Publications

  1. Demarest ST, Shellhaas RA, Gaillard WD, Keator C, Nickels KC, Hussain SA, Loddenkemper T, Patel AD, Saneto RP, Wirrell E, Sanchez Fernandez I, Chu CJ, Grinspan Z, Wusthoff CJ, Joshi S, Mohamed IS, Stafstrom CE, Stack CV, Yozawitz E, Bluvstein JS, Singh RK, Knupp KG, Pediatric Epilepsy Research Consortium. The impact of hypsarrhythmia on infantile spasms treatment response: Observational cohort study from the National Infantile Spasms Consortium. Epilepsia. 2017 Nov 03 [Epub ahead of print]
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  2. Shellhaas RA, Berg AT, Grinspan ZM, Wusthoff CJ, Millichap JJ, Loddenkemper T, Coryell J, Saneto RP, Chu CJ, Joshi SM, Sullivan JE, Knupp KG, Kossoff EH, Keator C, Wirrell EC, Mytinger JR, Valencia I, Massey S, Gaillard WD. Initial Treatment for Nonsyndromic Early-Life Epilepsy: An Unexpected Consensus. Pediatr Neurol. 2017 Oct; 75:73-79 Epub 2017 June 27
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  3. Sadleir LG, Mountier EI, Gill D, Davis S, Joshi C, DeVile C, Kurian MA, Mandelstam S, Wirrell E, Nickels KC, Murali HR, Carvill G, Myers CT, Mefford HC, Scheffer IE, DDD Study. Not all SCN1A epileptic encephalopathies are Dravet syndrome: Early profound Thr226Met phenotype. Neurology. 2017 Sep 05; 89 (10):1035-1042 Epub 2017 Aug 09
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  4. Berg AT, Coryell J, Saneto RP, Grinspan ZM, Alexander JJ, Kekis M, Sullivan JE, Wirrell EC, Shellhaas RA, Mytinger JR, Gaillard WD, Kossoff EH, Valencia I, Knupp KG, Wusthoff C, Keator C, Dobyns WB, Ryan N, Loddenkemper T, Chu CJ, Novotny EJ Jr, Koh S. Early-Life Epilepsies and the Emerging Role of Genetic Testing. JAMA Pediatr. 2017 Sep 01; 171 (9):863-871
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  5. Dubey D, Singh J, Britton JW, Pittock SJ, Flanagan EP, Lennon VA, Tillema JM, Wirrell E, Shin C, So E, Cascino GD, Wingerchuk DM, Hoerth MT, Shih JJ, Nickels KC, McKeon A. Predictive models in the diagnosis and treatment of autoimmune epilepsy. Epilepsia. 2017 Jul; 58 (7):1181-1189 Epub 2017 May 26
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  6. Donner EJ, Camfield P, Brooks L, Buchhalter J, Camfield C, Loddenkemper T, Wirrell E. Understanding Death in Children With Epilepsy. Pediatr Neurol. 2017 May; 70:7-15.
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  7. Nickels KC, Wirrell EC. Stiripentol in the Management of Epilepsy. CNS Drugs. 2017 May; 31 (5):405-416
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  8. deVeber GA, Kirton A, Booth FA, Yager JY, Wirrell EC, Wood E, Shevell M, Surmava AM, McCusker P, Massicotte MP, MacGregor D, MacDonald EA, Meaney B, Levin S, Lemieux BG, Jardine L, Humphreys P, David M, Chan AK, Buckley DJ, Bjornson BH. Epidemiology and Outcomes of Arterial Ischemic Stroke in Children: The Canadian Pediatric Ischemic Stroke Registry. Pediatr Neurol. 2017 Apr; 69:58-70.
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  9. Wirrell EC, Laux L, Donner E, Jette N, Knupp K, Meskis MA, Miller I, Sullivan J, Welborn M, Berg AT. Optimizing the Diagnosis and Management of Dravet Syndrome: Recommendations From a North American Consensus Panel. Pediatr Neurol. 2017 Mar; 68:18-34.e3.
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  10. Whealy M, Wirrell E, Wong-Kisiel L, Nickels K, Payne ET. Prevalence and Risk Factors of Peri-ictal Autonomic Changes in Children With Temporal Lobe Seizures. Pediatr Neurol. 2017 Feb; 67:36-39.
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  11. Wallace A, Shin C, Wirrell EC, Burkholder DB. False ictal-appearing EEG from a frontal sinus pseudomeningocele. Neurology. 2016 Dec 13; 87: (24)2600-2601.
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  12. Kenney-Jung DL, Vezzani A, Kahoud RJ, LaFrance-Corey RG, Ho ML, Wampler Muskardin T, Muskardin TW, Wirrell EC, Howe CL, Payne ET. Febrile infection-related epilepsy syndrome treated with anakinra. Ann Neurol. 2016 Dec; 80: (6)939-945.
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  13. Cooper MS, Mcintosh A, Crompton DE, McMahon JM, Schneider A, Farrell K, Ganesan V, Gill D, Kivity S, Lerman-Sagie T, McLellan A, Pelekanos J, Ramesh V, Sadleir L, Wirrell E, Scheffer IE. Mortality in Dravet syndrome. Epilepsy Res. 2016 Dec; 128:43-47.
