Publications

Bermudez C, Syrjanen JA, Stricker NH, Algeciras-Schimnich A, Kouri N, Kremers WK, Petersen RC, Jack CR Jr, Knopman DS, Dickson DW, Rothberg DM, Moloney CM, Boon BDC, Nguyen AT, Reichard RR, Murray ME, Mielke MM, Vemuri P, Graff-Radford J. Impact of cardiovascular risk factors on plasma biomarkers in prediction of Alzheimer's and cerebrovascular neuropathology. J Prev Alzheimers Dis. 2025 Jun 11; 100224. [Epub ahead of print]
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Aversa Z, Frank RD, Geske JR, White TA, Heeren AA, Kapoor E, Rocca WA, Schafer MJ, Fields JA, Kantarci K, Mielke MM, LeBrasseur NK. Associations of biomarkers of cellular senescence with physical and cognitive function among older women with or without a history of premenopausal bilateral oophorectomy. Maturitas. 2025 Jun 2; 199:108606 Epub 2025 June 02
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Singh-Reilly N, Graff-Radford J, Li D, Mielke MM, Machulda MM, Schwarz CG, Senjem ML, Jack CR Jr, Lowe VJ, Josephs KA, Whitwell JL. Abeta(42/40) and p-tau 181 as disease biomarkers in atypical Alzheimer's disease. J Alzheimers Dis. 2025 Jun; 105 (3):923-931 Epub 2025 Apr 23
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Mielke MM, Fielding RA, Atkinson EJ, Aversa Z, Schafer MJ, Cummings SR, Pahor M, Leeuwenburgh C, LeBrasseur NK. Biomarkers of cellular senescence predict risk of mild cognitive impairment: Results from the lifestyle interventions for elders (LIFE) study. J Nutr Health Aging. 2025 May; 29 (5):100529 Epub 2025 Mar 07
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Varghese BT, Girardo ME, Gupta R, Fischer KM, Duellman M, Mielke MM, Egan AM, Olson JE, Vella A, Bailey KR, Dugani SB. Algorithm to Identify Type 2 Diabetes Using Electronic Health Record and Self-Reported Data. Metab Syndr Relat Disord. 2025 May; 23 (4):186-192 Epub 2025 Apr 07
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Rodda J, Kuchenbecker LA, Borelli WV, DeMarco ML, Castilhos RM, Cawston EE, Chabrashvili T, Budelier MM, Duran-Aniotz C, Udeh-Momoh C, Akman-Anderson L, Mielke MM, Pereira AC, Algeciras-Schimnich A, Keshavan A. Global multi-specialty clinician perspectives on the implementation of Alzheimer's disease blood biomarkers. Alzheimers Dement. 2025 May; 21(5):e70201.
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Warner NS, Finnie DM, Smith JL, Verdoorn BP, Tung EE, Warner DO, Mielke MM, Griffin JM. A Qualitative Study of the Effects of Opioids on Chronic Pain, Function, and Cognition in Community-Dwelling Older Adults. J Appl Gerontol. 2025 Apr 1; 7334648251326347 Epub 2025 Apr 01
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Warner NS, Van Houten HK, Tung EE, Verdoorn BP, Warner DO, Mielke MM, Jeffery MM. Central Nervous System-Active Medication Use in Older Adults With and Without Dementia-A Retrospective Cohort Study. J Gen Intern Med. 2025 Mar 19 [Epub ahead of print]
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Coughlan GT, Klinger HM, Boyle R, Betthauser TJ, Binette AP, Christenson L, Chadwick T, Hansson O, Harrison TM, Healy B, Jacobs HIL, Hanseeuw B, Jonaitis E, Jack CR Jr, Johnson KA, Langhough RE, Properzi MJ, Rentz DM, Schultz AP, Smith R, Seto M, Johnson SC, Mielke MM, Shirzadi Z, Yau WW, Manson JE, Sperling RA, Vemuri P, Buckley RF, Alzheimer's Disease Neuroimaging Initiative. Sex Differences in Longitudinal Tau-PET in Preclinical Alzheimer Disease: A Meta-Analysis. JAMA Neurol. 2025 Mar 3 Epub 2025 Mar 03
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Ali F, Syrjanen JA, Figdore DJ, Kremers WK, Mielke MM, Jack CR, Knopman DS, Vemuri P, Graff-Radford J, Windham BG, Barnard LR, Petersen RC, Algeciras-Schimnich A. Association of plasma biomarkers of Alzheimer's pathology and neurodegeneration with gait performance in older adults. Commun Med (Lond). 2025 Jan 16; 5 (1):19
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Kantarci K, Kapoor E, Geske JR, Castillo A, Fields JA, Kara F, Knyazhanskaya EE, Schwarz CG, Senjem ML, Bailey KR, Lowe V, LeBrasseur NK, Rocca WA, Mielke MM. Premenopausal bilateral oophorectomy and Alzheimer's disease imaging biomarkers later in life. Alzheimers Dement. 2024 Dec 23 [Epub ahead of print]
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Singh NA, Alnobani A, Graff-Radford J, Machulda MM, Mielke MM, Schwarz CG, Senjem ML, Jack CR Jr, Lowe VJ, Kanekiyo T, Josephs KA, Whitwell JL. Alzheimer's Imaging Consortium. Alzheimers Dement. 2024 Dec; 20 Suppl 9:e094001
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Hu M, Moloney CM, Przybelski SA, Algeciras-Schimnich A, Fought AJ, Rothberg DM, Nguyen AT, Reichard RR, Dickson DW, Knopman DS, Jack CR Jr, Petersen RC, Mielke MM, Graff-Radford J, Murray ME, Vemuri P. Alzheimer's Imaging Consortium. Alzheimers Dement. 2024 Dec; 20 Suppl 9:e093893
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Shue F, White LJ, Hendrix R, Ulrich JD, Henson RL, Knight WC, Martens YA, Wang N, Roy B, Starling SC, Ren Y, Xiong C, Asmann YW, Syrjanen JA, Vassilaki M, Mielke MM, Cruchaga C, Holtzman DM, Bu G, Petersen RC, Heckman MG, Kanekiyo T. Alzheimer's Imaging Consortium. Alzheimers Dement. 2024 Dec; 20 Suppl 9:e093743
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Pike JR, Lu Y, Chen J, Walker KA, Sullivan KJ, Griswold ME, Thyagarajan B, Mielke MM, Lutsey PL, Wong DF, Knopman DS, Sharrett AR, Coresh J, Mosley TH, Gottesman RF, Palta P. Biomarkers. Alzheimers Dement. 2024 Dec; 20 Suppl 2:e091307
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Singh NA, Alnobani A, Graff-Radford J, Machulda MM, Mielke MM, Schwarz CG, Senjem ML, Jack CR Jr, Lowe VJ, Kanekiyo T, Josephs KA, Whitwell JL. Biomarkers. Alzheimers Dement. 2024 Dec; 20 Suppl 2:e091767
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Singh NA, Graff-Radford J, Li D, Mielke MM, Machulda MM, Schwarz CG, Senjem ML, Jack CR Jr, Lowe VJ, Josephs KA, Whitwell JL. Biomarkers. Alzheimers Dement. 2024 Dec; 20 Suppl 2:e091571
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Lowe VJ, Mester CT, Lundt ES, Lee J, Ghatamaneni S, Algeciras-Schimnich A, Campbell MR, Graff-Radford J, Nguyen AT, Min HK, Murray ME, Senjem ML, Schwarz CG, Kantarci K, Boeve BF, Vemuri P, Jones DT, Knopman DS, Jack CR Jr, Petersen RC, Mielke MM. Biomarkers. Alzheimers Dement. 2024 Dec; 20 Suppl 2:e092471
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Bermudez C, Syrjanen JA, Attia ZI, Friedman PA, Lopez-Jimenez F, Hu M, Petersen RC, Knopman DS, Ramanan VK, Jack CR Jr, Nguyen AT, Reichard RR, Kouri N, Moloney CM, Algeciras-Schimnich A, Murray ME, Mielke MM, Vemuri P, Noseworthy PA, Graff-Radford J. Biomarkers. Alzheimers Dement. 2024 Dec; 20 Suppl 2:e088037
