Publications

Bermudez C, Syrjanen JA, Stricker NH, Algeciras-Schimnich A, Kouri N, Kremers WK, Petersen RC, Jack CR Jr, Knopman DS, Dickson DW, Rothberg DM, Moloney CM, Boon BDC, Nguyen AT, Reichard RR, Murray ME, Mielke MM, Vemuri P, Graff-Radford J. Impact of cardiovascular risk factors on plasma biomarkers in prediction of Alzheimer's and cerebrovascular neuropathology. J Prev Alzheimers Dis. 2025 Jun 11; 100224 Epub 2025 June 11
View PubMed
Aversa Z, Frank RD, Geske JR, White TA, Heeren AA, Kapoor E, Rocca WA, Schafer MJ, Fields JA, Kantarci K, Mielke MM, LeBrasseur NK. Associations of biomarkers of cellular senescence with physical and cognitive function among older women with or without a history of premenopausal bilateral oophorectomy. Maturitas. 2025 Jun 2; 199:108606 Epub 2025 June 02
View PubMed
Singh-Reilly N, Graff-Radford J, Li D, Mielke MM, Machulda MM, Schwarz CG, Senjem ML, Jack CR Jr, Lowe VJ, Josephs KA, Whitwell JL. Abeta(42/40) and p-tau 181 as disease biomarkers in atypical Alzheimer's disease. J Alzheimers Dis. 2025 Jun; 105 (3):923-931 Epub 2025 Apr 23
View PubMed
Mielke MM, Fielding RA, Atkinson EJ, Aversa Z, Schafer MJ, Cummings SR, Pahor M, Leeuwenburgh C, LeBrasseur NK. Biomarkers of cellular senescence predict risk of mild cognitive impairment: Results from the lifestyle interventions for elders (LIFE) study. J Nutr Health Aging. 2025 May; 29 (5):100529 Epub 2025 Mar 07
View PubMed
Varghese BT, Girardo ME, Gupta R, Fischer KM, Duellman M, Mielke MM, Egan AM, Olson JE, Vella A, Bailey KR, Dugani SB. Algorithm to Identify Type 2 Diabetes Using Electronic Health Record and Self-Reported Data. Metab Syndr Relat Disord. 2025 May; 23 (4):186-192 Epub 2025 Apr 07
View PubMed
Rodda J, Kuchenbecker LA, Borelli WV, DeMarco ML, Castilhos RM, Cawston EE, Chabrashvili T, Budelier MM, Duran-Aniotz C, Udeh-Momoh C, Akman-Anderson L, Mielke MM, Pereira AC, Algeciras-Schimnich A, Keshavan A. Global multi-specialty clinician perspectives on the implementation of Alzheimer's disease blood biomarkers. Alzheimers Dement. 2025 May; 21 (5):e70201
View PubMed
Warner NS, Finnie DM, Smith JL, Verdoorn BP, Tung EE, Warner DO, Mielke MM, Griffin JM. A Qualitative Study of the Effects of Opioids on Chronic Pain, Function, and Cognition in Community-Dwelling Older Adults. J Appl Gerontol. 2025 Apr 1; 7334648251326347 Epub 2025 Apr 01
View PubMed
Warner NS, Van Houten HK, Tung EE, Verdoorn BP, Warner DO, Mielke MM, Jeffery MM. Central Nervous System-Active Medication Use in Older Adults With and Without Dementia-A Retrospective Cohort Study. J Gen Intern Med. 2025 Mar 19 [Epub ahead of print]
View PubMed
Coughlan GT, Klinger HM, Boyle R, Betthauser TJ, Binette AP, Christenson L, Chadwick T, Hansson O, Harrison TM, Healy B, Jacobs HIL, Hanseeuw B, Jonaitis E, Jack CR Jr, Johnson KA, Langhough RE, Properzi MJ, Rentz DM, Schultz AP, Smith R, Seto M, Johnson SC, Mielke MM, Shirzadi Z, Yau WW, Manson JE, Sperling RA, Vemuri P, Buckley RF, Alzheimer's Disease Neuroimaging Initiative. Sex Differences in Longitudinal Tau-PET in Preclinical Alzheimer Disease: A Meta-Analysis. JAMA Neurol. 2025 Mar 3 Epub 2025 Mar 03
View PubMed
Ali F, Syrjanen JA, Figdore DJ, Kremers WK, Mielke MM, Jack CR, Knopman DS, Vemuri P, Graff-Radford J, Windham BG, Barnard LR, Petersen RC, Algeciras-Schimnich A. Association of plasma biomarkers of Alzheimer's pathology and neurodegeneration with gait performance in older adults. Commun Med (Lond). 2025 Jan 16; 5 (1):19
View PubMed
Kantarci K, Kapoor E, Geske JR, Castillo A, Fields JA, Kara F, Knyazhanskaya EE, Schwarz CG, Senjem ML, Bailey KR, Lowe V, LeBrasseur NK, Rocca WA, Mielke MM. Premenopausal bilateral oophorectomy and Alzheimer's disease imaging biomarkers later in life. Alzheimers Dement. 2024 Dec 23 [Epub ahead of print]
View PubMed
Singh NA, Alnobani A, Graff-Radford J, Machulda MM, Mielke MM, Schwarz CG, Senjem ML, Jack CR Jr, Lowe VJ, Kanekiyo T, Josephs KA, Whitwell JL. Alzheimer's Imaging Consortium. Alzheimers Dement. 2024 Dec; 20 Suppl 9:e094001
View PubMed
Hu M, Moloney CM, Przybelski SA, Algeciras-Schimnich A, Fought AJ, Rothberg DM, Nguyen AT, Reichard RR, Dickson DW, Knopman DS, Jack CR Jr, Petersen RC, Mielke MM, Graff-Radford J, Murray ME, Vemuri P. Alzheimer's Imaging Consortium. Alzheimers Dement. 2024 Dec; 20 Suppl 9:e093893
View PubMed
Shue F, White LJ, Hendrix R, Ulrich JD, Henson RL, Knight WC, Martens YA, Wang N, Roy B, Starling SC, Ren Y, Xiong C, Asmann YW, Syrjanen JA, Vassilaki M, Mielke MM, Cruchaga C, Holtzman DM, Bu G, Petersen RC, Heckman MG, Kanekiyo T. Alzheimer's Imaging Consortium. Alzheimers Dement. 2024 Dec; 20 Suppl 9:e093743
View PubMed
Pike JR, Lu Y, Chen J, Walker KA, Sullivan KJ, Griswold ME, Thyagarajan B, Mielke MM, Lutsey PL, Wong DF, Knopman DS, Sharrett AR, Coresh J, Mosley TH, Gottesman RF, Palta P. Biomarkers. Alzheimers Dement. 2024 Dec; 20 Suppl 2:e091307
View PubMed
Singh NA, Alnobani A, Graff-Radford J, Machulda MM, Mielke MM, Schwarz CG, Senjem ML, Jack CR Jr, Lowe VJ, Kanekiyo T, Josephs KA, Whitwell JL. Biomarkers. Alzheimers Dement. 2024 Dec; 20 Suppl 2:e091767
View PubMed
Singh NA, Graff-Radford J, Li D, Mielke MM, Machulda MM, Schwarz CG, Senjem ML, Jack CR Jr, Lowe VJ, Josephs KA, Whitwell JL. Biomarkers. Alzheimers Dement. 2024 Dec; 20 Suppl 2:e091571
View PubMed
Lowe VJ, Mester CT, Lundt ES, Lee J, Ghatamaneni S, Algeciras-Schimnich A, Campbell MR, Graff-Radford J, Nguyen AT, Min HK, Murray ME, Senjem ML, Schwarz CG, Kantarci K, Boeve BF, Vemuri P, Jones DT, Knopman DS, Jack CR Jr, Petersen RC, Mielke MM. Biomarkers. Alzheimers Dement. 2024 Dec; 20 Suppl 2:e092471
View PubMed
Bermudez C, Syrjanen JA, Attia ZI, Friedman PA, Lopez-Jimenez F, Hu M, Petersen RC, Knopman DS, Ramanan VK, Jack CR Jr, Nguyen AT, Reichard RR, Kouri N, Moloney CM, Algeciras-Schimnich A, Murray ME, Mielke MM, Vemuri P, Noseworthy PA, Graff-Radford J. Biomarkers. Alzheimers Dement. 2024 Dec; 20 Suppl 2:e088037
View PubMed
Hu M, Moloney CM, Przybelski SA, Algeciras-Schimnich A, Fought AJ, Rothberg DM, Nguyen AT, Reichard RR, Dickson DW, Knopman DS, Jack CR Jr, Petersen RC, Mielke MM, Graff-Radford J, Murray ME, Vemuri P. Biomarkers. Alzheimers Dement. 2024 Dec; 20 Suppl 2:e090563
View PubMed
Shue F, White LJ, Hendrix R, Ulrich JD, Henson RL, Knight WC, Martens YA, Wang N, Roy B, Starling SC, Ren Y, Xiong C, Asmann YW, Syrjanen JA, Vassilaki M, Mielke MM, Cruchaga C, Holtzman DM, Bu G, Petersen RC, Heckman MG, Kanekiyo T. Biomarkers. Alzheimers Dement. 2024 Dec; 20 Suppl 2:e087693
View PubMed
Lowe VJ, Mester CT, Lundt ES, Lee J, Ghatamaneni S, Algeciras-Schimnich A, Campbell MR, Graff-Radford J, Nguyen A, Min HK, Senjem ML, Machulda MM, Schwarz CG, Dickson DW, Murray ME, Kandimalla KK, Kantarci K, Boeve B, Vemuri P, Jones DT, Knopman D, Jack CR Jr, Petersen RC, Mielke MM. Amyloid PET detects the deposition of brain Abeta earlier than CSF fluid biomarkers. Alzheimers Dement. 2024 Nov; 20 (11):8097-8112 Epub 2024 Oct 11
View PubMed
Therriault J, Janelidze S, Benedet AL, Ashton NJ, Arranz Martinez J, Gonzalez-Escalante A, Bellaver B, Alcolea D, Vrillon A, Karim H, Mielke MM, Hyung Hong C, Roh HW, Contador J, Puig Pijoan A, Algeciras-Schimnich A, Vemuri P, Graff-Radford J, Lowe VJ, Karikari TK, Jonaitis E, Brum W, Tissot C, Servaes S, Rahmouni N, Macedo AC, Stevenson J, Fernandez-Arias J, Wang YT, Woo MS, Friese MA, Jia WL, Dumurgier J, Hourregue C, Cognat E, Ferreira PL, Vitali P, Johnson S, Pascoal TA, Gauthier S, Lleo A, Paquet C, Petersen RC, Salmon D, Mattsson-Carlgren N, Palmqvist S, Stomrud E, Galasko D, Son SJ, Zetterberg H, Fortea J, Suarez-Calvet M, Jack CR Jr, Blennow K, Hansson O, Rosa-Neto P. Diagnosis of Alzheimer's disease using plasma biomarkers adjusted to clinical probability. Nat Aging. 2024 Nov; 4 (11):1529-1537 Epub 2024 Nov 12
View PubMed
Lu Y, Pike JR, Chen J, Walker KA, Sullivan KJ, Thyagarajan B, Mielke MM, Lutsey PL, Knopman D, Gottesman RF, Sharrett AR, Coresh J, Mosley TH, Palta P. Changes in Alzheimer Disease Blood Biomarkers and Associations With Incident All-Cause Dementia. JAMA 2024 Oct 15; 332 (15):1258-1269
View PubMed
Lee JK, Raghavan S, Christenson LR, Frank RD, Kantarci K, Rocca WA, Vemuri P, Mielke MM. Longitudinal associations of reproductive factors and exogeneous estrogens with neuroimaging biomarkers of Alzheimer's disease and cerebrovascular disease. Alzheimers Dement. 2024 Jul; 20(7):4613-4624. Epub 2024 Jun 11.
View PubMed
Schindler SE, Galasko D, Pereira AC, Rabinovici GD, Salloway S, Suarez-Calvet M, Khachaturian AS, Mielke MM, Udeh-Momoh C, Weiss J, Batrla R, Bozeat S, Dwyer JR, Holzapfel D, Jones DR, Murray JF, Partrick KA, Scholler E, Vradenburg G, Young D, Algeciras-Schimnich A, Aubrecht J, Braunstein JB, Hendrix J, Hu YH, Mattke S, Monane M, Reilly D, Somers E, Teunissen CE, Shobin E, Vanderstichele H, Weiner MW, Wilson D, Hansson O. Acceptable performance of blood biomarker tests of amyloid pathology - recommendations from the Global CEO Initiative on Alzheimer's Disease. Nat Rev Neurol. 2024 Jul; 20 (7):426-439 Epub 2024 June 12
View PubMed
Singh NA, Alnobani A, Graff-Radford J, Machulda MM, Mielke MM, Schwarz CG, Senjem ML, Jack CR Jr, Lowe VJ, Kanekiyo T, Josephs KA, Whitwell JL. Relationships between PET and blood plasma biomarkers in corticobasal syndrome. Alzheimers Dement. 2024 Jul; 20(7):4765-4774. Epub 2024 Jun 17.
View PubMed
Mielke MM, Frank RD, Christenson LR, Reid RI, Fields JA, Knyazhanskaya ZE, Kara F, Vemuri P, Rocca WA, Kantarci K. Premenopausal bilateral oophorectomy and brain white matter brain integrity in later-life. Alzheimers Dement. 2024 Jul; 20 (7):5054-5061 Epub 2024 June 20
View PubMed
Dugani SB, Lahr BD, Xie H, Mielke MM, Bailey KR, Vella A. County Rurality and Incidence and Prevalence of Diagnosed Diabetes in the United States. Mayo Clin Proc. 2024 Jul; 99 (7):1078-1090 Epub 2024 Mar 19
View PubMed
Warner NS, Hanson AC, Schulte PJ, Kara F, Reid RI, Schwarz CG, Benarroch EE, Graff-Radford J, Vemuri P, Jack CR, Petersen RC, Warner DO, Mielke MM, Kantarci K. Prescription Opioids and Brain Structure in Community-Dwelling Older Adults. Mayo Clin Proc. 2024 May; 99 (5):716-726
View PubMed
Sintini I, Singh NA, Li D, Mielke MM, Machulda MM, Schwarz CG, Senjem ML, Jack CR Jr, Lowe VJ, Graff-Radford J, Josephs KA, Whitwell JL. Plasma glial fibrillary acidic protein in the visual and language variants of Alzheimer's disease. Alzheimers Dement. 2024 May; 20 (5):3679-3686 Epub 2024 Mar 25
View PubMed
Karstens AJ, Christianson TJ, Lundt ES, Machulda MM, Mielke MM, Fields JA, Kremers WK, Graff-Radford J, Vemuri P, Jack CR Jr, Knopman DS, Petersen RC, Stricker NH. Mayo normative studies: regression-based normative data for ages 30-91 years with a focus on the Boston Naming Test, Trail Making Test and Category Fluency. J Int Neuropsychol Soc. 2024 May; 30 (4):389-401 Epub 2023 Nov 28
View PubMed
Shue F, White LJ, Hendrix R, Ulrich J, Henson RL, Knight W, Martens YA, Wang N, Roy B, Starling SC, Ren Y, Xiong C, Asmann YW, Syrjanen JA, Vassilaki M, Mielke MM, Timsina J, Sung YJ, Cruchaga C, Holtzman DM, Bu G, Petersen RC, Heckman MG, Kanekiyo T. CSF biomarkers of immune activation and Alzheimer's disease for predicting cognitive impairment risk in the elderly. Sci Adv. 2024 Apr 5; 10 (14):eadk3674 Epub 2024 Apr 03
View PubMed
Fielding RA, Atkinson EJ, Aversa Z, White TA, Heeren AA, Mielke MM, Cummings SR, Pahor M, Leeuwenburgh C, LeBrasseur NK. Biomarkers of Cellular Senescence Predict the Onset of Mobility Disability and Are Reduced by Physical Activity in Older Adults. J Gerontol A Biol Sci Med Sci. 2024 Mar 1; 79 (3)
View PubMed
Jack CR Jr, Wiste HJ, Algeciras-Schimnich A, Weigand SD, Figdore DJ, Lowe VJ, Vemuri P, Graff-Radford J, Ramanan VK, Knopman DS, Mielke MM, Machulda MM, Fields J, Schwarz CG, Cogswell PM, Senjem ML, Therneau TM, Petersen RC. Comparison of plasma biomarkers and amyloid PET for predicting memory decline in cognitively unimpaired individuals. Alzheimers Dement. 2024 Mar; 20(3):2143-2154. Epub 2024 Jan 24.
View PubMed
Stricker NH, Stricker JL, Frank RD, Fan WZ, Christianson TJ, Patel JS, Karstens AJ, Kremers WK, Machulda MM, Fields JA, Graff-Radford J, Jack CR Jr, Knopman DS, Mielke MM, Petersen RC. Stricker Learning Span criterion validity: a remote self-administered multi-device compatible digital word list memory measure shows similar ability to differentiate amyloid and tau PET-defined biomarker groups as in-person Auditory Verbal Learning Test. J Int Neuropsychol Soc. 2024 Feb; 30 (2):138-151 Epub 2023 June 30
View PubMed
Cogswell PM, Lundt ES, Therneau TM, Wiste HJ, Graff-Radford J, Algeciras-Schimnich A, Lowe VJ, Mielke MM, Schwarz CG, Senjem ML, Gunter JL, Knopman DS, Vemuri P, Petersen RC, Jack CR Jr. Modeling the temporal evolution of plasma p-tau in relation to amyloid beta and tau PET. Alzheimers Dement. 2024 Feb; 20 (2):1225-1238 Epub 2023 Nov 14
View PubMed
Lee JK, Frank RD, Christenson LR, Fields JA, Rocca WA, Mielke MM. Associations of reproductive factors and exogenous estrogens with global and domain-specific cognition in later life. Alzheimers Dement. 2024 Jan; 20 (1):63-73 Epub 2023 July 14
View PubMed
Shir D, Graff-Radford J, Fought AJ, Lesnick TG, Przybelski SA, Vassilaki M, Lowe VJ, Knopman DS, Machulda MM, Petersen RC, Jack CR Jr, Mielke MM, Vemuri P. Complex relationships of socioeconomic status with vascular and Alzheimer's pathways on cognition. Neuroimage Clin. 2024; 43:103634 Epub 2024 June 15
View PubMed
Krell-Roesch J, Syrjanen JA, Bezold J, Trautwein S, Barisch-Fritz B, Boes K, Woll A, Forzani E, Kremers WK, MacHulda MM, Mielke MM, Knopman DS, Petersen RC, Vassilaki M, Geda YE. Physical activity and trajectory of cognitive change in older persons: Mayo Clinic study of aging. Advances in Alzheimer's Disease. 2024; 10:3-14
Stricker NH, Christianson TJ, Pudumjee SB, Polsinelli AJ, Lundt ES, Frank RD, Kremers WK, Machulda MM, Fields JA, Jack CR, Knopman DS, Graff-Radford J, Vemuri P, Mielke MM, Petersen RC. Mayo Normative Studies: Amyloid and Neurodegeneration Negative Normative Data for the Auditory Verbal Learning Test and Sex-Specific Sensitivity to Mild Cognitive Impairment/Dementia. J Alzheimers Dis. 2024; 100 (3):879-897
View PubMed
St Sauver JL, Weston SA, Atkinson EJ, Mc Gree ME, Mielke MM, White TA, Heeren AA, Olson JE, Rocca WA, Palmer AK, Cummings SR, Fielding RA, Bielinski SJ, LeBrasseur NK. Biomarkers of cellular senescence and risk of death in humans. Aging Cell. 2023 Dec; 22 (12):e14006 Epub 2023 Oct 06
View PubMed
Ramanan VK, Gebre RK, Graff-Radford J, Hofrenning E, Algeciras-Schimnich A, Figdore DJ, Lowe VJ, Mielke MM, Knopman DS, Ross OA, Jack CR Jr, Petersen RC, Vemuri P. Genetic risk scores enhance the diagnostic value of plasma biomarkers of brain amyloidosis. Brain. 2023 Nov 2; 146 (11):4508-4519
View PubMed
Mielke MM, Dage JL, Frank RD, Algeciras-Schimnich A, Knopman DS, Lowe VJ, Bu G, Vemuri P, Graff-Radford J, Jack CR Jr, Petersen RC. Author Correction: Performance of plasma phosphorylated tau 181 and 217 in the community. Nat Med. 2023 Nov; 29 (11):2954
View PubMed
Mielke MM, Kapoor E, Geske JR, Fields JA, LeBrasseur NK, Morrow MM, Winham SJ, Faubion LL, Castillo AM, Hofrenning EI, Bailey KR, Rocca WA, Kantarci K. Long-term effects of premenopausal bilateral oophorectomy with or without hysterectomy on physical aging and chronic medical conditions. Menopause. 2023 Nov 1; 30 (11):1090-1097 Epub 2023 Sept 11
View PubMed
Li D, Singh S, Zhang CD, Kaur RJ, Ebbehoj A, Atkinson EJ, Achenbach SJ, Stricker NH, Mielke MM, Rocca W, Bancos I. Risk of dementia and psychiatric or sleep disorders after diagnosis of adrenal adenomas: a population-based cohort study. Eur J Endocrinol. 2023 Oct 17; 189 (4):429-437
View PubMed
Ramanan VK, Graff-Radford J, Syrjanen J, Shir D, Algeciras-Schimnich A, Lucas J, Martens YA, Carrasquillo MM, Day GS, Ertekin-Taner N, Lachner C, Willis FB, Knopman DS, Jack CR Jr, Petersen RC, Vemuri P, Graff-Radford N, Mielke MM. Association of Plasma Biomarkers of Alzheimer Disease With Cognition and Medical Comorbidities in a Biracial Cohort. Neurology. 2023 Oct 3; 101 (14):e1402-e1411 Epub 2023 Aug 14
View PubMed
Moser ED, Manemann SM, Larson NB, St Sauver JL, Takahashi PY, Mielke MM, Rocca WA, Olson JE, Roger VL, Remaley AT, Decker PA, Killian JM, Bielinski SJ. Association Between Fluctuations in Blood Lipid Levels Over Time With Incident Alzheimer Disease and Alzheimer Disease-Related Dementias. Neurology. 2023 Sep 12; 101 (11):e1127-e1136 Epub 2023 July 05
View PubMed
Dines VA, Kattah AG, Weaver AL, Vaughan LE, Chamberlain AM, Bielinski SJ, Mielke MM, Garovic VD. Risk of Adult Hypertension in Offspring From Pregnancies Complicated by Hypertension: Population-Based Estimates. Hypertension. 2023 Sep; 80 (9):1940-1948 Epub 2023 July 25
View PubMed
Morrow MMB, Schafer MJ, Kantarci K, Mielke MM, Vachon CM, Winham SJ. Leadership Development in Early Career Scientists: Themes and Feedback from Executive Coaching and Mindful Leadership Training. J Womens Health (Larchmt). 2023 Aug; 32 (8):877-882
View PubMed
Bermudez C, Graff-Radford J, Syrjanen JA, Stricker NH, Algeciras-Schimnich A, Kouri N, Kremers WK, Petersen RC, Jack CR Jr, Knopman DS, Dickson DW, Nguyen AT, Reichard RR, Murray ME, Mielke MM, Vemuri P. Plasma biomarkers for prediction of Alzheimer's disease neuropathologic change. Acta Neuropathol. 2023 Jul; 146 (1):13-29 Epub 2023 June 03
View PubMed
Stricker NH, Twohy EL, Albertson SM, Karstens AJ, Kremers WK, Machulda MM, Fields JA, Jack CR Jr, Knopman DS, Mielke MM, Petersen RC. Mayo-PACC: A parsimonious preclinical Alzheimer's disease cognitive composite comprised of public-domain measures to facilitate clinical translation. Alzheimers Dement. 2023 Jun; 19 (6):2575-2584 Epub 2022 Dec 24
View PubMed
Bornhorst JA, Figdore D, Campbell MR, Pazdernik VK, Mielke MM, Petersen RC, Algeciras-Schimnich A. Corrigendum to "Plasma neurofilament light chain (NfL) reference interval determination in an age-stratified cognitively unimpaired cohort" [Clin. Chim. Acta 535 (2022) 153-156]. Clin Chim Acta. 2023 Jun 1; 546:117396 Epub 2023 May 25
View PubMed
Mielke MM, Frank RD, Christenson LR, Fields JA, Rocca WA, Garovic VD. Association of Hypertensive Disorders of Pregnancy With Cognition in Later Life. Neurology. 2023 May 9; 100 (19):e2017-e2026 Epub 2023 Mar 01
View PubMed
Jack CR, Wiste HJ, Algeciras-Schimnich A, Figdore DJ, Schwarz CG, Lowe VJ, Ramanan VK, Vemuri P, Mielke MM, Knopman DS, Graff-Radford J, Boeve BF, Kantarci K, Cogswell PM, Senjem ML, Gunter JL, Therneau TM, Petersen RC. Predicting amyloid PET and tau PET stages with plasma biomarkers. Brain. 2023 May 2; 146 (5):2029-2044
View PubMed
St Sauver JL, LeBrasseur NK, Rocca WA, Olson JE, Bielinski SJ, Sohn S, Weston SA, McGree ME, Mielke MM. Cohort study examining associations between ceramide levels and risk of multimorbidity among persons participating in the Mayo Clinic Biobank. BMJ Open. 2023 Apr 21; 13(4):e069375.