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  14. Knupp KG, Leister E, Coryell J, Nickels KC, Ryan N, Juarez-Colunga E, Gaillard WD, Mytinger JR, Berg AT, Millichap J, Nordli DR Jr, Joshi S, Shellhaas RA, Loddenkemper T, Dlugos D, Wirrell E, Sullivan J, Hartman AL, Kossoff EH, Grinspan ZM, Hamikawa L, Pediatric Epilepsy Research Consortium. Response to second treatment after initial failed treatment in a multicenter prospective infantile spasms cohort. Epilepsia. 2016 Nov; 57: (11)1834-1842.
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  15. Kenney DL, Kelly-Williams KM, Krecke KN, Witte RJ, Watson RE Jr, Kotsenas AL, Wirrell EC, Nickels KC, Wong-Kisiel LC, So E. Usefulness of repeat review of head magnetic resonance images during presurgical epilepsy conferences. Epilepsy Res. 2016 Oct; 126:106-8.
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  16. Tovar Quiroga DF, Britton JW, Wirrell EC. Patient and caregiver view on seizure detection devices: A survey study. Seizure. 2016 Oct; 41:179-81.
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  17. Nickels KC, Zaccariello MJ, Hamiwka LD, Wirrell EC. Cognitive and neurodevelopmental comorbidities in paediatric epilepsy. Nat Rev Neurol. 2016 Aug; 12: (8)465-76.
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  18. Panjwani N, Wilson MD, Addis L, Crosbie J, Wirrell E, Auvin S, Caraballo RH, Kinali M, McCormick D, Oren C, Taylor J, Trounce J, Clarke T, Akman CI, Kugler SL, Mandelbaum DE, McGoldrick P, Wolf SM, Arnold P, Schachar R, Pal DK, Strug LJ. A microRNA-328 binding site in PAX6 is associated with centrotemporal spikes of rolandic epilepsy. Ann Clin Transl Neurol. 2016 Jul; 3: (7)512-22.
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  19. Wallace A, Wirrell E, Kenney-Jung DL. Pharmacotherapy for Dravet Syndrome. Paediatr Drugs. 2016 Jun; 18 (3):197-208
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  20. Wirrell EC. Treatment of Dravet Syndrome. Can J Neurol Sci. 2016 Jun; 43 Suppl 3:S13-8.
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  21. Feyissa AM, Wirrell EC, Jones DT, Young NP, Britton JW. Focal photoparoxysmal response in the Heidenhain variant of CJD: Hidden from view! Neurology. 2016 Apr 26; 86: (17)1647-8.
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  22. Burkholder DB, Britton JW, Rajasekaran V, Fabris RR, Cherian PJ, Kelly-Williams KM, So EL, Nickels KC, Wong-Kisiel LC, Lagerlund TD, Cascino GD, Worrell GA, Wirrell EC. Routine vs extended outpatient EEG for the detection of interictal epileptiform discharges. Neurology. 2016 Apr 19; 86: (16)1524-30.
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  23. Knupp KG, Coryell J, Nickels KC, Ryan N, Leister E, Loddenkemper T, Grinspan Z, Hartman AL, Kossoff EH, Gaillard WD, Mytinger JR, Joshi S, Shellhaas RA, Sullivan J, Dlugos D, Hamikawa L, Berg AT, Millichap J, Nordli DR Jr, Wirrell E, Pediatric Epilepsy Research Consortium. Response to treatment in a prospective national infantile spasms cohort. Ann Neurol. 2016 Mar; 79: (3)475-84.
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  24. Joshi C, Berg AT, Wirrell E. Do Patients Require Inpatient Admission to Receive Adrenocorticotropic Hormone (ACTH)? A Survey of US-Based Prescribers. J Child Neurol. 2016 Feb; 31: (2)164-9.
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  25. Wirrell E. Infantile, childhood, and adolescent epilepsies CONTINUUM: Lifelong Learning in Neurology. 2016 Feb; 22: (1)60-93.
  26. Mrelashvili A, Witte RJ, Wirrell EC, Nickels KC, Wong-Kisiel LC. Seizure Freedom in Children With Pathology-Confirmed Focal Cortical Dysplasia. Pediatr Neurol. 2015 Dec; 53: (6)513-8.
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  27. Devinsky O, Asato M, Camfield P, Geller E, Kanner AM, Keller S, Kerr M, Kossoff EH, Lau H, Kothare S, Singh BK, Wirrell E. Delivery of epilepsy care to adults with intellectual and developmental disabilities. Neurology. 2015 Oct 27; 85: (17)1512-21.
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  28. Fine AL, Wirrell EC, Wong-Kisiel LC, Nickels KC. Acetazolamide for electrical status epilepticus in slow-wave sleep. Epilepsia. 2015 Sep; 56: (9)e134-8.
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  29. Sun PY, Wyatt K, Nickels KC, Wong-Kisiel LC, Mandrekar J, Wirrell E. Predictors of Length of Stay in Children Admitted for Presurgical Evaluation for Epilepsy Surgery. Pediatr Neurol. 2015 Sep; 53: (3)207-10.