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Hu M, Moloney CM, Przybelski SA, Algeciras-Schimnich A, Fought AJ, Rothberg DM, Nguyen AT, Reichard RR, Dickson DW, Knopman DS, Jack CR Jr, Petersen RC, Mielke MM, Graff-Radford J, Murray ME, Vemuri P. Biomarkers. Alzheimers Dement. 2024 Dec; 20 Suppl 2:e090563
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Shue F, White LJ, Hendrix R, Ulrich JD, Henson RL, Knight WC, Martens YA, Wang N, Roy B, Starling SC, Ren Y, Xiong C, Asmann YW, Syrjanen JA, Vassilaki M, Mielke MM, Cruchaga C, Holtzman DM, Bu G, Petersen RC, Heckman MG, Kanekiyo T. Biomarkers. Alzheimers Dement. 2024 Dec; 20 Suppl 2:e087693
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Lowe VJ, Mester CT, Lundt ES, Lee J, Ghatamaneni S, Algeciras-Schimnich A, Campbell MR, Graff-Radford J, Nguyen A, Min HK, Senjem ML, Machulda MM, Schwarz CG, Dickson DW, Murray ME, Kandimalla KK, Kantarci K, Boeve B, Vemuri P, Jones DT, Knopman D, Jack CR Jr, Petersen RC, Mielke MM. Amyloid PET detects the deposition of brain Abeta earlier than CSF fluid biomarkers. Alzheimers Dement. 2024 Nov; 20 (11):8097-8112 Epub 2024 Oct 11
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Therriault J, Janelidze S, Benedet AL, Ashton NJ, Arranz Martínez J, Gonzalez-Escalante A, Bellaver B, Alcolea D, Vrillon A, Karim H, Mielke MM, Hyung Hong C, Roh HW, Contador J, Puig Pijoan A, Algeciras-Schimnich A, Vemuri P, Graff-Radford J, Lowe VJ, Karikari TK, Jonaitis E, Brum W, Tissot C, Servaes S, Rahmouni N, Macedo AC, Stevenson J, Fernandez-Arias J, Wang YT, Woo MS, Friese MA, Jia WL, Dumurgier J, Hourregue C, Cognat E, Ferreira PL, Vitali P, Johnson S, Pascoal TA, Gauthier S, Lleó A, Paquet C, Petersen RC, Salmon D, Mattsson-Carlgren N, Palmqvist S, Stomrud E, Galasko D, Son SJ, Zetterberg H, Fortea J, Suárez-Calvet M, Jack CR Jr, Blennow K, Hansson O, Rosa-Neto P. Diagnosis of Alzheimer's disease using plasma biomarkers adjusted to clinical probability. Nat Aging. 2024 Nov; 4(11):1529-1537. Epub 2024 Nov 12.
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Lu Y, Pike JR, Chen J, Walker KA, Sullivan KJ, Thyagarajan B, Mielke MM, Lutsey PL, Knopman D, Gottesman RF, Sharrett AR, Coresh J, Mosley TH, Palta P. Changes in Alzheimer Disease Blood Biomarkers and Associations With Incident All-Cause Dementia. JAMA 2024 Oct 15; 332 (15):1258-1269
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Lee JK, Raghavan S, Christenson LR, Frank RD, Kantarci K, Rocca WA, Vemuri P, Mielke MM. Longitudinal associations of reproductive factors and exogeneous estrogens with neuroimaging biomarkers of Alzheimer's disease and cerebrovascular disease. Alzheimers Dement. 2024 Jul; 20(7):4613-4624. Epub 2024 Jun 11.
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Schindler SE, Galasko D, Pereira AC, Rabinovici GD, Salloway S, Suarez-Calvet M, Khachaturian AS, Mielke MM, Udeh-Momoh C, Weiss J, Batrla R, Bozeat S, Dwyer JR, Holzapfel D, Jones DR, Murray JF, Partrick KA, Scholler E, Vradenburg G, Young D, Algeciras-Schimnich A, Aubrecht J, Braunstein JB, Hendrix J, Hu YH, Mattke S, Monane M, Reilly D, Somers E, Teunissen CE, Shobin E, Vanderstichele H, Weiner MW, Wilson D, Hansson O. Acceptable performance of blood biomarker tests of amyloid pathology - recommendations from the Global CEO Initiative on Alzheimer's Disease. Nat Rev Neurol. 2024 Jul; 20 (7):426-439 Epub 2024 June 12
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Singh NA, Alnobani A, Graff-Radford J, Machulda MM, Mielke MM, Schwarz CG, Senjem ML, Jack CR Jr, Lowe VJ, Kanekiyo T, Josephs KA, Whitwell JL. Relationships between PET and blood plasma biomarkers in corticobasal syndrome. Alzheimers Dement. 2024 Jul; 20(7):4765-4774. Epub 2024 Jun 17.
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Mielke MM, Frank RD, Christenson LR, Reid RI, Fields JA, Knyazhanskaya ZE, Kara F, Vemuri P, Rocca WA, Kantarci K. Premenopausal bilateral oophorectomy and brain white matter brain integrity in later-life. Alzheimers Dement. 2024 Jul; 20 (7):5054-5061 Epub 2024 June 20
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Dugani SB, Lahr BD, Xie H, Mielke MM, Bailey KR, Vella A. County Rurality and Incidence and Prevalence of Diagnosed Diabetes in the United States. Mayo Clin Proc. 2024 Jul; 99 (7):1078-1090 Epub 2024 Mar 19
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Warner NS, Hanson AC, Schulte PJ, Kara F, Reid RI, Schwarz CG, Benarroch EE, Graff-Radford J, Vemuri P, Jack CR, Petersen RC, Warner DO, Mielke MM, Kantarci K. Prescription Opioids and Brain Structure in Community-Dwelling Older Adults. Mayo Clin Proc. 2024 May; 99 (5):716-726
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Sintini I, Singh NA, Li D, Mielke MM, Machulda MM, Schwarz CG, Senjem ML, Jack CR Jr, Lowe VJ, Graff-Radford J, Josephs KA, Whitwell JL. Plasma glial fibrillary acidic protein in the visual and language variants of Alzheimer's disease. Alzheimers Dement. 2024 May; 20 (5):3679-3686 Epub 2024 Mar 25
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Karstens AJ, Christianson TJ, Lundt ES, Machulda MM, Mielke MM, Fields JA, Kremers WK, Graff-Radford J, Vemuri P, Jack CR Jr, Knopman DS, Petersen RC, Stricker NH. Mayo normative studies: regression-based normative data for ages 30-91 years with a focus on the Boston Naming Test, Trail Making Test and Category Fluency. J Int Neuropsychol Soc. 2024 May; 30 (4):389-401 Epub 2023 Nov 28
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Shue F, White LJ, Hendrix R, Ulrich J, Henson RL, Knight W, Martens YA, Wang N, Roy B, Starling SC, Ren Y, Xiong C, Asmann YW, Syrjanen JA, Vassilaki M, Mielke MM, Timsina J, Sung YJ, Cruchaga C, Holtzman DM, Bu G, Petersen RC, Heckman MG, Kanekiyo T. CSF biomarkers of immune activation and Alzheimer's disease for predicting cognitive impairment risk in the elderly. Sci Adv. 2024 Apr 5; 10 (14):eadk3674 Epub 2024 Apr 03
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Fielding RA, Atkinson EJ, Aversa Z, White TA, Heeren AA, Mielke MM, Cummings SR, Pahor M, Leeuwenburgh C, LeBrasseur NK. Biomarkers of Cellular Senescence Predict the Onset of Mobility Disability and Are Reduced by Physical Activity in Older Adults. J Gerontol A Biol Sci Med Sci. 2024 Mar 1; 79 (3)
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Jack CR Jr, Wiste HJ, Algeciras-Schimnich A, Weigand SD, Figdore DJ, Lowe VJ, Vemuri P, Graff-Radford J, Ramanan VK, Knopman DS, Mielke MM, Machulda MM, Fields J, Schwarz CG, Cogswell PM, Senjem ML, Therneau TM, Petersen RC. Comparison of plasma biomarkers and amyloid PET for predicting memory decline in cognitively unimpaired individuals. Alzheimers Dement. 2024 Mar; 20(3):2143-2154. Epub 2024 Jan 24.