View PubMed
Windham BG, Griswold ME, Ranadive R, Sullivan KJ, Mosley TH, Mielke MM, Jack CR, Knopman D, Petersen R, Vemuri P. Relationships of Cerebral Perfusion With Gait Speed Across Systolic Blood Pressure Levels and Age: A Cohort Study. J Gerontol A Biol Sci Med Sci. 2023 Mar 1; 78 (3):514-520
View PubMed
Vassilaki M, Aakre JA, Castillo A, Chamberlain AM, Wilson PM, Kremers WK, Mielke MM, Geda YE, Machulda MM, Alhurani RE, Graff-Radford J, Vemuri P, Lowe VJ, Jack CR Jr, Knopman DS, Petersen RC. Association of neighborhood socioeconomic disadvantage and cognitive impairment. Alzheimers Dement. 2023 Mar; 19 (3):761-770 Epub 2022 June 06
View PubMed
Moloney CM, Labuzan SA, Crook JE, Siddiqui H, Castanedes-Casey M, Lachner C, Petersen RC, Duara R, Graff-Radford NR, Dickson DW, Mielke MM, Murray ME. Phosphorylated tau sites that are elevated in Alzheimer's disease fluid biomarkers are visualized in early neurofibrillary tangle maturity levels in the post mortem brain. Alzheimers Dement. 2023 Mar; 19 (3):1029-1040 Epub 2022 Aug 03
View PubMed
Sprung J, Laporta ML, Knopman DS, Petersen RC, Mielke MM, Jack CR, Martin DP, Hanson AC, Schroeder DR, Schulte PJ, Przybelski SA, Valencia Morales DJ, Weingarten TN, Vemuri P, Warner DO. Association of Indication for Hospitalization With Subsequent Amyloid Positron Emission Tomography and Magnetic Resonance Imaging Biomarkers. J Gerontol A Biol Sci Med Sci. 2023 Feb 24; 78 (2):304-313
View PubMed
Fautsch KJ, Block DR, Graff-Radford J, Wang F, Craver EC, Hodge DO, Cutsforth-Gregory JK, Kilgore KP, Petersen RC, Knopman DS, Flanagan E, Toledano M, Mielke MM, Bhatti MT, Chen JJ. Population-Based Evaluation of Total Protein in Cerebrospinal Fluid. Mayo Clin Proc. 2023 Feb; 98(2):239-251.
View PubMed
Kara F, Lohse CM, Castillo AM, Tosakulwong N, Lesnick TG, Jack CR Jr, Petersen RC, Olson JE, Couch FJ, Ruddy KJ, Kantarci K, Mielke MM. Association of raloxifene and tamoxifen therapy with cognitive performance, odds of mild cognitive impairment, and brain MRI markers of neurodegeneration. Cancer Med. 2023 Feb; 12 (3):2805-2817 Epub 2022 Aug 30
View PubMed
Warner NS, Mielke MM, Verdoorn BP, Knopman DS, Hooten WM, Habermann EB, Warner DO. Pain, Opioid Analgesics, and Cognition: A Conceptual Framework in Older Adults. Pain Med. 2023 Feb 1; 24 (2):171-181
View PubMed
Shir D, Mielke MM, Hofrenning EI, Lesnick TG, Knopman DS, Petersen RC, Jack CR, Algeciras-Schimnich A, Vemuri P, Graff-Radford J. Associations of Neurodegeneration Biomarkers in Cerebrospinal Fluid with Markers of Alzheimer's Disease and Vascular Pathology. J Alzheimers Dis. 2023; 92 (3):887-898
View PubMed
Lilek J, Ajroud K, Feldman AZ, Krishnamachari S, Ghourchian S, Gefen T, Spencer CL, Kawles A, Mao Q, Tranovich JF, Jack CR, Mesulam MM, Reichard RR, Zhang H, Murray ME, Knopman D, Dickson DW, Petersen RC, Smith B, Ashe KH, Mielke MM, Nelson KM, Flanagan ME. Accumulation of pTau231 at the Postsynaptic Density in Early Alzheimer's Disease. J Alzheimers Dis. 2023; 92 (1):241-260
View PubMed
Bornhorst JA, Figdore D, Campbell MR, Pazdernik VK, Mielke MM, Petersen RC, Algeciras-Schimnich A. Corrigendum to "Plasma neurofilament light chain (NfL) reference interval determination in an age-stratified cognitively unimpaired cohort" [Clin. Chim. Acta 535 (2022) 153-156]. Clinica Chimica Acta. 2023; 546:117396
Kodishala C, Hulshizer CA, Kronzer VL, Davis JM 3rd, Ramanan VK, Vassilaki M, Mielke MM, Crowson CS, Myasoedova E. Risk Factors for Dementia in Patients With Incident Rheumatoid Arthritis: A Population-Based Cohort Study. J Rheumatol. 2023 Jan; 50 (1):48-55 Epub 2022 July 15
View PubMed
Murray ME, Moloney CM, Kouri N, Syrjanen JA, Matchett BJ, Rothberg DM, Tranovich JF, Sirmans TNH, Wiste HJ, Boon BDC, Nguyen AT, Reichard RR, Dickson DW, Lowe VJ, Dage JL, Petersen RC, Jack CR Jr, Knopman DS, Vemuri P, Graff-Radford J, Mielke MM. Global neuropathologic severity of Alzheimer's disease and locus coeruleus vulnerability influences plasma phosphorylated tau levels. Mol Neurodegener. 2022 Dec 27; 17 (1):85
View PubMed
Warner NS, Hanson AC, Schulte PJ, Habermann EB, Warner DO, Mielke MM. Prescription opioids and longitudinal changes in cognitive function in older adults: A population-based observational study. J Am Geriatr Soc. 2022 Dec; 70 (12):3526-3537 Epub 2022 Sept 18
View PubMed
Coon EA, Castillo AM, Lesnick TG, Raghavan S, Mielke MM, Reid RI, Windham BG, Petersen RC, Jack CR, Graff-Radford J, Vemuri P. Blood pressure changes impact corticospinal integrity and downstream gait and balance control. Neurobiol Aging. 2022 Dec; 120:60-67 Epub 2022 Aug 27
View PubMed
Fielding RA, Atkinson EJ, Aversa Z, White TA, Heeren AA, Achenbach SJ, Mielke MM, Cummings SR, Pahor M, Leeuwenburgh C, LeBrasseur NK. Associations between biomarkers of cellular senescence and physical function in humans: observations from the lifestyle interventions for elders (LIFE) study. Geroscience. 2022 Dec; 44 (6):2757-2770 Epub 2022 Nov 11
View PubMed
Mielke MM, Aggarwal NT, Vila-Castelar C, Agarwal P, Arenaza-Urquijo EM, Brett B, Brugulat-Serrat A, DuBose LE, Eikelboom WS, Flatt J, Foldi NS, Franzen S, Gilsanz P, Li W, McManus AJ, van Lent DM, Milani SA, Shaaban CE, Stites SD, Sundermann E, Suryadevara V, Trani JF, Turner AD, Vonk JMJ, Quiroz YT, Babulal GM, Diversity and Disparity Professional Interest Area Sex and Gender Special Interest Group. Consideration of sex and gender in Alzheimer's disease and related disorders from a global perspective. Alzheimers Dement. 2022 Dec; 18 (12):2707-2724 Epub 2022 Apr 08
View PubMed
Nguyen AT, Kouri N, Labuzan SA, Przybelski SA, Lesnick TG, Raghavan S, Reid RI, Reichard RR, Knopman DS, Petersen RC, Jack CR Jr, Mielke MM, Dickson DW, Graff-Radford J, Murray ME, Vemuri P. Neuropathologic scales of cerebrovascular disease associated with diffusion changes on MRI. Acta Neuropathol. 2022 Dec; 144 (6):1117-1125 Epub 2022 July 16
View PubMed
Graff-Radford J, Mielke MM, Hofrenning EI, Kouri N, Lesnick TG, Moloney CM, Rabinstein A, Cabrera-Rodriguez JN, Rothberg DM, Przybelski SA, Petersen RC, Knopman DS, Dickson DW, Jack CR, Algeciras-Schimnich A, Nguyen AT, Murray ME, Vemuri P. Association of plasma biomarkers of amyloid and neurodegeneration with cerebrovascular disease and Alzheimer's disease. Neurobiol Aging. 2022 Nov; 119:1-7 Epub 2022 July 24
View PubMed
Kapoor E, Faubion SS, Gazzuola Rocca L, Mielke MM, Smith CY, Rocca WA. Trajectories of metabolic parameters after bilateral oophorectomy in premenopausal women. Maturitas. 2022 Nov; 165:38-46 Epub 2022 July 21
View PubMed
Rocca WA, Smith CY, Gazzuola Rocca L, Savica R, Mielke MM. Association of Premenopausal Bilateral Oophorectomy With Parkinsonism and Parkinson Disease. JAMA Netw Open. 2022 Oct 3; 5 (10):e2238663 Epub 2022 Oct 03
View PubMed
Bornhorst JA, Figdore D, Campbell MR, Pazdernik VK, Mielke MM, Petersen RC, Algeciras-Schimnich A. Plasma neurofilament light chain (NfL) reference interval determination in an Age-stratified cognitively unimpaired cohort. Clin Chim Acta. 2022 Oct 01; 535:153-156. Epub 2022 Aug 27.
View PubMed
Chang BK, Day GS, Graff-Radford J, McKeon A, Flanagan EP, Algeciras-Schimnich A, Mielke MM, Nguyen A, Jones DT, Toledano M, Kremers WK, Knopman DS, Petersen RC, Li W. Alzheimer's disease cerebrospinal fluid biomarkers differentiate patients with Creutzfeldt-Jakob disease and autoimmune encephalitis. Eur J Neurol. 2022 Oct; 29 (10):2905-2912 Epub 2022 July 05
View PubMed
Dugani SB, Wood-Wentz CM, Mielke MM, Bailey KR, Vella A. Assessment of Disparities in Diabetes Mortality in Adults in US Rural vs Nonrural Counties, 1999-2018. JAMA Netw Open. 2022 Sep 1; 5 (9):e2232318 Epub 2022 Sept 01
View PubMed
Cogswell PM, Wiste HJ, Mielke MM, Schwarz CG, Weigand SD, Lowe VJ, Therneau TM, Knopman DS, Graff-Radford J, Vemuri P, Senjem ML, Gunter JL, Algeciras-Schimnich A, Petersen RC, Jack CR Jr. CSF phosphorylated tau as an indicator of subsequent tau accumulation. Neurobiol Aging. 2022 Sep; 117:189-200 Epub 2022 May 26
View PubMed
Skillback T, Blennow K, Zetterberg H, Skoog J, Ryden L, Wetterberg H, Guo X, Sacuiu S, Mielke MM, Zettergren A, Skoog I, Kern S. Slowing gait speed precedes cognitive decline by several years. Alzheimers Dement. 2022 Sep; 18 (9):1667-1676 Epub 2022 Feb 09
View PubMed
Cogswell PM, Aakre JA, Castillo AM, Knopman DS, Kantarci K, Rabinstein AA, Petersen RC, Jack CR Jr, Mielke MM, Vemuri P, Graff-Radford J. Population-Based Prevalence of Infarctions on 3D Fluid-Attenuated Inversion Recovery (FLAIR) Imaging. J Stroke Cerebrovasc Dis. 2022 Aug; 31 (8):106583 Epub 2022 June 08
View PubMed
Mielke MM, Dage JL, Frank RD, Algeciras-Schimnich A, Knopman DS, Lowe VJ, Bu G, Vemuri P, Graff-Radford J, Jack CR Jr, Petersen RC. Performance of plasma phosphorylated tau 181 and 217 in the community. Nat Med. 2022 Jul; 28 (7):1398-1405 Epub 2022 May 26
View PubMed
St Sauver J, Rocca W, LeBrasseur N, Chamberlain A, Olson J, Jacobson D, McGree M, Mielke M. Inflammatory biomarkers, multi-morbidity, and biologic aging. J Int Med Res. 2022 Jul; 50 (7):3000605221109393
View PubMed
Zong N, Wen A, Moon S, Fu S, Wang L, Zhao Y, Yu Y, Huang M, Wang Y, Zheng G, Mielke MM, Cerhan JR, Liu H. Computational drug repurposing based on electronic health records: a scoping review. NPJ Digit Med 2022 Jun 14; 5 (1):77 Epub 2022 June 14
View PubMed
Fu S, Ibrahim OA, Wang Y, Vassilaki M, Petersen RC, Mielke MM, St Sauver J, Sohn S. Prediction of Incident Dementia Using Patient Temporal Health Status. Stud Health Technol Inform. 2022 Jun 6; 290:757-761
View PubMed
Ibrahim OA, Fu S, Vassilaki M, Mielke MM, St Sauver J, Petersen RC, Sohn S. Detection of Dementia Signals from Longitudinal Clinical Visits Using One-Class Classification. IEEE Int Conf Healthc Inform. 2022 Jun; 2022:211-216 Epub 2022 Sept 08
View PubMed
Syrjanen JA, Campbell MR, Algeciras-Schimnich A, Vemuri P, Graff-Radford J, Machulda MM, Bu G, Knopman DS, Jack CR Jr, Petersen RC, Mielke MM. Associations of amyloid and neurodegeneration plasma biomarkers with comorbidities. Alzheimers Dement. 2022 Jun; 18 (6):1128-1140 Epub 2021 Sept 27
View PubMed
Weil EL, Noseworthy PA, Lopez CL, Rabinstein AA, Friedman PA, Attia ZI, Yao X, Siontis KC, Kremers WK, Christopoulos G, Mielke MM, Vemuri P, Jack CR Jr, Gersh BJ, Machulda MM, Knopman DS, Petersen RC, Graff-Radford J. Artificial Intelligence-Enabled Electrocardiogram for Atrial Fibrillation Identifies Cognitive Decline Risk and Cerebral Infarcts. Mayo Clin Proc. 2022 May; 97 (5):871-880
View PubMed
Ramanan VK, Heckman MG, Lesnick TG, Przybelski SA, Cahn EJ, Kosel ML, Murray ME, Mielke MM, Botha H, Graff-Radford J, Jones DT, Lowe VJ, Machulda MM, Jack CR Jr, Knopman DS, Petersen RC, Ross OA, Vemuri P. Tau polygenic risk scoring: a cost-effective aid for prognostic counseling in Alzheimer's disease. Acta Neuropathol. 2022 May; 143 (5):571-583 Epub 2022 Apr 12
View PubMed
Shelly S, Mielke MM, Paul P, Milone M, Tracy JA, Mills JR, Klein CJ, Ernste FC, Mandrekar J, Liewluck T. Incidence and prevalence of immune-mediated necrotizing myopathy in adults in Olmsted County, Minnesota. Muscle Nerve. 2022 May; 65 (5):541-546 Epub 2022 Feb 28
View PubMed
Erickson Z, Rocca WA, Smith CY, Gazzuola Rocca L, Stewart EA, Laughlin-Tommaso SK, Mielke MM. Time Trends in Unilateral and Bilateral Oophorectomy in a Geographically Defined American Population. Obstet Gynecol. 2022 May 1; 139 (5):724-734 Epub 2022 Apr 05
View PubMed
Saboo KV, Hu C, Varatharajah Y, Przybelski SA, Reid RI, Schwarz CG, Graff-Radford J, Knopman DS, Machulda MM, Mielke MM, Petersen RC, Arnold PM, Worrell GA, Jones DT, Jack CR Jr, Iyer RK, Vemuri P. Deep learning identifies brain structures that predict cognition and explain heterogeneity in cognitive aging. Neuroimage. 2022 May 1; 251:119020 Epub 2022 Feb 20
View PubMed
Vaughan L, White WM, Tobah YSB, Kattah A, Parashuram S, Gunaratne MD, Vermunt JV, Mielke M, Milic NM, Suvakov S, Bielinski S, Chamberlain AM, Garovic VD. Cohort profile: the Olmsted County hypertensive disorders of pregnancy (HDP) cohort using the Rochester Epidemiology Project. BMJ Open. 2022 Apr 26; 12 (4):e055057
View PubMed
Sandness DJ, McCarter SJ, Dueffert LG, Shepard PW, Enke AM, Fields J, Mielke MM, Boeve BF, Silber MH, St Louis EK. Cognition and driving ability in isolated and symptomatic REM sleep behavior disorder. Sleep. 2022 Apr 11; 45 (4)
View PubMed
van Harten AC, Wiste HJ, Weigand SD, Mielke MM, Kremers WK, Eichenlaub U, Dyer RB, Algeciras-Schimnich A, Knopman DS, Jack CR Jr, Petersen RC. Detection of Alzheimer's disease amyloid beta 1-42, p-tau, and t-tau assays. Alzheimers Dement. 2022 Apr; 18 (4):635-644 Epub 2021 July 26
View PubMed
Mielke MM, Aakre JA, Algeciras-Schimnich A, Proctor NK, Machulda MM, Eichenlaub U, Knopman DS, Vemuri P, Graff-Radford J, Jack CR Jr, Petersen RC, Dage JL. Comparison of CSF phosphorylated tau 181 and 217 for cognitive decline. Alzheimers Dement. 2022 Apr; 18 (4):602-611 Epub 2021 July 26
View PubMed
Kara F, Joers JM, Deelchand DK, Park YW, Przybelski SA, Lesnick TG, Senjem ML, Zeydan B, Knopman DS, Lowe VJ, Vemuri P, Mielke MM, Machulda MM, Jack CR, Petersen RC, Oz G, Kantarci K. (1)H MR spectroscopy biomarkers of neuronal and synaptic function are associated with tau deposition in cognitively unimpaired older adults. Neurobiol Aging. 2022 Apr; 112:16-26 Epub 2022 Jan 05
View PubMed
Huo N, Smith CY, Gazzuola Rocca L, Rocca WA, Mielke MM. Risk of de novo cancer after premenopausal bilateral oophorectomy. Am J Obstet Gynecol. 2022 Apr; 226 (4):539.e1-539.e16 Epub 2021 Nov 10
View PubMed
Vassilaki M, Aakre JA, Kremers WK, Mielke MM, Geda YE, Machulda MM, Knopman DS, Vemuri P, Lowe VJ, Jack CR Jr, Roberson ED, Gerstenecker A, Martin RC, Kennedy RE, Marson DC, Petersen RC. Association of Performance on the Financial Capacity Instrument-Short Form With Brain Amyloid Load and Cortical Thickness in Older Adults. Neurol Clin Pract. 2022 Apr; 12 (2):113-124
View PubMed
Long KH, Smith C, Petersen R, Emerson J, Ransom J, Mielke MM, Hass S, Leibson C. Medical and nursing home costs: From cognitively unimpaired through dementia. Alzheimers Dement. 2022 Mar; 18 (3):393-407 Epub 2021 Sept 05
View PubMed
Huo N, Vemuri P, Graff-Radford J, Syrjanen J, Machulda M, Knopman DS, Jack CR Jr, Petersen R, Mielke MM. Sex Differences in the Association Between Midlife Cardiovascular Conditions or Risk Factors With Midlife Cognitive Decline. Neurology. 2022 Feb 8; 98 (6):e623-e632 Epub 2022 Jan 05
View PubMed
Raghavan S, Przybelski SA, Reid RI, Lesnick TG, Ramanan VK, Botha H, Matchett BJ, Murray ME, Reichard RR, Knopman DS, Graff-Radford J, Jones DT, Lowe VJ, Mielke MM, Machulda MM, Petersen RC, Kantarci K, Whitwell JL, Josephs KA, Jack CR Jr, Vemuri P. White matter damage due to vascular, tau, and TDP-43 pathologies and its relevance to cognition. Acta Neuropathol Commun. 2022 Feb 5; 10 (1):16 Epub 2022 Feb 05
View PubMed
Clouston SAP, Hall CB, Kritikos M, Bennett DA, DeKosky S, Edwards J, Finch C, Kreisl WC, Mielke M, Peskind ER, Raskind M, Richards M, Sloan RP, Spiro A 3rd, Vasdev N, Brackbill R, Farfel M, Horton M, Lowe S, Lucchini RG, Prezant D, Reibman J, Rosen R, Seil K, Zeig-Owens R, Deri Y, Diminich ED, Fausto BA, Gandy S, Sano M, Bromet EJ, Luft BJ. Cognitive impairment and World Trade Centre-related exposures. Nat Rev Neurol. 2022 Feb; 18 (2):103-116 Epub 2021 Nov 18
View PubMed
Graff-Radford J, Jones DT, Wiste HJ, Cogswell PM, Weigand SD, Lowe V, Elder BD, Vemuri P, Van Harten A, Mielke MM, Knopman DS, Graff-Radford NR, Petersen RC, Jack CR Jr, Gunter JL. Cerebrospinal fluid dynamics and discordant amyloid biomarkers. Neurobiol Aging. 2022 Feb; 110:27-36 Epub 2021 Nov 01
View PubMed
O'Bryant SE, Zhang F, Petersen M, Hall JR, Johnson LA, Yaffe K, Mason D, Braskie M, Barber RA, Rissman RA, Mapstone M, Mielke MM, Toga AW, HABLE Study Team. A blood screening tool for detecting mild cognitive impairment and Alzheimer's disease among community-dwelling Mexican Americans and non-Hispanic Whites: A method for increasing representation of diverse populations in clinical research. Alzheimers Dement. 2022 Jan; 18 (1):77-87 Epub 2021 May 31
View PubMed
Vassilaki M, Crowson CS, Davis Iii JM, Duong SQ, Jones DT, Nguyen A, Mielke MM, Vemuri P, Myasoedova E. Rheumatoid Arthritis, Cognitive Impairment, and Neuroimaging Biomarkers: Results from the Mayo Clinic Study of Aging. J Alzheimers Dis. 2022; 89 (3):943-954
View PubMed
