Publications

  1. Justilien V, Lewis KC, Murray NR, Fields AP. Oncogenic Ect2 signaling regulates rRNA synthesis in NSCLC. Small GTPases. 2019 Sep; 10 (5):388-394 Epub 2017 July 05
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  2. Yin N, Liu Y, Khoor A, Wang X, Thompson EA, Leitges M, Justilien V, Weems C, Murray NR, Fields AP. Protein Kinase Ciota and Wnt/beta-Catenin Signaling: Alternative Pathways to Kras/Trp53-Driven Lung Adenocarcinoma. Cancer Cell. 2019 Aug 12; 36 (2):156-167.e7 Epub 2019 Aug 01
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  3. Fields AP, Ali SA, Justilien V, Murray NR. Protein kinase Ciota: A versatile oncogene in the lung. Mol Cell Oncol. 2018; 5 (5):e1190886 Epub 2018 May 10
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  4. Justilien V, Ali SA, Jamieson L, Yin N, Cox AD, Der CJ, Murray NR, Fields AP. Ect2-Dependent rRNA Synthesis Is Required for KRAS-TRP53-Driven Lung Adenocarcinoma. Cancer Cell. 2017 Feb 13; 31 (2):256-269 Epub 2017 Jan 19
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  5. Wang Y, Justilien V, Brennan KI, Jamieson L, Murray NR, Fields AP. PKCiota regulates nuclear YAP1 localization and ovarian cancer tumorigenesis. Oncogene. 2017 Jan 26; 36 (4):534-545 Epub 2016 June 20
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  6. Fields AP, Ali SA, Justilien V, Murray NR. Targeting oncogenic protein kinase Ciota for treatment of mutant KRAS LADC. Small GTPases. 2017 Jan 2; 8 (1):58-64 Epub 2016 May 31
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  7. Murray NR, Justilien V, Fields AP. SOX2 Determines Lineage Restriction: Modeling Lung Squamous Cell Carcinoma in the Mouse. Cancer Cell 2016 Oct 10; 30 (4):505-507
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  8. Ali SA, Justilien V, Jamieson L, Murray NR, Fields AP. Protein Kinase Ciota Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma. Cancer Cell. 2016 Mar 14; 29 (3):367-378
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  9. Ali SA, Yin N, Rehman A, Justilien V. Parkinson Disease-Mediated Gastrointestinal Disorders and Rational for Combinatorial Therapies. Med Sci (Basel). 2016 Jan 20; 4 (1)
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  10. Fields AP, Justilien V, Murray NR. The chromosome 3q26 OncCassette: A multigenic driver of human cancer. Adv Biol Regul. 2016 Jan; 60:47-63 Epub 2015 Dec 23
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  11. Justilien V, Fields AP. Molecular pathways: novel approaches for improved therapeutic targeting of Hedgehog signaling in cancer stem cells. Clin Cancer Res. 2015 Feb 1; 21 (3):505-13
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  12. Ali SA, Justilien V, Bukhari SZH, Lee J, Shakoori AR. Role of transcription regulatory complexes and epigenetic modifications in driving the cell fate decisions. Pakistan Journal of Zoology. 2015; 47(1):287-93.
  13. Parker PJ, Justilien V, Riou P, Linch M, Fields AP. Atypical protein kinase Ciota as a human oncogene and therapeutic target. Biochem Pharmacol. 2014 Mar 1; 88 (1):1-11 Epub 2013 Nov 11
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  14. Justilien V, Walsh MP, Ali SA, Thompson EA, Murray NR, Fields AP. The PRKCI and SOX2 oncogenes are coamplified and cooperate to activate Hedgehog signaling in lung squamous cell carcinoma. Cancer Cell. 2014 Feb 10; 25 (2):139-51
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  15. Justilien V, Fields AP. Utility and applications of orthotopic models of human non-small cell lung cancer (NSCLC) for the evaluation of novel and emerging cancer therapeutics. Curr Protoc Pharmacol. 2013 Oct 8; 62:Unit 14.27. Epub 2013 Oct 08
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  16. Justilien V, Regala RP, Tseng IC, Walsh MP, Batra J, Radisky ES, Murray NR, Fields AP. Matrix metalloproteinase-10 is required for lung cancer stem cell maintenance, tumor initiation and metastatic potential. PLoS One. 2012; 7 (4):e35040 Epub 2012 Apr 24
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  17. Justilien V, Jameison L, Der CJ, Rossman KL, Fields AP. Oncogenic activity of Ect2 is regulated through protein kinase C iota-mediated phosphorylation. J Biol Chem. 2011 Mar 11; 286 (10):8149-57 Epub 2010 Dec 28
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  18. Regala RP, Justilien V, Walsh MP, Weems C, Khoor A, Murray NR, Fields AP. Matrix metalloproteinase-10 promotes Kras-mediated bronchio-alveolar stem cell expansion and lung cancer formation. PLoS One. 2011; 6 (10):e26439 Epub 2011 Oct 17
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  19. Fields AP, Justilien V. The guanine nucleotide exchange factor (GEF) Ect2 is an oncogene in human cancer. Adv Enzyme Regul. 2010; 50 (1):190-200 Epub 2009 Nov 06
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  20. Justilien V, Fields AP. Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation. Oncogene. 2009 Oct 15; 28 (41):3597-607 Epub 2009 July 20
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  21. Frederick LA, Matthews JA, Jamieson L, Justilien V, Thompson EA, Radisky DC, Fields AP. Matrix metalloproteinase-10 is a critical effector of protein kinase Ciota-Par6alpha-mediated lung cancer. Oncogene. 2008 Aug 14; 27 (35):4841-53 Epub 2008 Apr 21
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  22. Justilien V, Pang JJ, Renganathan K, Zhan X, Crabb JW, Kim SR, Sparrow JR, Hauswirth WW, Lewin AS. SOD2 knockdown mouse model of early AMD. Invest Ophthalmol Vis Sci. 2007 Oct; 48: (10)4407-20.
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  23. Gorbatyuk M, Justilien V, Liu J, Hauswirth WW, Lewin AS. Suppression of mouse rhodopsin expression in vivo by AAV mediated siRNA delivery. Vision Res. 2007 Apr; 47: (9)1202-8.
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  24. Gorbatyuk M, Justilien V, Liu J, Hauswirth WW, Lewin AS. Preservation of photoreceptor morphology and function in P23H rats using an allele independent ribozyme. Exp Eye Res. 2007 Jan; 84: (1)44-52.
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