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  30. Aypar U, Wirrell EC, Hoppman NL. CNKSR2 deletions: a novel cause of X-linked intellectual disability and seizures. Am J Med Genet A. 2015 Jul; 167: (7)1668-70.
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  31. Haque OJ, Mandrekar J, Wyatt K, Nickels KC, Wong-Kisiel L, Wetjen N, Wirrell EC. Yield and Predictors of Epilepsy Surgery Candidacy in Children Admitted for Surgical Evaluation. Pediatr Neurol. 2015 Jul; 53: (1)58-64.
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  32. Bower RS, Wirrell EC, Eckel LJ, Wong-Kisiel LC, Nickels KC, Wetjen NM. Repeat resective surgery in complex pediatric refractory epilepsy: lessons learned. J Neurosurg Pediatr. 2015 Jul; 16(1):94-100. Epub 2015 Apr 24.
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  33. Bitton JY, Demos M, Elkouby K, Connolly M, Weiss SK, Donner EJ, Whiting S, Ronen GM, Bello-Espinosa L, Wirrell EC, Mohamed IS, Dooley JM, Carmant L. Does treatment have an impact on incidence and risk factors for autism spectrum disorders in children with infantile spasms? Epilepsia. 2015 Jun; 56(6):856-63. Epub 2015 May 05.
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  34. Wirrell EC, Shellhaas RA, Joshi C, Keator C, Kumar S, Mitchell WG, Pediatric Epilepsy Research Consortium. How should children with West syndrome be efficiently and accurately investigated? Results from the National Infantile Spasms Consortium. Epilepsia. 2015 Apr; 56: (4)617-25.
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  35. Tobin WO, Lennon VA, Komorowski L, Probst C, Clardy SL, Aksamit AJ, Appendino JP, Lucchinetti CF, Matsumoto JY, Pittock SJ, Sandroni P, Tippmann-Peikert M, Wirrell EC, McKeon A. DPPX potassium channel antibody: frequency, clinical accompaniments, and outcomes in 20 patients. Neurology. 2014 Nov 11; 83: (20)1797-803.
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  36. Lee RW, Mandrekar J, Worrell GA, Cascino GD, Wetjen NM, Meyer FB, Wirrell EC, Marsh WR, So E. Factors contributing to the yield of asymmetric bilateral implantation of intracranial electrodes. Epilepsia. 2014 Oct; 55(10):1620-5. Epub 2014 Sep 05.
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  37. Camfield CS, Berg A, Stephani U, Wirrell EC. Transition issues for benign epilepsy with centrotemporal spikes, nonlesional focal epilepsy in otherwise normal children, childhood absence epilepsy, and juvenile myoclonic epilepsy. Epilepsia. 2014 Aug; 55:16-20.
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  38. Lee RW, Hoogs MM, Burkholder DB, Trenerry MR, Drazkowski JF, Shih JJ, Doll KE, Tatum WO 4th, Cascino GD, Marsh WR, Wirrell EC, Worrell GA, So EL. Outcome of intracranial electroencephalography monitoring and surgery in magnetic resonance imaging-negative temporal lobe epilepsy. Epilepsy Res. 2014 Jul; 108(5):937-44. Epub 2014 Mar 27.
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  39. Lee RW, Worrell GA, Marsh WR, Cascino GD, Wetjen NM, Meyer FB, Wirrell EC, So EL. Diagnostic outcome of surgical revision of intracranial electrode placements for seizure localization. J Clin Neurophysiol. 2014 Jun; 31: (3)199-202.
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  40. Ahmadi L, Wirrell E. Intractable epilepsy, hemispheric malformation, and generalized electroencephalography abnormalities. Semin Pediatr Neurol. 2014 Jun; 21(2):73-5. Epub 2014 Apr 18.
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  41. Nozile-Firth K, Wirrell E, Giannini C. Bizarre semiology and medically intractable seizures. Semin Pediatr Neurol. 2014 Jun; 21: (2)154-9.
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  42. Wirrell E. Early-onset focal seizures and spasms--is it surgical? Semin Pediatr Neurol. 2014 Jun; 21(2):101-3. Epub 2014 Apr 13.
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  43. Toledano M, Britton JW, McKeon A, Shin C, Lennon VA, Quek AM, So E, Worrell GA, Cascino GD, Klein CJ, Lagerlund TD, Wirrell EC, Nickels KC, Pittock SJ. Utility of an immunotherapy trial in evaluating patients with presumed autoimmune epilepsy. Neurology. 2014 May 06; 82: (18)1578-86.
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  44. Dhamija R, Erickson MK, St Louis EK, Wirrell E, Kotagal S. Sleep abnormalities in children with Dravet syndrome. Pediatr Neurol. 2014 May; 50(5):474-8. Epub 2014 Jan 07.
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  45. Shull S, Diaz-Medina G, Wong-Kisiel L, Nickels K, Eckert S, Wirrell E. Early efficacy of the ketogenic diet is not affected by initial body mass index percentile. Pediatr Neurol. 2014 May; 50(5):469-73. Epub 2014 Jan 07.