Sperl MA, Esterov D, Ransom JE, Mielke MM, Witkowski JE, Brown AW. Long-Term Risk of Stroke after Traumatic Brain Injury: A Population-Based Medical Record Review Study. Neuroepidemiology. 2022; 56 (4):283-290 Epub 2022 May 25
View PubMed
Lachner C, Day GS, Camsari GB, Kouri N, Ertekin-Taner N, Boeve BF, Labuzan SA, Lucas JA, Thompson EA, Siddiqui H, Crook JE, Cabrera-Rodriguez JN, Josephs KA, Petersen RC, Dickson DW, Reichard RR, Mielke MM, Knopman DS, Graff-Radford NR, Murray ME. Cancer and Vascular Comorbidity Effects on Dementia Risk and Neuropathology in the Oldest-Old. J Alzheimers Dis. 2022; 90 (1):405-417
View PubMed
Lucien F, Benarroch EE, Mullan A, Ali F, Boeve BF, Mielke MM, Petersen RC, Kim Y, Stang C, Camerucci E, Ross OA, Wszolek ZK, Knopman D, Bower J, Singer W, Savica R. Poly (ADP-Ribose) and alpha-synuclein extracellular vesicles in patients with Parkinson disease: A possible biomarker of disease severity. PLoS One. 2022; 17 (4):e0264446 Epub 2022 Apr 08
View PubMed
McCarter SJ, Lesnick TG, Lowe VJ, Rabinstein AA, Przybelski SA, Algeciras-Schimnich A, Ramanan VK, Jack CR, Petersen RC, Knopman DS, Boeve BF, Kantarci K, Vemuri P, Mielke MM, Graff-Radford J. Association Between Plasma Biomarkers of Amyloid, Tau, and Neurodegeneration with Cerebral Microbleeds. J Alzheimers Dis. 2022; 87 (4):1537-1547
View PubMed
Mielke MM, Ransom JE, Mandrekar J, Turcano P, Savica R, Brown AW. Traumatic Brain Injury and Risk of Alzheimer's Disease and Related Dementias in the Population. J Alzheimers Dis. 2022; 88 (3):1049-1059
View PubMed
Shen X, Raghavan S, Przybelski SA, Lesnick TG, Ma S, Reid RI, Graff-Radford J, Mielke MM, Knopman DS, Petersen RC, Jack CR Jr, Simon GJ, Vemuri P. Causal structure discovery identifies risk factors and early brain markers related to evolution of white matter hyperintensities. Neuroimage Clin. 2022; 35:103077 Epub 2022 June 07
View PubMed
Bretzman JP, Tseng AS, Graff-Radford J, Lee HC, Asirvatham SJ, Mielke MM, Knopman DS, Petersen RC, Jack CR Jr, Vemuri P, Rabinstein AA, DeSimone CV. Silent cerebral infarcts in patients with atrial fibrillation: Clinical implications of an imaging-adjusted CHA2DS2-VASc score. Cardiol J. 2022; 29 (5):766-772 Epub 2022 June 15
View PubMed
Alden EC, Lundt ES, Twohy EL, Christianson TJ, Kremers WK, Machulda MM, Jack CR Jr, Knopman DS, Mielke MM, Petersen RC, Stricker NH. Mayo normative studies: A conditional normative model for longitudinal change on the Auditory Verbal Learning Test and preliminary validation in preclinical Alzheimer's disease. Alzheimers Dement (Amst). 2022; 14 (1):e12325 Epub 2022 July 15
View PubMed
Carvalho DZ, St Louis EK, Przybelski SA, Morgenthaler TI, Machulda MM, Boeve BF, Petersen RC, Jack CR Jr, Graff-Radford J, Vemuri P, Mielke MM. Sleepiness in Cognitively Unimpaired Older Adults Is Associated With CSF Biomarkers of Inflammation and Axonal Integrity. Front Aging Neurosci. 2022; 14:930315 Epub 2022 July 11
View PubMed
Stricker NH, Stricker JL, Karstens AJ, Geske JR, Fields JA, Hassenstab J, Schwarz CG, Tosakulwong N, Wiste HJ, Jack CR Jr, Kantarci K, Mielke MM. A novel computer adaptive word list memory test optimized for remote assessment: Psychometric properties and associations with neurodegenerative biomarkers in older women without dementia. Alzheimers Dement (Amst). 2022; 14 (1):e12299 Epub 2022 Mar 09
View PubMed
Jack CR Jr, Therneau TM, Lundt ES, Wiste HJ, Mielke MM, Knopman DS, Graff-Radford J, Lowe VJ, Vemuri P, Schwarz CG, Senjem ML, Gunter JL, Petersen RC. Long-term associations between amyloid positron emission tomography, sex, apolipoprotein E and incident dementia and mortality among individuals without dementia: hazard ratios and absolute risk. Brain Commun. 2022; 4 (2):fcac017 Epub 2022 Feb 02
View PubMed
Stang CD, Mullan AF, Camerucci E, Hajeb M, Turcano P, Martin P, Mielke MM, Josephs KA, Splett M, Abler V, Boeve BF, Bower JH, Savica R. Incidence, Prevalence, and Mortality of Psychosis Associated with Parkinson's Disease (1991-2010). J Parkinsons Dis. 2022; 12 (4):1319-1327
View PubMed
Shir D, Graff-Radford J, Hofrenning EI, Lesnick TG, Przybelski SA, Lowe VJ, Knopman DS, Petersen RC, Jack CR Jr, Vemuri P, Algeciras-Schimnich A, Campbell MR, Stricker NH, Mielke MM. Association of plasma glial fibrillary acidic protein (GFAP) with neuroimaging of Alzheimer's disease and vascular pathology. Alzheimers Dement (Amst). 2022; 14 (1):e12291 Epub 2022 Feb 28
View PubMed
Teunissen CE, Verberk IMW, Thijssen EH, Vermunt L, Hansson O, Zetterberg H, van der Flier WM, Mielke MM, Del Campo M. Blood-based biomarkers for Alzheimer's disease: towards clinical implementation. Lancet Neurol. 2022 Jan; 21 (1):66-77 Epub 2021 Nov 24
View PubMed
Marks JD, Syrjanen JA, Graff-Radford J, Petersen RC, Machulda MM, Campbell MR, Algeciras-Schimnich A, Lowe V, Knopman DS, Jack CR Jr, Vemuri P, Mielke MM, Alzheimer's Disease Neuroimaging Initiative. Comparison of plasma neurofilament light and total tau as neurodegeneration markers: associations with cognitive and neuroimaging outcomes. Alzheimers Res Ther. 2021 Dec 14; 13 (1):199
View PubMed
Krell-Roesch J, Syrjanen JA, Rakusa M, Vemuri P, Machulda MM, Kremers WK, Mielke MM, Lowe VJ, Jack CR Jr, Knopman DS, Stokin GB, Petersen RC, Vassilaki M, Geda YE. Association of Cortical and Subcortical beta-Amyloid With Standardized Measures of Depressive and Anxiety Symptoms in Adults Without Dementia. J Neuropsychiatry Clin Neurosci. 2021 Winter; 33 (1):64-71 Epub 2020 Oct 22
View PubMed
Morgan DG, Mielke MM. Knowledge gaps in Alzheimer's disease immune biomarker research. Alzheimers Dement. 2021 Dec; 17 (12):2030-2042 Epub 2021 May 13
View PubMed
Ibrahim OA, Fu S, Vassilaki M, Petersen RC, Mielke MM, St Sauver J, Sohn S. Early Alert of Elderly Cognitive Impairment using Temporal Streaming Clustering. Proceedings (IEEE Int Conf Bioinformatics Biomed). 2021 Dec; 2021:905-912
View PubMed
Winham SJ, Mielke MM. What about sex? Nat Metab 2021 Dec; 3 (12):1586-1588
View PubMed
Therneau TM, Knopman DS, Lowe VJ, Botha H, Graff-Radford J, Jones DT, Vemuri P, Mielke MM, Schwarz CG, Senjem ML, Gunter JL, Petersen RC, Jack CR Jr. Relationships between beta-amyloid and tau in an elderly population: An accelerated failure time model. Neuroimage. 2021 Nov 15; 242:118440 Epub 2021 July 29
View PubMed
McCarter SJ, Lesnick TG, Lowe V, Mielke MM, Constantopoulos E, Rabinstein AA, Przybelski SA, Botha H, Jones DT, Ramanan VK, Jack CR, Petersen RC, Knopman D, Boeve BF, Murray ME, Dickson DW, Vemuri P, Kantarci K, Reichard RR, Graff-Radford J. Cerebral Amyloid Angiopathy Pathology and Its Association With Amyloid-beta PET Signal. Neurology. 2021 Nov 2; 97 (18):e1799-e1808 Epub 2021 Sept 09
View PubMed
Rocca WA, Lohse CM, Smith CY, Fields JA, Machulda MM, Mielke MM. Association of Premenopausal Bilateral Oophorectomy With Cognitive Performance and Risk of Mild Cognitive Impairment. JAMA Netw Open. 2021 Nov 1; 4 (11):e2131448 Epub 2021 Nov 01
View PubMed
Mielke MM, Miller VM. Improving clinical outcomes through attention to sex and hormones in research. Nat Rev Endocrinol. 2021 Oct; 17 (10):625-635 Epub 2021 July 27
View PubMed
Rocca WA, Mielke MM, Gazzuola Rocca L, Stewart EA. Premature or early bilateral oophorectomy: a 2021 update. Climacteric. 2021 Oct; 24 (5):466-473 Epub 2021 Mar 15
View PubMed
Sullivan KJ, Blackshear C, Simino J, Tin A, Walker KA, Sharrett AR, Younkin S, Gottesman RF, Mielke MM, Knopman D, Windham BG, Griswold ME, Mosley TH. Association of Midlife Plasma Amyloid-beta Levels With Cognitive Impairment in Late Life: The ARIC Neurocognitive Study. Neurology. 2021 Sep 14; 97 (11):e1123-e1131 Epub 2021 Aug 04
View PubMed
Sprung J, Laporta M, Knopman DS, Petersen RC, Mielke MM, Weingarten TN, Vassilaki M, Martin DP, Schulte PJ, Hanson AC, Schroeder DR, Vemuri P, Warner DO. Gait Speed and Instrumental Activities of Daily Living in Older Adults After Hospitalization: A Longitudinal Population-Based Study. J Gerontol A Biol Sci Med Sci. 2021 Sep 13; 76 (10):e272-e280
View PubMed
Dugani SB, Christenson LR, Aakre JA, Bui HH, Vella A, Mielke MM. Association of plasma ceramides with prevalent and incident type 2 diabetes mellitus in middle and older aged adults. Diabetes Res Clin Pract. 2021 Sep; 179:108991 Epub 2021 July 29
View PubMed
Mielke MM, Frank RD, Dage JL, Jeromin A, Ashton NJ, Blennow K, Karikari TK, Vanmechelen E, Zetterberg H, Algeciras-Schimnich A, Knopman DS, Lowe V, Bu G, Vemuri P, Graff-Radford J, Jack CR Jr, Petersen RC. Comparison of Plasma Phosphorylated Tau Species With Amyloid and Tau Positron Emission Tomography, Neurodegeneration, Vascular Pathology, and Cognitive Outcomes. JAMA Neurol. 2021 Sep 1; 78 (9):1108-1117
View PubMed
Krell-Roesch J, Syrjanen JA, Machulda MM, Christianson TJ, Kremers WK, Mielke MM, Knopman DS, Petersen RC, Vassilaki M, Geda YE. Neuropsychiatric symptoms and the outcome of cognitive trajectories in older adults free of dementia: The Mayo Clinic Study of Aging. Int J Geriatr Psychiatry. 2021 Sep; 36 (9):1362-1369 Epub 2021 Mar 24
View PubMed
Kronzer VL, Crowson CS, Davis JM 3rd, Vassilaki M, Mielke MM, Myasoedova E. Trends in incidence of dementia among patients with rheumatoid arthritis: A population-based cohort study. Semin Arthritis Rheum. 2021 Aug; 51 (4):853-857 Epub 2021 June 15
View PubMed
Dugani SB, Mielke MM, Vella A. Burden and management of type 2 diabetes in rural United States. Diabetes Metab Res Rev. 2021 Jul; 37 (5):e3410 Epub 2020 Oct 05
View PubMed
Graff-Radford J, Lesnick T, Rabinstein AA, Gunter JL, Przybelski SA, Noseworthy PA, Preboske GM, Mielke MM, Lowe VJ, Knopman DS, Petersen RC, Kremers WK, Jack CR Jr, Vemuri P, Kantarci K. Cerebral Microbleeds: Relationship to Antithrombotic Medications. Stroke. 2021 Jul; 52 (7):2347-2355 Epub 2021 May 10
View PubMed
Petersen RC, Wiste HJ, Weigand SD, Fields JA, Geda YE, Graff-Radford J, Knopman DS, Kremers WK, Lowe V, Machulda MM, Mielke MM, Stricker NH, Therneau TM, Vemuri P, Jack CR Jr. NIA-AA Alzheimer's Disease Framework: Clinical Characterization of Stages. Ann Neurol. 2021 Jun; 89 (6):1145-1156 Epub 2021 Apr 06
View PubMed
Shelly S, Mielke MM, Mandrekar J, Milone M, Ernste FC, Naddaf E, Liewluck T. Epidemiology and Natural History of Inclusion Body Myositis: A 40-Year Population-Based Study. Neurology. 2021 May 25; 96 (21):e2653-e2661 Epub 2021 Apr 20
View PubMed
Mielke MM, Przybelski SA, Lesnick TG, Kern S, Zetterberg H, Blennow K, Knopman DS, Graff-Radford J, Petersen RC, Jack CR Jr, Vemuri P. Comparison of CSF neurofilament light chain, neurogranin, and tau to MRI markers. Alzheimers Dement. 2021 May; 17 (5):801-812 Epub 2021 Mar 04
View PubMed
Lerche S, Schulte C, Wurster I, Machetanz G, Roeben B, Zimmermann M, Deuschle C, Hauser AK, Bohringer J, Krageloh-Mann I, Waniek K, Lachmann I, Petterson XT, Chiang R, Park H, Wang B, Liepelt-Scarfone I, Maetzler W, Galasko D, Scherzer CR, Gasser T, Mielke MM, Hutten SJ, Mollenhauer B, Sardi SP, Berg D, Brockmann K. The Mutation Matters: CSF Profiles of GCase, Sphingolipids, alpha-Synuclein in PDGBA. Mov Disord. 2021 May; 36 (5):1216-1228 Epub 2021 Feb 06
View PubMed
Dugani SB, Girardo ME, De Filippis E, Mielke MM, Vella A. Risk Factors and Wellness Measures Associated with Prediabetes and Newly Diagnosed Type 2 Diabetes Mellitus in Hispanic Adults. Metab Syndr Relat Disord. 2021 Apr; 19 (3):180-189 Epub 2021 Jan 15
View PubMed
Alden EC, Pudumjee SB, Lundt ES, Albertson SM, Machulda MM, Kremers WK, Jack CR Jr, Knopman DS, Petersen RC, Mielke MM, Stricker NH. Diagnostic accuracy of the Cogstate Brief Battery for prevalent MCI and prodromal AD (MCI A(+) T(+) ) in a population-based sample. Alzheimers Dement. 2021 Apr; 17 (4):584-594 Epub 2021 Mar 01
View PubMed
Sprung J, Warner DO, Knopman DS, Petersen RC, Mielke MM, Jack CR Jr, Martin DP, Hanson AC, Schroeder DR, Przybelski SA, Schulte PJ, Laporta ML, Weingarten TN, Vemuri P. Brain MRI after critical care admission: A longitudinal imaging study. J Crit Care. 2021 Apr; 62:117-123 Epub 2020 Dec 05
View PubMed
Ramanan VK, Lesnick TG, Przybelski SA, Heckman MG, Knopman DS, Graff-Radford J, Lowe VJ, Machulda MM, Mielke MM, Jack CR Jr, Petersen RC, Ross OA, Vemuri P, Alzheimer's Disease Neuroimaging Initiative (ADNI). Coping with brain amyloid: genetic heterogeneity and cognitive resilience to Alzheimer's pathophysiology. Acta Neuropathol Commun. 2021 Mar 23; 9 (1):48
View PubMed
Stricker NH, Christianson TJ, Lundt ES, Alden EC, Machulda MM, Fields JA, Kremers WK, Jack CR, Knopman DS, Mielke MM, Petersen RC. Mayo Normative Studies: Regression-Based Normative Data for the Auditory Verbal Learning Test for Ages 30-91 Years and the Importance of Adjusting for Sex. J Int Neuropsychol Soc. 2021 Mar; 27 (3):211-226 Epub 2020 Aug 20
View PubMed
Sprung J, Knopman DS, Petersen RC, Mielke MM, Weingarten TN, Vassilaki M, Martin DP, Schulte PJ, Hanson AC, Schroeder DR, Laporta ML, White RJ, Vemuri P, Warner DO. Association of Hospitalization with Long-Term Cognitive Trajectories in Older Adults. J Am Geriatr Soc. 2021 Mar; 69 (3):660-668 Epub 2020 Oct 31
View PubMed
Crivelli SM, Luo Q, Stevens JAA, Giovagnoni C, van Kruining D, Bode G, den Hoedt S, Hobo B, Scheithauer AL, Walter J, Mulder MT, Exley C, Mold M, Mielke MM, De Vries HE, Wouters K, van den Hove DLA, Berkes D, Ledesma MD, Verhaagen J, Losen M, Bieberich E, Martinez-Martinez P. CERT(L) reduces C16 ceramide, amyloid-beta levels, and inflammation in a model of Alzheimer's disease. Alzheimers Res Ther. 2021 Feb 17; 13 (1):45
View PubMed
Krell-Roesch J, Syrjanen JA, Vassilaki M, Lowe VJ, Vemuri P, Mielke MM, Machulda MM, Stokin GB, Christianson TJ, Kremers WK, Jack CR Jr, Knopman DS, Petersen RC, Geda YE. Brain Regional Glucose Metabolism, Neuropsychiatric Symptoms, and the Risk of Incident Mild Cognitive Impairment: The Mayo Clinic Study of Aging. Am J Geriatr Psychiatry. 2021 Feb; 29 (2):179-191 Epub 2020 June 17
View PubMed
Knopman DS, Lundt ES, Therneau TM, Albertson SM, Gunter JL, Senjem ML, Schwarz CG, Mielke MM, Machulda MM, Boeve BF, Jones DT, Graff-Radford J, Vemuri P, Kantarci K, Lowe VJ, Petersen RC, Jack CR Jr, Alzheimer's Disease Neuroimaging Initiative. Association of Initial beta-Amyloid Levels With Subsequent Flortaucipir Positron Emission Tomography Changes in Persons Without Cognitive Impairment. JAMA Neurol. 2021 Feb 1; 78 (2):217-228
View PubMed
Stang CD, Mullan AF, Hajeb M, Camerucci E, Turcano P, Martin P, Mielke MM, Josephs KA, Bower JH, St Louis EK, Boeve BF, Savica R. Timeline of Rapid Eye Movement Sleep Behavior Disorder in Overt Alpha-Synucleinopathies. Ann Neurol. 2021 Feb; 89 (2):293-303 Epub 2020 Nov 20
View PubMed
Huo N, Smith CY, Gazzuola Rocca L, Rocca WA, Mielke MM. Association of Premenopausal Bilateral Oophorectomy With Restless Legs Syndrome. JAMA Netw Open. 2021 Feb 1; 4 (2):e2036058 Epub 2021 Feb 01
View PubMed
Daniels RD, Clouston SAP, Hall CB, Anderson KR, Bennett DA, Bromet EJ, Calvert GM, Carreon T, DeKosky ST, Diminich ED, Finch CE, Gandy S, Kreisl WC, Kritikos M, Kubale TL, Mielke MM, Peskind ER, Raskind MA, Richards M, Sano M, Santiago-Colon A, Sloan RP, Spiro A 3rd, Vasdev N, Luft BJ, Reissman DB. A Workshop on Cognitive Aging and Impairment in the 9/11-Exposed Population. Int J Environ Res Public Health. 2021 Jan 14; 18 (2)
View PubMed
Enders FT, Golembiewski EH, Pacheco-Spann LM, Allyse M, Mielke MM, Balls-Berry JE. Building a framework for inclusion in health services research: Development of and pre-implementation faculty and staff attitudes toward the Diversity, Equity, and Inclusion (DEI) plan at Mayo Clinic. J Clin Transl Sci. 2021 Jan 5; 5 (1):e88 Epub 2021 Jan 05
View PubMed
Cogswell PM, Wiste HJ, Senjem ML, Gunter JL, Weigand SD, Schwarz CG, Arani A, Therneau TM, Lowe VJ, Knopman DS, Botha H, Graff-Radford J, Jones DT, Kantarci K, Vemuri P, Boeve BF, Mielke MM, Petersen RC, Jack CR Jr. Associations of quantitative susceptibility mapping with Alzheimer's disease clinical and imaging markers. Neuroimage. 2021 Jan 1; 224:117433 Epub 2020 Oct 06
View PubMed
Krell-Roesch J, Syrjanen JA, Bezold J, Trautwein S, Barisch-Fritz B, Boes K, Woll A, Forzani E, Kremers WK, Machulda MM, Mielke MM, Knopman DS, Petersen RC, Vassilaki M, Geda YE. Physical Activity and Trajectory of Cognitive Change in Older Persons: Mayo Clinic Study of Aging. J Alzheimers Dis. 2021; 79 (1):377-388
View PubMed
Alonso-Quiñones H, Stish BJ, Aakre JA, Hagen CE, Petersen RC, Mielke MM. Androgen Deprivation Therapy Use and Risk of Mild Cognitive Impairment in Prostate Cancer Patients. Alzheimer Dis Assoc Disord. 2021 Jan-Mar 01; 35(1):44-47.
