Publications

  1. Arab JP, Sehrawat TS, Simonetto DA, Verma VK, Feng D, Tang T, Dreyer K, Yan X, Daley WL, Sanyal A, Chalasani N, Radaeva S, Yang L, Vargas H, Ibacache M, Gao B, Gores GJ, Malhi H, Kamath PS, Shah VH. An Open Label, Dose Escalation Study To Assess The Safety And Efficacy Of IL-22 Agonist F-652 In Patients With Alcoholic Hepatitis. Hepatology. 2019 Nov 27 [Epub ahead of print]
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  2. Croome KP, Mao S, Yang L, Pungpoapong S, Wadei HM, Taner CB. Improved National Results with Simultaneous Liver and Kidney Transplantation using Donation after Cardiac Death Donors. Liver Transpl. 2019 Oct 9 Epub 2019 Oct 09
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  3. Chen Y, Hata T, Rehman F, Kang L, Yang L, Kim BYS, Nguyen JH. Visualization of Hepatocellular Regeneration in Mice After Partial Hepatectomy. J Surg Res. 2019 Mar; 235:494-500 Epub 2018 Nov 26
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  4. Yang X, Xu Y, Gao D, Yang L, Qian SY. Dihomo-gamma-linolenic acid inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA. Redox Biol. 2019 Jan; 20:236-246 Epub 2018 Oct 15
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  5. Xu Y, Yang X, Gao D, Yang L, Miskimins K, Qian SY. Dihomo-gamma-linolenic acid inhibits xenograft tumor growth in mice bearing shRNA-transfected HCA-7 cells targeting delta-5-desaturase. BMC Cancer. 2018 Dec 19; 18 (1):1268
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  6. Xu Y, Yang X, Wang T, Yang L, He YY, Miskimins K, Qian SY. Knockdown delta-5-desaturase in breast cancer cells that overexpress COX-2 results in inhibition of growth, migration and invasion via a dihomo-gamma-linolenic acid peroxidation dependent mechanism. BMC Cancer. 2018 Mar 27; 18 (1):330
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  7. Bhanji RA, Carey EJ, Yang L, Watt KD. The Long Winding Road to Transplant: How Sarcopenia and Debility Impact Morbidity and Mortality on the Waitlist. Clin Gastroenterol Hepatol. 2017 Oct; 15 (10):1492-1497 Epub 2017 Apr 08
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  8. Yin M, Glaser KJ, Manduca A, Mounajjed T, Malhi H, Simonetto DA, Wang R, Yang L, Mao SA, Glorioso JM, Elgilani FM, Ward CJ, Harris PC, Nyberg SL, Shah VH, Ehman RL. Distinguishing between Hepatic Inflammation and Fibrosis with MR Elastography. Radiology. 2017 Sep; 284 (3):694-705 Epub 2017 Jan 27
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  9. Huang J, Zhang X, Du J, Duan R, Yang L, Moore JH, Chen Y, Tao C. Comparing Different Adverse Effects Among Multiple Drugs Using FAERS Data. Stud Health Technol Inform. 2017; 245:1268
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  10. Simonetto DA, Yang HY, Yin M, de Assuncao TM, Kwon JH, Hilscher M, Pan S, Yang L, Bi Y, Beyder A, Cao S, Simari RD, Ehman R, Kamath PS, Shah VH. Chronic passive venous congestion drives hepatic fibrogenesis via sinusoidal thrombosis and mechanical forces. Hepatology. 2015 Feb; 61 (2):648-59 Epub 2015 Jan 05
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  11. Bi Y, Li J, Ji B, Kang N, Yang L, Simonetto DA, Kwon JH, Kamath M, Cao S, Shah V. Sphingosine-1-phosphate mediates a reciprocal signaling pathway between stellate cells and cancer cells that promotes pancreatic cancer growth. Am J Pathol. 2014 Oct; 184 (10):2791-802 Epub 2014 Aug 08
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  12. Yang L, Kwon J, Popov Y, Gajdos GB, Ordog T, Brekken RA, Mukhopadhyay D, Schuppan D, Bi Y, Simonetto D, Shah VH. Vascular endothelial growth factor promotes fibrosis resolution and repair in mice. Gastroenterology. 2014 May; 146 (5):1339-50.e1 Epub 2014 Feb 04
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  13. Seo YS, Kwon JH, Yaqoob U, Yang L, De Assuncao TM, Simonetto DA, Verma VK, Shah VH. HMGB1 recruits hepatic stellate cells and liver endothelial cells to sites of ethanol-induced parenchymal cell injury. Am J Physiol Gastrointest Liver Physiol. 2013 Dec; 305 (11):G838-48 Epub 2013 Oct 03