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  46. Wirrell EC, Wong-Kisiel LC, Nickels KC. Seizure outcome after AED failure in pediatric focal epilepsy: impact of underlying etiology. Epilepsy Behav. 2014 May; 34:20-4. Epub 2014 Mar 25.
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  47. Wyatt KD, Mandrekar J, Wong-Kisiel L, Nickels K, Wirrell E. Predictors of recording an event during prolonged inpatient video electroencephalogram monitoring in children. Pediatr Neurol. 2014 May; 50(5):458-63. Epub 2014 Jan 24.
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  48. Child ND, Stead M, Wirrell EC, Nickels KC, Wetjen NM, Lee KH, Klassen BT. Chronic subthreshold subdural cortical stimulation for the treatment of focal epilepsy originating from eloquent cortex. Epilepsia. 2014 Mar; 55(3):e18-21. Epub 2014 Feb 26.
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  49. Kenney D, Wirrell E. Patient considerations in the management of focal seizures in children and adolescents. Adolesc Health Med Ther. 2014; 5:49-65.
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  50. Dhamija R, Wirrell E, Falcao G, Kirmani S, Wong-Kisiel LC. Novel de novo SCN2A mutation in a child with migrating focal seizures of infancy. Pediatr Neurol. 2013 Dec; 49(6):486-8. Epub 2013 Aug 26.
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  51. Bower RS, Wirrell E, Nwojo M, Wetjen NM, Marsh WR, Meyer FB. Seizure outcomes after corpus callosotomy for drop attacks. Neurosurgery. 2013 Dec; 73(6):993-1000.
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  52. Wirrell EC, Laux L, Franz DN, Sullivan J, Saneto RP, Morse RP, Devinsky O, Chugani H, Hernandez A, Hamiwka L, Mikati MA, Valencia I, Le Guern ME, Chancharme L, de Menezes MS. Stiripentol in Dravet syndrome: results of a retrospective U.S. study. Epilepsia. 2013 Sep; 54(9):1595-604. Epub 2013 Jul 12.
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  53. Moseley BD, So E, Wirrell EC, Nelson C, Lee RW, Mandrekar J, Britton JW. Characteristics of postictal generalized EEG suppression in children. Epilepsy Res. 2013 Sep; 106(1-2):123-7. Epub 2013 Jun 17.
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  54. Mulley JC, Hodgson B, McMahon JM, Iona X, Bellows S, Mullen SA, Farrell K, Mackay M, Sadleir L, Bleasel A, Gill D, Webster R, Wirrell EC, Harbord M, Sisodiya S, Andermann E, Kivity S, Berkovic SF, Scheffer IE, Dibbens LM. Role of the sodium channel SCN9A in genetic epilepsy with febrile seizures plus and Dravet syndrome. Epilepsia. 2013 Sep; 54(9):e122-6. Epub 2013 Jul 29.
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  55. Noe K, Sulc V, Wong-Kisiel L, Wirrell E, Van Gompel JJ, Wetjen N, Britton J, So E, Cascino GD, Marsh WR, Meyer F, Horinek D, Giannini C, Watson R, Brinkmann BH, Stead M, Worrell GA. Long-term outcomes after nonlesional extratemporal lobe epilepsy surgery. JAMA Neurol. 2013 Aug; 70: (8)1003-8.
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  56. Moseley BD, Wirrell EC, Wong-Kisiel LC, Nickels K. Early onset epilepsy is associated with increased mortality: a population-based study. Epilepsy Res. 2013 Aug; 105(3):410-4. Epub 2013 Apr 11.
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  57. Berg AT, Nickels K, Wirrell EC, Geerts AT, Callenbach PM, Arts WF, Rios C, Camfield PR, Camfield CS. Mortality risks in new-onset childhood epilepsy. Pediatrics. 2013 Jul; 132(1):124-31. Epub 2013 Jun 10.
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  58. Wirrell EC, Wong-Kisiel LC, Mandrekar J, Nickels KC. What predicts enduring intractability in children who appear medically intractable in the first 2 years after diagnosis? Epilepsia. 2013 Jun; 54: (6)1056-64.
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  59. Wirrell EC. Predicting pharmacoresistance in pediatric epilepsy. Epilepsia. 2013 May; 54 Suppl 2:19-22.
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  60. Wirrell E. Review of Dietary treatment of epilepsy. Practical implementation of ketogenic therapy. The Canadian Journal of Neurological Sciences / Le Journal Canadien Des Sciences Neurologiques. 2013 May; 40(3):440.
  61. Mirzaa GM, Paciorkowski AR, Marsh ED, Berry-Kravis EM, Medne L, Alkhateeb A, Grix A, Wirrell EC, Powell BR, Nickels KC, Burton B, Paras A, Kim K, Chung W, Dobyns WB, Das S. CDKL5 and ARX mutations in males with early-onset epilepsy. Pediatr Neurol. 2013 May; 48(5):367-77.
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  62. Dhamija R, Eckert S, Wirrell E. Ketogenic diet. Can J Neurol Sci. 2013 Mar; 40(2):158-67.