View PubMed
Raghavan S, Reid RI, Przybelski SA, Lesnick TG, Graff-Radford J, Schwarz CG, Knopman DS, Mielke MM, Machulda MM, Petersen RC, Jack CR Jr, Vemuri P. Diffusion models reveal white matter microstructural changes with ageing, pathology and cognition. Brain Commun. 2021; 3 (2):fcab106 Epub 2021 May 19
View PubMed
Pudumjee SB, Lundt ES, Albertson SM, Machulda MM, Kremers WK, Jack CR, Knopman DS, Petersen RC, Mielke MM, Stricker NH. A Comparison of Cross-Sectional and Longitudinal Methods of Defining Objective Subtle Cognitive Decline in Preclinical Alzheimer's Disease Based on Cogstate One Card Learning Accuracy Performance. J Alzheimers Dis. 2021; 83 (2):861-877
View PubMed
Campbell MR, Ashrafzadeh-Kian S, Petersen RC, Mielke MM, Syrjanen JA, van Harten AC, Lowe VJ, Jack CR Jr, Bornhorst JA, Algeciras-Schimnich A. P-tau/Abeta42 and Abeta42/40 ratios in CSF are equally predictive of amyloid PET status. Alzheimers Dement (Amst). 2021; 13 (1):e12190 Epub 2021 May 18
View PubMed
Poulakis K, Reid RI, Przybelski SA, Knopman DS, Graff-Radford J, Lowe VJ, Mielke MM, Machulda MM, Jack CR Jr, Petersen RC, Westman E, Vemuri P. Longitudinal deterioration of white-matter integrity: heterogeneity in the ageing population. Brain Commun. 2021; 3 (1):fcaa238 Epub 2021 Jan 22
View PubMed
Skillback T, Blennow K, Zetterberg H, Shams S, Machado A, Pereira J, Lindberg O, Mielke MM, Zettergren A, Ryden L, Westman E, Wahlund LO, Skoog I, Kern S. Sex differences in CSF biomarkers for neurodegeneration and blood-brain barrier integrity. Alzheimers Dement (Amst). 2021; 13 (1):e12141 Epub 2021 Mar 17
View PubMed
Vemuri P, Graff-Radford J, Lesnick TG, Przybelski SA, Reid RI, Reddy AL, Lowe VJ, Mielke MM, Machulda MM, Petersen RC, Knopman DS, Jack CR Jr. White matter abnormalities are key components of cerebrovascular disease impacting cognitive decline. Brain Commun. 2021; 3 (2):fcab076 Epub 2021 Apr 12
View PubMed
Raghavan S, Graff-Radford J, Scharf E, Przybelski SA, Lesnick TG, Gregg B, Schwarz CG, Gunter JL, Zuk SM, Rabinstein A, Mielke MM, Petersen RC, Knopman DS, Kantarci K, Jack CR Jr, Vemuri P. Study of Symptomatic vs. Silent Brain Infarctions on MRI in Elderly Subjects. Front Neurol. 2021; 12:615024 Epub 2021 Feb 17
View PubMed
Camerucci E, Stang CD, Hajeb M, Turcano P, Mullan AF, Martin P, Ross OA, Bower JH, Mielke MM, Savica R. Early-Onset Parkinsonism and Early-Onset Parkinson's Disease: A Population-Based Study (2010-2015). J Parkinsons Dis. 2021; 11 (3):1197-1207
View PubMed
Graff-Radford J, Lesnick TG, Mielke MM, Constantopoulos E, Rabinstein AA, Przybelski SA, Vemuri P, Botha H, Jones DT, Ramanan VK, Petersen RC, Knopman DS, Boeve BF, Murray ME, Dickson DW, Jack CR, Kantarci K, Reichard RR. Cerebral Amyloid Angiopathy Burden and Cerebral Microbleeds: Pathological Evidence for Distinct Phenotypes. J Alzheimers Dis. 2021; 81 (1):113-122
View PubMed
Wang X, Bui H, Vemuri P, Graff-Radford J, Jack CR Jr, Petersen RC, Mielke MM. Lipidomic Network of Mild Cognitive Impairment from the Mayo Clinic Study of Aging. J Alzheimers Dis. 2021; 81 (2):533-543
View PubMed
Jayachandran M, Miller VM, Lahr BD, Bailey KR, Lowe VJ, Fields JA, Mielke MM, Kantarci K. Peripheral Markers of Neurovascular Unit Integrity and Amyloid-beta in the Brains of Menopausal Women. J Alzheimers Dis. 2021; 80 (1):397-405
View PubMed
Li D, Zhang L, Nelson NW, Mielke MM, Yu F. Plasma Neurofilament Light and Future Declines in Cognition and Function in Alzheimer's Disease in the FIT-AD Trial. J Alzheimers Dis Rep. 2021; 5 (1):601-611 Epub 2021 July 21
View PubMed
Machulda MM, Lundt ES, Mester CT, Albertson SM, Raghavan S, Reid RI, Schwarz CG, Graff-Radford J, Jack CR Jr, Knopman DS, Mielke MM, Kremers WK, Petersen RC, Bondi MW, Vemuri P. White matter changes in empirically derived incident MCI subtypes in the Mayo Clinic Study of Aging. Alzheimers Dement (Amst). 2021; 13 (1):e12269 Epub 2021 Dec 31
View PubMed
Chusyd DE, Ackermans NL, Austad SN, Hof PR, Mielke MM, Sherwood CC, Allison DB. Aging: What We Can Learn From Elephants. Front Aging. 2021; 2:726714 Epub 2021 Aug 26
View PubMed
Najar J, Aakre JA, Vassilaki M, Wetterberg H, Ryden L, Zettergren A, Skoog I, Jack CR, Knopman DS, Petersen RC, Kern S, Mielke MM. Sex Difference in the Relation Between Marital Status and Dementia Risk in Two Population-Based Cohorts. J Alzheimers Dis. 2021; 83 (3):1269-1279
View PubMed
Raghavan S, Przybelski SA, Reid RI, Graff-Radford J, Lesnick TG, Zuk SM, Knopman DS, Machulda MM, Mielke MM, Petersen RC, Jack CR Jr, Vemuri P. Reduced fractional anisotropy of the genu of the corpus callosum as a cerebrovascular disease marker and predictor of longitudinal cognition in MCI. Neurobiol Aging. 2020 Dec; 96:176-183 Epub 2020 Sept 08
View PubMed
Christopoulos G, Graff-Radford J, Lopez CL, Yao X, Attia ZI, Rabinstein AA, Petersen RC, Knopman DS, Mielke MM, Kremers W, Vemuri P, Siontis KC, Friedman PA, Noseworthy PA. Artificial Intelligence-Electrocardiography to Predict Incident Atrial Fibrillation: A Population-Based Study. Circ Arrhythm Electrophysiol. 2020 Dec; 13 (12):e009355 Epub 2020 Nov 13
View PubMed
Ighodaro ET, Graff-Radford J, Syrjanen JA, Bui HH, Petersen RC, Knopman DS, Jack CR Jr, Zuk SM, Vemuri P, Mielke MM. Associations Between Plasma Ceramides and Cerebral Microbleeds or Lacunes. Arterioscler Thromb Vasc Biol. 2020 Nov; 40 (11):2785-2793 Epub 2020 Sept 03
View PubMed
Jack CR, Wiste HJ, Weigand SD, Therneau TM, Lowe VJ, Knopman DS, Botha H, Graff-Radford J, Jones DT, Ferman TJ, Boeve BF, Kantarci K, Vemuri P, Mielke MM, Whitwell J, Josephs K, Schwarz CG, Senjem ML, Gunter JL, Petersen RC. Predicting future rates of tau accumulation on PET. Brain. 2020 Oct 1; 143 (10):3136-3150
View PubMed
Li D, Hagen C, Bui HH, Knopman D, Jack CR, Machulda M, Petersen RC, Mielke MM. Associations between cerebrospinal fluid total phosphatidylcholines, neurodegeneration, cognitive decline, and risk of mild cognitive impairment in the Mayo Clinic Study of Aging. Neurobiol Aging. 2020 Sep; 93:52-54 Epub 2020 Apr 28
View PubMed
Hasan S, Mielke MM, Ahlskog JE, Bower J, Turcano P, Savica R. Infections or Sepsis Preceding Clinically Diagnosed alpha-Synucleinopathies: A Case-Control Study. Mov Disord. 2020 Sep; 35 (9):1684-1689 Epub 2020 June 01
View PubMed
Devick KL, Sprung J, Mielke M, Petersen RC, Schulte PJ. Association between surgery with anesthesia and cognitive decline in older adults: Analysis using shared parameter models for informative dropout. J Clin Transl Sci. 2020 Aug 4; 5 (1):e27 Epub 2020 Aug 04
View PubMed
Sprung J, Abcejo ASA, Knopman DS, Petersen RC, Mielke MM, Hanson AC, Schroeder DR, Schulte PJ, Martin DP, Weingarten TN, Pasternak JJ, Warner DO. Anesthesia With and Without Nitrous Oxide and Long-term Cognitive Trajectories in Older Adults. Anesth Analg. 2020 Aug; 131 (2):594-604
View PubMed
Faubion L, White TA, Peterson BJ, Geske JR, LeBrasseur NK, Schafer MJ, Mielke MM, Miller VM. Effect of menopausal hormone therapy on proteins associated with senescence and inflammation. Physiol Rep. 2020 Aug; 8 (16):e14535
View PubMed
Van Harten AC, Wiste HJ, Weigand SD, Mielke MM, Kremers WK, Eichenlaub U, Batrla-Utermann R, Dyer RB, Algeciras-Schimnich A, Knopman DS, Jack CR Jr, Petersen RC. CSF biomarkers in Olmsted County: Evidence of 2 subclasses and associations with demographics. Neurology. 2020 Jul 21; 95 (3):e256-e267 Epub 2020 June 26
View PubMed
Machulda MM, Lundt ES, Albertson SM, Spychalla AJ, Schwarz CG, Mielke MM, Jack CR Jr, Kremers WK, Vemuri P, Knopman DS, Jones DT, Bondi MW, Petersen RC. Cortical atrophy patterns of incident MCI subtypes in the Mayo Clinic Study of Aging. Alzheimers Dement. 2020 Jul; 16 (7):1013-1022 Epub 2020 May 17
View PubMed
Vassilaki M, Syrjanen JA, Kremers WK, Hagen PT, Knopman DS, Mielke MM, Geda YE, Alhurani RE, Machulda MM, Roberts RO, Petersen RC. Medical Doctors and Dementia: A Longitudinal Study. J Am Geriatr Soc. 2020 Jun; 68 (6):1250-1255 Epub 2020 Feb 22
View PubMed
Graff-Radford J, Aakre JA, Knopman DS, Schwarz CG, Flemming KD, Rabinstein AA, Gunter JL, Ward CP, Zuk SM, Spychalla AJ, Preboske GM, Petersen RC, Kantarci K, Huston J 3rd, Jack CR Jr, Mielke MM, Vemuri P. Prevalence and Heterogeneity of Cerebrovascular Disease Imaging Lesions. Mayo Clin Proc. 2020 Jun; 95 (6):1195-1205
View PubMed
Garovic VD, White WM, Vaughan L, Saiki M, Parashuram S, Garcia-Valencia O, Weissgerber TL, Milic N, Weaver A, Mielke MM. Incidence and Long-Term Outcomes of Hypertensive Disorders of Pregnancy. J Am Coll Cardiol. 2020 May 12; 75 (18):2323-2334
View PubMed
Sprung J, Warner DO, Knopman DS, Petersen RC, Mielke MM, Jack CR Jr, Lowe VJ, Martin DP, Hanson AC, Schroeder DR, Przybelski SA, Schulte PJ, Weingarten TN, Vemuri P. Exposure to surgery with general anaesthesia during adult life is not associated with increased brain amyloid deposition in older adults. Br J Anaesth. 2020 May; 124 (5):594-602 Epub 2020 Mar 12
View PubMed
Carvalho DZ, St Louis EK, Schwarz CG, Lowe VJ, Boeve BF, Przybelski SA, Reddy A, Mielke MM, Knopman DS, Petersen RC, Jack CR Jr, Vemuri P. Witnessed apneas are associated with elevated tau-PET levels in cognitively unimpaired elderly. Neurology. 2020 Apr 28; 94 (17):e1793-e1802 Epub 2020 Mar 26
View PubMed
Arenaza-Urquijo EM, Przybelski SA, Machulda MM, Knopman DS, Lowe VJ, Mielke MM, Reddy AL, Geda YE, Jack CR Jr, Petersen RC, Vemuri P. Better stress coping associated with lower tau in amyloid-positive cognitively unimpaired older adults. Neurology. 2020 Apr 14; 94 (15):e1571-e1579 Epub 2020 Jan 21
View PubMed
Zeydan B, Lowe VJ, Reichard RR, Przybelski SA, Lesnick TG, Schwarz CG, Senjem ML, Gunter JL, Parisi JE, Machulda MM, Vemuri P, Mielke MM, Knopman DS, Petersen RC, Jack CR Jr, Kantarci OH, Kantarci K. Imaging Biomarkers of Alzheimer Disease in Multiple Sclerosis. Ann Neurol. 2020 Apr; 87 (4):556-567 Epub 2020 Feb 08
View PubMed
McCarter SJ, Stang C, Turcano P, Mielke MM, Ali F, Bower JH, Savica R. Higher vitamin B12 level at Parkinson's disease diagnosis is associated with lower risk of future dementia. Parkinsonism Relat Disord. 2020 Apr; 73:19-22 Epub 2020 Mar 16
View PubMed
Alonso Quinones HJ, Stish BJ, Hagen C, Petersen RC, Mielke MM. Prostate Cancer, Use of Androgen Deprivation Therapy, and Cognitive Impairment: A Population-based Study. Alzheimer Dis Assoc Disord. 2020 Apr-Jun; 34 (2):118-121
View PubMed
Turcano P, Stang CD, Bower JH, Ahlskog JE, Boeve BF, Mielke MM, Savica R. Levodopa-induced dyskinesia in dementia with Lewy bodies and Parkinson disease with dementia. Neurol Clin Pract. 2020 Apr; 10 (2):156-161
View PubMed
Vassilaki M, Aakre JA, Kremers WK, Lesnick TG, Mielke MM, Geda YE, Machulda MM, Knopman DS, Butler L, Traber M, Vemuri P, Lowe VJ, Jack CR Jr, Roberts RO, Petersen RC. Brain amyloid, cortical thickness, and changes in activities of daily living. Ann Clin Transl Neurol. 2020 Apr; 7 (4):474-485 Epub 2020 Apr 21
View PubMed
Saleem M, Herrmann N, Dinoff A, Marzolini S, Mielke MM, Andreazza A, Oh PI, Vattem Venkata SL, Haughey NJ, Lanctot KL. Association Between Sphingolipids and Cardiopulmonary Fitness in Coronary Artery Disease Patients Undertaking Cardiac Rehabilitation. J Gerontol A Biol Sci Med Sci. 2020 Mar 9; 75 (4):671-679
View PubMed
Turcano P, Stang CD, Mielke MM, Martin PR, Upadhyaya SG, Josephs KA, Boeve BF, Knopman DS, Petersen RC, Savica R. Incidence of frontotemporal disorders in Olmsted County: A population-based study. Alzheimers Dement. 2020 Mar; 16 (3):482-490 Epub 2020 Jan 04
View PubMed
Hasan S, Mielke MM, Turcano P, Ahlskog JE, Bower JH, Savica R. Traumatic brain injury preceding clinically diagnosed alpha-synucleinopathies: A case-control study. Neurology. 2020 Feb 25; 94 (8):e764-e773 Epub 2020 Jan 28
View PubMed
Tian Q, Resnick SM, Mielke MM, Yaffe K, Launer LJ, Jonsson PV, Grande G, Welmer AK, Laukka EJ, Bandinelli S, Cherubini A, Rosano C, Kritchevsky SB, Simonsick EM, Studenski SA, Ferrucci L. Association of Dual Decline in Memory and Gait Speed With Risk for Dementia Among Adults Older Than 60 Years: A Multicohort Individual-Level Meta-analysis. JAMA Netw Open. 2020 Feb 5; 3 (2):e1921636 Epub 2020 Feb 05
View PubMed
Graff-Radford J, Lesnick T, Rabinstein AA, Gunter J, Aakre J, Przybelski SA, Spychalla AJ, Huston J 3rd, Brown RD Jr, Mielke MM, Lowe VJ, Knopman DS, Petersen RC, Jack CR Jr, Vemuri P, Kremers W, Kantarci K. Cerebral microbleed incidence, relationship to amyloid burden: The Mayo Clinic Study of Aging. Neurology. 2020 Jan 14; 94 (2):e190-e199 Epub 2019 Dec 04
View PubMed
McCarter SJ, Tabatabai GM, Jong HY, Sandness DJ, Timm PC, Johnson KL, McCarter AR, Savica R, Vemuri P, Machulda MM, Kantarci K, Mielke MM, Boeve BF, Silber MH, St Louis EK. REM sleep atonia loss distinguishes synucleinopathy in older adults with cognitive impairment. Neurology. 2020 Jan 7; 94 (1):e15-e29 Epub 2019 Dec 12
View PubMed
Li D, Mielke MM, Bell WR, Reilly C, Zhang L, Lin FV, Yu F. Blood biomarkers as surrogate endpoints of treatment responses to aerobic exercise and cognitive training (ACT) in amnestic mild cognitive impairment: the blood biomarkers study protocol of a randomized controlled trial (the ACT Trial). Trials. 2020 Jan 6; 21 (1):19 Epub 2020 Jan 06
View PubMed
Stang CD, Turcano P, Mielke MM, Josephs KA, Bower JH, Ahlskog JE, Boeve BF, Martin PR, Upadhyaya SG, Savica R. Incidence and Trends of Progressive Supranuclear Palsy and Corticobasal Syndrome: A Population-Based Study. J Parkinsons Dis. 2020; 10 (1):179-184
View PubMed
Miller VM, Jayachandran M, Barnes JN, Mielke MM, Kantarci K, Rocca WA. Risk factors of neurovascular ageing in women. J Neuroendocrinol. 2020 Jan; 32 (1):e12777 Epub 2019 Sept 03
View PubMed
Mielke MM. Consideration of Sex Differences in the Measurement and Interpretation of Alzheimer Disease-Related Biofluid-Based Biomarkers. J Appl Lab Med. 2020 Jan 1; 5 (1):158-169
View PubMed
van Kruining D, Luo Q, van Echten-Deckert G, Mielke MM, Bowman A, Ellis S, Oliveira TG, Martinez-Martinez P. Sphingolipids as prognostic biomarkers of neurodegeneration, neuroinflammation, and psychiatric diseases and their emerging role in lipidomic investigation methods. Adv Drug Deliv Rev. 2020; 159:232-244 Epub 2020 Apr 28
View PubMed
Stricker NH, Lundt ES, Albertson SM, Machulda MM, Pudumjee SB, Kremers WK, Jack CR, Knopman DS, Petersen RC, Mielke MM. Diagnostic and Prognostic Accuracy of the Cogstate Brief Battery and Auditory Verbal Learning Test in Preclinical Alzheimer's Disease and Incident Mild Cognitive Impairment: Implications for Defining Subtle Objective Cognitive Impairment. J Alzheimers Dis. 2020; 76 (1):261-274
View PubMed
Stricker NH, Lundt ES, Alden EC, Albertson SM, Machulda MM, Kremers WK, Knopman DS, Petersen RC, Mielke MM. Longitudinal Comparison of in Clinic and at Home Administration of the Cogstate Brief Battery and Demonstrated Practice Effects in the Mayo Clinic Study of Aging. J Prev Alzheimers Dis. 2020; 7 (1):21-28
View PubMed
Sprung J, Knopman DS, Petersen RC, Vemuri P, Mielke MM, Weingarten TN, Schulte PJ, Schroeder DR, Warner DO. Exposure to surgery with regional anesthesia and cortical thickness in older adults. Alzheimers Dement (N Y). 2020; 6 (1):e12012 Epub 2020 Apr 07
View PubMed
Ramanan VK, Wang X, Przybelski SA, Raghavan S, Heckman MG, Batzler A, Kosel ML, Hohman TJ, Knopman DS, Graff-Radford J, Lowe VJ, Mielke MM, Jack CR Jr, Petersen RC, Ross OA, Vemuri P. Variants in PPP2R2B and IGF2BP3 are associated with higher tau deposition. Brain Commun. 2020; 2 (2):fcaa159 Epub 2020 Sept 26
View PubMed
Krell-Roesch J, Syrjanen JA, Mielke MM, Christianson TJ, Kremers WK, Machulda MM, Knopman DS, Petersen RC, Vassilaki M, Geda YE. Association Between Neuropsychiatric Symptoms and Functional Change in Older Non-Demented Adults: Mayo Clinic Study of Aging. J Alzheimers Dis 2020; 78 (3):911-917
View PubMed
Peterson BJ, Rocca WA, Bower JH, Savica R, Mielke MM. Identifying incident Parkinson's disease using administrative diagnostic codes: a validation study. Clin Park Relat Disord. 2020; 3 Epub 2020 June 02
View PubMed
Graff-Radford J, Gunter JL, Jones DT, Przybelski SA, Schwarz CG, Huston J 3rd, Lowe V, Elder BD, Machulda MM, Gunter NB, Petersen RC, Kantarci K, Vemuri P, Mielke MM, Knopman DS, Graff-Radford NR, Jack CR Jr. Cerebrospinal fluid dynamics disorders: Relationship to Alzheimer biomarkers and cognition. Neurology. 2019 Dec 10; 93 (24):e2237-e2246 Epub 2019 Nov 12
View PubMed
Vemuri P, Lesnick TG, Knopman DS, Przybelski SA, Reid RI, Mielke MM, Graff-Radford J, Lowe VJ, Machulda MM, Petersen RC, Jack CR Jr. Amyloid, vascular, and resilience pathways associated with cognitive aging Ann Neurol. 2019; 86(6):866-877. Epub 2019 Oct 17.
View PubMed
Sprung J, Kruthiventi SC, Warner DO, Knopman DS, Petersen RC, Mielke MM, Jack CR Jr, Graff-Radford J, Martin DP, Hanson AC, Schroeder DR, Przybelski SA, Schulte PJ, Weingarten TN, Vemuri P. Exposure to surgery under general anaesthesia and brain magnetic resonance imaging changes in older adults. Br J Anaesth. 2019 Dec; 123 (6):808-817 Epub 2019 Oct 03
View PubMed
Yost M, Fiebelkorn CA, Fiebelkorn CA, Rabinstein AA, Klaas J, Aakre JA, Brown RD Jr, Mielke MM, Knopman DS, Lowe V, Petersen RC, Jack CR Jr, Vemuri P, Graff-Radford J. Incidence of Convexal Subarachnoid Hemorrhage in the Elderly: The Mayo Clinic Study of Aging. J Stroke Cerebrovasc Dis. 2019 Dec; 28 (12):104451 Epub 2019 Oct 24
View PubMed
Vemuri P, Lesnick TG, Knopman DS, Przybelski SA, Reid RI, Mielke MM, Graff-Radford J, Lowe VJ, Machulda MM, Petersen RC, Jack CR Jr. Amyloid, Vascular, and Resilience Pathways Associated with Cognitive Aging. Ann Neurol. 2019 Dec; 86 (6):866-877 Epub 2019 Oct 17
View PubMed
Maserejian N, Bian S, Wang W, Jaeger J, Syrjanen JA, Aakre J, Jack CR Jr, Mielke MM, Gao F. Practical algorithms for amyloid beta probability in subjective or mild cognitive impairment. Alzheimers Dement (Amst). 2019 Dec; 11:180 Epub 2019 Oct 22
View PubMed
Krell-Roesch J, Syrjanen JA, Vassilaki M, Barisch-Fritz B, Trautwein S, Boes K, Woll A, Kremers WK, Machulda MM, Mielke MM, Knopman DS, Petersen RC, Geda YE. Association of non-exercise physical activity in mid- and late-life with cognitive trajectories and the impact of APOE epsilon4 genotype status: the Mayo Clinic Study of Aging. Eur J Ageing. 2019 Dec; 16 (4):491-502 Epub 2019 Apr 12
View PubMed
Li D, Mielke MM. An Update on Blood-Based Markers of Alzheimer's Disease Using the SiMoA Platform. Neurol Ther. 2019 Dec; 8 (Suppl 2):73-82 Epub 2019 Dec 12
View PubMed
Sundermann EE, Maki P, Biegon A, Lipton RB, Mielke MM, Machulda M, Bondi MW, Alzheimer's Disease Neuroimaging Initiative. Sex-specific norms for verbal memory tests may improve diagnostic accuracy of amnestic MCI. Neurology. 2019 Nov 12; 93 (20):e1881-e1889 Epub 2019 Oct 09
View PubMed
Vassilaki M, Aakre JA, Knopman DS, Kremers WK, Mielke MM, Geda YE, Machulda MM, Al Fakir R, Undavalli C, Roberts RO, Petersen RC. Informant-based hearing difficulties and the risk for mild cognitive impairment and dementia. Age Ageing. 2019 Nov 1; 48 (6):888-894
View PubMed
Mielke MM, Syrjanen JA, Blennow K, Zetterberg H, Skoog I, Vemuri P, Machulda MM, Graff-Radford J, Knopman DS, Jack CR Jr, Petersen RC, Kern S. Comparison of variables associated with cerebrospinal fluid neurofilament, total-tau, and neurogranin. Alzheimers Dement. 2019 Nov; 15 (11):1437-1447 Epub 2019 Oct 23
View PubMed
Mielke MM, Syrjanen JA, Bui HH, Petersen RC, Knopman DS, Jack CR Jr, Graff-Radford J, Vemuri P. Elevated Plasma Ceramides Are Associated With Higher White Matter Hyperintensity Volume-Brief Report. Arterioscler Thromb Vasc Biol. 2019 Nov; 39 (11):2431-2436 Epub 2019 Sept 12
View PubMed
Scharf EL, Graff-Radford J, Przybelski SA, Lesnick TG, Mielke MM, Knopman DS, Preboske GM, Schwarz CG, Senjem ML, Gunter JL, Machulda M, Kantarci K, Petersen RC, Jack CR Jr, Vemuri P. Cardiometabolic Health and Longitudinal Progression of White Matter Hyperintensity: The Mayo Clinic Study of Aging. Stroke. 2019 Nov; 50 (11):3037-3044 Epub 2019 Sept 12
View PubMed
Fouladvand S, Mielke MM, Vassilaki M, Sauver JS, Petersen RC, Sohn S. Deep Learning Prediction of Mild Cognitive Impairment using Electronic Health Records. Proceedings (IEEE Int Conf Bioinformatics Biomed). 2019 Nov; 2019:799-806. Epub 2020 Feb 06.
