Publications

1. Corujo-Ramirez AM, Dua M, Yoo KH, Oliveros A, Jang MH. Genetic Inhibition of sFRP3 Prevents Glial Reactivity in a Mouse Model of Accelerated Aging. Int Neurourol J. 2020 Nov; 24 (Suppl 2):72-78 Epub 2020 Nov 23
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2. Peyton L, Oliveros A, Cho CH, Starski P, Lindberg D, Jang MH, Choi DS. Waiting impulsivity during reward seeking increases adult hippocampal neurogenesis in mice. Neurosci Lett. 2019 Jul 27; 706:169-175 Epub 2019 May 19
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3. Simmons AJ, Park R, Sterling NA, Jang MH, van Deursen JMA, Yen TJ, Cho SH, Kim S. Nearly complete deletion of BubR1 causes microcephaly through shortened mitosis and massive cell death. Hum Mol Genet. 2019 Jun 1; 28 (11):1822-1836
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4. Cho CH, Yoo KH, Oliveros A, Paulson S, Hussaini SMQ, van Deursen JM, Jang MH. sFRP3 inhibition improves age-related cellular changes in BubR1 progeroid mice. Aging Cell. 2019 Apr; 18 (2):e12899 Epub 2019 Jan 04
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5. Tang J, Oliveros A, Jang MH. Dysfunctional Mitochondrial Bioenergetics and Synaptic Degeneration in Alzheimer Disease. Int Neurourol J. 2019 Feb; 23 (Suppl 1):S5-10 Epub 2019 Feb 28
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6. Hussaini SMQ, Jang MH. New Roles for Old Glue: Astrocyte Function in Synaptic Plasticity and Neurological Disorders. Int Neurourol J. 2018 Oct; 22 (Suppl 3):S106-114 Epub 2018 Oct 31
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7. Cho CH, Yang Z, Yoo KH, Oliveros A, Jang MH. BubR1 Insufficiency Impairs Affective Behavior and Memory Function in Mice. Int Neurourol J. 2018 Oct; 22 (Suppl 3):S122-130 Epub 2018 Oct 31
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8. Hussaini SMQ, Jang MH. BubR1 and brain aging. Aging (Albany NY) 2017 Oct 2; 9 (9):1955-1956
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9. Terrillion CE, Abazyan B, Yang Z, Crawford J, Shevelkin AV, Jouroukhin Y, Yoo KH, Cho CH, Roychaudhuri R, Snyder SH, Jang MH, Pletnikov MV. DISC1 in Astrocytes Influences Adult Neurogenesis and Hippocampus-Dependent Behaviors in Mice. Neuropsychopharmacology. 2017 Oct; 42 (11):2242-2251 Epub 2017 June 20
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10. Tang JJ, Podratz JL, Lange M, Scrable HJ, Jang MH, Windebank AJ. Mechano growth factor, a splice variant of IGF-1, promotes neurogenesis in the aging mouse brain. Mol Brain. 2017 Jul 7; 10 (1):23 Epub 2017 July 07
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11. Yang Z, Jun H, Choi CI, Yoo KH, Cho CH, Hussaini SMQ, Simmons AJ, Kim S, van Deursen JM, Baker DJ, Jang MH. Age-related decline in BubR1 impairs adult hippocampal neurogenesis. Aging Cell. 2017 Jun; 16 (3):598-601 Epub 2017 Apr 06
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12. Oliveros A, Cho CH, Cui A, Choi S, Lindberg D, Hinton D, Jang MH, Choi DS. Adenosine A2A receptor and ERK-driven impulsivity potentiates hippocampal neuroblast proliferation. Transl Psychiatry. 2017 Apr 18; 7 (4):e1095
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13. Choi CI, Yoo KH, Hussaini SM, Jeon BT, Welby J, Gan H, Scarisbrick IA, Zhang Z, Baker DJ, van Deursen JM, Rodriguez M, Jang MH. The progeroid gene BubR1 regulates axon myelination and motor function. Aging (Albany NY). 2016 Sep 12; 8 (11):2667-2688
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14. Jun H, Mohammed Qasim Hussaini S, Cho CH, Welby J, Jang MH. Gadd45b Mediates Electroconvulsive Shock Induced Proliferation of Hippocampal Neural Stem Cells. Brain Stimul. 2015 Nov-Dec; 8 (6):1021-1024 Epub 2015 July 28
