbons DL. ZEB1 suppression sensitizes KRAS mutant cancers to MEK inhibition by an IL17RD-dependent mechanism. Sci Transl Med. 2019 Mar 13; 11 (483)
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  2. Wang Y, Han Y, Guo Z, Yang Y, Ren T. Nuclear TAZ activity distinctly associates with subtypes of non-small cell lung cancer. Biochem Biophys Res Commun. 2019 Feb 12; 509 (3):828-832 Epub 2019 Jan 11
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  3. Wang Y, Zhang T, Guo L, Ren T, Yang Y. Stromal extracellular matrix is a microenvironmental cue promoting resistance to EGFR tyrosine kinase inhibitors in lung cancer cells. Int J Biochem Cell Biol. 2019 Jan; 106:96-106 Epub 2018 Nov 22
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  4. Ren Y, Huang S, Dai C, Xie D, Zheng L, Xie H, Zheng H, She Y, Zhou F, Wang Y, Li P, Fei K, Jiang G, Zhang Y, Su B, Sweet-Cordero EA, Tran NL, Yang Y, Patel JN, Rolfo C, Rocco G, Cardona AF, Tuzi A, Suter MB, Yang P, Xu W, Chen C. Germline Predisposition and Copy Number Alteration in Pre-stage Lung Adenocarcinomas Presenting as Ground-Glass Nodules. Front Oncol. 2019; 9:288 Epub 2019 Apr 18
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  5. Zhang T, Guo L, Wang Y, Yang Y. Macroautophagy Regulates Nuclear NOTCH1 Activity Through Multiple p62 Binding Sites. IUBMB Life. 2018 Oct; 70 (10):985-994 Epub 2018 Sept 12
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  6. Liu W, Zhang T, Guo L, Wang Y, Yang Y, Yang Y. Lysyl hydroxylases are transcription targets for GATA3 driving lung cancer cell metastasis. Sci Rep. 2018 Aug 9; 8 (1):11905 Epub 2018 Aug 09
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  7. Hogan KA, Cho DS, Arneson PC, Samani A, Palines P, Yang Y, Doles JD. Tumor-derived cytokines impair myogenesis and alter the skeletal muscle immune microenvironment. Cytokine. 2018 Jul; 107:9-17 Epub 2017 Nov 17
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  8. Yan F, Shen N, Pang J, Zhao N, Deng B, Li B, Yang Y, Yang P, Yang P, Yang P, Molina JR, Liu S. A regulatory circuit composed of DNA methyltransferases and receptor tyrosine kinases controls lung cancer cell aggressiveness. Oncogene. 2017 Dec 14; 36 (50):6919-6928 Epub 2017 Sept 04
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  9. Yan F, Shen N, Pang J, Zhao N, Deng B, Li B, Yang Y, Yang P, Yang P, Yang P, Molina JR, Liu S. A regulatory circuit composed of DNA methyltransferases and receptor tyrosine kinases controls lung cancer cell aggressiveness. Oncogene. 2017 Dec 14; 36 (50):6919-6928 Epub 2017 Sept 04
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  10. Yan F, Shen N, Pang J, Zhao N, Deng B, Li B, Yang Y, Yang P, Yang P, Yang P, Molina JR, Liu S. A regulatory circuit composed of DNA methyltransferases and receptor tyrosine kinases controls lung cancer cell aggressiveness. Oncogene. 2017 Dec 14; 36 (50):6919-6928 Epub 2017 Sept 04
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  11. Huang J, Dou D, She J, Limper AH, Yang Y, Yang P. A comprehensive (biological and computational) investigation on the role of microRNA::mRNA regulations performed in chronic obstructive pulmonary disease and lung cancer Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016. 2017; 1062-7.
  12. Huang J, Dou D, She J, Limper AH, Yang Y, Yang P. A comprehensive (biological and computational) investigation on the role of microRNA::mRNA regulations performed in chronic obstructive pulmonary disease and lung cancer Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016. 2017; 1062-7.