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  63. Moseley B, Bateman L, Millichap JJ, Wirrell E, Panayiotopoulos CP. Autonomic epileptic seizures, autonomic effects of seizures, and SUDEP. Epilepsy Behav. 2013 Mar; 26(3):375-85. Epub 2012 Oct 23.
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  64. Nickels KC, Grossardt BR, Wirrell EC. Epilepsy-related mortality is low in children: a 30-year population-based study in Olmsted County, MN. Epilepsia. 2012 Dec; 53: (12)2164-71.
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  65. Wirrell EC. What's new in the medical management of pediatric epilepsy? Can J Neurol Sci. 2012 Nov; 39(6):S30-4.
  66. Jette N, Quan H, Tellez-Zenteno JF, MacRodimitris S, Hader WJ, Sherman EM, Hamiwka LD, Wirrell EC, Burneo JG, Metcalfe A, Faris PD, Hernandez-Ronquillo L, Kwon CS, Kirk A, Wiebe S, CASES Expert Panelists. Development of an online tool to determine appropriateness for an epilepsy surgery evaluation. Neurology. 2012 Sep 11; 79(11):1084-93. Epub 2012 Aug 15.
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  67. Wirrell E, Wong-Kisiel L, Mandrekar J, Nickels K. Predictors and course of medically intractable epilepsy in young children presenting before 36 months of age: a retrospective, population-based study. Epilepsia. 2012 Sep; 53: (9)1563-9.
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  68. Bitton JY, Sauerwein HC, Weiss SK, Donner EJ, Whiting S, Dooley JM, Snead C, Farrell K, Wirrell EC, Mohamed IS, Ronen GM, Salas-Prato M, Amre D, Lassonde M, Carmant L. A randomized controlled trial of flunarizine as add-on therapy and effect on cognitive outcome in children with infantile spasms. Epilepsia. 2012 Sep; 53(9):1570-6. Epub 2012 Aug 13.
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  69. Moseley BD, Nickels K, Wirrell EC. Surgical outcomes for intractable epilepsy in children with epileptic spasms. J Child Neurol. 2012 Jun; 27(6):713-20. Epub 2011 Nov 28.
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  70. Quek AM, Britton JW, McKeon A, So E, Lennon VA, Shin C, Klein C, Watson RE Jr, Kotsenas AL, Lagerlund TD, Cascino GD, Worrell GA, Wirrell EC, Nickels KC, Aksamit AJ, Noe KH, Pittock SJ. Autoimmune epilepsy: clinical characteristics and response to immunotherapy. Arch Neurol. 2012 May; 69: (5)582-93.
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  71. Dhamija R, Patterson MC, Wirrell EC. Epilepsy in children--when should we think neurometabolic disease? J Child Neurol. 2012 May; 27(5):663-71. Epub 2012 Feb 28.
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  72. Wong-Kisiel LC, McKeon A, Wirrell EC. Autoimmune encephalopathies and epilepsies in children and teenagers. Can J Neurol Sci. 2012 Mar; 39(2):134-44.
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  73. Moseley BD, Dhamija R, Wirrell EC, Nickels KC. Historic, clinical, and prognostic features of epileptic encephalopathies caused by CDKL5 mutations. Pediatr Neurol. 2012 Feb; 46(2):101-5.
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  74. Moseley BD, Dhamija R, Wirrell EC. The cessation of continuous spike wave in slow-wave sleep following a temporal lobectomy. J Child Neurol. 2012 Jan; 27(1):113-6. Epub 2011 Aug 23.
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  75. Crepeau AZ, Moseley BD, Wirrell EC. Specific safety and tolerability considerations in the use of anticonvulsant medications in children. Drug Healthc Patient Saf. 2012; 4:39-54.
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  76. Nickels KC, Wong-Kisiel LC, Moseley BD, Wirrell EC. Temporal lobe epilepsy in children. Epilepsy Res Treat. 2012; 2012:849540.
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  77. Dhamija R, Gavrilova RH, Wirrell EC. Valproate-induced worsening of seizures: clue to underlying diagnosis. J Child Neurol. 2011 Oct; 26(10):1319-21. Epub 2011 Mar 31.
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  78. Moseley BD, Wirrell EC, Nickels K, Johnson JN, Ackerman MJ, Britton J. Electrocardiographic and oximetric changes during partial complex and generalized seizures. Epilepsy Res. 2011 Aug; 95(3):237-45. Epub 2011 May 10
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  79. Dhamija R, Moseley BD, Cascino GD, Wirrell EC. A population-based study of long-term outcome of epilepsy in childhood with a focal or hemispheric lesion on neuroimaging. Epilepsia. 2011 Aug; 52: (8)1522-6.
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  80. Aboian MS, Wong-Kisiel LC, Rank M, Wetjen NM, Wirrell EC, Witte RJ. SISCOM in children with tuberous sclerosis complex-related epilepsy. Pediatr Neurol. 2011 Aug; 45(2):83-8.