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Stricker NH, Stricker JL, Frank RD, Fan WZ, Christianson TJ, Patel JS, Karstens AJ, Kremers WK, Machulda MM, Fields JA, Graff-Radford J, Jack CR Jr, Knopman DS, Mielke MM, Petersen RC. Stricker Learning Span criterion validity: a remote self-administered multi-device compatible digital word list memory measure shows similar ability to differentiate amyloid and tau PET-defined biomarker groups as in-person Auditory Verbal Learning Test. J Int Neuropsychol Soc. 2024 Feb; 30 (2):138-151 Epub 2023 June 30
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Cogswell PM, Lundt ES, Therneau TM, Wiste HJ, Graff-Radford J, Algeciras-Schimnich A, Lowe VJ, Mielke MM, Schwarz CG, Senjem ML, Gunter JL, Knopman DS, Vemuri P, Petersen RC, Jack CR Jr. Modeling the temporal evolution of plasma p-tau in relation to amyloid beta and tau PET. Alzheimers Dement. 2024 Feb; 20 (2):1225-1238 Epub 2023 Nov 14
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Lee JK, Frank RD, Christenson LR, Fields JA, Rocca WA, Mielke MM. Associations of reproductive factors and exogenous estrogens with global and domain-specific cognition in later life. Alzheimers Dement. 2024 Jan; 20 (1):63-73 Epub 2023 July 14
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Krell-Roesch J, Syrjanen JA, Bezold J, Trautwein S, Barisch-Fritz B, Boes K, Woll A, Forzani E, Kremers WK, MacHulda MM, Mielke MM, Knopman DS, Petersen RC, Vassilaki M, Geda YE. Physical activity and trajectory of cognitive change in older persons: Mayo Clinic study of aging. Advances in Alzheimer's Disease. 2024; 10:3-14
Shir D, Graff-Radford J, Fought AJ, Lesnick TG, Przybelski SA, Vassilaki M, Lowe VJ, Knopman DS, Machulda MM, Petersen RC, Jack CR Jr, Mielke MM, Vemuri P. Complex relationships of socioeconomic status with vascular and Alzheimer's pathways on cognition. Neuroimage Clin. 2024; 43:103634 Epub 2024 June 15
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Stricker NH, Christianson TJ, Pudumjee SB, Polsinelli AJ, Lundt ES, Frank RD, Kremers WK, Machulda MM, Fields JA, Jack CR, Knopman DS, Graff-Radford J, Vemuri P, Mielke MM, Petersen RC. Mayo Normative Studies: Amyloid and Neurodegeneration Negative Normative Data for the Auditory Verbal Learning Test and Sex-Specific Sensitivity to Mild Cognitive Impairment/Dementia. J Alzheimers Dis. 2024; 100 (3):879-897
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St Sauver JL, Weston SA, Atkinson EJ, Mc Gree ME, Mielke MM, White TA, Heeren AA, Olson JE, Rocca WA, Palmer AK, Cummings SR, Fielding RA, Bielinski SJ, LeBrasseur NK. Biomarkers of cellular senescence and risk of death in humans. Aging Cell. 2023 Dec; 22 (12):e14006 Epub 2023 Oct 06
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Ramanan VK, Gebre RK, Graff-Radford J, Hofrenning E, Algeciras-Schimnich A, Figdore DJ, Lowe VJ, Mielke MM, Knopman DS, Ross OA, Jack CR Jr, Petersen RC, Vemuri P. Genetic risk scores enhance the diagnostic value of plasma biomarkers of brain amyloidosis. Brain. 2023 Nov 2; 146 (11):4508-4519
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Mielke MM, Dage JL, Frank RD, Algeciras-Schimnich A, Knopman DS, Lowe VJ, Bu G, Vemuri P, Graff-Radford J, Jack CR Jr, Petersen RC. Author Correction: Performance of plasma phosphorylated tau 181 and 217 in the community. Nat Med. 2023 Nov; 29 (11):2954
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Mielke MM, Kapoor E, Geske JR, Fields JA, LeBrasseur NK, Morrow MM, Winham SJ, Faubion LL, Castillo AM, Hofrenning EI, Bailey KR, Rocca WA, Kantarci K. Long-term effects of premenopausal bilateral oophorectomy with or without hysterectomy on physical aging and chronic medical conditions. Menopause. 2023 Nov 1; 30 (11):1090-1097 Epub 2023 Sept 11
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Li D, Singh S, Zhang CD, Kaur RJ, Ebbehoj A, Atkinson EJ, Achenbach SJ, Stricker NH, Mielke MM, Rocca W, Bancos I. Risk of dementia and psychiatric or sleep disorders after diagnosis of adrenal adenomas: a population-based cohort study. Eur J Endocrinol. 2023 Oct 17; 189 (4):429-437
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Ramanan VK, Graff-Radford J, Syrjanen J, Shir D, Algeciras-Schimnich A, Lucas J, Martens YA, Carrasquillo MM, Day GS, Ertekin-Taner N, Lachner C, Willis FB, Knopman DS, Jack CR Jr, Petersen RC, Vemuri P, Graff-Radford N, Mielke MM. Association of Plasma Biomarkers of Alzheimer Disease With Cognition and Medical Comorbidities in a Biracial Cohort. Neurology. 2023 Oct 3; 101 (14):e1402-e1411 Epub 2023 Aug 14
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Moser ED, Manemann SM, Larson NB, St Sauver JL, Takahashi PY, Mielke MM, Rocca WA, Olson JE, Roger VL, Remaley AT, Decker PA, Killian JM, Bielinski SJ. Association Between Fluctuations in Blood Lipid Levels Over Time With Incident Alzheimer Disease and Alzheimer Disease-Related Dementias. Neurology. 2023 Sep 12; 101 (11):e1127-e1136 Epub 2023 July 05
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Dines VA, Kattah AG, Weaver AL, Vaughan LE, Chamberlain AM, Bielinski SJ, Mielke MM, Garovic VD. Risk of Adult Hypertension in Offspring From Pregnancies Complicated by Hypertension: Population-Based Estimates. Hypertension. 2023 Sep; 80 (9):1940-1948 Epub 2023 July 25
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Morrow MMB, Schafer MJ, Kantarci K, Mielke MM, Vachon CM, Winham SJ. Leadership Development in Early Career Scientists: Themes and Feedback from Executive Coaching and Mindful Leadership Training. J Womens Health (Larchmt). 2023 Aug; 32 (8):877-882
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Bermudez C, Graff-Radford J, Syrjanen JA, Stricker NH, Algeciras-Schimnich A, Kouri N, Kremers WK, Petersen RC, Jack CR Jr, Knopman DS, Dickson DW, Nguyen AT, Reichard RR, Murray ME, Mielke MM, Vemuri P. Plasma biomarkers for prediction of Alzheimer's disease neuropathologic change. Acta Neuropathol. 2023 Jul; 146 (1):13-29 Epub 2023 June 03
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Bornhorst JA, Figdore D, Campbell MR, Pazdernik VK, Mielke MM, Petersen RC, Algeciras-Schimnich A. Corrigendum to "Plasma neurofilament light chain (NfL) reference interval determination in an age-stratified cognitively unimpaired cohort" [Clin. Chim. Acta 535 (2022) 153-156]. Clin Chim Acta. 2023 Jun 1; 546:117396 Epub 2023 May 25
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Stricker NH, Twohy EL, Albertson SM, Karstens AJ, Kremers WK, Machulda MM, Fields JA, Jack CR Jr, Knopman DS, Mielke MM, Petersen RC. Mayo-PACC: A parsimonious preclinical Alzheimer's disease cognitive composite comprised of public-domain measures to facilitate clinical translation. Alzheimers Dement. 2023 Jun; 19 (6):2575-2584 Epub 2022 Dec 24
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Mielke MM, Frank RD, Christenson LR, Fields JA, Rocca WA, Garovic VD. Association of Hypertensive Disorders of Pregnancy With Cognition in Later Life. Neurology. 2023 May 9; 100 (19):e2017-e2026 Epub 2023 Mar 01
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Jack CR, Wiste HJ, Algeciras-Schimnich A, Figdore DJ, Schwarz CG, Lowe VJ, Ramanan VK, Vemuri P, Mielke MM, Knopman DS, Graff-Radford J, Boeve BF, Kantarci K, Cogswell PM, Senjem ML, Gunter JL, Therneau TM, Petersen RC. Predicting amyloid PET and tau PET stages with plasma biomarkers. Brain. 2023 May 2; 146 (5):2029-2044
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St Sauver JL, LeBrasseur NK, Rocca WA, Olson JE, Bielinski SJ, Sohn S, Weston SA, McGree ME, Mielke MM. Cohort study examining associations between ceramide levels and risk of multimorbidity among persons participating in the Mayo Clinic Biobank. BMJ Open. 2023 Apr 21; 13(4):e069375.