View PubMed
Ramanan VK, Castillo AM, Knopman DS, Graff-Radford J, Lowe VJ, Petersen RC, Jack CR Jr, Mielke MM, Vemuri P. Association of Apolipoprotein E varepsilon4, Educational Level, and Sex With Tau Deposition and Tau-Mediated Metabolic Dysfunction in Older Adults. JAMA Netw Open. 2019 Oct 2; 2 (10):e1913909 Epub 2019 Oct 02
View PubMed
Sprung J, Schulte PJ, Knopman DS, Mielke MM, Petersen RC, Weingarten TN, Martin DP, Hanson AC, Schroeder DR, Warner DO. Cognitive function after surgery with regional or general anesthesia: A population-based study. Alzheimers Dement. 2019 Oct; 15 (10):1243-1252 Epub 2019 Sept 05
View PubMed
Jack CR, Wiste HJ, Botha H, Weigand SD, Therneau TM, Knopman DS, Graff-Radford J, Jones DT, Ferman TJ, Boeve BF, Kantarci K, Lowe VJ, Vemuri P, Mielke MM, Fields JA, Machulda MM, Schwarz CG, Senjem ML, Gunter JL, Petersen RC. The bivariate distribution of amyloid-beta and tau: relationship with established neurocognitive clinical syndromes. Brain. 2019 Oct 1; 142 (10):3230-3242
View PubMed
Jack CR Jr, Therneau TM, Weigand SD, Wiste HJ, Knopman DS, Vemuri P, Lowe VJ, Mielke MM, Roberts RO, Machulda MM, Graff-Radford J, Jones DT, Schwarz CG, Gunter JL, Senjem ML, Rocca WA, Petersen RC. Prevalence of Biologically vs Clinically Defined Alzheimer Spectrum Entities Using the National Institute on Aging-Alzheimer's Association Research Framework. JAMA Neurol 2019 Oct 1; 76 (10):1174-1183
View PubMed
Savica R, Turcano P, Bower JH, Ahlskog JE, Mielke MM. Survival and Progression in Synucleinopathy Phenotypes With Parkinsonism: A Population-Based Study. Mayo Clin Proc. 2019 Sep; 94 (9):1825-1831 Epub 2019 Aug 09
View PubMed
Goudarzvand S, St Sauver J, Mielke MM, Takahashi PY, Lee Y, Sohn S. Early temporal characteristics of elderly patient cognitive impairment in electronic health records. BMC Med Inform Decis Mak. 2019 Aug 8; 19 (Suppl 4):149 Epub 2019 Aug 08
View PubMed
Krell-Roesch J, Syrjanen JA, Vassilaki M, Machulda MM, Mielke MM, Knopman DS, Kremers WK, Petersen RC, Geda YE. Quantity and quality of mental activities and the risk of incident mild cognitive impairment. Neurology. 2019 Aug 6; 93 (6):e548-e558 Epub 2019 July 10
View PubMed
Graff-Radford J, Arenaza-Urquijo EM, Knopman DS, Schwarz CG, Brown RD, Rabinstein AA, Gunter JL, Senjem ML, Przybelski SA, Lesnick T, Ward C, Mielke MM, Lowe VJ, Petersen RC, Kremers WK, Kantarci K, Jack CR, Vemuri P. White matter hyperintensities: relationship to amyloid and tau burden. Brain. 2019 Aug 1; 142 (8):2483-2491
View PubMed
Schulte PJ, Warner DO, Martin DP, Deljou A, Mielke MM, Knopman DS, Petersen RC, Weingarten TN, Warner MA, Rabinstein AA, Hanson AC, Schroeder DR, Sprung J. Association Between Critical Care Admissions and Cognitive Trajectories in Older Adults. Crit Care Med. 2019 Aug; 47 (8):1116-1124
View PubMed
Stricker NH, Lundt ES, Edwards KK, Machulda MM, Kremers WK, Roberts RO, Knopman DS, Petersen RC, Mielke MM. Comparison of PC and iPad administrations of the Cogstate Brief Battery in the Mayo Clinic Study of Aging: Assessing cross-modality equivalence of computerized neuropsychological tests. Clin Neuropsychol. 2019 Aug; 33(6):1102-1126. Epub 2018 Nov 10.
View PubMed
Mielke MM, Syrjanen JA, Blennow K, Zetterberg H, Vemuri P, Skoog I, Machulda MM, Kremers WK, Knopman DS, Jack C Jr, Petersen RC, Kern S. Plasma and CSF neurofilament light: Relation to longitudinal neuroimaging and cognitive measures. Neurology. 2019 Jul 16; 93 (3):e252-e260 Epub 2019 June 10
View PubMed
Wennberg AMV, Hagen CE, Machulda MM, Knopman DS, Petersen RC, Mielke MM. The Cross-sectional and Longitudinal Associations Between IL-6, IL-10, and TNFalpha and Cognitive Outcomes in the Mayo Clinic Study of Aging. J Gerontol A Biol Sci Med Sci. 2019 Jul 12; 74 (8):1289-1295
View PubMed
Lowe VJ, Bruinsma TJ, Wiste HJ, Min HK, Weigand SD, Fang P, Senjem ML, Therneau TM, Boeve BF, Josephs KA, Pandey MK, Murray ME, Kantarci K, Jones DT, Vemuri P, Graff-Radford J, Schwarz CG, Machulda MM, Mielke MM, Roberts RO, Knopman DS, Petersen RC, Jack CR Jr. Cross-sectional associations of tau-PET signal with cognition in cognitively unimpaired adults. Neurology. 2019 Jul 2; 93 (1):e29-e39 Epub 2019 May 30
View PubMed
Li D, Hagen C, Fett AR, Bui HH, Knopman D, Vemuri P, Machulda MM, Jack CR Jr, Petersen RC, Mielke MM. Longitudinal association between phosphatidylcholines, neuroimaging measures of Alzheimer's disease pathophysiology, and cognition in the Mayo Clinic Study of Aging. Neurobiol Aging. 2019 Jul; 79:43-49 Epub 2019 Mar 18
View PubMed
Machulda MM, Lundt ES, Albertson SM, Kremers WK, Mielke MM, Knopman DS, Bondi MW, Petersen RC. Neuropsychological subtypes of incident mild cognitive impairment in the Mayo Clinic Study of Aging. Alzheimers Dement. 2019 Jul; 15 (7):878-887 Epub 2019 May 23
View PubMed
Jack CR Jr, Wiste HJ, Therneau TM, Weigand SD, Knopman DS, Mielke MM, Lowe VJ, Vemuri P, Machulda MM, Schwarz CG, Gunter JL, Senjem ML, Graff-Radford J, Jones DT, Roberts RO, Rocca WA, Petersen RC. Associations of Amyloid, Tau, and Neurodegeneration Biomarker Profiles With Rates of Memory Decline Among Individuals Without Dementia. JAMA. 2019 Jun 18; 321 (23):2316-2325
View PubMed
Boeve A, Ferman TJ, Aakre J, St Louis E, Silber M, Machulda M, Fields J, Graff-Radford N, Mielke M, Geda Y, Jones D, Graff-Radford J, Knopman D, Petersen R, Boeve B. Excessive Daytime Sleepiness in Major Dementia Syndromes. Am J Alzheimers Dis Other Demen. 2019 Jun; 34 (4):261-264 Epub 2019 Feb 10
View PubMed
Vassilaki M, Aakre JA, Kremers WK, Mielke MM, Geda YE, Alhurani RE, Dutt T, Machulda MM, Knopman DS, Vemuri P, Coloma PM, Schauble B, Lowe VJ, Jack CR, Petersen RC, Roberts RO. The Association of Multimorbidity With Preclinical AD Stages and SNAP in Cognitively Unimpaired Persons. J Gerontol A Biol Sci Med Sci. 2019 May 16; 74 (6):877-883
View PubMed
Wennberg AM, Whitwell JL, Tosakulwong N, Weigand SD, Murray ME, Machulda MM, Petrucelli L, Mielke MM, Jack CR Jr, Knopman DS, Parisi JE, Petersen RC, Dickson DW, Josephs KA. The influence of tau, amyloid, alpha-synuclein, TDP-43, and vascular pathology in clinically normal elderly individuals. Neurobiol Aging. 2019 May; 77:26-36 Epub 2019 Jan 21
View PubMed
Li D, Misialek JR, Jack CR, Mielke MM, Knopman D, Gottesman R, Mosley T, Alonso A. Plasma Metabolites Associated with Brain MRI Measures of Neurodegeneration in Older Adults in the Atherosclerosis Risk in Communities(-)Neurocognitive Study (ARIC-NCS). Int J Mol Sci. 2019 Apr 9; 20 (7) Epub 2019 Apr 09
View PubMed
Arenaza-Urquijo EM, Przybelski SA, Lesnick TL, Graff-Radford J, Machulda MM, Knopman DS, Schwarz CG, Lowe VJ, Mielke MM, Petersen RC, Jack CR, Vemuri P. The metabolic brain signature of cognitive resilience in the 80+: beyond Alzheimer pathologies. Brain. 2019 Apr 1; 142 (4):1134-1147
View PubMed
Knopman DS, Lundt ES, Therneau TM, Vemuri P, Lowe VJ, Kantarci K, Gunter JL, Senjem ML, Mielke MM, Machulda MM, Boeve BF, Jones DT, Graff-Radford J, Albertson SM, Schwarz CG, Petersen RC, Jack CR. Entorhinal cortex tau, amyloid-beta, cortical thickness and memory performance in non-demented subjects. Brain. 2019 Apr 1; 142 (4):1148-1160
View PubMed
Krell-Roesch J, Vassilaki M, Mielke MM, Kremers WK, Lowe VJ, Vemuri P, Machulda MM, Christianson TJ, Syrjanen JA, Stokin GB, Butler LM, Traber M, Jack CR Jr, Knopman DS, Roberts RO, Petersen RC, Geda YE. Cortical beta-amyloid burden, neuropsychiatric symptoms, and cognitive status: the Mayo Clinic Study of Aging. Transl Psychiatry. 2019 Mar 28; 9 (1):123
View PubMed
Babulal GM, Quiroz YT, Albensi BC, Arenaza-Urquijo E, Astell AJ, Babiloni C, Bahar-Fuchs A, Bell J, Bowman GL, Brickman AM, Chetelat G, Ciro C, Cohen AD, Dilworth-Anderson P, Dodge HH, Dreux S, Edland S, Esbensen A, Evered L, Ewers M, Fargo KN, Fortea J, Gonzalez H, Gustafson DR, Head E, Hendrix JA, Hofer SM, Johnson LA, Jutten R, Kilborn K, Lanctot KL, Manly JJ, Martins RN, Mielke MM, Morris MC, Murray ME, Oh ES, Parra MA, Rissman RA, Roe CM, Santos OA, Scarmeas N, Schneider LS, Schupf N, Sikkes S, Snyder HM, Sohrabi HR, Stern Y, Strydom A, Tang Y, Terrera GM, Teunissen C, Melo van Lent D, Weinborn M, Wesselman L, Wilcock DM, Zetterberg H, O'Bryant SE, International Society to Advance Alzheimer's Research and Treatment, Alzheimer's Association. Perspectives on ethnic and racial disparities in Alzheimer's disease and related dementias: Update and areas of immediate need. Alzheimers Dement. 2019 Feb; 15 (2):292-312 Epub 2018 Dec 13
View PubMed
Kern S, Syrjanen JA, Blennow K, Zetterberg H, Skoog I, Waern M, Hagen CE, van Harten AC, Knopman DS, Jack CR Jr, Petersen RC, Mielke MM. Association of Cerebrospinal Fluid Neurofilament Light Protein With Risk of Mild Cognitive Impairment Among Individuals Without Cognitive Impairment. JAMA Neurol. 2019 Feb 1; 76 (2):187-193
View PubMed
Graff-Radford J, Botha H, Rabinstein AA, Gunter JL, Przybelski SA, Lesnick T, Huston J 3rd, Flemming KD, Preboske GM, Senjem ML, Brown RD Jr, Mielke MM, Roberts RO, Lowe VJ, Knopman DS, Petersen RC, Kremers W, Vemuri P, Jack CR Jr, Kantarci K. Cerebral microbleeds: Prevalence and relationship to amyloid burden. Neurology. 2019 Jan 15; 92 (3):e253-e262 Epub 2018 Dec 19
View PubMed
Wang F, Lesser ER, Cutsforth-Gregory JK, Bhatti MT, Kilgore KP, Hodge DO, Graff-Radford J, Petersen RC, Knopman DS, Mielke MM, Lanzino G, Leavitt JA, Chen JJ. Population-Based Evaluation of Lumbar Puncture Opening Pressures. Front Neurol. 2019; 10:899 Epub 2019 Aug 16
View PubMed
Hasan S, Mielke MM, Ahlskog JE, Bower J, Turcano P, Savica R. Erectile Dysfunction Preceding Clinically Diagnosed alpha-Synucleinopathies: A Case-Control Study in Olmsted County. Parkinsons Dis. 2019; 2019:6303945 Epub 2019 Apr 09
View PubMed
Eakin KA, Saleem M, Herrmann N, Cogo-Moreira H, Mielke MM, Oh PI, Haughey NJ, Venkata SLV, Lanctot KL, Swardfager W. Plasma Sphingolipids Mediate a Relationship Between Type 2 Diabetes and Memory Outcomes in Patients with Coronary Artery Disease Undertaking Exercise. J Alzheimers Dis. 2019; 69 (3):717-727
View PubMed
Petersen RC, Lundt ES, Therneau TM, Weigand SD, Knopman DS, Mielke MM, Roberts RO, Lowe VJ, Machulda MM, Kremers WK, Geda YE, Jack CR Jr. Predicting Progression to Mild Cognitive Impairment. Ann Neurol. 2019 Jan; 85 (1):155-160 Epub 2019 Jan 07
View PubMed
Neth BJ, Graff-Radford J, Mielke MM, Przybelski SA, Lesnick TG, Schwarz CG, Reid RI, Senjem ML, Lowe VJ, Machulda MM, Petersen RC, Jack CR Jr, Knopman DS, Vemuri P. Relationship Between Risk Factors and Brain Reserve in Late Middle Age: Implications for Cognitive Aging. Front Aging Neurosci. 2019; 11:355 Epub 2020 Jan 09
View PubMed
Krell-Roesch J, Cerhan LP, Machulda MM, Roberts RO, Mielke MM, Knopman DS, Syrjanen JA, Christianson TJ, Petersen RC, Geda YE. Functional Activity and Neuropsychiatric Symptoms in Normal Aging and Mild Cognitive Impairment: The Mayo Clinic Study of Aging. Alzheimer Dis Assoc Disord. 2019 Jan-Mar; 33 (1):68-71
View PubMed
Zeydan B, Tosakulwong N, Schwarz CG, Senjem ML, Gunter JL, Reid RI, Gazzuola Rocca L, Lesnick TG, Smith CY, Bailey KR, Lowe VJ, Roberts RO, Jack CR Jr, Petersen RC, Miller VM, Mielke MM, Rocca WA, Kantarci K. Association of Bilateral Salpingo-Oophorectomy Before Menopause Onset With Medial Temporal Lobe Neurodegeneration. JAMA Neurol. 2019 Jan 1; 76 (1):95-100
View PubMed
Turcano P, Mielke MM, Bower JH, Parisi JE, Cutsforth-Gregory JK, Ahlskog JE, Savica R. Levodopa-induced dyskinesia in Parkinson disease: A population-based cohort study. Neurology. 2018 Dec 11; 91 (24):e2238-e2243 Epub 2018 Nov 07
View PubMed
Milic NM, Codsi E, Butler Tobah YS, White WM, Kattah AG, Weissgerber TL, Saiki M, Parashuram S, Vaughan LE, Weaver AL, Savic M, Mielke MM, Garovic VD. Electronic Algorithm Is Superior to Hospital Discharge Codes for Diagnoses of Hypertensive Disorders of Pregnancy in Historical Cohorts. Mayo Clin Proc. 2018 Dec; 93 (12):1707-1719
View PubMed
Molinuevo JL, Ayton S, Batrla R, Bednar MM, Bittner T, Cummings J, Fagan AM, Hampel H, Mielke MM, Mikulskis A, O'Bryant S, Scheltens P, Sevigny J, Shaw LM, Soares HD, Tong G, Trojanowski JQ, Zetterberg H, Blennow K. Current state of Alzheimer's fluid biomarkers. Acta Neuropathol. 2018 Dec; 136 (6):821-853 Epub 2018 Nov 28
View PubMed
Vassilaki M, Aakre JA, Kremers WK, Mielke MM, Geda YE, Machulda MM, Knopman DS, Coloma PM, Schauble B, Vemuri P, Lowe VJ, Jack CR Jr, Petersen RC, Roberts RO. Association Between Functional Performance and Alzheimer's Disease Biomarkers in Individuals Without Dementia. J Am Geriatr Soc. 2018 Dec; 66 (12):2274-2281 Epub 2018 Nov 21
View PubMed
Mielke MM. Sex and Gender Differences in Alzheimer's Disease Dementia. Psychiatr Times. 2018 Nov; 35 (11):14-17 Epub 2018 Dec 30
View PubMed
Rocca WA, Gazzuola Rocca L, Smith CY, Grossardt BR, Faubion SS, Shuster LT, Kirkland JL, LeBrasseur NK, Schafer MJ, Mielke MM, Kantarci K, Stewart EA, Miller VM. Loss of Ovarian Hormones and Accelerated Somatic and Mental Aging. Physiology (Bethesda). 2018 Nov 1; 33 (6):374-383
View PubMed
Vemuri P, Lesnick TG, Przybelski SA, Graff-Radford J, Reid RI, Lowe VJ, Zuk SM, Senjem ML, Schwarz CG, Gunter JL, Kantarci K, Machulda MM, Mielke MM, Petersen RC, Knopman DS, Jack CR Jr. Development of a cerebrovascular magnetic resonance imaging biomarker for cognitive aging. Ann Neurol. 2018 Nov; 84 (5):705-716 Epub 2018 Oct 25
View PubMed
Rocca WA, Gazzuola Rocca L, Smith CY, Grossardt BR, Faubion SS, Shuster LT, Stewart EA, Mielke MM, Kantarci K, Miller VM. Personal, reproductive, and familial characteristics associated with bilateral oophorectomy in premenopausal women: A population-based case-control study. Maturitas. 2018 Nov; 117:64-77 Epub 2018 Sept 14
View PubMed
Nebel RA, Aggarwal NT, Barnes LL, Gallagher A, Goldstein JM, Kantarci K, Mallampalli MP, Mormino EC, Scott L, Yu WH, Maki PM, Mielke MM. Understanding the impact of sex and gender in Alzheimer's disease: A call to action. Alzheimers Dement. 2018 Sep; 14 (9):1171-1183 Epub 2018 June 12
View PubMed
Savica R, Boeve BF, Mielke MM. Orthostatic Hypotension as a Prodromal Marker of alpha-Synucleinopathies-Reply. JAMA Neurol 2018 Sep 1; 75 (9):1155
View PubMed
Espeland MA, Carmichael O, Yasar S, Hugenschmidt C, Hazzard W, Hayden KM, Rapp SR, Neiberg R, Johnson KC, Hoscheidt S, Mielke MM, Action for Health in Diabetes (Look AHEAD) Research Group. Sex-related differences in the prevalence of cognitive impairment among overweight and obese adults with type 2 diabetes. Alzheimers Dement. 2018 Sep; 14 (9):1184-1192 Epub 2018 July 05
View PubMed
Wennberg AMV, Lesnick TG, Schwarz CG, Savica R, Hagen CE, Roberts RO, Knopman DS, Hollman JH, Vemuri P, Jack CR Jr, Petersen RC, Mielke MM. Longitudinal Association Between Brain Amyloid-Beta and Gait in the Mayo Clinic Study of Aging. J Gerontol A Biol Sci Med Sci. 2018 Aug 10; 73 (9):1244-1250
View PubMed
Mielke MM, Hagen CE, Xu J, Chai X, Vemuri P, Lowe VJ, Airey DC, Knopman DS, Roberts RO, Machulda MM, Jack CR Jr, Petersen RC, Dage JL. Plasma phospho-tau181 increases with Alzheimer's disease clinical severity and is associated with tau- and amyloid-positron emission tomography. Alzheimers Dement. 2018 Aug; 14 (8):989-997 Epub 2018 Apr 05
View PubMed
Roberts RO, Aakre JA, Kremers WK, Vassilaki M, Knopman DS, Mielke MM, Alhurani R, Geda YE, Machulda MM, Coloma P, Schauble B, Lowe VJ, Jack CR Jr, Petersen RC. Prevalence and Outcomes of Amyloid Positivity Among Persons Without Dementia in a Longitudinal, Population-Based Setting. JAMA Neurol. 2018 Aug 1; 75 (8):970-979
View PubMed
Wennberg AMV, Hagen CE, Edwards K, Roberts RO, Machulda MM, Knopman DS, Petersen RC, Mielke MM. Association of antidiabetic medication use, cognitive decline, and risk of cognitive impairment in older people with type 2 diabetes: Results from the population-based Mayo Clinic Study of Aging. Int J Geriatr Psychiatry. 2018 Aug; 33 (8):1114-1120 Epub 2018 June 05