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15. Sun J, Bonaguidi MA, Jun H, Guo JU, Sun GJ, Will B, Yang Z, Jang MH, Song H, Ming GL, Christian KM. A septo-temporal molecular gradient of sfrp3 in the dentate gyrus differentially regulates quiescent adult hippocampal neural stem cell activation. Mol Brain. 2015 Sep 4; 8:52 Epub 2015 Sept 04
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16. Hussaini SM, Choi CI, Cho CH, Kim HJ, Jun H, Jang MH. Wnt signaling in neuropsychiatric disorders: ties with adult hippocampal neurogenesis and behavior. Neurosci Biobehav Rev. 2014 Nov; 47:369-83 Epub 2014 Sept 28
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17. Hussaini SM, Jun H, Cho CH, Kim HJ, Kim WR, Jang MH. Heat-induced antigen retrieval: an effective method to detect and identify progenitor cell types during adult hippocampal neurogenesis. J Vis Exp. 2013 Aug 30; (78)
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18. Jang MH, Bonaguidi MA, Kitabatake Y, Sun J, Song J, Kang E, Jun H, Zhong C, Su Y, Guo JU, Wang MX, Sailor KA, Kim JY, Gao Y, Christian KM, Ming GL, Song H. Secreted frizzled-related protein 3 regulates activity-dependent adult hippocampal neurogenesis. Cell Stem Cell. 2013 Feb 7; 12(2):215-23.
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19. Jun H, Mohammed Qasim Hussaini S, Rigby MJ, Jang MH. Functional role of adult hippocampal neurogenesis as a therapeutic strategy for mental disorders. Neural Plast. 2012; 2012:854285 Epub 2012 Dec 31
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20. Guo JU, Ma DK, Mo H, Ball MP, Jang MH, Bonaguidi MA, Balazer JA, Eaves HL, Xie B, Ford E, Zhang K, Ming GL, Gao Y, Song H. Neuronal activity modifies the DNA methylation landscape in the adult brain. Nat Neurosci. 2011 Oct; 14(10):1345-51. Epub 2011 Aug 28.
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21. Ford EC, Achanta P, Purger D, Armour M, Reyes J, Fong J, Kleinberg L, Redmond K, Wong J, Jang MH, Jun H, Song HJ, Quinones-Hinojosa A. Localized CT-guided irradiation inhibits neurogenesis in specific regions of the adult mouse brain. Radiat Res. 2011 Jun; 175(6):774-83. Epub 2011 Mar 30.
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22. Lee MH, Wang T, Jang MH, Steiner J, Haughey N, Ming GL, Song H, Nath A, Venkatesan A. Rescue of adult hippocampal neurogenesis in a mouse model of HIV neurologic disease. Neurobiol Dis. 2011 Mar; 41(3):678-87. Epub 2010 Dec 10.
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23. Ma DK*, Jang MH*, Guo JU, Kitabatake Y, Chang ML, Pow-anpongkul N, Flavell RA, Lu B, Ming GL, Song H. Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science (*co-first author).2009;323:(5917):1074-1077.
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24. Kim JY, Duan X, Liu CY, Jang MH, Guo JU, Pow-anpongkul N, Kang E, Song H, Ming G-l. DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212. Neuron.2009;63:(6):761-773.
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25. Faulkner RL*, Jang MH*, Liu XB*, Duan X, Sailor KA, Ge S, Jones EG, Ming GL, Song H, Cheng H-J. Development of hippocampal mossy fiber synaptic outputs by new neurons in the adult brain. Proc Nat Acad Sci (*co-first author).2008;105:14157-14162.
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26. Jang MH, Kim CJ, Kim EH, Kim MG, Leem KH, Kim J. Effects of Platycodon grandiflorum on lipopolysaccharide-stimulated production of prostaglandin E2, nitric oxide, and interleukin-8 in mouse microglial BV2 cells. J Med Food.2006;9:169-174.
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27. Jang MH, Jung SB, Lee MH, Kim H, Lee SJ, Sim YJ, Lee HH, Kim EK, Kim CJ, Shin HS, Kim J, Kim EH. Influence of maternal alcohol administration on c-Fos expression in the hippocampus of infant rats. Neurosci Lett. 2005; 378:44-48.
    