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Windham BG, Griswold ME, Ranadive R, Sullivan KJ, Mosley TH, Mielke MM, Jack CR, Knopman D, Petersen R, Vemuri P. Relationships of Cerebral Perfusion With Gait Speed Across Systolic Blood Pressure Levels and Age: A Cohort Study. J Gerontol A Biol Sci Med Sci. 2023 Mar 1; 78 (3):514-520
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Vassilaki M, Aakre JA, Castillo A, Chamberlain AM, Wilson PM, Kremers WK, Mielke MM, Geda YE, Machulda MM, Alhurani RE, Graff-Radford J, Vemuri P, Lowe VJ, Jack CR Jr, Knopman DS, Petersen RC. Association of neighborhood socioeconomic disadvantage and cognitive impairment. Alzheimers Dement. 2023 Mar; 19 (3):761-770 Epub 2022 June 06
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Moloney CM, Labuzan SA, Crook JE, Siddiqui H, Castanedes-Casey M, Lachner C, Petersen RC, Duara R, Graff-Radford NR, Dickson DW, Mielke MM, Murray ME. Phosphorylated tau sites that are elevated in Alzheimer's disease fluid biomarkers are visualized in early neurofibrillary tangle maturity levels in the post mortem brain. Alzheimers Dement. 2023 Mar; 19 (3):1029-1040 Epub 2022 Aug 03
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Sprung J, Laporta ML, Knopman DS, Petersen RC, Mielke MM, Jack CR, Martin DP, Hanson AC, Schroeder DR, Schulte PJ, Przybelski SA, Valencia Morales DJ, Weingarten TN, Vemuri P, Warner DO. Association of Indication for Hospitalization With Subsequent Amyloid Positron Emission Tomography and Magnetic Resonance Imaging Biomarkers. J Gerontol A Biol Sci Med Sci. 2023 Feb 24; 78 (2):304-313
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Fautsch KJ, Block DR, Graff-Radford J, Wang F, Craver EC, Hodge DO, Cutsforth-Gregory JK, Kilgore KP, Petersen RC, Knopman DS, Flanagan E, Toledano M, Mielke MM, Bhatti MT, Chen JJ. Population-Based Evaluation of Total Protein in Cerebrospinal Fluid. Mayo Clin Proc. 2023 Feb; 98(2):239-251.
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Kara F, Lohse CM, Castillo AM, Tosakulwong N, Lesnick TG, Jack CR Jr, Petersen RC, Olson JE, Couch FJ, Ruddy KJ, Kantarci K, Mielke MM. Association of raloxifene and tamoxifen therapy with cognitive performance, odds of mild cognitive impairment, and brain MRI markers of neurodegeneration. Cancer Med. 2023 Feb; 12 (3):2805-2817 Epub 2022 Aug 30
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Warner NS, Mielke MM, Verdoorn BP, Knopman DS, Hooten WM, Habermann EB, Warner DO. Pain, Opioid Analgesics, and Cognition: A Conceptual Framework in Older Adults. Pain Med. 2023 Feb 1; 24 (2):171-181
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Bornhorst JA, Figdore D, Campbell MR, Pazdernik VK, Mielke MM, Petersen RC, Algeciras-Schimnich A. Corrigendum to "Plasma neurofilament light chain (NfL) reference interval determination in an age-stratified cognitively unimpaired cohort" [Clin. Chim. Acta 535 (2022) 153-156]. Clinica Chimica Acta. 2023; 546:117396
Shir D, Mielke MM, Hofrenning EI, Lesnick TG, Knopman DS, Petersen RC, Jack CR, Algeciras-Schimnich A, Vemuri P, Graff-Radford J. Associations of Neurodegeneration Biomarkers in Cerebrospinal Fluid with Markers of Alzheimer's Disease and Vascular Pathology. J Alzheimers Dis. 2023; 92 (3):887-898
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Lilek J, Ajroud K, Feldman AZ, Krishnamachari S, Ghourchian S, Gefen T, Spencer CL, Kawles A, Mao Q, Tranovich JF, Jack CR, Mesulam MM, Reichard RR, Zhang H, Murray ME, Knopman D, Dickson DW, Petersen RC, Smith B, Ashe KH, Mielke MM, Nelson KM, Flanagan ME. Accumulation of pTau231 at the Postsynaptic Density in Early Alzheimer's Disease. J Alzheimers Dis. 2023; 92 (1):241-260
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Kodishala C, Hulshizer CA, Kronzer VL, Davis JM 3rd, Ramanan VK, Vassilaki M, Mielke MM, Crowson CS, Myasoedova E. Risk Factors for Dementia in Patients With Incident Rheumatoid Arthritis: A Population-Based Cohort Study. J Rheumatol. 2023 Jan; 50 (1):48-55 Epub 2022 July 15
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Murray ME, Moloney CM, Kouri N, Syrjanen JA, Matchett BJ, Rothberg DM, Tranovich JF, Sirmans TNH, Wiste HJ, Boon BDC, Nguyen AT, Reichard RR, Dickson DW, Lowe VJ, Dage JL, Petersen RC, Jack CR Jr, Knopman DS, Vemuri P, Graff-Radford J, Mielke MM. Global neuropathologic severity of Alzheimer's disease and locus coeruleus vulnerability influences plasma phosphorylated tau levels. Mol Neurodegener. 2022 Dec 27; 17 (1):85
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Warner NS, Hanson AC, Schulte PJ, Habermann EB, Warner DO, Mielke MM. Prescription opioids and longitudinal changes in cognitive function in older adults: A population-based observational study. J Am Geriatr Soc. 2022 Dec; 70 (12):3526-3537 Epub 2022 Sept 18
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Coon EA, Castillo AM, Lesnick TG, Raghavan S, Mielke MM, Reid RI, Windham BG, Petersen RC, Jack CR, Graff-Radford J, Vemuri P. Blood pressure changes impact corticospinal integrity and downstream gait and balance control. Neurobiol Aging. 2022 Dec; 120:60-67 Epub 2022 Aug 27
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Fielding RA, Atkinson EJ, Aversa Z, White TA, Heeren AA, Achenbach SJ, Mielke MM, Cummings SR, Pahor M, Leeuwenburgh C, LeBrasseur NK. Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study. Geroscience. 2022 Dec; 44 (6):2757-2770 Epub 2022 Nov 11
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Jack CR Jr, Wiste HJ, Schwarz CG, Lowe VJ, Senjem ML, Vemuri P, Weigand SD, Therneau TM, Knopman DS, Gunter JL, Jones DT, Graff-Radford J, Kantarci K, Roberts RO, Mielke MM, Machulda MM, Petersen RC. Longitudinal tau PET in ageing and Alzheimer's disease. Brain. 2018 May 1; 141 (5):1517-1528