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  81. Carranza Rojo D, Hamiwka L, McMahon JM, Dibbens LM, Arsov T, Suls A, Stodberg T, Kelley K, Wirrell E, Appleton B, Mackay M, Freeman JL, Yendle SC, Berkovic SF, Bienvenu T, De Jonghe P, Thorburn DR, Mulley JC, Mefford HC, Scheffer IE. De novo SCN1A mutations in migrating partial seizures of infancy. Neurology. 2011 Jul 26; 77(4):380-3. Epub 2011 Jul 13.
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  82. Moseley BD, Wirrell EC, Nickels K. Generalized periodic epileptiform discharges in a child with Dravet syndrome. J Child Neurol. 2011 Jul; 26(7):907-10. Epub 2011 Feb 18.
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  83. Dhamija R, Breningstall G, Wong-Kisiel L, Dolan M, Hirsch B, Wirrell E. Microdeletion of chromosome 15q26.1 in a child with intractable generalized epilepsy. Pediatr Neurol. 2011 Jul; 45(1):60-2.
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  84. Hamiwka LD, Hamiwka LA, Sherman EM, Wirrell E. Social skills in children with epilepsy: how do they compare to healthy and chronic disease controls? Epilepsy Behav. 2011 Jul; 21(3):238-41. Epub 2011 May 13.
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  85. Wirrell EC, Grossardt BR, Wong-Kisiel LC, Nickels KC. Incidence and classification of new-onset epilepsy and epilepsy syndromes in children in Olmsted County, Minnesota from 1980 to 2004: a population-based study. Epilepsy Res. 2011 Jun; 95: (1-2)110-8.
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  86. Wirrell EC, Grossardt BR, So EL, Nickels KC. A population-based study of long-term outcomes of cryptogenic focal epilepsy in childhood: cryptogenic epilepsy is probably not symptomatic epilepsy. Epilepsia. 2011 Apr; 52: (4)738-45.
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  87. Dhamija R, Renaud DL, Pittock SJ, McKeon A, Lachance DH, Nickels KC, Wirrell EC, Kuntz NL, King MD, Lennon VA. Neuronal voltage-gated potassium channel complex autoimmunity in children. Pediatr Neurol. 2011 Apr; 44(4):275-81.
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  88. Dhamija R, Moseley BD, Wirrell EC. Clinical reasoning: a 10-month-old boy with myoclonic status epilepticus. Neurology. 2011 Feb 1; 76(5):e22-5.
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  89. Kwon CS, Liu M, Quan H, Wiebe S, McChesney J, Wirrell E, Hamiwka L, Jette N. The incidence of injuries in persons with and without epilepsy--a population-based study. Epilepsia. 2010 Nov; 51(11):2247-53. Epub 2010 Aug 17.
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  90. Hnojcikova M, Nickels KC, Wetjen NM, Buchhalter JR, Raffel C, Wirrell EC. EEG and neuroimaging studies in young children having epilepsy surgery. Pediatr Neurol. 2010 Nov; 43(5):335-40.
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  91. Wirrell EC. Prognostic significance of interictal epileptiform discharges in newly diagnosed seizure disorders. J Clin Neurophysiol. 2010 Aug; 27(4):239-48.
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  92. Moseley BD, Nickels K, Britton J, Wirrell E. How common is ictal hypoxemia and bradycardia in children with partial complex and generalized convulsive seizures? Epilepsia. 2010 Jul; 51: (7)1219-24.
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  93. Diaz GE, Wirrell EC, Matsumoto JY, Krecke KN. Bilateral striopallidodentate calcinosis with paroxysmal kinesigenic dyskinesia. Pediatr Neurol. 2010 Jul; 43(1):46-8.
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  94. Wirrell E, Nickels KC. Pediatric epilepsy syndromes. Continuum. 2010 Jun; 16(3):57-85.
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  95. Davis SM, Katusic SK, Barbaresi WJ, Killian J, Weaver AL, Ottman R, Wirrell EC. Epilepsy in children with attention-deficit/hyperactivity disorder. Pediatr Neurol. 2010 May; 42: (5)325-30.
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  96. Chioza BA, Aicardi J, Aschauer H, Brouwer O, Callenbach P, Covanis A, Dooley JM, Dulac O, Durner M, Eeg-Olofsson O, Feucht M, Friis ML, Guerrini R, Kjeldsen MJ, Nabbout R, Nashef L, Sander T, Siren A, Wirrell E, McKeigue P, Robinson R, Gardiner RM, Everett KV. Genome wide high density SNP-based linkage analysis of childhood absence epilepsy identifies a susceptibility locus on chromosome 3p23-p14. Epilepsy Res. 2009 Dec; 87(2-3):247-55. Epub 2009 Oct 17.
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  97. Aboian MS, Junna MR, Krecke KN, Wirrell EC. Mesial temporal sclerosis after posterior reversible encephalopathy syndrome. Pediatr Neurol. 2009 Sep; 41(3):226-8.
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  98. Hamiwka LD, Yu CG, Hamiwka LA, Sherman EM, Anderson B, Wirrell E. Are children with epilepsy at greater risk for bullying than their peers? Epilepsy Behav. 2009 Aug; 15(4):500-5. Epub 2009 Jul 23.