View PubMed
van Harten AC, Mielke MM, Swenson-Dravis DM, Hagen CE, Edwards KK, Roberts RO, Geda YE, Knopman DS, Petersen RC. Subjective cognitive decline and risk of MCI: The Mayo Clinic Study of Aging. Neurology. 2018 Jul 24; 91 (4):e300-e312 Epub 2018 June 29
View PubMed
Wennberg AMV, Schafer MJ, LeBrasseur NK, Savica R, Bui HH, Hagen CE, Hollman JH, Petersen RC, Mielke MM. Plasma Sphingolipids are Associated With Gait Parameters in the Mayo Clinic Study of Aging. J Gerontol A Biol Sci Med Sci. 2018 Jun 14; 73 (7):960-965
View PubMed
Carvalho DZ, St Louis EK, Knopman DS, Boeve BF, Lowe VJ, Roberts RO, Mielke MM, Przybelski SA, Machulda MM, Petersen RC, Jack CR Jr, Vemuri P. Association of Excessive Daytime Sleepiness With Longitudinal beta-Amyloid Accumulation in Elderly Persons Without Dementia. JAMA Neurol. 2018 Jun 1; 75 (6):672-680
View PubMed
Wennberg AMV, Hagen CE, Machulda MM, Hollman JH, Roberts RO, Knopman DS, Petersen RC, Mielke MM. The association between peripheral total IGF-1, IGFBP-3, and IGF-1/IGFBP-3 and functional and cognitive outcomes in the Mayo Clinic Study of Aging. Neurobiol Aging. 2018 Jun; 66:68-74 Epub 2018 Feb 19
View PubMed
Wennberg AMV, Hagen CE, Petersen RC, Mielke MM. Trajectories of plasma IGF-1, IGFBP-3, and their ratio in the Mayo Clinic Study of Aging. Exp Gerontol. 2018 Jun; 106:67-73 Epub 2018 Feb 21
View PubMed
Scantlebury DC, Kattah AG, Weissgerber TL, Agarwal S, Mielke MM, Weaver AL, Vaughan LE, Henkin S, Zimmerman K, Miller VM, White WM, Hayes SN, Garovic VD. Impact of a History of Hypertension in Pregnancy on Later Diagnosis of Atrial Fibrillation. J Am Heart Assoc. 2018 May 13; 7 (10)
View PubMed
Zeydan B, Lowe VJ, Schwarz CG, Przybelski SA, Tosakulwong N, Zuk SM, Senjem ML, Gunter JL, Roberts RO, Mielke MM, Benarroch EE, Rodriguez M, Machulda MM, Lesnick TG, Knopman DS, Petersen RC, Jack CR Jr, Kantarci K, Kantarci OH. Pittsburgh compound-B PET white matter imaging and cognitive function in late multiple sclerosis. Mult Scler. 2018 May; 24 (6):739-749 Epub 2017 May 05
View PubMed
Jack CR Jr, Wiste HJ, Schwarz CG, Lowe VJ, Senjem ML, Vemuri P, Weigand SD, Therneau TM, Knopman DS, Gunter JL, Jones DT, Graff-Radford J, Kantarci K, Roberts RO, Mielke MM, Machulda MM, Petersen RC. Longitudinal tau PET in ageing and Alzheimer's disease. Brain. 2018 May 1; 141 (5):1517-1528
View PubMed
Knopman DS, Lundt ES, Therneau TM, Vemuri P, Lowe VJ, Kantarci K, Gunter JL, Senjem ML, Mielke MM, Machulda MM, Roberts RO, Boeve BF, Jones DT, Petersen RC, Jack CR Jr. Joint associations of beta-amyloidosis and cortical thickness with cognition. Neurobiol Aging. 2018 May; 65:121-131 Epub 2018 Feb 02
View PubMed
Savica R, Boeve BF, Mielke MM. When Do alpha-Synucleinopathies Start? An Epidemiological Timeline: A Review. JAMA Neurol. 2018 Apr 1; 75 (4):503-509
View PubMed
Arnold Fiebelkorn C, Vemuri P, Rabinstein AA, Mielke MM, Przybelski SA, Kantarci K, Jones DT, Brown RD Jr, Knopman DS, Petersen RC, Jack CR Jr, Graff-Radford J. Frequency of Acute and Subacute Infarcts in a Population-Based Study. Mayo Clin Proc. 2018 Mar; 93 (3):300-306 Epub 2018 Feb 14
View PubMed
Fatemi F, Kantarci K, Graff-Radford J, Preboske GM, Weigand SD, Przybelski SA, Knopman DS, Machulda MM, Roberts RO, Mielke MM, Petersen RC, Jack CR Jr, Vemuri P. Sex differences in cerebrovascular pathologies on FLAIR in cognitively unimpaired elderly. Neurology. 2018 Feb 6; 90 (6):e466-e473 Epub 2018 Jan 17
View PubMed
Sacktor N, Skolasky RL, Moxley R, Wang S, Mielke MM, Munro C, Steiner J, Nath A, Haughey N, McArthur J. Paroxetine and fluconazole therapy for HIV-associated neurocognitive impairment: results from a double-blind, placebo-controlled trial. J Neurovirol. 2018 Feb; 24 (1):16-27 Epub 2017 Oct 23
View PubMed
Krell-Roesch J, Lowe VJ, Neureiter J, Pink A, Roberts RO, Mielke MM, Vemuri P, Stokin GB, Christianson TJ, Jack CR, Knopman DS, Boeve BF, Kremers WK, Petersen RC, Geda YE. Depressive and anxiety symptoms and cortical amyloid deposition among cognitively normal elderly persons: the Mayo Clinic Study of Aging. Int Psychogeriatr. 2018 Feb; 30 (2):245-251 Epub 2017 Dec 04
View PubMed
Krell-Roesch J, Feder NT, Roberts RO, Mielke MM, Christianson TJ, Knopman DS, Petersen RC, Geda YE. Leisure-Time Physical Activity and the Risk of Incident Dementia: The Mayo Clinic Study of Aging. J Alzheimers Dis. 2018; 63 (1):149-155
View PubMed
Chan P, Saleem M, Herrmann N, Mielke MM, Haughey NJ, Oh PI, Kiss A, Lanctot KL. Ceramide Accumulation Is Associated with Declining Verbal Memory in Coronary Artery Disease Patients: An Observational Study. J Alzheimers Dis. 2018; 64 (4):1235-1246
View PubMed
Vassilaki M, Aakre JA, Syrjanen JA, Mielke MM, Geda YE, Kremers WK, Machulda MM, Alhurani RE, Staubo SC, Knopman DS, Petersen RC, Lowe VJ, Jack CR, Roberts RO. Mediterranean Diet, Its Components, and Amyloid Imaging Biomarkers. J Alzheimers Dis. 2018; 64 (1):281-290
View PubMed
Ramanan VK, Przybelski SA, Graff-Radford J, Castillo AM, Lowe VJ, Mielke MM, Roberts RO, Reid RI, Knopman DS, Jack CR, Petersen RC, Vemuri P. Statins and Brain Health: Alzheimer's Disease and Cerebrovascular Disease Biomarkers in Older Adults. J Alzheimers Dis. 2018; 65 (4):1345-1352
View PubMed
Lowe VJ, Wiste HJ, Senjem ML, Weigand SD, Therneau TM, Boeve BF, Josephs KA, Fang P, Pandey MK, Murray ME, Kantarci K, Jones DT, Vemuri P, Graff-Radford J, Schwarz CG, Machulda MM, Mielke MM, Roberts RO, Knopman DS, Petersen RC, Jack CR Jr. Widespread brain tau and its association with ageing, Braak stage and Alzheimer's dementia. Brain. 2018 Jan 1; 141 (1):271-287
View PubMed
Pink A, Przybelski SA, Krell-Roesch J, Stokin GB, Roberts RO, Mielke MM, Spangehl KA, Knopman DS, Jack CR Jr, Petersen RC, Geda YE. Cortical Thickness and Anxiety Symptoms Among Cognitively Normal Elderly Persons: The Mayo Clinic Study of Aging. J Neuropsychiatry Clin Neurosci. 2017 Winter; 29 (1):60-66 Epub 2016 Aug 31
View PubMed
Raman MR, Tosakulwong N, Zuk SM, Senjem ML, White WM, Fields JA, Mielke MM, Lesnick TG, Bailey KR, Jack CR Jr, Miller VM, Garovic VD, Kantarci K. Influence of preeclampsia and late-life hypertension on MRI measures of cortical atrophy. J Hypertens. 2017 Dec; 35 (12):2479-2485
View PubMed
Pichler M, Vemuri P, Rabinstein AA, Aakre J, Flemming KD, Brown RD Jr, Kumar N, Kantarci K, Kremers W, Mielke MM, Knopman DS, Jack CR Jr, Petersen RC, Lowe V, Graff-Radford J. Prevalence and Natural History of Superficial Siderosis: A Population-Based Study. Stroke. 2017 Dec; 48 (12):3210-3214 Epub 2017 Oct 25
View PubMed
Rocca WA, Gazzuola Rocca L, Smith CY, Grossardt BR, Faubion SS, Shuster LT, Stewart EA, Mielke MM, Kantarci K, Miller VM. Cohort profile: the Mayo Clinic Cohort Study of Oophorectomy and Aging-2 (MOA-2) in Olmsted County, Minnesota (USA). BMJ Open. 2017 Nov 20; 7 (11):e018861
View PubMed
Roberts RO, Knopman DS, Syrjanen JA, Aakre JA, Vassilaki M, Kremers WK, Mielke MM, Machulda MM, Graff-Radford J, Geda YE, Vemuri P, Lowe V, Jack CR Jr, Petersen RC. Weighting and standardization of frequencies to determine prevalence of AD imaging biomarkers. Neurology. 2017 Nov 14; 89 (20):2039-2048 Epub 2017 Oct 13
View PubMed
Dinoff A, Saleem M, Herrmann N, Mielke MM, Oh PI, Venkata SLV, Haughey NJ, Lanctot KL. Plasma sphingolipids and depressive symptoms in coronary artery disease. Brain Behav. 2017 Nov; 7 (11):e00836 Epub 2017 Sept 26
View PubMed
Vemuri P, Lesnick TG, Przybelski SA, Knopman DS, Lowe VJ, Graff-Radford J, Roberts RO, Mielke MM, Machulda MM, Petersen RC, Jack CR Jr. Age, vascular health, and Alzheimer disease biomarkers in an elderly sample. Ann Neurol. 2017 Nov; 82 (5):706-718 Epub 2017 Oct 26
View PubMed
Savica R, Mielke MM. Overall Survival and Causes of Death in Neurodegeneration-An Overlooked and Underreported Theme-Reply. JAMA Neurol 2017 Nov 1; 74 (11):1379-1380
View PubMed
Turcano P, Mielke MM, Josephs KA, Bower JH, Parisi JE, Boeve BF, Savica R. Clinicopathologic discrepancies in a population-based incidence study of parkinsonism in olmsted county: 1991-2010. Mov Disord. 2017 Oct; 32 (10):1439-1446 Epub 2017 Aug 26
View PubMed
Nedelska Z, Przybelski SA, Lesnick TG, Schwarz CG, Lowe VJ, Machulda MM, Kremers WK, Mielke MM, Roberts RO, Boeve BF, Knopman DS, Petersen RC, Jack CR Jr, Kantarci K. (1)H-MRS metabolites and rate of beta-amyloid accumulation on serial PET in clinically normal adults. Neurology. 2017 Sep 26; 89 (13):1391-1399 Epub 2017 Aug 25
View PubMed
Mielke MM, Hagen CE, Wennberg AMV, Airey DC, Savica R, Knopman DS, Machulda MM, Roberts RO, Jack CR Jr, Petersen RC, Dage JL. Association of Plasma Total Tau Level With Cognitive Decline and Risk of Mild Cognitive Impairment or Dementia in the Mayo Clinic Study on Aging. JAMA Neurol. 2017 Sep 1; 74 (9):1073-1080
View PubMed
Garovic VD, Milic NM, Weissgerber TL, Mielke MM, Bailey KR, Lahr B, Jayachandran M, White WM, Hodis HN, Miller VM. Carotid Artery Intima-Media Thickness and Subclinical Atherosclerosis in Women With Remote Histories of Preeclampsia: Results From a Rochester Epidemiology Project-Based Study and Meta-analysis. Mayo Clin Proc. 2017 Sep; 92 (9):1328-1340 Epub 2017 Aug 25
View PubMed
Flemming KD, Graff-Radford J, Aakre J, Kantarci K, Lanzino G, Brown RD Jr, Mielke MM, Roberts RO, Kremers W, Knopman DS, Petersen RC, Jack CR Jr. Population-Based Prevalence of Cerebral Cavernous Malformations in Older Adults: Mayo Clinic Study of Aging. JAMA Neurol. 2017 Jul 1; 74 (7):801-805
View PubMed
Savica R, Grossardt BR, Bower JH, Ahlskog JE, Boeve BF, Graff-Radford J, Rocca WA, Mielke MM. Survival and Causes of Death Among People With Clinically Diagnosed Synucleinopathies With Parkinsonism: A Population-Based Study. JAMA Neurol. 2017 Jul 1; 74 (7):839-846
View PubMed
Fields JA, Garovic VD, Mielke MM, Kantarci K, Jayachandran M, White WM, Butts AM, Graff-Radford J, Lahr BD, Bailey KR, Miller VM. Preeclampsia and cognitive impairment later in life. Am J Obstet Gynecol. 2017 Jul; 217 (1):74.e1-74.e11 Epub 2017 Mar 18
View PubMed
Ubaida-Mohien C, Lamberty B, Dickens AM, Mielke MM, Marcotte T, Sacktor N, Grant I, Letendre S, Franklin D, Cibrowski P, Tharakan R, McArthur JC, Fox H, Haughey NJ. Modifications in acute phase and complement systems predict shifts in cognitive status of HIV-infected patients. AIDS. 2017 Jun 19; 31 (10):1365-1378
View PubMed
Vemuri P, Knopman DS, Lesnick TG, Przybelski SA, Mielke MM, Graff-Radford J, Murray ME, Roberts RO, Vassilaki M, Lowe VJ, Machulda MM, Jones DT, Petersen RC, Jack CR Jr. Evaluation of Amyloid Protective Factors and Alzheimer Disease Neurodegeneration Protective Factors in Elderly Individuals. JAMA Neurol. 2017 Jun 1; 74 (6):718-726
View PubMed
Jack CR Jr, Wiste HJ, Weigand SD, Therneau TM, Knopman DS, Lowe V, Vemuri P, Mielke MM, Roberts RO, Machulda MM, Senjem ML, Gunter JL, Rocca WA, Petersen RC. Age-specific and sex-specific prevalence of cerebral beta-amyloidosis, tauopathy, and neurodegeneration in cognitively unimpaired individuals aged 50-95 years: a cross-sectional study. Lancet Neurol. 2017 Jun; 16 (6):435-444 Epub 2017 Apr 26
View PubMed
Vassilaki M, Christianson TJ, Mielke MM, Geda YE, Kremers WK, Machulda MM, Knopman DS, Petersen RC, Lowe VJ, Jack CR Jr, Roberts RO. Neuroimaging biomarkers and impaired olfaction in cognitively normal individuals. Ann Neurol. 2017 Jun; 81 (6):871-882 Epub 2017 June 09
View PubMed
Carvalho DZ, St Louis EK, Boeve BF, Mielke MM, Przybelski SA, Knopman DS, Machulda MM, Roberts RO, Geda YE, Petersen RC, Jack CR Jr, Vemuri P. Excessive daytime sleepiness and fatigue may indicate accelerated brain aging in cognitively normal late middle-aged and older adults. Sleep Med. 2017 Apr; 32:236-243 Epub 2016 Nov 03
View PubMed
Wennberg AMV, Savica R, Hagen CE, Roberts RO, Knopman DS, Hollman JH, Vemuri P, Jack CR Jr, Petersen RC, Mielke MM. Cerebral Amyloid Deposition Is Associated with Gait Parameters in the Mayo Clinic Study of Aging. J Am Geriatr Soc. 2017 Apr; 65 (4):792-799 Epub 2016 Nov 21
View PubMed
Kattah AG, Scantlebury DC, Agarwal S, Mielke MM, Rocca WA, Weaver AL, Vaughan LE, Miller VM, Weissgerber TL, White W, Garovic VD. Preeclampsia and ESRD: The Role of Shared Risk Factors. Am J Kidney Dis. 2017 Apr; 69 (4):498-505 Epub 2016 Oct 01
View PubMed
Krell-Roesch J, Vemuri P, Pink A, Roberts RO, Stokin GB, Mielke MM, Christianson TJ, Knopman DS, Petersen RC, Kremers WK, Geda YE. Association Between Mentally Stimulating Activities in Late Life and the Outcome of Incident Mild Cognitive Impairment, With an Analysis of the APOE epsilon4 Genotype. JAMA Neurol. 2017 Mar 1; 74 (3):332-338
View PubMed
Jack CR Jr, Wiste HJ, Weigand SD, Therneau TM, Lowe VJ, Knopman DS, Gunter JL, Senjem ML, Jones DT, Kantarci K, Machulda MM, Mielke MM, Roberts RO, Vemuri P, Reyes DA, Petersen RC. Defining imaging biomarker cut points for brain aging and Alzheimer's disease. Alzheimers Dement. 2017 Mar; 13 (3):205-216 Epub 2016 Sept 30
View PubMed
Staubo SC, Aakre JA, Vemuri P, Syrjanen JA, Mielke MM, Geda YE, Kremers WK, Machulda MM, Knopman DS, Petersen RC, Jack CR Jr, Roberts RO. Mediterranean diet, micronutrients and macronutrients, and MRI measures of cortical thickness. Alzheimers Dement. 2017 Feb; 13(2):168-177. Epub 2016 Jul 25.
View PubMed
Savica R, Grossardt BR, Bower JH, Ahlskog JE, Mielke MM, Rocca WA. Incidence and time trends of drug-induced parkinsonism: A 30-year population-based study. Mov Disord. 2017 Feb; 32 (2):227-234 Epub 2016 Oct 25
View PubMed
McFarlane SI, Mielke MM, Uglialoro A, Keating SM, Holman S, Minkoff H, Crystal HA, Gustafson DR. Ghrelin, Amylin, Gastric Inhibitory Peptide and Cognition in Middle-Aged HIV-Infected and Uninfected Women: The Women's Interagency HIV Study. J Neurol Neurophysiol. 2017 Feb; 8 (1) Epub 2017 Feb 08
View PubMed
Mielke MM, Haughey NJ, Han D, An Y, Bandaru VVR, Lyketsos CG, Ferrucci L, Resnick SM. The Association Between Plasma Ceramides and Sphingomyelins and Risk of Alzheimer's Disease Differs by Sex and APOE in the Baltimore Longitudinal Study of Aging. J Alzheimers Dis. 2017; 60 (3):819-828
View PubMed
Janssen PH, Mandrekar J, Mielke MM, Ahlskog JE, Boeve BF, Josephs K, Savica R. High School Football and Late-Life Risk of Neurodegenerative Syndromes, 1956-1970. Mayo Clin Proc. 2017 Jan; 92 (1):66-71 Epub 2016 Dec 12
View PubMed
Wennberg AM, Savica R, Mielke MM. Association between Various Brain Pathologies and Gait Disturbance. Dement Geriatr Cogn Disord. 2017; 43 (3-4):128-143 Epub 2017 Feb 03
View PubMed
O'Bryant SE, Mielke MM, Rissman RA, Lista S, Vanderstichele H, Zetterberg H, Lewczuk P, Posner H, Hall J, Johnson L, Fong YL, Luthman J, Jeromin A, Batrla-Utermann R, Villarreal A, Britton G, Snyder PJ, Henriksen K, Grammas P, Gupta V, Martins R, Hampel H, Biofluid Based Biomarker Professional Interest Area. Blood-based biomarkers in Alzheimer disease: Current state of the science and a novel collaborative paradigm for advancing from discovery to clinic. Alzheimers Dement. 2017 Jan; 13 (1):45-58 Epub 2016 Nov 18
View PubMed
Machulda MM, Hagen CE, Wiste HJ, Mielke MM, Knopman DS, Roberts RO, Vemuri P, Lowe VJ, Jack CR Jr, Petersen RC. [Formula: see text]Practice effects and longitudinal cognitive change in clinically normal older adults differ by Alzheimer imaging biomarker status. Clin Neuropsychol. 2017 Jan; 31 (1):99-117 Epub 2016 Oct 11
View PubMed
Savica R, Wennberg AM, Hagen C, Edwards K, Roberts RO, Hollman JH, Knopman DS, Boeve BF, Machulda MM, Petersen RC, Mielke MM. Comparison of Gait Parameters for Predicting Cognitive Decline: The Mayo Clinic Study of Aging. J Alzheimers Dis. 2017; 55(2):559-567.