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Ramanan VK, Przybelski SA, Graff-Radford J, Castillo AM, Lowe VJ, Mielke MM, Roberts RO, Reid RI, Knopman DS, Jack CR, Petersen RC, Vemuri P. Statins and Brain Health: Alzheimer's Disease and Cerebrovascular Disease Biomarkers in Older Adults. J Alzheimers Dis. 2018; 65 (4):1345-1352
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Pink A, Przybelski SA, Krell-Roesch J, Stokin GB, Roberts RO, Mielke MM, Spangehl KA, Knopman DS, Jack CR Jr, Petersen RC, Geda YE. Cortical Thickness and Anxiety Symptoms Among Cognitively Normal Elderly Persons: The Mayo Clinic Study of Aging. J Neuropsychiatry Clin Neurosci. 2017 Winter; 29 (1):60-66 Epub 2016 Aug 31
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Roberts RO, Knopman DS, Przybelski SA, Mielke MM, Kantarci K, Preboske GM, Senjem ML, Pankratz VS, Geda YE, Boeve BF, Ivnik RJ, Rocca WA, Petersen RC, Jack CR Jr. Association of type 2 diabetes with brain atrophy and cognitive impairment. Neurology. 2014 Apr 1; 82 (13):1132-41 Epub 2014 Mar 19
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Steinberg M, Hess K, Corcoran C, Mielke MM, Norton M, Breitner J, Green R, Leoutsakos J, Welsh-Bohmer K, Lyketsos C, Tschanz J. Vascular risk factors and neuropsychiatric symptoms in Alzheimer's disease: the Cache County Study. Int J Geriatr Psychiatry. 2014 Feb; 29(2):153-9. Epub 2013 May 17.
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Roberts RO, Knopman DS, Mielke MM, Cha RH, Pankratz VS, Christianson TJ, Geda YE, Boeve BF, Ivnik RJ, Tangalos EG, Rocca WA, Petersen RC. Higher risk of progression to dementia in mild cognitive impairment cases who revert to normal. Neurology. 2014 Jan 28; 82 (4):317-25 Epub 2013 Dec 18
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Mielke MM, Savica R, Wiste HJ, Weigand SD, Vemuri P, Knopman DS, Lowe VJ, Roberts RO, Machulda MM, Geda YE, Petersen RC, Jack CR Jr. Head trauma and in vivo measures of amyloid and neurodegeneration in a population-based study. Neurology. 2014 Jan 07; 82(1):70-6. Epub 2013 Dec 26.
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Knopman DS, Roberts RO, Pankratz VS, Cha RH, Rocca WA, Mielke MM, Boeve BF, Tangalos EG, Ivnik RJ, Geda YE, Petersen RC. Incidence of dementia among participants and nonparticipants in a longitudinal study of cognitive aging. Am J Epidemiol. 2014; 180(4):414-23.
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Singh B, Parsaik AK, Mielke MM, Erwin PJ, Knopman DS, Petersen RC, Roberts RO. Association of mediterranean diet with mild cognitive impairment and Alzheimer's disease: a systematic review and meta-analysis. J Alzheimers Dis. 2014; 39 (2):271-82
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Roberts RO, Knopman DS, Geda YE, Cha RH, Pankratz VS, Baertlein L, Boeve BF, Tangalos EG, Ivnik RJ, Mielke MM, Petersen RC. Association of diabetes with amnestic and nonamnestic mild cognitive impairment. Alzheimers Dement. 2014 Jan; 10 (1):18-26 Epub 2013 Apr 03
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Snyder HM, Carrillo MC, Grodstein F, Henriksen K, Jeromin A, Lovestone S, Mielke MM, O'Bryant S, Sarasa M, Sjogren M, Soares H, Teeling J, Trushina E, Ward M, West T, Bain LJ, Shineman DW, Weiner M, Fillit HM. Developing novel blood-based biomarkers for Alzheimer's disease. Alzheimers Dement. 2014 Jan; 10 (1):109-14
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Mielke MM, Vemuri P, Rocca WA. Clinical epidemiology of Alzheimer's disease: assessing sex and gender differences. Clin Epidemiol. 2014; 6:37-48 Epub 2014 Jan 08
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Geda YE, Roberts RO, Mielke MM, Knopman DS, Christianson TJH, Pankratz VS, Boeve BF, Sochor O, Tangalos EG, Petersen RC, Rocca WA. Baseline neuropsychiatric symptoms and the risk of incident mild cognitive impairment: A population-based study. Am J Psychiatry. 2014; 171(5):572-81.
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Gustafson DR, Mielke MM, Tien PC, Valcour V, Cohen M, Anastos K, Liu C, Pearce L, Golub ET, Minkoff H, Crystal HA. Anthropometric measures and cognition in middle-aged HIV-infected and uninfected women. The Women's Interagency HIV Study. J Neurovirol. 2013 Dec; 19(6):574-85. Epub 2013 Dec 12.
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Jack CR Jr, Wiste HJ, Weigand SD, Knopman DS, Lowe V, Vemuri P, Mielke MM, Jones DT, Senjem ML, Gunter JL, Gregg BE, Pankratz VS, Petersen RC. Amyloid-first and neurodegeneration-first profiles characterize incident amyloid PET positivity. Neurology. 2013 Nov 12; 81 (20):1732-40 Epub 2013 Oct 16
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McDade EM, Boot BP, Christianson TJ, Pankratz VS, Boeve BF, Ferman TJ, Bieniek K, Hollman JH, Roberts RO, Mielke MM, Knopman DS, Petersen RC. Subtle gait changes in patients with REM sleep behavior disorder. Mov Disord. 2013 Nov; 28 (13):1847-53 Epub 2013 Oct 15
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Singh B, Parsaik AK, Mielke MM, Roberts RO, Scanlon PD, Geda YE, Pankratz VS, Christianson T, Yawn BP, Petersen RC. Chronic obstructive pulmonary disease and association with mild cognitive impairment: the Mayo Clinic Study of Aging. Mayo Clin Proc. 2013 Nov; 88 (11):1222-30
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Bandaru VV, Mielke MM, Sacktor N, McArthur JC, Grant I, Letendre S, Chang L, Wojna V, Pardo C, Calabresi P, Munsaka S, Haughey NJ. A lipid storage-like disorder contributes to cognitive decline in HIV-infected subjects. Neurology. 2013 Oct 22; 81 (17):1492-9 Epub 2013 Sept 11
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Nowrangi MA, Lyketsos CG, Leoutsakos JM, Oishi K, Albert M, Mori S, Mielke MM. Longitudinal, region-specific course of diffusion tensor imaging measures in mild cognitive impairment and Alzheimer's disease. Alzheimers Dement. 2013 Sep; 9(5):519-28. Epub 2012 Dec 12.