  13. Zhang T, Guo L, Creighton CJ, Lu Q, Gibbons DL, Yi ES, Deng B, Molina JR, Sun Z, Yang P, Yang Y. A genetic cell context-dependent role for ZEB1 in lung cancer. Nat Commun. 2016 Jul 26; 7:12231 Epub 2016 July 26
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  14. Guo L, Wang J, Zhang T, Yang Y. Glypican-5 is a tumor suppressor in non-small cell lung cancer cells. Biochem Biophys Rep. 2016 Jul; 6:108-112
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  15. Liu W, Zhang T, Guo L, Yang Y. Lipophilic bisphosphonates plus rapamycin: a deadly combination for KRAS-mutated lung adenocarcinoma. Ann Transl Med. 2015 Nov; 3 (19):289
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  16. Guo L, Wang J, Yang P, Lu Q, Zhang T, Yang Y. MicroRNA-200 promotes lung cancer cell growth through FOG2-independent AKT activation. IUBMB Life. 2015 Sep; 67 (9):720-5 Epub 2015 Aug 27
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  17. Jang JS, Lee A, Li J, Liyanage H, Yang Y, Guo L, Asmann YW, Li PW, Erickson-Johnson M, Sakai Y, Sun Z, Jeon HS, Hwang H, Bungum AO, Edell ES, Simon VA, Kopp KJ, Eckloff B, Oliveira AM, Wieben E, Aubry MC, Yi E, Wigle D, Diasio RB, Yang P, Jen J. Common Oncogene Mutations and Novel SND1-BRAF Transcript Fusion in Lung Adenocarcinoma from Never Smokers. Sci Rep. 2015 May 18; 5:9755
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  18. Guo L, Zhang T, Xiong Y, Yang Y. Roles of NOTCH1 as a Therapeutic Target and a Biomarker for Lung Cancer: Controversies and Perspectives. Dis Markers. 2015; 2015:520590 Epub 2015 Sept 27
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  19. Chen Y, Terajima M, Yang Y, Sun L, Ahn YH, Pankova D, Puperi DS, Watanabe T, Kim MP, Blackmon SH, Rodriguez J, Liu H, Behrens C, Wistuba II, Minelli R, Scott KL, Sanchez-Adams J, Guilak F, Pati D, Thilaganathan N, Burns AR, Creighton CJ, Martinez ED, Zal T, Grande-Allen KJ, Yamauchi M, Kurie JM. Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma. J Clin Invest. 2015; 125(3):1147-62.
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  20. Yang Y, Ahn YH, Chen Y, Tan X, Guo L, Gibbons DL, Ungewiss C, Peng DH, Liu X, Lin SH, Thilaganathan N, Wistuba II, Rodriguez-Canales J, McLendon G, Creighton CJ, Kurie JM. ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism. J Clin Invest. 2014; 124(6):2696-708.
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  21. Baird BN, Schliekelman MJ, Ahn YH, Chen Y, Roybal JD, Gill BJ, Mishra DK, Erez B, O'Reilly M, Yang Y, Patel M, Liu X, Thilaganathan N, Larina IV, Dickinson ME, West JL, Gibbons DL, Liu DD, Kim MP, Hicks JM, Wistuba II, Hanash SM, Kurie JM. Fibulin-2 is a driver of malignant progression in lung adenocarcinoma. PLoS One. 2013 Jun 10; 8(6):e67054.
  22. Roybal J, Zang Y, Ahn YH, Yang Y, Gibbons DL, Alvarez C, Thilaganathan N, Liu DD, Saintigny P, Heymach JV, Creighton CJ, Kurie JM. MiR-200 Inhibits Lung Adenocarcinoma Cell Invasion and Metastasis by Targeting Flt1/VEGFR1. Molecular Cancer Research. 2011; 9:25-35.
  23. Yang Y, Ahn YH, Gibbons DL, Zang Y, Lin W, Thilaganthan N, Moreira DC, Creighton CJ, Gregory PA, Goodall GJ, Kurie JM. The Notch Ligand Jagged2 Promotes Lung Adenocarcinoma Metastasis Through a miR-200-dependent Pathway in Mice. Journal of Clinical Investigation. 2011; 121:1373-1385.
  24. Ahn YH, Yang Y, Gibbons D, Creighton C, Yang F, Wistuba I, Lin W, Thilaganathan N, Alvarez C, Roybal J, Goldsmith E, Tournier C, Kurie JM. MAP2K4 Functions as a Tumor Suppressor in Lung Adenocarcinoma and Inhibits Tumor Cell Invasion by Decreasing PPAR gamma. Molecular and Cellular Biology. 2011; 31:4270-4285.