View PubMed
Saleem M, Herrmann N, Dinoff A, Mielke MM, Oh PI, Shammi P, Cao X, Venkata SLV, Haughey NJ, Lanctot KL. A Lipidomics Approach to Assess the Association Between Plasma Sphingolipids and Verbal Memory Performance in Coronary Artery Disease Patients Undertaking Cardiac Rehabilitation: A C18:0 Signature for Cognitive Response to Exercise. J Alzheimers Dis. 2017; 60 (3):829-841
View PubMed
Jung Y, Boot BP, Mielke MM, Ferman TJ, Geda YE, McDade E, Christianson TJH, Knopman DS, St Louis EK, Silber MH, Petersen RC, Boeve BF. Phenoconversion from probable rapid eye movement sleep behavior disorder to mild cognitive impairment to dementia in a population-based sample. Alzheimers Dement (Amst). 2017; 8:127-130 Epub 2017 May 30
View PubMed
Jayachandran M, Garovic VD, Mielke MM, Bailey KR, Lahr BD, Miller VM. Characterization of intravascular cellular activation in relationship to subclinical atherosclerosis in postmenopausal women. PLoS One. 2017; 12 (9):e0183159 Epub 2017 Sept 14
View PubMed
Martinez Martinez P, Mielke MM. Sphingolipids in Alzheimer's Disease and Related Disorders. J Alzheimers Dis 2017; 60 (3):753-756
View PubMed
Pink A, Przybelski SA, Krell-Roesch J, Stokin GB, Roberts RO, Mielke MM, Knopman DS, Jack CR, Petersen RC, Geda YE. Cortical Thickness and Depressive Symptoms in Cognitively Normal Individuals: The Mayo Clinic Study of Aging. J Alzheimers Dis. 2017; 58 (4):1273-1281
View PubMed
Krell-Roesch J, Pink A, Roberts RO, Stokin GB, Mielke MM, Spangehl KA, Bartley MM, Knopman DS, Christianson TJ, Petersen RC, Geda YE. Timing of Physical Activity, Apolipoprotein E epsilon4 Genotype, and Risk of Incident Mild Cognitive Impairment. J Am Geriatr Soc. 2016 Dec; 64 (12):2479-2486 Epub 2016 Nov 01
View PubMed
Dage JL, Wennberg AMV, Airey DC, Hagen CE, Knopman DS, Machulda MM, Roberts RO, Jack CR Jr, Petersen RC, Mielke MM. Levels of tau protein in plasma are associated with neurodegeneration and cognitive function in a population-based elderly cohort. Alzheimers Dement. 2016 Dec; 12 (12):1226-1234 Epub 2016 July 18
View PubMed
Snyder HM, Asthana S, Bain L, Brinton R, Craft S, Dubal DB, Espeland MA, Gatz M, Mielke MM, Raber J, Rapp PR, Yaffe K, Carrillo MC. Sex biology contributions to vulnerability to Alzheimer's disease: A think tank convened by the Women's Alzheimer's Research Initiative. Alzheimers Dement. 2016 Nov; 12 (11):1186-1196 Epub 2016 Sept 27
View PubMed
Knopman DS, Jack CR Jr, Lundt ES, Weigand SD, Vemuri P, Lowe VJ, Kantarci K, Gunter JL, Senjem ML, Mielke MM, Machulda MM, Roberts RO, Boeve BF, Jones DT, Petersen RC. Evolution of neurodegeneration-imaging biomarkers from clinically normal to dementia in the Alzheimer disease spectrum. Neurobiol Aging. 2016 Oct; 46:32-42 Epub 2016 June 16
View PubMed
Miller VM, Garovic VD, Bailey KR, Lahr BD, Mielke MM, White WM, Jayachandran M. Pregnancy history and blood-borne microvesicles in middle aged women with and without coronary artery calcification. Atherosclerosis. 2016 Oct; 253:150-155 Epub 2016 Sept 09
View PubMed
Fabbri E, Yang A, Simonsick EM, Chia CW, Zoli M, Haughey NJ, Mielke MM, Ferrucci L, Coen PM. Circulating ceramides are inversely associated with cardiorespiratory fitness in participants aged 54-96 years from the Baltimore Longitudinal Study of Aging. Aging Cell. 2016 Oct; 15 (5):825-31 Epub 2016 May 02
View PubMed
Knopman DS, Jack CR Jr, Wiste HJ, Weigand SD, Vemuri P, Lowe VJ, Kantarci K, Gunter JL, Senjem ML, Mielke MM, Machulda MM, Roberts RO, Boeve BF, Jones DT, Petersen RC. Age and neurodegeneration imaging biomarkers in persons with Alzheimer disease dementia. Neurology. 2016 Aug 16; 87 (7):691-8 Epub 2016 July 15
View PubMed
Krell-Roesch J, Ruider H, Lowe VJ, Stokin GB, Pink A, Roberts RO, Mielke MM, Knopman DS, Christianson TJ, Machulda MM, Jack CR, Petersen RC, Geda YE. FDG-PET and Neuropsychiatric Symptoms among Cognitively Normal Elderly Persons: The Mayo Clinic Study of Aging. J Alzheimers Dis. 2016 Jul 14; 53 (4):1609-16
View PubMed
Gonzalez CE, Venkatraman VK, An Y, Landman BA, Davatzikos C, Ratnam Bandaru VV, Haughey NJ, Ferrucci L, Mielke MM, Resnick SM. Peripheral sphingolipids are associated with variation in white matter microstructure in older adults. Neurobiol Aging. 2016 Jul; 43:156-63 Epub 2016 Apr 21
View PubMed
Vassilaki M, Aakre JA, Mielke MM, Geda YE, Kremers WK, Alhurani RE, Machulda MM, Knopman DS, Petersen RC, Lowe VJ, Jack CR Jr, Roberts RO. Multimorbidity and neuroimaging biomarkers among cognitively normal persons. Neurology. 2016 May 31; 86 (22):2077-84 Epub 2016 Apr 13
View PubMed
Kantarci K, Lowe VJ, Lesnick TG, Tosakulwong N, Bailey KR, Fields JA, Shuster LT, Zuk SM, Senjem ML, Mielke MM, Gleason C, Jack CR, Rocca WA, Miller VM. Early Postmenopausal Transdermal 17beta-Estradiol Therapy and Amyloid-beta Deposition. J Alzheimers Dis. 2016 May 7; 53 (2):547-56
View PubMed
Wennberg AM, Gustafson D, Hagen CE, Roberts RO, Knopman D, Jack C, Petersen RC, Mielke MM. Serum Adiponectin Levels, Neuroimaging, and Cognition in the Mayo Clinic Study of Aging. J Alzheimers Dis. 2016 May 4; 53 (2):573-81
View PubMed
Graff-Radford J, Madhavan M, Vemuri P, Rabinstein AA, Cha RH, Mielke MM, Kantarci K, Lowe V, Senjem ML, Gunter JL, Knopman DS, Petersen RC, Jack CR Jr, Roberts RO. Atrial fibrillation, cognitive impairment, and neuroimaging. Alzheimers Dement. 2016 Apr; 12 (4):391-8 Epub 2015 Oct 23
View PubMed
Alhurani RE, Vassilaki M, Aakre JA, Mielke MM, Kremers WK, Machulda MM, Geda YE, Knopman DS, Petersen RC, Roberts RO. Decline in Weight and Incident Mild Cognitive Impairment: Mayo Clinic Study of Aging. JAMA Neurol. 2016 Apr; 73 (4):439-46
View PubMed
White WM, Mielke MM, Araoz PA, Lahr BD, Bailey KR, Jayachandran M, Miller VM, Garovic VD. A history of preeclampsia is associated with a risk for coronary artery calcification 3 decades later. Am J Obstet Gynecol. 2016 Apr; 214 (4):519.e1-519.e8 Epub 2016 Feb 10
View PubMed
Vemuri P, Lesnick TG, Przybelski SA, Knopman DS, Machulda M, Lowe VJ, Mielke MM, Roberts RO, Gunter JL, Senjem ML, Geda YE, Rocca WA, Petersen RC, Jack CR Jr. Effect of intellectual enrichment on AD biomarker trajectories: Longitudinal imaging study. Neurology. 2016 Mar 22; 86 (12):1128-35 Epub 2016 Feb 24
View PubMed
Mielke MM, Machulda MM, Hagen CE, Christianson TJ, Roberts RO, Knopman DS, Vemuri P, Lowe VJ, Kremers WK, Jack CR Jr, Petersen RC. Influence of amyloid and APOE on cognitive performance in a late middle-aged cohort. Alzheimers Dement. 2016 Mar; 12 (3):281-91 Epub 2015 Nov 19
View PubMed
Mielke MM, Milic NM, Weissgerber TL, White WM, Kantarci K, Mosley TH, Windham BG, Simpson BN, Turner ST, Garovic VD. Impaired Cognition and Brain Atrophy Decades After Hypertensive Pregnancy Disorders. Circ Cardiovasc Qual Outcomes. 2016 Feb; 9 (2 Suppl 1):S70-6
View PubMed
Roberts RO, Christianson TJ, Kremers WK, Mielke MM, Machulda MM, Vassilaki M, Alhurani RE, Geda YE, Knopman DS, Petersen RC. Association Between Olfactory Dysfunction and Amnestic Mild Cognitive Impairment and Alzheimer Disease Dementia. JAMA Neurol. 2016 Jan; 73 (1):93-101
View PubMed
Petersen RC, Wiste HJ, Weigand SD, Rocca WA, Roberts RO, Mielke MM, Lowe VJ, Knopman DS, Pankratz VS, Machulda MM, Geda YE, Jack CR Jr. Association of Elevated Amyloid Levels With Cognition and Biomarkers in Cognitively Normal People From the Community. JAMA Neurol. 2016 Jan; 73 (1):85-92
View PubMed
Jack CR Jr, Therneau TM, Wiste HJ, Weigand SD, Knopman DS, Lowe VJ, Mielke MM, Vemuri P, Roberts RO, Machulda MM, Senjem ML, Gunter JL, Rocca WA, Petersen RC. Transition rates between amyloid and neurodegeneration biomarker states and to dementia: a population-based, longitudinal cohort study. Lancet Neurol. 2016 Jan; 15 (1):56-64 Epub 2015 Nov 18
View PubMed
Savica R, Murray ME, Persson XM, Kantarci K, Parisi JE, Dickson DW, Petersen RC, Ferman TJ, Boeve BF, Mielke MM. Plasma sphingolipid changes with autopsy-confirmed Lewy Body or Alzheimer's pathology. Alzheimers Dement (Amst). 2016; 3:43-50
View PubMed
Jack CR Jr, Wiste HJ, Weigand SD, Knopman DS, Mielke MM, Vemuri P, Lowe V, Senjem ML, Gunter JL, Reyes D, Machulda MM, Roberts R, Petersen RC. Different definitions of neurodegeneration produce similar amyloid/neurodegeneration biomarker group findings. Brain. 2015 Dec; 138 (Pt 12):3747-59 Epub 2015 Sept 30
View PubMed
Knopman DS, Jack CR Jr, Lundt ES, Wiste HJ, Weigand SD, Vemuri P, Lowe VJ, Kantarci K, Gunter JL, Senjem ML, Mielke MM, Machulda MM, Roberts RO, Boeve BF, Jones DT, Petersen RC. Role of beta-Amyloidosis and Neurodegeneration in Subsequent Imaging Changes in Mild Cognitive Impairment. JAMA Neurol. 2015 Dec; 72 (12):1475-83
View PubMed
Mielke MM, Bandaru VV, Han D, An Y, Resnick SM, Ferrucci L, Haughey NJ. Demographic and clinical variables affecting mid- to late-life trajectories of plasma ceramide and dihydroceramide species. Aging Cell. 2015 Dec; 14 (6):1014-23 Epub 2015 July 20
View PubMed
Knopman DS, Beiser A, Machulda MM, Fields J, Roberts RO, Pankratz VS, Aakre J, Cha RH, Rocca WA, Mielke MM, Boeve BF, Devine S, Ivnik RJ, Au R, Auerbach S, Wolf PA, Seshadri S, Petersen RC. Spectrum of cognition short of dementia: Framingham Heart Study and Mayo Clinic Study of Aging. Neurology. 2015 Nov 10; 85 (19):1712-21 Epub 2015 Oct 09
View PubMed
Mielke MM, Machulda MM, Hagen CE, Edwards KK, Roberts RO, Pankratz VS, Knopman DS, Jack CR Jr, Petersen RC. Performance of the CogState computerized battery in the Mayo Clinic Study on Aging. Alzheimers Dement. 2015 Nov; 11(11):1367-76. Epub 2015 Apr 06.
View PubMed
Peterlin BL, Mielke MM, Dickens AM, Chatterjee S, Dash P, Alexander G, Vieira RV, Bandaru VV, Dorskind JM, Tietjen GE, Haughey NH. Interictal, circulating sphingolipids in women with episodic migraine: A case-control study. Neurology. 2015 Oct 6; 85 (14):1214-23 Epub 2015 Sept 09
View PubMed
Gustafson DR, Mielke MM, Keating SA, Holman S, Minkoff H, Crystal HA. Leptin, Adiponectin and Cognition in Middle-aged HIV-infected and Uninfected Women. The Brooklyn Women's Interagency HIV Study. J Gerontol Geriatr Res. 2015 Oct; 4 (5) Epub 2015 Sept 23
View PubMed
Rabin LA, Smart CM, Crane PK, Amariglio RE, Berman LM, Boada M, Buckley RF, Chetelat G, Dubois B, Ellis KA, Gifford KA, Jefferson AL, Jessen F, Katz MJ, Lipton RB, Luck T, Maruff P, Mielke MM, Molinuevo JL, Naeem F, Perrotin A, Petersen RC, Rami L, Reisberg B, Rentz DM, Riedel-Heller SG, Risacher SL, Rodriguez O, Sachdev PS, Saykin AJ, Slavin MJ, Snitz BE, Sperling RA, Tandetnik C, van der Flier WM, Wagner M, Wolfsgruber S, Sikkes SA. Subjective Cognitive Decline in Older Adults: An Overview of Self-Report Measures Used Across 19 International Research Studies. J Alzheimers Dis. 2015 Sep 24; 48 Suppl 1 (0 1):S63-86
View PubMed
Vassilaki M, Aakre JA, Cha RH, Kremers WK, St Sauver JL, Mielke MM, Geda YE, Machulda MM, Knopman DS, Petersen RC, Roberts RO. Multimorbidity and Risk of Mild Cognitive Impairment. J Am Geriatr Soc. 2015 Sep; 63 (9):1783-90 Epub 2015 Aug 27
View PubMed
Roberts RO, Cha RH, Mielke MM, Geda YE, Boeve BF, Machulda MM, Knopman DS, Petersen RC. Risk and protective factors for cognitive impairment in persons aged 85 years and older. Neurology. 2015 May 5; 84 (18):1854-61 Epub 2015 Apr 08
View PubMed
Jack CR Jr, Wiste HJ, Weigand SD, Knopman DS, Vemuri P, Mielke MM, Lowe V, Senjem ML, Gunter JL, Machulda MM, Gregg BE, Pankratz VS, Rocca WA, Petersen RC. Age, Sex, and APOE epsilon4 Effects on Memory, Brain Structure, and beta-Amyloid Across the Adult Life Span. JAMA Neurol. 2015 May; 72 (5):511-9
View PubMed
Pankratz VS, Roberts RO, Mielke MM, Knopman DS, Jack CR Jr, Geda YE, Rocca WA, Petersen RC. Predicting the risk of mild cognitive impairment in the Mayo Clinic Study of Aging. Neurology. 2015 Apr 7; 84 (14):1433-42 Epub 2015 Mar 18
View PubMed
Dickens AM, Anthony DC, Deutsch R, Mielke MM, Claridge TD, Grant I, Franklin D, Rosario D, Marcotte T, Letendre S, McArthur JC, Haughey NJ. Cerebrospinal fluid metabolomics implicate bioenergetic adaptation as a neural mechanism regulating shifts in cognitive states of HIV-infected patients. AIDS. 2015 Mar 13; 29 (5):559-69
View PubMed
Pink A, Stokin GB, Bartley MM, Roberts RO, Sochor O, Machulda MM, Krell-Roesch J, Knopman DS, Acosta JI, Christianson TJ, Pankratz VS, Mielke MM, Petersen RC, Geda YE. Neuropsychiatric symptoms, APOE epsilon4, and the risk of incident dementia: a population-based study. Neurology. 2015 Mar 3; 84 (9):935-43 Epub 2015 Feb 04
View PubMed
Vemuri P, Lesnick TG, Przybelski SA, Knopman DS, Preboske GM, Kantarci K, Raman MR, Machulda MM, Mielke MM, Lowe VJ, Senjem ML, Gunter JL, Rocca WA, Roberts RO, Petersen RC, Jack CR Jr. Vascular and amyloid pathologies are independent predictors of cognitive decline in normal elderly. Brain. 2015 Mar; 138 (Pt 3):761-71 Epub 2015 Jan 15
View PubMed
Mielke MM, Bandaru VV, Han D, An Y, Resnick SM, Ferrucci L, Haughey NJ. Factors affecting longitudinal trajectories of plasma sphingomyelins: the Baltimore Longitudinal Study of Aging. Aging Cell. 2015 Feb; 14 (1):112-21 Epub 2014 Oct 24
View PubMed
Roberts RO, Aakre JA, Cha RH, Kremers WK, Mielke MM, Velgos SN, Geda YE, Knopman DS, Petersen RC. Association of Pancreatic Polypeptide with Mild Cognitive Impairment Varies by APOE epsilon4 Allele. Front Aging Neurosci. 2015; 7:172 Epub 2015 Sept 08
View PubMed
Nowrangi MA, Okonkwo O, Lyketsos C, Oishi K, Mori S, Albert M, Mielke MM. Atlas-based diffusion tensor imaging correlates of executive function. J Alzheimers Dis. 2015; 44 (2):585-98
View PubMed
Vassilaki M, Cha RH, Aakre JA, Therneau TM, Geda YE, Mielke MM, Knopman DS, Petersen RC, Roberts RO. Mortality in mild cognitive impairment varies by subtype, sex, and lifestyle factors: the Mayo Clinic Study of Aging. J Alzheimers Dis. 2015; 45 (4):1237-45
View PubMed
Jessen F, Amariglio RE, van Boxtel M, Breteler M, Ceccaldi M, Chetelat G, Dubois B, Dufouil C, Ellis KA, van der Flier WM, Glodzik L, van Harten AC, de Leon MJ, McHugh P, Mielke MM, Molinuevo JL, Mosconi L, Osorio RS, Perrotin A, Petersen RC, Rabin LA, Rami L, Reisberg B, Rentz DM, Sachdev PS, de la Sayette V, Saykin AJ, Scheltens P, Shulman MB, Slavin MJ, Sperling RA, Stewart R, Uspenskaya O, Vellas B, Visser PJ, Wagner M, Subjective Cognitive Decline Initiative (SCD-I) Working Group. A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease. Alzheimers Dement. 2014 Nov; 10 (6):844-52 Epub 2014 May 03
View PubMed
Mielke MM, Weigand SD, Wiste HJ, Vemuri P, Machulda MM, Knopman DS, Lowe V, Roberts RO, Kantarci K, Rocca WA, Jack CR Jr, Petersen RC. Independent comparison of CogState computerized testing and a standard cognitive battery with neuroimaging. Alzheimers Dement. 2014 Nov; 10 (6):779-89 Epub 2014 Nov 15
View PubMed
Mielke MM, Haughey NJ, Bandaru VVR, Zetterberg H, Blennow K, Andreasson U, Johnson SC, Gleason CE, Blazel HM, Puglielli L, Sager MA, Asthana S, Carlsson CM. Cerebrospinal fluid sphingolipids, beta-amyloid, and tau in adults at risk for Alzheimer's disease. Neurobiol Aging. 2014 Nov; 35 (11):2486-2494 Epub 2014 May 27
View PubMed
Jack CR Jr, Wiste HJ, Weigand SD, Rocca WA, Knopman DS, Mielke MM, Lowe VJ, Senjem ML, Gunter JL, Preboske GM, Pankratz VS, Vemuri P, Petersen RC. Age-specific population frequencies of cerebral beta-amyloidosis and neurodegeneration among people with normal cognitive function aged 50-89 years: a cross-sectional study. Lancet Neurol. 2014 Oct; 13 (10):997-1005 Epub 2014 Sept 04
View PubMed
Rocca WA, Mielke MM, Vemuri P, Miller VM. Sex and gender differences in the causes of dementia: a narrative review. Maturitas. 2014 Oct; 79 (2):196-201 Epub 2014 May 27
View PubMed
Knopman DS, Jack CR Jr, Wiste HJ, Lundt ES, Weigand SD, Vemuri P, Lowe VJ, Kantarci K, Gunter JL, Senjem ML, Mielke MM, Roberts RO, Boeve BF, Petersen RC. 18F-fluorodeoxyglucose positron emission tomography, aging, and apolipoprotein E genotype in cognitively normal persons. Neurobiol Aging. 2014 Sep; 35 (9):2096-106 Epub 2014 Mar 11
View PubMed
Trushina E, Mielke MM. Recent advances in the application of metabolomics to Alzheimer's Disease. Biochim Biophys Acta. 2014 Aug; 1842 (8):1232-9 Epub 2013 June 29
View PubMed
Vemuri P, Lesnick TG, Przybelski SA, Machulda M, Knopman DS, Mielke MM, Roberts RO, Geda YE, Rocca WA, Petersen RC, Jack CR Jr. Association of lifetime intellectual enrichment with cognitive decline in the older population. JAMA Neurol. 2014 Aug; 71 (8):1017-24
View PubMed
Nicholson AM, Finch NA, Thomas CS, Wojtas A, Rutherford NJ, Mielke MM, Roberts RO, Boeve BF, Knopman DS, Petersen RC, Rademakers R. Progranulin protein levels are differently regulated in plasma and CSF. Neurology. 2014 May 27; 82 (21):1871-8 Epub 2014 Apr 25
View PubMed
Jack CR Jr, Wiste HJ, Knopman DS, Vemuri P, Mielke MM, Weigand SD, Senjem ML, Gunter JL, Lowe V, Gregg BE, Pankratz VS, Petersen RC. Rates of beta-amyloid accumulation are independent of hippocampal neurodegeneration. Neurology. 2014 May 6; 82 (18):1605-12 Epub 2014 Apr 04
View PubMed
Singh B, Mielke MM, Parsaik AK, Cha RH, Roberts RO, Scanlon PD, Geda YE, Christianson TJ, Pankratz VS, Petersen RC. A prospective study of chronic obstructive pulmonary disease and the risk for mild cognitive impairment. JAMA Neurol. 2014 May; 71 (5):581-8
View PubMed
Roberts RO, Knopman DS, Cha RH, Mielke MM, Pankratz VS, Boeve BF, Kantarci K, Geda YE, Jack CR Jr, Petersen RC, Lowe VJ. Diabetes and elevated hemoglobin A1c levels are associated with brain hypometabolism but not amyloid accumulation. J Nucl Med. 2014 May; 55 (5):759-64 Epub 2014 Mar 20
View PubMed
Roberts RO, Knopman DS, Przybelski SA, Mielke MM, Kantarci K, Preboske GM, Senjem ML, Pankratz VS, Geda YE, Boeve BF, Ivnik RJ, Rocca WA, Petersen RC, Jack CR Jr. Association of type 2 diabetes with brain atrophy and cognitive impairment. Neurology. 2014 Apr 1; 82 (13):1132-41 Epub 2014 Mar 19
View PubMed
Steinberg M, Hess K, Corcoran C, Mielke MM, Norton M, Breitner J, Green R, Leoutsakos J, Welsh-Bohmer K, Lyketsos C, Tschanz J. Vascular risk factors and neuropsychiatric symptoms in Alzheimer's disease: the Cache County Study. Int J Geriatr Psychiatry. 2014 Feb; 29(2):153-9. Epub 2013 May 17.
View PubMed
Roberts RO, Knopman DS, Mielke MM, Cha RH, Pankratz VS, Christianson TJ, Geda YE, Boeve BF, Ivnik RJ, Tangalos EG, Rocca WA, Petersen RC. Higher risk of progression to dementia in mild cognitive impairment cases who revert to normal. Neurology. 2014 Jan 28; 82 (4):317-25 Epub 2013 Dec 18
View PubMed
Mielke MM, Savica R, Wiste HJ, Weigand SD, Vemuri P, Knopman DS, Lowe VJ, Roberts RO, Machulda MM, Geda YE, Petersen RC, Jack CR Jr. Head trauma and in vivo measures of amyloid and neurodegeneration in a population-based study. Neurology. 2014 Jan 07; 82(1):70-6. Epub 2013 Dec 26.
View PubMed
Knopman DS, Roberts RO, Pankratz VS, Cha RH, Rocca WA, Mielke MM, Boeve BF, Tangalos EG, Ivnik RJ, Geda YE, Petersen RC. Incidence of dementia among participants and nonparticipants in a longitudinal study of cognitive aging. Am J Epidemiol. 2014; 180(4):414-23.
View PubMed
Singh B, Parsaik AK, Mielke MM, Erwin PJ, Knopman DS, Petersen RC, Roberts RO. Association of mediterranean diet with mild cognitive impairment and Alzheimer's disease: a systematic review and meta-analysis. J Alzheimers Dis. 2014; 39 (2):271-82
View PubMed
Roberts RO, Knopman DS, Geda YE, Cha RH, Pankratz VS, Baertlein L, Boeve BF, Tangalos EG, Ivnik RJ, Mielke MM, Petersen RC. Association of diabetes with amnestic and nonamnestic mild cognitive impairment. Alzheimers Dement. 2014 Jan; 10 (1):18-26 Epub 2013 Apr 03
View PubMed
Snyder HM, Carrillo MC, Grodstein F, Henriksen K, Jeromin A, Lovestone S, Mielke MM, O'Bryant S, Sarasa M, Sjogren M, Soares H, Teeling J, Trushina E, Ward M, West T, Bain LJ, Shineman DW, Weiner M, Fillit HM. Developing novel blood-based biomarkers for Alzheimer's disease. Alzheimers Dement. 2014 Jan; 10 (1):109-14
View PubMed
Mielke MM, Vemuri P, Rocca WA. Clinical epidemiology of Alzheimer's disease: assessing sex and gender differences. Clin Epidemiol. 2014; 6:37-48 Epub 2014 Jan 08
View PubMed
Geda YE, Roberts RO, Mielke MM, Knopman DS, Christianson TJH, Pankratz VS, Boeve BF, Sochor O, Tangalos EG, Petersen RC, Rocca WA. Baseline neuropsychiatric symptoms and the risk of incident mild cognitive impairment: A population-based study. Am J Psychiatry. 2014; 171(5):572-81.
View PubMed
Gustafson DR, Mielke MM, Tien PC, Valcour V, Cohen M, Anastos K, Liu C, Pearce L, Golub ET, Minkoff H, Crystal HA. Anthropometric measures and cognition in middle-aged HIV-infected and uninfected women. The Women's Interagency HIV Study. J Neurovirol. 2013 Dec; 19(6):574-85. Epub 2013 Dec 12.
View PubMed
Jack CR Jr, Wiste HJ, Weigand SD, Knopman DS, Lowe V, Vemuri P, Mielke MM, Jones DT, Senjem ML, Gunter JL, Gregg BE, Pankratz VS, Petersen RC. Amyloid-first and neurodegeneration-first profiles characterize incident amyloid PET positivity. Neurology. 2013 Nov 12; 81 (20):1732-40 Epub 2013 Oct 16
View PubMed
McDade EM, Boot BP, Christianson TJ, Pankratz VS, Boeve BF, Ferman TJ, Bieniek K, Hollman JH, Roberts RO, Mielke MM, Knopman DS, Petersen RC. Subtle gait changes in patients with REM sleep behavior disorder. Mov Disord. 2013 Nov; 28 (13):1847-53 Epub 2013 Oct 15
View PubMed
Singh B, Parsaik AK, Mielke MM, Roberts RO, Scanlon PD, Geda YE, Pankratz VS, Christianson T, Yawn BP, Petersen RC. Chronic obstructive pulmonary disease and association with mild cognitive impairment: the Mayo Clinic Study of Aging. Mayo Clin Proc. 2013 Nov; 88 (11):1222-30
View PubMed
Bandaru VV, Mielke MM, Sacktor N, McArthur JC, Grant I, Letendre S, Chang L, Wojna V, Pardo C, Calabresi P, Munsaka S, Haughey NJ. A lipid storage-like disorder contributes to cognitive decline in HIV-infected subjects. Neurology. 2013 Oct 22; 81 (17):1492-9 Epub 2013 Sept 11
View PubMed
Nowrangi MA, Lyketsos CG, Leoutsakos JM, Oishi K, Albert M, Mori S, Mielke MM. Longitudinal, region-specific course of diffusion tensor imaging measures in mild cognitive impairment and Alzheimer's disease. Alzheimers Dement. 2013 Sep; 9(5):519-28. Epub 2012 Dec 12.