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  99. Hamiwka LD, Wirrell EC. Comorbidities in pediatric epilepsy: beyond "just'' treating the seizures. J Child Neurol. 2009 Jun; 24(6):734-42. Epub 2009 Apr 08.
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  100. Glass HC, Wirrell E. Controversies in neonatal seizure management. J Child Neurol. 2009 May; 24(5):591-9. Epub 2009 Feb 13.
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  101. Wirrell EC. Epileptic encephalopathies: cognitive and behavioural aspects. Paediatr. Child Health (CAN). 2009; 19: (Suppl 2)S226-30.
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  110. Cai S, Hamiwka LD, Wirrell EC. Peri-ictal headache in children: prevalence and character. Pediatr Neurol. 2008 Aug; 39(2):91-6.
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  116. Nickels K, Wirrell E. Electrical status epilepticus in sleep. Semin Pediatr Neurol. 2008 Jun; 15(2):50-60.
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  122. Everett K, Chioza B, Aicardi J, Aschauer H, Brouwer O, Callenbach P, Covanis A, Dooley J, Dulac O, Durner M, Eeg-Olofsson O, Feucht M, Friis M, Guerrini R, Heils A, Kjeldsen M, Nabbout R, Sander T, Wirrell E, McKeigue P, Robinson R, Taske N, Gardiner M. Linkage and mutational analysis of CLCN2 in childhood absence epilepsy. Epilepsy Res. 2007 Jul; 75(2-3):145-53. Epub 2007 Jun 18.
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  124. Glass HC, Wirrell E, Sarnat HB, Dunham C, Lewis V, Morrish W. MRI findings in an immunocompromised boy with CNS fungal infection. Can J Neurol Sci. 2007 Feb; 34(1):88-91.
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  126. Wirrell EC, Hamiwka LD. Do children with benign rolandic epilepsy have a higher prevalence of migraine than those with other partial epilepsies or nonepilepsy controls? Epilepsia. 2006 Oct; 47(10):1674-81.
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  127. Heng K, Wirrell E. Sleep disturbance in children with migraine. J Child Neurol. 2006 Sep; 21(9):761-6.
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  128. Wirrell E, Ho AW, Hamiwka L. Sulthiame therapy for continuous spike and wave in slow-wave sleep. Pediatr Neurol. 2006 Sep; 35(3):204-8.
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  129. Berkovic SF, Harkin L, McMahon JM, Pelekanos JT, Zuberi SM, Wirrell EC, Gill DS, Iona X, Mulley JC, Scheffer IE. De-novo mutations of the sodium channel gene SCN1A in alleged vaccine encephalopathy: a retrospective study. Lancet Neurol. 2006 Jun; 5(6):488-92.
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  130. Kirton A, Diggle J, Hu W, Wirrell E. A pediatric case of reversible segmental cerebral vasoconstriction. Can J Neurol Sci. 2006 May; 33(2):250-3.
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  131. Cheung C, Wirrell E. Adolescents' perception of epilepsy compared with other chronic diseases: "through a teenager's eyes". J Child Neurol. 2006 Mar; 21(3):214-22.
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  132. Wong J, Wirrell E. Physical activity in children/teens with epilepsy compared with that in their siblings without epilepsy. Epilepsia. 2006 Mar; 47(3):631-9.
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  133. Wirrell E, Cheung C, Spier S. How do teens view the physical and social impact of asthma compared to other chronic diseases? J Asthma. 2006 Mar; 43(2):155-60.
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  138. Lu C, Wirrell E, Blackman M. Where do families of children with epilepsy obtain their information? J Child Neurol. 2005 Nov; 20(11):905-10.
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  139. Soo I, Mah JK, Barlow K, Hamiwka L, Wirrell E. Use of complementary and alternative medical therapies in a pediatric neurology clinic. Can J Neurol Sci. 2005 Nov; 32(4):524-8.
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  140. Wirrell E, Farrell K, Whiting S. The epileptic encephalopathies of infancy and childhood. Can J Neurol Sci. 2005 Nov; 32(4):409-18.
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  142. Glass HC, Boycott KM, Adams C, Barlow K, Scott JN, Chudley AE, Fujiwara TM, Morgan K, Wirrell E, McLeod DR. Autosomal recessive cerebellar hypoplasia in the Hutterite population. Dev Med Child Neurol. 2005 Oct; 47(10):691-5.
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  143. Boycott KM, Flavelle S, Bureau A, Glass HC, Fujiwara TM, Wirrell E, Davey K, Chudley AE, Scott JN, McLeod DR, Parboosingh JS. Homozygous deletion of the very low density lipoprotein receptor gene causes autosomal recessive cerebellar hypoplasia with cerebral gyral simplification. Am J Hum Genet. 2005 Sep; 77(3):477-83. Epub 2005 Jul 22.
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  145. Wirrell EC. Neonatal seizures: to treat or not to treat? Semin Pediatr Neurol. 2005 Jun; 12(2):97-105.