28. Jang MH, Jung SB, Lee MH, Kim CJ, Oh YT, Kang I, Kim J, Kim EH. Melatonin attenuates amyloid beta25-35-induced apoptosis in mouse microglial BV2 cells. Neurosci Lett. 2005; 380:26-31.
    
29. Jang MH, Lee MH, Kim H, Lee SJ, Sim YJ, Kim CJ, Park SK, Kim J, Kim EH. Maternal alcohol administration suppresses expression of nitric oxide synthase in the hippocampus of offspring rats. J Pharmacol Sci. 2005; 98:459-462.
    
30. Hong SJ, Rim GS, Yang HI, Yin CS, Koh HG, Jang MH, Kim CJ, Choe BK, Chung JH. Bee venom induces apoptosis through caspase-3 activation in synovial fibroblasts of patients with rheumatoid arthritis. Toxicon. 2005; 46:39-45.
    
31. Kim KH, Joo KJ, Park HJ, Kwon CH, Jang MH, Kim CJ. Nicotine induces apoptosis in TM3 mouse Leydig cells. Fertil Steril. 2005; 83:1093-1099.
    
32. Kim YP, Kim H, Shin MS, Chang HK, Jang MH, Shin MC, Lee SJ, Lee HH, Yoon JH, Jeong IG, Kim CJ. Age-dependence of the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats. Neurosci Lett. 2004; 355:152-154.
    
33. Jang MH, Lim S, Han SM, Park HJ, Shin I, Kim JW, Kim NJ, Lee JS, Kim KA, Kim CJ. Harpagophytum procumbens suppresses lipopolysaccharide-stimulated expressions of cyclooxygenase-2 and inducible nitric oxide synthase in fibroblast cell line L929. J Pharmacol Sci. 2003; 93(3):367-371.
    
34. Jang MH, Shin MC, Koo GS, Lee CY, Kim EH, Kim CJ. Acupuncture decreases nitric oxide synthase expression in periaqueductal gray area of rats with streptozotocin-induced diabetes. Neurosci Lett. 2003; 337:155-158.
    
35. Jang MH, Shin MC, Kim KH, Cho SY, Bahn GH, Kim EH, Kim CJ. Nicotine administration decreases neuropeptide Y expression and increase leptin receptor expression in the hypothalamus of food-deprived rats. Brain Res. 2003; 964:311-315.
    
36. Jang MH, Shin MC, Lee TH, Bahn GH, Shin HS, Lim S, Kim EH, Kim CJ. Effect of Puerariae Radix on c-Fos expression in hippocampus of alcohol-intoxicated juvenile rats. Biol Pharm Bull. 2003; 26:37-40.
    
37. Jang MH, Chang HK, Shin MC, Lee TH, Kim YP, Kim EH, Kim CJ. Effect of Ginseng Radix in c-Fos expression in the hippocampus of streptozotocin-induced diabetic rats. J Pharmacol Sci. 2003; 91:149-152.
    
38. Jang MH, Shin MC, Lim S, Han SM, Park HJ, Shin I, Lee JS, Kim KA, Kim EH, Kim CJ. Bee venom induces apoptosis and inhibits expression of cyclooxygenase-2 mRNA in human lung cancer cell line NCI-H1299. J Pharmacol Sci. 2003; 91:95-104.
    
39. Jang MH, Shin MC, Lee TH, Lim BV, Shin MS, Min BI, Kim H, Cho S, Kim EH, Kim CJ. Acupuncture suppresses ischemia-induced increase in c-Fos expression and apoptosis in the hippocampal CA1 region in gerbils. Neurosci Lett. 2003; 347:5-8.
    
40. Lee TH, Jang MH, Shin MC, Lim BV, Kim YP, Kim H, Choi HH, Lee KS, Kim EH, Kim CJ. Dependence of rat hippocampal c-Fos expression on intensity and duration of exercise. Life Sci. 2003; 72:1421-1436.
    
41. Yang HJ, Shin MC, Chang HK, Jang MH, Lee TH, Kim YJ, Chung JH, Kim CJ. Bupivacaine and ropivacaine suppresses glycine- and glutamate-induced ion currents in acutely dissociated rat hippocampal neurons. Neurosci Lett. 2003; 344:33-36.
    
42. Shin MS, Kim H, Chang HK, Lee TH, Jang MH, Shin MC, Lim BV, Lee HH, Kim YP, Yoon JH, Jeong IG, Kim CJ. Treadmill exercise suppresses diabetes-induced increment of neuropeptide Y expression in the hypothalamus of rats. Neurosci Lett. 2003; 346:157-160.
    
43. Lee MH, Kim H, Kim SS, Lee TH, Lim BV, Chang HK, Jang MH, Shin MC, Shin MS, Kim CJ. Treadmill exercise suppresses ischemia-induced increment in apoptosis and cell proliferation in hippocampal dentate gyrus of gerbils. Life Sci. 2003; 73(19):2455-2465.
    
44. Lee HH, Kim H, Lee MH, Chang HK, Lee TH, Jang MH, Shin MC, Lim BV, Shin MS, Kim YP, Yoon JH, Jeong IG, Kim CJ. Treadmill exercise decreases intrastriatal hemorrhage-induced neuronal cell death via suppression on caspase-3 expression in rats. Neurosci Lett. 2003; 352(1):33-36.
    