View PubMed
Knopman DS, Jack CR Jr, Wiste HJ, Weigand SD, Vemuri P, Lowe VJ, Kantarci K, Gunter JL, Senjem ML, Mielke MM, Roberts RO, Boeve BF, Petersen RC. Selective worsening of brain injury biomarker abnormalities in cognitively normal elderly persons with beta-amyloidosis. JAMA Neurol. 2013 Aug; 70 (8):1030-8
View PubMed
Petersen RC, Aisen P, Boeve BF, Geda YE, Ivnik RJ, Knopman DS, Mielke M, Pankratz VS, Roberts R, Rocca WA, Weigand S, Weiner M, Wiste H, Jack CR Jr. Mild cognitive impairment due to Alzheimer disease in the community. Ann Neurol. 2013 Aug; 74 (2):199-208
View PubMed
Mielke MM, Roberts RO, Savica R, Cha R, Drubach DI, Christianson T, Pankratz VS, Geda YE, Machulda MM, Ivnik RJ, Knopman DS, Boeve BF, Rocca WA, Petersen RC. Assessing the temporal relationship between cognition and gait: slow gait predicts cognitive decline in the Mayo Clinic Study of Aging. J Gerontol A Biol Sci Med Sci. 2013 Aug; 68 (8):929-37 Epub 2012 Dec 18
View PubMed
Rosenberg PB, Mielke MM, Appleby BS, Oh ES, Geda YE, Lyketsos CG. The association of neuropsychiatric symptoms in MCI with incident dementia and Alzheimer disease. Am J Geriatr Psychiatry. 2013 Jul; 21(7):685-95. Epub 2013 Feb 06.
View PubMed
Knopman DS, Jack CR Jr, Wiste HJ, Weigand SD, Vemuri P, Lowe VJ, Kantarci K, Gunter JL, Senjem ML, Mielke MM, Roberts RO, Boeve BF, Petersen RC. Brain injury biomarkers are not dependent on beta-amyloid in normal elderly. Ann Neurol. 2013 Apr; 73 (4):472-80 Epub 2013 Feb 19
View PubMed
Miller VM, Garovic VD, Kantarci K, Barnes JN, Jayachandran M, Mielke MM, Joyner MJ, Shuster LT, Rocca WA. Sex-specific risk of cardiovascular disease and cognitive decline: pregnancy and menopause. Biol Sex Differ. 2013 Mar 28; 4 (1):6
View PubMed
Jack CR Jr, Wiste HJ, Lesnick TG, Weigand SD, Knopman DS, Vemuri P, Pankratz VS, Senjem ML, Gunter JL, Mielke MM, Lowe VJ, Boeve BF, Petersen RC. Brain beta-amyloid load approaches a plateau. Neurology. 2013 Mar 5; 80 (10):890-6 Epub 2013 Feb 27
View PubMed
Roberts RO, Geda YE, Knopman DS, Cha RH, Pankratz VS, Boeve BF, Tangalos EG, Ivnik RJ, Mielke MM, Petersen RC. Cardiac disease associated with increased risk of nonamnestic cognitive impairment: stronger effect on women. JAMA Neurol. 2013 Mar 1; 70 (3):374-82
View PubMed
Rabins PV, Schwartz S, Black BS, Corcoran C, Fauth E, Mielke M, Christensen J, Lyketsos C, Tschanz J. Predictors of progression to severe Alzheimer's disease in an incidence sample. Alzheimers Dement. 2013 Mar; 9(2):204-7. Epub 2012 Nov 02.
View PubMed
Parker DC, Mielke MM, Yu Q, Rosenberg PB, Jain A, Lyketsos CG, Fedarko NS, Oh ES. Plasma neopterin level as a marker of peripheral immune activation in amnestic mild cognitive impairment and Alzheimer's disease. Int J Geriatr Psychiatry. 2013 Feb; 28(2):149-54. Epub 2012 Apr 27.
View PubMed
Mielke MM, Maetzler W, Haughey NJ, Bandaru VV, Savica R, Deuschle C, Gasser T, Hauser AK, Graber-Sultan S, Schleicher E, Berg D, Liepelt-Scarfone I. Plasma ceramide and glucosylceramide metabolism is altered in sporadic Parkinson's disease and associated with cognitive impairment: a pilot study. PLoS One. 2013; 8 (9):e73094 Epub 2013 Sept 18
View PubMed
Machulda MM, Pankratz VS, Christianson TJ, Ivnik RJ, Mielke MM, Roberts RO, Knopman DS, Boeve BF, Petersen RC. Practice effects and longitudinal cognitive change in normal aging vs. incident mild cognitive impairment and dementia in the Mayo Clinic Study of Aging. Clin Neuropsychol. 2013; 27 (8):1247-64 Epub 2013 Sept 17
View PubMed
Sachdev PS, Lipnicki DM, Kochan NA, Crawford JD, Rockwood K, Xiao S, Li J, Li X, Brayne C, Matthews FE, Stephan BC, Lipton RB, Katz MJ, Ritchie K, Carriere I, Ancelin ML, Seshadri S, Au R, Beiser AS, Lam LC, Wong CH, Fung AW, Kim KW, Han JW, Kim TH, Petersen RC, Roberts RO, Mielke MM, Ganguli M, Dodge HH, Hughes T, Anstey KJ, Cherbuin N, Butterworth P, Ng TP, Gao Q, Reppermund S, Brodaty H, Meguro K, Schupf N, Manly J, Stern Y, Lobo A, Lopez-Anton R, Santabarbara J, Cosmic. COSMIC (Cohort Studies of Memory in an International Consortium): an international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups. BMC Neurol. 2013; 13:165. Epub 2013 Nov 06.
View PubMed
Saleem M, Ratnam Bandaru VV, Herrmann N, Swardfager W, Mielke MM, Oh PI, Shammi P, Kiss A, Haughey NJ, Rovinski R, Lanctot KL. Ceramides predict verbal memory performance in coronary artery disease patients undertaking exercise: a prospective cohort pilot study. BMC Geriatr. 2013; 13:135. Epub 2013 Dec 12.
View PubMed
Trushina E, Dutta T, Persson XM, Mielke MM, Petersen RC. Identification of altered metabolic pathways in plasma and CSF in mild cognitive impairment and Alzheimer's disease using metabolomics. PLoS One. 2013; 8 (5):e63644 Epub 2013 May 20
View PubMed
Leyhe T, Darreh-Shori T, Laske C, Mielke MM, Maetzler W. Biomarkers in Alzheimer's disease and lewy body disorders with dementia. Int J Alzheimers Dis. 2013; 2013:473181 Epub 2013 Jan 09
View PubMed
Geda YE, Ragossnig M, Roberts LA, Roberts RO, Pankratz VS, Christianson TJ, Mielke MM, Levine JA, Boeve BF, Sochor O, Tangalos EG, Knopman DS, Petersen RC. Caloric intake, aging, and mild cognitive impairment: a population-based study. J Alzheimers Dis. 2013; 34 (2):501-7
View PubMed
Rosenberg PB, Mielke MM, Han D, Leoutsakos JS, Lyketsos CG, Rabins PV, Zandi PP, Breitner JC, Norton MC, Welsh-Bohmer KA, Zuckerman IH, Rattinger GB, Green RC, Corcoran C, Tschanz JT. The association of psychotropic medication use with the cognitive, functional, and neuropsychiatric trajectory of Alzheimer's disease. Int J Geriatr Psychiatry. 2012 Dec; 27(12):1248-57. Epub 2012 Feb 29.
View PubMed
Mielke MM, Wiste HJ, Weigand SD, Knopman DS, Lowe VJ, Roberts RO, Geda YE, Swenson-Dravis DM, Boeve BF, Senjem ML, Vemuri P, Petersen RC, Jack CR Jr. Indicators of amyloid burden in a population-based study of cognitively normal elderly. Neurology. 2012 Oct 9; 79 (15):1570-7 Epub 2012 Sept 12
View PubMed
Oishi K, Mielke MM, Albert M, Lyketsos CG, Mori S. The fornix sign: A potential sign for Alzheimer's disease based on diffusion tensor imaging. J Neuroimaging PMCID PMC3256282. 2012 Oct; 22(4):365-74.
Mielke MM, Haughey NJ. Could plasma sphingolipids be diagnostic or prognostic biomarkers for Alzheimer's disease? Clin Lipidol. 2012 Oct; 7 (5):525-536
View PubMed
Leoutsakos JM, Han D, Mielke MM, Forrester SN, Tschanz JT, Corcoran CD, Green RC, Norton MC, Welsh-Bohmer KA, Lyketsos CG. Effects of general medical health on Alzheimer's progression: the Cache County Dementia Progression Study. Int Psychogeriatr. 2012 Oct; 24(10):1561-70. Epub 2012 Jun 12.
View PubMed
Mielke MM, Bandaru VV, Haughey NJ, Xia J, Fried LP, Yasar S, Albert M, Varma V, Harris G, Schneider EB, Rabins PV, Bandeen-Roche K, Lyketsos CG, Carlson MC. Serum ceramides increase the risk of Alzheimer disease: the Women's Health and Aging Study II. Neurology. 2012 Aug 14; 79 (7):633-41 Epub 2012 July 18
View PubMed
Rao V, Mielke M, Xu X, Smith GS, McCann UD, Bergey A, Doshi V, Pham DL, Yousem D, Mori S. Diffusion tensor imaging atlas-based analyses in major depression after mild traumatic brain injury. J Neuropsychiatry Clin Neurosci. 2012 Summer; 24(3):309-15.
View PubMed
Mielke MM, Leoutsakos JM, Corcoran CD, Green RC, Norton MC, Welsh-Bohmer KA, Tschanz JT, Lyketsos CG. Effects of Food and Drug Administration-approved medications for Alzheimer's disease on clinical progression. Alzheimers Dement. 2012 May; 8(3):180-7. Epub 2012 Feb 01.
View PubMed
Tighe SK, Oishi K, Mori S, Smith GS, Albert M, Lyketsos CG, Mielke MM. Diffusion tensor imaging of neuropsychiatric symptoms in mild cognitive impairment and Alzheimer’s dementia J Neuropsychiatry Clin Neurosci 2012.2012; 24:(4)484-8.
Mielke MM, Okonkwo OC, Oishi K, Mori S, Tighe S, Miller MI, Ceritoglu C, Brown T, Albert M, Lyketsos CG. Fornix integrity and hippocampal volume predict memory decline and progression to Alzheimer's disease. Alzheimers Dement. 2012; 8 (2):105-13
View PubMed
Tschanz JT, Corcoran CD, Schwartz S, Treiber K, Green RC, Norton MC, Mielke MM, Piercy K, Steinberg M, Rabins PV, Leoutsakos JM, Welsh-Bohmer KA, Breitner JC, Lyketsos CG. Progression of cognitive, functional, and neuropsychiatric symptom domains in a population cohort with Alzheimer dementia: the Cache County Dementia Progression study. Am J Geriatr Psychiatry. 2011 Jun; 19(6):532-42.
View PubMed
Rosenberg PB, Mielke MM, Appleby B, Oh E, Leoutsakos JM, Lyketsos CG. Neuropsychiatric symptoms in MCI subtypes: the importance of executive dysfunction. Int J Geriatr Psychiatry. 2011 Apr; 26(4):364-72. Epub 2010 Sep 15.
View PubMed
Gracia-Garcia P, Rao V, Haughey NJ, Ratnam Banduru VV, Smith G, Rosenberg PB, Lobo A, Lyketsos CG, Mielke MM. Elevated plasma ceramides in depression. J Neuropsychiatry Clin Neurosci. 2011 Spring; 23(2):215-8.
View PubMed
Oishi K, Mielke MM, Albert M, Lyketsos CG, Mori S. DTI analyses and clinical applications in Alzheimer's disease. J Alzheimers Dis. 2011; 26 Suppl 3:287-96.
View PubMed
Mielke MM, Haughey NJ, Bandaru VV, Weinberg DD, Darby E, Zaidi N, Pavlik V, Doody RS, Lyketsos CG. Plasma sphingomyelins are associated with cognitive progression in Alzheimer's disease. J Alzheimers Dis. 2011; 27 (2):259-69
View PubMed
Okonkwo OC, Mielke MM, Griffith HR, Moghekar AR, O'Brien RJ, Shaw LM, Trojanowski JQ, Albert MS, Alzheimer's Disease Neuroimaging Initiative. Cerebrospinal fluid profiles and prospective course and outcome in patients with amnestic mild cognitive impairment. Arch Neurol. 2011 Jan; 68(1):113-9.
View PubMed
Mielke MM, Leoutsakos JM, Tschanz JT, Green RC, Tripodis Y, Corcoran CD, Norton MC, Lyketsos CG. Interaction between vascular factors and the APOE epsilon4 allele in predicting rate of progression in Alzheimer's disease. J Alzheimers Dis. 2011; 26(1):127-34.
View PubMed
Oishi K, Akhter K, Mielke M, Ceritoglu C, Zhang J, Jiang H, Li X, Younes L, Miller MI, van Zijl PC, Albert M, Lyketsos CG, Mori S. Multi-modal MRI analysis with disease-specific spatial filtering: initial testing to predict mild cognitive impairment patients who convert to Alzheimer's disease. Front Neurol (Aug) Volume 2. 2011; Article 54:1-8.
Yasar S, Ko JY, Nothelle S, Mielke MM, Carlson MC. Evaluation of the effect of systolic blood pressure and pulse pressure on cognitive function: the Women's Health and Aging Study II. PLoS One. 2011; 6(12):e27976. Epub 2011 Dec 09.
View PubMed
Rao V, Bertrand M, Rosenberg P, Makley M, Schretlen DJ, Brandt J, Mielke MM. Predictors of new-onset depression after mild traumatic brain injury. J Neuropsychiatry Clin Neurosci. 2010 Winter; 22(1):100-4.
View PubMed
Mielke MM, Lyketsos CG. Alterations of the sphingolipid pathway in Alzheimer's disease: new biomarkers and treatment targets? Neuromolecular Med. 2010 Dec; 12(4):331-40. Epub 2010 Jun 23.
View PubMed
Mielke MM, Zandi PP, Shao H, Waern M, Ostling S, Guo X, Bjorkelund C, Lissner L, Skoog I, Gustafson DR. The 32-year relationship between cholesterol and dementia from midlife to late life. Neurology. 2010 Nov 23; 75(21):1888-95. Epub 2010 Nov 10.
View PubMed
Mielke MM, Bandaru VV, McArthur JC, Chu M, Haughey NJ. Disturbance in cerebral spinal fluid sphingolipid content is associated with memory impairment in subjects infected with the human immunodeficiency virus. J Neurovirol. 2010 Nov; 16(6):445-56. Epub 2010 Nov 18.
View PubMed
Mielke MM, Haughey NJ, Ratnam Bandaru VV, Schech S, Carrick R, Carlson MC, Mori S, Miller MI, Ceritoglu C, Brown T, Albert M, Lyketsos CG. Plasma ceramides are altered in mild cognitive impairment and predict cognitive decline and hippocampal volume loss. Alzheimers Dement. 2010 Sep; 6(5):378-85.
View PubMed
Okonkwo OC, Alosco ML, Griffith HR, Mielke MM, Shaw LM, Trojanowski JQ, Tremont G, Alzheimer's Disease Neuroimaging Initiative. Cerebrospinal fluid abnormalities and rate of decline in everyday function across the dementia spectrum: normal aging, mild cognitive impairment, and Alzheimer disease. Arch Neurol. 2010 Jun; 67(6):688-96.
View PubMed
Rosenberg PB, Mielke MM, Xue QL, Carlson MC. Depressive symptoms predict incident cognitive impairment in cognitive healthy older women. Am J Geriatr Psychiatry. 2010 Mar; 18(3):204-11.
View PubMed
Mielke MM, Bandaru VV, Haughey NJ, Rabins PV, Lyketsos CG, Carlson MC. Serum sphingomyelins and ceramides are early predictors of memory impairment. Neurobiol Aging. 2010 Jan; 31(1):17-24. Epub 2008 May 05.
View PubMed
Oh ES, Mielke MM, Rosenberg PB, Jain A, Fedarko NS, Lyketsos CG, Mehta PD. Comparison of conventional ELISA with electrochemiluminescence technology for detection of amyloid-beta in plasma. J Alzheimers Dis. 2010; 21(3):769-73.
View PubMed
Ewers M, Mielke MM, Hampel H. Blood-based biomarkers of microvascular pathology in Alzheimer's disease. Exp Gerontol. 2010 Jan; 45(1):75-9. Epub 2009 Sep 24.
View PubMed
Carlson MC, Erickson KI, Kramer AF, Voss MW, Bolea N, Mielke M, McGill S, Rebok GW, Seeman T, Fried LP. Evidence for neurocognitive plasticity in at-risk older adults: the experience corps program. J Gerontol A Biol Sci Med Sci. 2009 Dec; 64(12):1275-82. Epub 2009 Aug 19.
View PubMed
Gustafson DR, Backman K, Waern M, Ostling S, Guo X, Zandi P, Mielke MM, Bengtsson C, Skoog I. Adiposity indicators and dementia over 32 years in Sweden. Neurology. 2009 Nov 10; 73(19):1559-66.
View PubMed
Mielke MM, Kozauer NA, Chan KC, George M, Toroney J, Zerrate M, Bandeen-Roche K, Wang MC, Vanzijl P, Pekar JJ, Mori S, Lyketsos CG, Albert M. Regionally-specific diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease. Neuroimage. 2009 May 15; 46(1):47-55. Epub 2009 Feb 5
View PubMed
Rosenberg PB, Mielke MM, Tschanz J, Cook L, Corcoran C, Hayden KM, Norton M, Rabins PV, Green RC, Welsh-Bohmer KA, Breitner JC, Munger R, Lyketsos CG. Effects of cardiovascular medications on rate of functional decline in Alzheimer disease. Am J Geriatr Psychiatry. 2008 Nov; 16(11):883-92.
View PubMed
Lyketsos CG, Szekely CA, Mielke MM, Rosenberg PB, Zandi PP. Developing new treatments for Alzheimer's disease: the who, what, when, and how of biomarker-guided therapies. Int Psychogeriatr. 2008 Oct; 20(5):871-89. Epub 2008 May 23.
View PubMed
Mielke MM, Xue QL, Zhou J, Chaves PH, Fried LP, Carlson MC. Baseline serum cholesterol is selectively associated with motor speed and not rates of cognitive decline: the Women's Health and Aging Study II. J Gerontol A Biol Sci Med Sci. 2008 Jun; 63(6):619-24.
View PubMed
Rao V, Spiro J, Vaishnavi S, Rastogi P, Mielke M, Noll K, Cornwell E, Schretlen D, Makley M. Prevalence and types of sleep disturbances acutely after traumatic brain injury. Brain Inj. 2008 May; 22(5):381-6.
View PubMed
Kozauer NA, Mielke MM, Chan GK, Rebok GW, Lyketsos CG. Apolipoprotein E genotype and lifetime cognitive decline. Int Psychogeriatr. 2008 Feb; 20(1):109-23. Epub 2007 Aug 22.
View PubMed
Mielke MM, Rosenberg PB, Tschanz J, Cook L, Corcoran C, Hayden KM, Norton M, Rabins PV, Green RC, Welsh-Bohmer KA, Breitner JC, Munger R, Lyketsos CG. Vascular factors predict rate of progression in Alzheimer disease. Neurology. 2007 Nov 6; 69(19):1850-8.
View PubMed
Morgan MD, Mielke MM, O'Brien R, Troncoso JC, Zonderman AB, Lyketsos CG. Rates of depression in individuals with pathologic but not clinical Alzheimer disease are lower than those in individuals without the disease: findings from the Baltimore Longitudinal Study on Aging (BLSA). Alzheimer Dis Assoc Disord. 2007 Jul-Sep; 21(3):199-204.
View PubMed
Jerome GJ, Glass TA, Mielke M, Xue QL, Andersen RE, Fried LP. Physical activity participation by presence and type of functional deficits in older women: The Women's Health and Aging Studies. J Gerontol A Biol Sci Med Sci. 2006 Nov; 61(11):1171-6.
View PubMed
Mielke MM, Lyketsos CG. Lipids and the pathogenesis of Alzheimer's disease: is there a link? Int Rev Psychiatry. 2006 Apr; 18(2):173-86.
View PubMed
Rosenberg PB, Mielke MM, Samus QM, Rosenblatt A, Baker A, Brandt J, Rabins PV, Lyketsos CG. Transition to nursing home from assisted living is not associated with dementia or dementia-related problem behaviors. J Am Med Dir Assoc. 2006 Feb; 7(2):73-8. Epub 2005 Aug 08.
View PubMed
Sjogren M, Mielke M, Gustafson D, Zandi P, Skoog I. Cholesterol and Alzheimer's disease--is there a relation? Mech Ageing Dev. 2006 Feb; 127(2):138-47. Epub 2005 Dec 05.
View PubMed
Mielke MM, Zandi PP, Blennow K, Gustafson D, Sjogren M, Rosengren L, Skoog I. Low serum potassium in mid life associated with decreased cerebrospinal fluid Abeta42 in late life. Alzheimer Dis Assoc Disord. 2006 Jan-Mar; 20(1):30-6.
View PubMed
Mielke MM, Zandi PP. Hematologic risk factors of vascular disease and their relation to dementia. Dement Geriatr Cogn Disord. 2006; 21(5-6):335-52. Epub 2006 Feb 27.
View PubMed
Rosenberg PB, Mielke MM, Lyketsos CG. Caregiver assessment of patients' depression in Alzheimer disease: longitudinal analysis in a drug treatment study. Am J Geriatr Psychiatry. 2005 Sep; 13(9):822-6.
View PubMed
Mielke MM, Zandi PP, Sjogren M, Gustafson D, Ostling S, Steen B, Skoog I. High total cholesterol levels in late life associated with a reduced risk of dementia. Neurology. 2005 May 24; 64(10):1689-95.
View PubMed
Donny EC, Caggiula AR, Rowell PP, Gharib MA, Maldovan V, Booth S, Mielke MM, Hoffman A, McCallum S. Nicotine self-administration in rats: estrous cycle effects, sex differences and nicotinic receptor binding. Psychopharmacology (Berl). 2000 Sep; 151(4):392-405.
View PubMed
Donny EC, Caggiula AR, Rose C, Jacobs KS, Mielke MM, Sved AF. Differential effects of response-contingent and response-independent nicotine in rats. Eur J Pharmacol. 2000 Aug 25; 402(3):231-40.
View PubMed
Donny EC, Caggiula AR, Mielke MM, Booth S, Gharib MA, Hoffman A, Maldovan V, Shupenko C, McCallum SE. Nicotine self-administration in rats on a progressive ratio schedule of reinforcement. Psychopharmacology (Berl). 1999 Nov; 147(2):135-42.
View PubMed
Donny EC, Caggiula AR, Mielke MM, Jacobs KS, Rose C, Sved AF. Acquisition of nicotine self-administration in rats: the effects of dose, feeding schedule, and drug contingency. Psychopharmacology (Berl). 1998 Mar; 136(1):83-90.
View PubMed

Publications

Mayo Clinic Footer

Legal Conditions and Terms

Advertising

Reprint Permissions