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Knopman DS, Jack CR Jr, Wiste HJ, Weigand SD, Vemuri P, Lowe VJ, Kantarci K, Gunter JL, Senjem ML, Mielke MM, Roberts RO, Boeve BF, Petersen RC. Selective worsening of brain injury biomarker abnormalities in cognitively normal elderly persons with beta-amyloidosis. JAMA Neurol. 2013 Aug; 70 (8):1030-8
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Petersen RC, Aisen P, Boeve BF, Geda YE, Ivnik RJ, Knopman DS, Mielke M, Pankratz VS, Roberts R, Rocca WA, Weigand S, Weiner M, Wiste H, Jack CR Jr. Mild cognitive impairment due to Alzheimer disease in the community. Ann Neurol. 2013 Aug; 74 (2):199-208
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Mielke MM, Roberts RO, Savica R, Cha R, Drubach DI, Christianson T, Pankratz VS, Geda YE, Machulda MM, Ivnik RJ, Knopman DS, Boeve BF, Rocca WA, Petersen RC. Assessing the temporal relationship between cognition and gait: slow gait predicts cognitive decline in the Mayo Clinic Study of Aging. J Gerontol A Biol Sci Med Sci. 2013 Aug; 68 (8):929-37 Epub 2012 Dec 18
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Rosenberg PB, Mielke MM, Appleby BS, Oh ES, Geda YE, Lyketsos CG. The association of neuropsychiatric symptoms in MCI with incident dementia and Alzheimer disease. Am J Geriatr Psychiatry. 2013 Jul; 21(7):685-95. Epub 2013 Feb 06.
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Knopman DS, Jack CR Jr, Wiste HJ, Weigand SD, Vemuri P, Lowe VJ, Kantarci K, Gunter JL, Senjem ML, Mielke MM, Roberts RO, Boeve BF, Petersen RC. Brain injury biomarkers are not dependent on beta-amyloid in normal elderly. Ann Neurol. 2013 Apr; 73 (4):472-80 Epub 2013 Feb 19
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Miller VM, Garovic VD, Kantarci K, Barnes JN, Jayachandran M, Mielke MM, Joyner MJ, Shuster LT, Rocca WA. Sex-specific risk of cardiovascular disease and cognitive decline: pregnancy and menopause. Biol Sex Differ. 2013 Mar 28; 4 (1):6
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Jack CR Jr, Wiste HJ, Lesnick TG, Weigand SD, Knopman DS, Vemuri P, Pankratz VS, Senjem ML, Gunter JL, Mielke MM, Lowe VJ, Boeve BF, Petersen RC. Brain beta-amyloid load approaches a plateau. Neurology. 2013 Mar 5; 80 (10):890-6 Epub 2013 Feb 27
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Roberts RO, Geda YE, Knopman DS, Cha RH, Pankratz VS, Boeve BF, Tangalos EG, Ivnik RJ, Mielke MM, Petersen RC. Cardiac disease associated with increased risk of nonamnestic cognitive impairment: stronger effect on women. JAMA Neurol. 2013 Mar 1; 70 (3):374-82
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Rabins PV, Schwartz S, Black BS, Corcoran C, Fauth E, Mielke M, Christensen J, Lyketsos C, Tschanz J. Predictors of progression to severe Alzheimer's disease in an incidence sample. Alzheimers Dement. 2013 Mar; 9(2):204-7. Epub 2012 Nov 02.
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Parker DC, Mielke MM, Yu Q, Rosenberg PB, Jain A, Lyketsos CG, Fedarko NS, Oh ES. Plasma neopterin level as a marker of peripheral immune activation in amnestic mild cognitive impairment and Alzheimer's disease. Int J Geriatr Psychiatry. 2013 Feb; 28(2):149-54. Epub 2012 Apr 27.
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Mielke MM, Maetzler W, Haughey NJ, Bandaru VV, Savica R, Deuschle C, Gasser T, Hauser AK, Graber-Sultan S, Schleicher E, Berg D, Liepelt-Scarfone I. Plasma ceramide and glucosylceramide metabolism is altered in sporadic Parkinson's disease and associated with cognitive impairment: a pilot study. PLoS One. 2013; 8 (9):e73094 Epub 2013 Sept 18
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Machulda MM, Pankratz VS, Christianson TJ, Ivnik RJ, Mielke MM, Roberts RO, Knopman DS, Boeve BF, Petersen RC. Practice effects and longitudinal cognitive change in normal aging vs. incident mild cognitive impairment and dementia in the Mayo Clinic Study of Aging. Clin Neuropsychol. 2013; 27 (8):1247-64 Epub 2013 Sept 17
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Sachdev PS, Lipnicki DM, Kochan NA, Crawford JD, Rockwood K, Xiao S, Li J, Li X, Brayne C, Matthews FE, Stephan BC, Lipton RB, Katz MJ, Ritchie K, Carriere I, Ancelin ML, Seshadri S, Au R, Beiser AS, Lam LC, Wong CH, Fung AW, Kim KW, Han JW, Kim TH, Petersen RC, Roberts RO, Mielke MM, Ganguli M, Dodge HH, Hughes T, Anstey KJ, Cherbuin N, Butterworth P, Ng TP, Gao Q, Reppermund S, Brodaty H, Meguro K, Schupf N, Manly J, Stern Y, Lobo A, Lopez-Anton R, Santabarbara J, Cosmic. COSMIC (Cohort Studies of Memory in an International Consortium): an international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups. BMC Neurol. 2013; 13:165. Epub 2013 Nov 06.
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Saleem M, Ratnam Bandaru VV, Herrmann N, Swardfager W, Mielke MM, Oh PI, Shammi P, Kiss A, Haughey NJ, Rovinski R, Lanctot KL. Ceramides predict verbal memory performance in coronary artery disease patients undertaking exercise: a prospective cohort pilot study. BMC Geriatr. 2013; 13:135. Epub 2013 Dec 12.
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Trushina E, Dutta T, Persson XM, Mielke MM, Petersen RC. Identification of altered metabolic pathways in plasma and CSF in mild cognitive impairment and Alzheimer's disease using metabolomics. PLoS One. 2013; 8 (5):e63644 Epub 2013 May 20
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Leyhe T, Darreh-Shori T, Laske C, Mielke MM, Maetzler W. Biomarkers in Alzheimer's disease and lewy body disorders with dementia. Int J Alzheimers Dis. 2013; 2013:473181 Epub 2013 Jan 09
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Geda YE, Ragossnig M, Roberts LA, Roberts RO, Pankratz VS, Christianson TJ, Mielke MM, Levine JA, Boeve BF, Sochor O, Tangalos EG, Knopman DS, Petersen RC. Caloric intake, aging, and mild cognitive impairment: a population-based study. J Alzheimers Dis. 2013; 34 (2):501-7
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Rosenberg PB, Mielke MM, Han D, Leoutsakos JS, Lyketsos CG, Rabins PV, Zandi PP, Breitner JC, Norton MC, Welsh-Bohmer KA, Zuckerman IH, Rattinger GB, Green RC, Corcoran C, Tschanz JT. The association of psychotropic medication use with the cognitive, functional, and neuropsychiatric trajectory of Alzheimer's disease. Int J Geriatr Psychiatry. 2012 Dec; 27(12):1248-57. Epub 2012 Feb 29.