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  14. Michelotti GA, Xie G, Swiderska M, Choi SS, Karaca G, Kruger L, Premont R, Yang L, Syn WK, Metzger D, Diehl AM. Smoothened is a master regulator of adult liver repair. J Clin Invest. 2013 Jun; 123 (6):2380-94
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  15. Liu C, Billadeau DD, Abdelhakim H, Leof E, Kaibuchi K, Bernabeu C, Bloom GS, Yang L, Boardman L, Shah VH, Kang N. IQGAP1 suppresses TbetaRII-mediated myofibroblastic activation and metastatic growth in liver. J Clin Invest. 2013 Mar; 123 (3):1138-56 Epub 2013 Feb 01
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  16. Omenetti A, Yang L, Gainetdinov RR, Guy CD, Choi SS, Chen W, Caron MG, Diehl AM. Paracrine modulation of cholangiocyte serotonin synthesis orchestrates biliary remodeling in adults. Am J Physiol Gastrointest Liver Physiol. 2011 Feb; 300 (2):G303-15 Epub 2010 Nov 11
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  17. Yang L, Stimpson SA, Chen L, Wallace Harrington W, Rockey DC. Effectiveness of the PPARgamma agonist, GW570, in liver fibrosis. Inflamm Res. 2010 Dec; 59(12):1061-71. Epub 2010 Jun 29.
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  18. Pereira Tde A, Witek RP, Syn WK, Choi SS, Bradrick S, Karaca GF, Agboola KM, Jung Y, Omenetti A, Moylan CA, Yang L, Fernandez-Zapico ME, Jhaveri R, Shah VH, Pereira FE, Diehl AM. Viral factors induce Hedgehog pathway activation in humans with viral hepatitis, cirrhosis, and hepatocellular carcinoma. Lab Invest. 2010 Dec; 90(12):1690-703. Epub 2010 Aug 9
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  19. Choi SS, Witek RP, Yang L, Omenetti A, Syn WK, Moylan CA, Jung Y, Karaca GF, Teaberry VS, Pereira TA, Wang J, Ren XR, Diehl AM. Activation of Rac1 promotes hedgehog-mediated acquisition of the myofibroblastic phenotype in rat and human hepatic stellate cells. Hepatology. 2010 Jul; 52 (1):278-90
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  20. Choi SS, Omenetti A, Witek RP, Moylan CA, Syn WK, Jung Y, Yang L, Sudan DL, Sicklick JK, Michelotti GA, Rojkind M, Diehl AM. Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis. Am J Physiol Gastrointest Liver Physiol. 2009 Dec; 297 (6):G1093-106 Epub 2009 Oct 08
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  21. Syn WK, Jung Y, Omenetti A, Abdelmalek M, Guy CD, Yang L, Wang J, Witek RP, Fearing CM, Pereira TA, Teaberry V, Choi SS, Conde-Vancells J, Karaca GF, Diehl AM. Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease. Gastroenterology. 2009 Oct; 137 (4):1478-1488.e8 Epub 2009 July 03
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  22. Wang MH, Palmeri ML, Guy CD, Yang L, Hedlund LW, Diehl AM, Nightingale KR. In vivo quantification of liver stiffness in a rat model of hepatic fibrosis with acoustic radiation force. Ultrasound Med Biol. 2009 Oct; 35 (10):1709-21 Epub 2009 Aug 14
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  23. Syn WK, Yang L, Chiang DJ, Qian Y, Jung Y, Karaca G, Choi SS, Witek RP, Omenetti A, Pereira TA, Diehl AM. Genetic differences in oxidative stress and inflammatory responses to diet-induced obesity do not alter liver fibrosis in mice. Liver Int. 2009 Sep; 29 (8):1262-72 Epub 2009 Apr 20
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  24. Sun B, Li S, Yang L, Damodaran T, Desai D, Diehl AM, Alzate O, Koeberl DD. Activation of glycolysis and apoptosis in glycogen storage disease type Ia. Mol Genet Metab. 2009 Aug; 97 (4):267-71 Epub 2009 Apr 10
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  25. Omenetti A, Syn WK, Jung Y, Francis H, Porrello A, Witek RP, Choi SS, Yang L, Mayo MJ, Gershwin ME, Alpini G, Diehl AM. Repair-related activation of hedgehog signaling promotes cholangiocyte chemokine production. Hepatology. 2009 Aug; 50 (2):518-27
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  26. Qiang G, Yang L, Witek RP, Jhaveri R. Recombinant adenoviruses expressing steatosis-associated hepatitis C virus genotype 3 core protein produce intracellular lipid accumulation in cultured and primary hepatocytes. Virus Res. 2009 Jan; 139 (1):127-30 Epub 2008 Dec 04