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  146. Kirton A, Busche K, Ross C, Wirrell E. Acute necrotizing encephalopathy in caucasian children: two cases and review of the literature. J Child Neurol. 2005 Jun; 20(6):527-32.
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  147. Wirrell E, Hill MD, Jadavji T, Kirton A, Barlow K. Stroke after varicella vaccination. J Pediatr. 2004 Dec; 145(6):845-7.
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  148. Kirton A, Wirrell E, Zhang J, Hamiwka L. Seizure-alerting and -response behaviors in dogs living with epileptic children. Neurology. 2004 Jun 22; 62(12):2303-5.
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  149. Yager JY, Armstrong EA, Jaharus C, Saucier DM, Wirrell EC. Preventing hyperthermia decreases brain damage following neonatal hypoxic-ischemic seizures. Brain Res. 2004 Jun 11; 1011(1):48-57.
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  150. Kirton A, Darwish H, Wirrell E. Unique clinical phenomenology can help distinguish primary from secondary generalized seizures in children. J Child Neurol. 2004 Apr; 19(4):265-70.
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  151. Wirrell EC. Natural history of absence epilepsy in children. Can J Neurol Sci. 2003 Aug; 30(3):184-8.
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  152. Wirrell EC. Valproic acid-associated weight gain in older children and teens with epilepsy. Pediatr Neurol. 2003 Feb; 28(2):126-9.
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  153. Wirrell EC, Darwish HZ, Williams-Dyjur C, Blackman M, Lange V. Is a fast necessary when initiating the ketogenic diet? J Child Neurol. 2002 Mar; 17(3):179-82.
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  154. Yager JY, Armstrong EA, Miyashita H, Wirrell EC. Prolonged neonatal seizures exacerbate hypoxic-ischemic brain damage: correlation with cerebral energy metabolism and excitatory amino acid release. Dev Neurosci. 2002; 24(5):367-81.
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  155. Wirrell EC, Armstrong EA, Osman LD, Yager JY. Prolonged seizures exacerbate perinatal hypoxic-ischemic brain damage. Pediatr Res. 2001 Oct; 50(4):445-54.
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  156. Wirrell E, Camfield C, Camfield P, Dooley J. Prognostic significance of failure of the initial antiepileptic drug in children with absence epilepsy. Epilepsia. 2001 Jun; 42(6):760-3.
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  157. Kirsch R, Wirrell E. Do cognitively normal children with epilepsy have a higher rate of injury than their nonepileptic peers? J Child Neurol. 2001 Feb; 16(2):100-4.
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  158. Wirrell E, Turner T. Parental anxiety and family disruption following a first febrile seizure in children. Paediatr Child Health. 2001; 6:139-43.
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  159. Datta AN, Wirrell EC. Prognosis of seizures occurring in the first year. Pediatr Neurol. 2000 May; 22(5):386-91.
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  160. Barnard C, Wirrell E. Does status epilepticus in children cause developmental deterioration and exacerbation of epilepsy? J Child Neurol. 1999 Dec; 14(12):787-94.
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  161. Holt-Seitz A, Wirrell EC, Sundaram MB. Seizures in the elderly: etiology and prognosis. Can J Neurol Sci. 1999 May; 26(2):110-4.
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  162. Wirrell E, Tong K. Pachygyria associated with childhood-onset epileptic spasms. J Child Neurol. 1998 Sep; 13(9):461-4.
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  166. Wirrell EC, Camfield PR, Camfield CS, Dooley JM, Gordon KE. Accidental injury is a serious risk in children with typical absence epilepsy. Arch Neurol. 1996 Sep; 53(9):929-32.
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  167. Wirrell EC, Camfield PR, Gordon KE, Camfield CS, Dooley JM, Hanna BD. Will a critical level of hyperventilation-induced hypocapnia always induce an absence seizure? Epilepsia. 1996 May; 37(5):459-62.
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  168. Dooley J, Camfield P, Camfield C, Gordon K, Wirrell E, Smith E. Lamotrigine induced skin rash in children. Neurology. 1996; 46:240-2.
  169. Camfield CS, Camfield PR, Gordon K, Wirrell E, Dooley JM. Incidence of epilepsy in childhood and adolescence: a population-based study in Nova Scotia from 1977 to 1985. Epilepsia. 1996 Jan; 37(1):19-23.
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  170. Dooley J, Camfield P, Gordon K, Camfield C, Wirrell E, Smith E. Lamotrigine-induced rash in children. Neurology. 1996 Jan; 46(1):240-2.
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  171. Wirrell EC, Camfield PR, Gordon KE, Dooley JM, Camfield CS. Benign rolandic epilepsy: atypical features are very common. J Child Neurol. 1995 Nov; 10(6):455-8.
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  172. Wirrell EC, Pelausa EO, Allen AC, Stinson DA, Hanna BD. Massive pericardial effusion as a cause for sudden deterioration of a very low birthweight infant. Am J Perinatol. 1993 Nov; 10(6):419-23.
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  173. Wirrell EC, Pelausa EO, Allen AC, Stinson DA, Hanna BD. An unusual, massive pericardial effusion in a very low birthweight infant. Am J Perinatology. 1993; 10:419-23.