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Mielke MM, Wiste HJ, Weigand SD, Knopman DS, Lowe VJ, Roberts RO, Geda YE, Swenson-Dravis DM, Boeve BF, Senjem ML, Vemuri P, Petersen RC, Jack CR Jr. Indicators of amyloid burden in a population-based study of cognitively normal elderly. Neurology. 2012 Oct 9; 79 (15):1570-7 Epub 2012 Sept 12
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Oishi K, Mielke MM, Albert M, Lyketsos CG, Mori S. The fornix sign: A potential sign for Alzheimer's disease based on diffusion tensor imaging. J Neuroimaging PMCID PMC3256282. 2012 Oct; 22(4):365-74.
Mielke MM, Haughey NJ. Could plasma sphingolipids be diagnostic or prognostic biomarkers for Alzheimer's disease? Clin Lipidol. 2012 Oct; 7 (5):525-536
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Leoutsakos JM, Han D, Mielke MM, Forrester SN, Tschanz JT, Corcoran CD, Green RC, Norton MC, Welsh-Bohmer KA, Lyketsos CG. Effects of general medical health on Alzheimer's progression: the Cache County Dementia Progression Study. Int Psychogeriatr. 2012 Oct; 24(10):1561-70. Epub 2012 Jun 12.
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Mielke MM, Bandaru VV, Haughey NJ, Xia J, Fried LP, Yasar S, Albert M, Varma V, Harris G, Schneider EB, Rabins PV, Bandeen-Roche K, Lyketsos CG, Carlson MC. Serum ceramides increase the risk of Alzheimer disease: the Women's Health and Aging Study II. Neurology. 2012 Aug 14; 79 (7):633-41 Epub 2012 July 18
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Rao V, Mielke M, Xu X, Smith GS, McCann UD, Bergey A, Doshi V, Pham DL, Yousem D, Mori S. Diffusion tensor imaging atlas-based analyses in major depression after mild traumatic brain injury. J Neuropsychiatry Clin Neurosci. 2012 Summer; 24(3):309-15.
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Mielke MM, Leoutsakos JM, Corcoran CD, Green RC, Norton MC, Welsh-Bohmer KA, Tschanz JT, Lyketsos CG. Effects of Food and Drug Administration-approved medications for Alzheimer's disease on clinical progression. Alzheimers Dement. 2012 May; 8(3):180-7. Epub 2012 Feb 01.
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Tighe SK, Oishi K, Mori S, Smith GS, Albert M, Lyketsos CG, Mielke MM. Diffusion tensor imaging of neuropsychiatric symptoms in mild cognitive impairment and Alzheimer’s dementia J Neuropsychiatry Clin Neurosci 2012.2012; 24:(4)484-8.
Mielke MM, Okonkwo OC, Oishi K, Mori S, Tighe S, Miller MI, Ceritoglu C, Brown T, Albert M, Lyketsos CG. Fornix integrity and hippocampal volume predict memory decline and progression to Alzheimer's disease. Alzheimers Dement. 2012; 8 (2):105-13
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Tschanz JT, Corcoran CD, Schwartz S, Treiber K, Green RC, Norton MC, Mielke MM, Piercy K, Steinberg M, Rabins PV, Leoutsakos JM, Welsh-Bohmer KA, Breitner JC, Lyketsos CG. Progression of cognitive, functional, and neuropsychiatric symptom domains in a population cohort with Alzheimer dementia: the Cache County Dementia Progression study. Am J Geriatr Psychiatry. 2011 Jun; 19(6):532-42.
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Rosenberg PB, Mielke MM, Appleby B, Oh E, Leoutsakos JM, Lyketsos CG. Neuropsychiatric symptoms in MCI subtypes: the importance of executive dysfunction. Int J Geriatr Psychiatry. 2011 Apr; 26(4):364-72. Epub 2010 Sep 15.
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Gracia-Garcia P, Rao V, Haughey NJ, Ratnam Banduru VV, Smith G, Rosenberg PB, Lobo A, Lyketsos CG, Mielke MM. Elevated plasma ceramides in depression. J Neuropsychiatry Clin Neurosci. 2011 Spring; 23(2):215-8.
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Oishi K, Mielke MM, Albert M, Lyketsos CG, Mori S. DTI analyses and clinical applications in Alzheimer's disease. J Alzheimers Dis. 2011; 26 Suppl 3:287-96.
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Mielke MM, Haughey NJ, Bandaru VV, Weinberg DD, Darby E, Zaidi N, Pavlik V, Doody RS, Lyketsos CG. Plasma sphingomyelins are associated with cognitive progression in Alzheimer's disease. J Alzheimers Dis. 2011; 27 (2):259-69
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Okonkwo OC, Mielke MM, Griffith HR, Moghekar AR, O'Brien RJ, Shaw LM, Trojanowski JQ, Albert MS, Alzheimer's Disease Neuroimaging Initiative. Cerebrospinal fluid profiles and prospective course and outcome in patients with amnestic mild cognitive impairment. Arch Neurol. 2011 Jan; 68(1):113-9.
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Mielke MM, Leoutsakos JM, Tschanz JT, Green RC, Tripodis Y, Corcoran CD, Norton MC, Lyketsos CG. Interaction between vascular factors and the APOE epsilon4 allele in predicting rate of progression in Alzheimer's disease. J Alzheimers Dis. 2011; 26(1):127-34.
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Oishi K, Akhter K, Mielke M, Ceritoglu C, Zhang J, Jiang H, Li X, Younes L, Miller MI, van Zijl PC, Albert M, Lyketsos CG, Mori S. Multi-modal MRI analysis with disease-specific spatial filtering: initial testing to predict mild cognitive impairment patients who convert to Alzheimer's disease. Front Neurol (Aug) Volume 2. 2011; Article 54:1-8.
Yasar S, Ko JY, Nothelle S, Mielke MM, Carlson MC. Evaluation of the effect of systolic blood pressure and pulse pressure on cognitive function: the Women's Health and Aging Study II. PLoS One. 2011; 6(12):e27976. Epub 2011 Dec 09.
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Rao V, Bertrand M, Rosenberg P, Makley M, Schretlen DJ, Brandt J, Mielke MM. Predictors of new-onset depression after mild traumatic brain injury. J Neuropsychiatry Clin Neurosci. 2010 Winter; 22(1):100-4.
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Mielke MM, Lyketsos CG. Alterations of the sphingolipid pathway in Alzheimer's disease: new biomarkers and treatment targets? Neuromolecular Med. 2010 Dec; 12(4):331-40. Epub 2010 Jun 23.
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Mielke MM, Zandi PP, Shao H, Waern M, Ostling S, Guo X, Bjorkelund C, Lissner L, Skoog I, Gustafson DR. The 32-year relationship between cholesterol and dementia from midlife to late life. Neurology. 2010 Nov 23; 75(21):1888-95. Epub 2010 Nov 10.
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Mielke MM, Bandaru VV, McArthur JC, Chu M, Haughey NJ. Disturbance in cerebral spinal fluid sphingolipid content is associated with memory impairment in subjects infected with the human immunodeficiency virus. J Neurovirol. 2010 Nov; 16(6):445-56. Epub 2010 Nov 18.
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Mielke MM, Haughey NJ, Ratnam Bandaru VV, Schech S, Carrick R, Carlson MC, Mori S, Miller MI, Ceritoglu C, Brown T, Albert M, Lyketsos CG. Plasma ceramides are altered in mild cognitive impairment and predict cognitive decline and hippocampal volume loss. Alzheimers Dement. 2010 Sep; 6(5):378-85.