45. Kim SS, Kim H, Lee SJ, Chang HK, Shin MC, Jang MH, Shin MS, Kim CJ. Treadmill exercise supresses food-deprivation-induced increase of nitric oxide synthase expression in rat paraventricular nucleus. Neurosci Lett. 2003; 353(1):41-44.
    
46. Jang MH, Shin MC, Jung SB, Lee TH, Bahn GH, Kim KY, Kim EH, Kim CJ. Alcohol and nicotine reduce cell proliferation and enhance apoptosis in dentate gyrus. NeuroReport. 2002; 13:1509-1513.
    
47. Jang MH, Shin MC, Shin HS, Kim KH, Park HJ, Kim EH, Kim CJ. Alcohol induces apoptosis in TM3 mouse Leydig cells via bax-dependent caspase-3 activation. Eur J Pharmacol. 2002; 449:39-45.
    
48. Jang MH, Shin MC, Lim BV, Chung JH, Kang HS, Kang SA, Choue RW, Kim EH, Kim CJ. Nicotine administration decreases nitric oxide synthase expression in the hypothalamus of food-deprived rats. Neurosci Lett. 2002; 322:29-32.
    
49. Jang MH, Shin MC, Kim EH, Kim CJ. Acute alcohol intoxication decreases cell proliferation and nitric oxide synthase expression in dentate gyrus of rats. Toxicol Lett. 2002; 133:255-262.
    
50. Jang MH, Lee TH, Shin MC, Bahn GH, Kim JW, Shin DH, Kim EH, Kim CJ. Protective effect of Hypericum perforatum Linn (St. John's wort) against hydrogen peroxide-induced apoptosis on human neuroblastoma cells Neurosci Lett. 2002; 329:177-180.
    
51. Jang MH, Shin MC, Lee TH, Kim YP, Jung SB, Shin DH, Kim H, Kim SS, Kim EH, Kim CJ. Alcohol and nicotine administration inhibits serotonin synthesis and trytophan hydroxylase expression in dorsal and median raphe of young rats. Neurosci Lett. 2002; 329:141-144.
    
52. Jang MH, Shin MC, Chung JH, Shin HD, Kim Y, Kim EH, Kim CJ. Effects of Puerariae radix on cell proliferation and nitric oxide synthase expression in dentate gyrus of alcohol-intoxicated Sprague-Dawley rats. Jpn J Pharmacol. 2002; 88:355-358.
    
53. Jang MH, Kim H, Shin MC, Lim BV, Lee TH, Jung SB, Kim CJ, Kim EH. Administration of Folium mori extract decreases nitric oxide synthase expression in the hypothalamus of streptozotocin-induced diabetic rats. Jpn J Pharmacol. 2002; 90:189-192.
    
54. Kim SH, Kim HB, Jang MH, Lim BV, Kim YJ, Kim YP, Kim SS, Kim EH, Kim CJ. Treadmill exercise increases cell proliferation without altering of apoptosis in dentate gyrus of Sprague-Dawley rats. Life Sci. 2002; 71:1331-1340.
    
55. Lee KS, Lim BV, Jang MH, Shin MC, Lee TH, Kim YP, Shin HS, Cho WY, Kim H, Shin MS, Kim EH, Kim CJ. Hypothermia inhibits cell proliferation and nitric oxide synthase expression in rats. Neurosci Lett. 2002; 329:53-56.
    
56. Ra SM, Kim H, Jang MH, Shin MC, Lee TH, Lim BV, Kim CJ, Kim EH, Kim KM, Kim SS. Treadmill running and swimming increase cell proliferation in the hippocampal dentate gyrus of rats. Neurosci Lett. 2002; 333:123-126.
    
57. Jang MH, Shin MC, Kim YJ, Chung JH, Yim SV, Kim EH, Kim Y, Kim CJ. Protective effects of Puerariae flos against ethanol-induced apoptosis on human neuroblastoma cell line SK-N-MC. Jpn J Pharmacol. 2001; 87:338-342.
    
58. Kim EH, Kim Y, Jang MH, Lim BV, Kim YJ, Chung JH, Kim CJ. Auricular acupuncture decreases neuropeptide Y expression in the hypothalamus of food-deprived Sprague-Dawley rats. Neurosci Lett. 2001; 307:113-116.
    
59. Lim BV, Jang MH, Shin MC, Kim HB, Kim YJ, Kim YP, Chung JH, Kim H, Shin MS, Kim SS, Kim EH, Kim CJ. Caffeine inhibits exercise-induced increase in tryptophan hydroxylase expression in dorsal and median raphe of Sprague-Dawley rats. Neurosci Lett. 2001; 308:25-28.