  25. Xu L, Nilsson MB, Saintigny P, Cascone T, Herynk MH, Du Z, Nikolinakos PG, Yang Y, Prudkin L, Liu D, Lee JJ, Johnson FM, Wong KK, Girard L, Gazdar AF, Minna JD, Kurie JM, Wistuba II, Heymach JV. Epidermal growth factor receptor regulates MET levels and invasiveness through hypoxia-inducible factor-1alpha in non-small cell lung cancer cells. Oncogene. 2010; 29:2616-2627.
  26. Lei W, Zhang K, Pan X, Wang D, Hu Y, Yang Y, Song J. Histone deacetylase 1 and 2 differentially regulate apoptosis via opposing effects on extracellular signal-regulated kinase 1/2. Cell Death and Disease. 2010; 1:e44.
  27. Lee D, Yu M, Lee E, Kim H, Yang Y, Kim K, Pannicia C, Kurie JM, Threadgill DW. Tumor-specific apoptosis caused by deletion of the ERBB3 pseudo-kinase in the intestinal epithelium. Journal of Clinical Investigation. 2009; 119(9):2702-2713.
  28. Pan X, Wang X, Lei W, Min L, Yang Y, Wang X, Song J. Nitric oxide suppresses transforming growth factor-beta1-induced epithelial-to-mesenchymal transition and apoptosis in mouse hepatocytes. Hepatology. 2009; 50:1577-1587.
  29. Jin N, Cho SN, Raso MG, Wistuba II, Smith Y, Yang Y, Kurie JM, Yen R, Evans CM, Jeong JW, DeMayo FJ. Mig-6 is Required for Lung Development and Adult Lung Homeostasis. Development. 2009; 136:3347-3356.
  30. Gibbons DL, Lin W, Creighton CJ, Zheng S, Berel D, Yang Y, Raso MG, Liu DD, Wistuba II, Lozano G, Kurie JM. Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma. PLoS One. 2009; 4(4):e5401.
  31. Yang Y, Iwanaga K, Raso MG, Wislez M, Hanna AE, Wieder ED, Molldrem JJ, Wistuba II, Powis G, Demayo FJ, Kim CF, Kurie JM. Phosphatidylinositol 3-kinase stimulates the proliferation of bronchioalveolar stem cells in mouse models of oncogenic K-ras-induced lung cancer. PLoS One. 2008; 3:e2220.
  32. Yang Y, Wislez M, Fujimoto N, Prudkin L, Izzo JG, Uno F, Ji L, Hanna AE, Langley RR, Liu D, Johnson FM, Wistuba I, Kurie JM. A selective small molecule inhibitor of c-Met, PHA-665752, has anti-tumor activity in a mouse model of mutant K-ras-induced lung cancer. Molecular Cancer Therapeutics. 2008; 7:952-960.
  33. Li F, Wang D, Zhou Y, Zhou B, Yang Y, Chen H, Song J. Protein kinase A suppresses the differentiation of 3T3-L1 preadipocytes. Cell Research. 2008; 18:311-323.
  34. Iwanaga K, Yang Y, Raso MG, Ma L, Hanna AE, Thilaganathan N, Li H, Cai WW, Sato M, Minna JD, Wu H, Creighton C, Demayo FJ, Wistuba II, Kurie JM. Pten Inactivation Accelerates Oncogenic K-ras-initiated Tumorigenesis in a Mouse Model of Lung Cancer. Cancer Research. 2008; 68:1119-1127.
  35. Yang Y, Pan X, Lei W, Wang J, Song JG. Transforming growth factor beta 1 induces epithelial-to-mesenchymal transition and apoptosis via a cell cycle-dependent mechanism. Oncogene. 2006; 25:7235-7244.
  36. Yang Y, Pan X, Lei W, Wang J, Shi J, Li F, Song JG. Regulation of transforming growth factor beta 1-Induced apoptosis and epithelial to mesenchymal transition by protein kinase A and signal transducers and activators of transcription 3. Cancer Research. 2006; 66:8617-8624.
  37. Yang Y, Zhao S, Song JG. Caspase-dependent apoptosis and -independent poly(ADP-ribose) polymerase cleavage induced by transforming growth factor-beta1. International Journal of Biochemistry and Cell Biology. 2004; 36:223-234.
  38. Zhao S, Yang Y, Song JG. Ceramide induces caspase-dependent and -independent apoptosis in A-431 cells. Journal of Cellular Physiology. 2004; 199:47-56.