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  27. Witek RP, Yang L, Liu R, Jung Y, Omenetti A, Syn WK, Choi SS, Cheong Y, Fearing CM, Agboola KM, Chen W, Diehl AM. Liver cell-derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells. Gastroenterology. 2009 Jan; 136 (1):320-330.e2 Epub 2008 Oct 07
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  28. Omenetti A, Porrello A, Jung Y, Yang L, Popov Y, Choi SS, Witek RP, Alpini G, Venter J, Vandongen HM, Syn WK, Baroni GS, Benedetti A, Schuppan D, Diehl AM. Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. J Clin Invest. 2008 Oct; 118 (10):3331-42
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  29. Omenetti A, Popov Y, Jung Y, Choi SS, Witek RP, Yang L, Brown KD, Schuppan D, Diehl AM. The hedgehog pathway regulates remodelling responses to biliary obstruction in rats. Gut. 2008 Sep; 57 (9):1275-82 Epub 2008 Mar 28
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  30. Yang L, Jung Y, Omenetti A, Witek RP, Choi S, Vandongen HM, Huang J, Alpini GD, Diehl AM. Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers. Stem Cells. 2008 Aug; 26 (8):2104-13 Epub 2008 May 29
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  31. Jung Y, Brown KD, Witek RP, Omenetti A, Yang L, Vandongen M, Milton RJ, Hines IN, Rippe RA, Spahr L, Rubbia-Brandt L, Diehl AM. Accumulation of hedgehog-responsive progenitors parallels alcoholic liver disease severity in mice and humans. Gastroenterology. 2008 May; 134 (5):1532-43 Epub 2008 Feb 14
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  32. Yamaguchi K, Yang L, McCall S, Huang J, Yu XX, Pandey SK, Bhanot S, Monia BP, Li YX, Diehl AM. Diacylglycerol acyltranferase 1 anti-sense oligonucleotides reduce hepatic fibrosis in mice with nonalcoholic steatohepatitis. Hepatology. 2008 Feb; 47 (2):625-35
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  33. Yang L, Wang Y, Mao H, Fleig S, Omenetti A, Brown KD, Sicklick JK, Li YX, Diehl AM. Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells. J Hepatol. 2008 Jan; 48 (1):98-106 Epub 2007 Oct 18
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  34. Fleig SV, Choi SS, Yang L, Jung Y, Omenetti A, VanDongen HM, Huang J, Sicklick JK, Diehl AM. Hepatic accumulation of Hedgehog-reactive progenitors increases with severity of fatty liver damage in mice. Lab Invest. 2007 Dec; 87 (12):1227-39 Epub 2007 Oct 22
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  35. Yang L, Jhaveri R, Huang J, Qi Y, Diehl AM. Endoplasmic reticulum stress, hepatocyte CD1d and NKT cell abnormalities in murine fatty livers. Lab Invest. 2007 Sep; 87 (9):927-37 Epub 2007 July 02
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  36. Yamaguchi K, Yang L, McCall S, Huang J, Yu XX, Pandey SK, Bhanot S, Monia BP, Li YX, Diehl AM. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis. Hepatology. 2007 Jun; 45 (6):1366-74
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  37. Omenetti A, Yang L, Li YX, McCall SJ, Jung Y, Sicklick JK, Huang J, Choi S, Suzuki A, Diehl AM. Hedgehog-mediated mesenchymal-epithelial interactions modulate hepatic response to bile duct ligation. Lab Invest. 2007 May; 87 (5):499-514 Epub 2007 Mar 05
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  38. Zhao C, Chen W, Yang L, Chen L, Stimpson SA, Diehl AM. PPARgamma agonists prevent TGFbeta1/Smad3-signaling in human hepatic stellate cells. Biochem Biophys Res Commun. 2006 Nov 17; 350 (2):385-91 Epub 2006 Sept 22
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  39. Yang L, Chan CC, Kwon OS, Liu S, McGhee J, Stimpson SA, Chen LZ, Harrington WW, Symonds WT, Rockey DC. Regulation of peroxisome proliferator-activated receptor-gamma in liver fibrosis. Am J Physiol Gastrointest Liver Physiol. 2006 Nov; 291 (5):G902-11 Epub 2006 June 22
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  40. Choi SS, Sicklick JK, Ma Q, Yang L, Huang J, Qi Y, Chen W, Li YX, Goldschmidt-Clermont PJ, Diehl AM. Sustained activation of Rac1 in hepatic stellate cells promotes liver injury and fibrosis in mice. Hepatology. 2006 Nov; 44 (5):1267-77