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Okonkwo OC, Alosco ML, Griffith HR, Mielke MM, Shaw LM, Trojanowski JQ, Tremont G, Alzheimer's Disease Neuroimaging Initiative. Cerebrospinal fluid abnormalities and rate of decline in everyday function across the dementia spectrum: normal aging, mild cognitive impairment, and Alzheimer disease. Arch Neurol. 2010 Jun; 67(6):688-96.
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Rosenberg PB, Mielke MM, Xue QL, Carlson MC. Depressive symptoms predict incident cognitive impairment in cognitive healthy older women. Am J Geriatr Psychiatry. 2010 Mar; 18(3):204-11.
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Mielke MM, Bandaru VV, Haughey NJ, Rabins PV, Lyketsos CG, Carlson MC. Serum sphingomyelins and ceramides are early predictors of memory impairment. Neurobiol Aging. 2010 Jan; 31(1):17-24. Epub 2008 May 05.
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Oh ES, Mielke MM, Rosenberg PB, Jain A, Fedarko NS, Lyketsos CG, Mehta PD. Comparison of conventional ELISA with electrochemiluminescence technology for detection of amyloid-beta in plasma. J Alzheimers Dis. 2010; 21(3):769-73.
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Ewers M, Mielke MM, Hampel H. Blood-based biomarkers of microvascular pathology in Alzheimer's disease. Exp Gerontol. 2010 Jan; 45(1):75-9. Epub 2009 Sep 24.
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Carlson MC, Erickson KI, Kramer AF, Voss MW, Bolea N, Mielke M, McGill S, Rebok GW, Seeman T, Fried LP. Evidence for neurocognitive plasticity in at-risk older adults: the experience corps program. J Gerontol A Biol Sci Med Sci. 2009 Dec; 64(12):1275-82. Epub 2009 Aug 19.
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Gustafson DR, Backman K, Waern M, Ostling S, Guo X, Zandi P, Mielke MM, Bengtsson C, Skoog I. Adiposity indicators and dementia over 32 years in Sweden. Neurology. 2009 Nov 10; 73(19):1559-66.
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Mielke MM, Kozauer NA, Chan KC, George M, Toroney J, Zerrate M, Bandeen-Roche K, Wang MC, Vanzijl P, Pekar JJ, Mori S, Lyketsos CG, Albert M. Regionally-specific diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease. Neuroimage. 2009 May 15; 46(1):47-55. Epub 2009 Feb 5
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Rosenberg PB, Mielke MM, Tschanz J, Cook L, Corcoran C, Hayden KM, Norton M, Rabins PV, Green RC, Welsh-Bohmer KA, Breitner JC, Munger R, Lyketsos CG. Effects of cardiovascular medications on rate of functional decline in Alzheimer disease. Am J Geriatr Psychiatry. 2008 Nov; 16(11):883-92.
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Lyketsos CG, Szekely CA, Mielke MM, Rosenberg PB, Zandi PP. Developing new treatments for Alzheimer's disease: the who, what, when, and how of biomarker-guided therapies. Int Psychogeriatr. 2008 Oct; 20(5):871-89. Epub 2008 May 23.
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Mielke MM, Xue QL, Zhou J, Chaves PH, Fried LP, Carlson MC. Baseline serum cholesterol is selectively associated with motor speed and not rates of cognitive decline: the Women's Health and Aging Study II. J Gerontol A Biol Sci Med Sci. 2008 Jun; 63(6):619-24.
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Rao V, Spiro J, Vaishnavi S, Rastogi P, Mielke M, Noll K, Cornwell E, Schretlen D, Makley M. Prevalence and types of sleep disturbances acutely after traumatic brain injury. Brain Inj. 2008 May; 22(5):381-6.
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Kozauer NA, Mielke MM, Chan GK, Rebok GW, Lyketsos CG. Apolipoprotein E genotype and lifetime cognitive decline. Int Psychogeriatr. 2008 Feb; 20(1):109-23. Epub 2007 Aug 22.
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Mielke MM, Rosenberg PB, Tschanz J, Cook L, Corcoran C, Hayden KM, Norton M, Rabins PV, Green RC, Welsh-Bohmer KA, Breitner JC, Munger R, Lyketsos CG. Vascular factors predict rate of progression in Alzheimer disease. Neurology. 2007 Nov 6; 69(19):1850-8.
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Morgan MD, Mielke MM, O'Brien R, Troncoso JC, Zonderman AB, Lyketsos CG. Rates of depression in individuals with pathologic but not clinical Alzheimer disease are lower than those in individuals without the disease: findings from the Baltimore Longitudinal Study on Aging (BLSA). Alzheimer Dis Assoc Disord. 2007 Jul-Sep; 21(3):199-204.
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Jerome GJ, Glass TA, Mielke M, Xue QL, Andersen RE, Fried LP. Physical activity participation by presence and type of functional deficits in older women: The Women's Health and Aging Studies. J Gerontol A Biol Sci Med Sci. 2006 Nov; 61(11):1171-6.
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Mielke MM, Lyketsos CG. Lipids and the pathogenesis of Alzheimer's disease: is there a link? Int Rev Psychiatry. 2006 Apr; 18(2):173-86.
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Rosenberg PB, Mielke MM, Samus QM, Rosenblatt A, Baker A, Brandt J, Rabins PV, Lyketsos CG. Transition to nursing home from assisted living is not associated with dementia or dementia-related problem behaviors. J Am Med Dir Assoc. 2006 Feb; 7(2):73-8. Epub 2005 Aug 08.
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Sjogren M, Mielke M, Gustafson D, Zandi P, Skoog I. Cholesterol and Alzheimer's disease--is there a relation? Mech Ageing Dev. 2006 Feb; 127(2):138-47. Epub 2005 Dec 05.
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Mielke MM, Zandi PP, Blennow K, Gustafson D, Sjogren M, Rosengren L, Skoog I. Low serum potassium in mid life associated with decreased cerebrospinal fluid Abeta42 in late life. Alzheimer Dis Assoc Disord. 2006 Jan-Mar; 20(1):30-6.
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Mielke MM, Zandi PP. Hematologic risk factors of vascular disease and their relation to dementia. Dement Geriatr Cogn Disord. 2006; 21(5-6):335-52. Epub 2006 Feb 27.
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Rosenberg PB, Mielke MM, Lyketsos CG. Caregiver assessment of patients' depression in Alzheimer disease: longitudinal analysis in a drug treatment study. Am J Geriatr Psychiatry. 2005 Sep; 13(9):822-6.
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Mielke MM, Zandi PP, Sjogren M, Gustafson D, Ostling S, Steen B, Skoog I. High total cholesterol levels in late life associated with a reduced risk of dementia. Neurology. 2005 May 24; 64(10):1689-95.
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Donny EC, Caggiula AR, Rowell PP, Gharib MA, Maldovan V, Booth S, Mielke MM, Hoffman A, McCallum S. Nicotine self-administration in rats: estrous cycle effects, sex differences and nicotinic receptor binding. Psychopharmacology (Berl). 2000 Sep; 151(4):392-405.
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Donny EC, Caggiula AR, Rose C, Jacobs KS, Mielke MM, Sved AF. Differential effects of response-contingent and response-independent nicotine in rats. Eur J Pharmacol. 2000 Aug 25; 402(3):231-40.
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Donny EC, Caggiula AR, Mielke MM, Booth S, Gharib MA, Hoffman A, Maldovan V, Shupenko C, McCallum SE. Nicotine self-administration in rats on a progressive ratio schedule of reinforcement. Psychopharmacology (Berl). 1999 Nov; 147(2):135-42.
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Donny EC, Caggiula AR, Mielke MM, Jacobs KS, Rose C, Sved AF. Acquisition of nicotine self-administration in rats: the effects of dose, feeding schedule, and drug contingency. Psychopharmacology (Berl). 1998 Mar; 136(1):83-90.
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