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  41. Zhong Z, Schwabe RF, Kai Y, He L, Yang L, Bunzendahl H, Brenner DA, Lemasters JJ. Liver regeneration is suppressed in small-for-size liver grafts after transplantation: involvement of c-Jun N-terminal kinase, cyclin D1, and defective energy supply. Transplantation. 2006 Jul 27; 82 (2):241-50
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  42. Yang L, Magness ST, Bataller R, Rippe RA, Brenner DA. NF-kappaB activation in Kupffer cells after partial hepatectomy. Am J Physiol Gastrointest Liver Physiol. 2005 Sep; 289 (3):G530-8 Epub 2005 May 19
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  43. Yang L, Bataller R, Dulyx J, Coffman TM, Gines P, Rippe RA, Brenner DA. Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice. J Hepatol. 2005 Aug; 43 (2):317-23
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  44. Bataller R, Gabele E, Parsons CJ, Morris T, Yang L, Schoonhoven R, Brenner DA, Rippe RA. Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct-ligated rats. Hepatology. 2005 May; 41 (5):1046-55
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  45. Magness ST, Bataller R, Yang L, Brenner DA. A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. Hepatology. 2004 Nov; 40 (5):1151-9
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  46. Zhong Z, Froh M, Lehnert M, Schoonhoven R, Yang L, Lind H, Lemasters JJ, Thurman RG. Polyphenols from Camellia sinenesis attenuate experimental cholestasis-induced liver fibrosis in rats. Am J Physiol Gastrointest Liver Physiol. 2003 Nov; 285 (5):G1004-13 Epub 2003 June 04
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  47. Bataller R, Schwabe RF, Choi YH, Yang L, Paik YH, Lindquist J, Qian T, Schoonhoven R, Hagedorn CH, Lemasters JJ, Brenner DA. NADPH oxidase signal transduces angiotensin II in hepatic stellate cells and is critical in hepatic fibrosis. J Clin Invest. 2003 Nov; 112 (9):1383-94
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  48. Wei HB, Wang ZL, Yang L, Chen Y, Tang QL. Diagnosis and treatment of biliocardiac reflex and biliocardiac syndrome World Chinese Journal of Digestion. 2003; 11(11).
  49. Bataller R, Gabele E, Schoonhoven R, Morris T, Lehnert M, Yang L, Brenner DA, Rippe RA. Prolonged infusion of angiotensin II into normal rats induces stellate cell activation and proinflammatory events in liver. Am J Physiol Gastrointest Liver Physiol. 2003 Sep; 285 (3):G642-51 Epub 2003 May 28
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  50. Yata Y, Scanga A, Gillan A, Yang L, Reif S, Breindl M, Brenner DA, Rippe RA. DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. Hepatology. 2003 Feb; 37 (2):267-76
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  51. Qiu WS, Xu RY, Yang L. The application of tension-free hernia repair in old patient with inguinal hernia Chinese Journal of General Surgery. 2002; 11(8).
  52. Yang L, Wei ZC. The experimental study on recombinant human growth hormone therapy of Posttraumatic limb Swelling Chinese Journal of Clinical Practical Medicine. 2002; 3(2).
  53. Qiu WS, Xu RY, Yang L. Use of polytetrafluoroethylene (PTFE) mesh in tension-free inguinal hernia repair in old patient Chinese Journal of geriatrics. 2001; 20.
  54. Xu RY, Qiu WS, Den MH, Wang ZL, Liu B, Ling YB, Tang ZF, Yang L. Hand-assisted laparoscopic surgery for splenectomy in portal hypertension patient. China Journal of Endoscopy. 2001; 7.
  55. Liu B, Xu RY, Liu XY, Wang ZL, Yang L, Chen TF, Lin N. Clinical analysis of long-term endoscopic variceal ligation therapy for esophageal varices Guangdong Medical Journal. 2001; 22.
  56. Qiu WS, Xu RY, Wang ZL, Yang L. The therapeutic effect of enteral nutrition for gastric stasis after major abdominal surgery The Journal of Practical Medicine. 2001; 3.
  57. Xu RY, Wang ZL, Qiu WS, Ling YB, Yang L. The effect of rhGH on liver function and metabolism of post operational portal hypertension patient China Journal of Modern Medicine. 1999; 9.
  58. Ling YB, Xu RY, Yang L, Ke LS, Ou QJ. One Case report for successful surgical remove of huge hepatic angioleiomyoma Journal of clinical general surgery. 1999; 3.