Publications

  1. Xie J, Covassin N, Fan Z, Singh P, Gao W, Li G, Kara T, Somers VK. Association Between Hypoxemia and Mortality in Patients With COVID-19. Mayo Clin Proc. 2020 Jun; 95 (6):1138-1147 Epub 2020 Apr 11
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  2. Polonis K, Becari C, Chahal CAA, Zhang Y, Allen AM, Kellogg TA, Somers VK, Singh P. Chronic Intermittent Hypoxia Triggers a Senescence-like Phenotype in Human White Preadipocytes. Sci Rep. 2020 Apr 22; 10 (1):6846
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  3. Polonis K, Sompalli S, Becari C, Xie J, Covassin N, Schulte PJ, Druliner BR, Johnson RA, Narkiewicz K, Boardman LA, Singh P, Somers VK. Telomere Length and Risk of Major Adverse Cardiac Events and Cancer in Obstructive Sleep Apnea Patients. Cells. 2019 Apr 26; 8 (5)
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  4. Xie J, Covassin N, Chahal AA, Schulte PJ, Singh P, Somers VK, Caples SM. Effect of Adaptive Servo-Ventilation on Periodic Limb Movements in Sleep in Patients With Heart Failure. Am J Cardiol. 2019 Feb 15; 123 (4):632-637 Epub 2018 Nov 24
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  5. Sharma P, Dong Y, Somers VK, Peterson TE, Zhang Y, Wang S, Li G, Singh P. Intermittent hypoxia regulates vasoactive molecules and alters insulin-signaling in vascular endothelial cells. Sci Rep. 2018 Sep 20; 8 (1):14110 Epub 2018 Sept 20
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  6. Covassin N, Greene EL, Singh P, Somers VK. Disparities in Hypertension Among African-Americans: Implications of Insufficient Sleep. Curr Hypertens Rep. 2018 Jun 8; 20 (7):57 Epub 2018 June 08
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  7. Covassin N, Sert-Kuniyoshi FH, Singh P, Romero-Corral A, Davison DE, Lopez-Jimenez F, Jensen MD, Somers VK. Experimental Weight Gain Increases Ambulatory Blood Pressure in Healthy Subjects: Implications of Visceral Fat Accumulation. Mayo Clin Proc. 2018 May; 93 (5):618-626
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  8. Cundrle I Jr, Somers VK, Singh P, Johnson BD, Scott CG, Olson LJ. Low leptin concentration may identify heart failure patients with central sleep apnea. J Sleep Res. 2018 Apr; 27 (2):240-243 Epub 2017 June 23
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  9. Xie J, Sert Kuniyoshi FH, Covassin N, Singh P, Gami AS, Chahal CAA, Somers VK. Excessive Daytime Sleepiness Independently Predicts Increased Cardiovascular Risk After Myocardial Infarction. J Am Heart Assoc. 2018 Jan 19; 7 (2)
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  10. Singh P, Zhang Y, Sharma P, Covassin N, Soucek F, Friedman PA, Somers VK. Statins decrease leptin expression in human white adipocytes. Physiol Rep. 2018 Jan; 6 (2)
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  11. Zhang Y, Somers KR, Becari C, Polonis K, Pfeifer MA, Allen AM, Kellogg TA, Covassin N, Singh P. Comparative Expression of Renin-Angiotensin Pathway Proteins in Visceral Versus Subcutaneous Fat. Front Physiol. 2018; 9:1370 Epub 2018 Oct 10
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  12. Baheti S, Singh P, Zhang Y, Evans J, Jensen MD, Somers VK, Kocher JA, Sun Z, Chakkera HA. Adipose tissue DNA methylome changes in development of new-onset diabetes after kidney transplantation. Epigenomics. 2017 Nov; 9 (11):1423-1435 Epub 2017 Oct 02
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  13. Polonis K, Somers VK, Becari C, Covassin N, Schulte PJ, Druliner BR, Johnson RA, Narkiewicz K, Boardman LA, Singh P. Moderate-to-severe obstructive sleep apnea is associated with telomere lengthening. Am J Physiol Heart Circ Physiol. 2017 Nov 1; 313 (5):H1022-H1030 Epub 2017 Aug 19
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  14. Xie J, Chahal CAA, Covassin N, Schulte PJ, Singh P, Srivali N, Somers VK, Caples SM. Periodic limb movements of sleep are associated with an increased prevalence of atrial fibrillation in patients with mild sleep-disordered breathing. Int J Cardiol. 2017 Aug 15; 241:200-204. Epub 2017 Apr 22.
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  15. Cundrle I Jr, Somers VK, Singh P, Johnson BD, Scott CG, Olson LJ. Sex differences in leptin modulate ventilation in heart failure. Heart Lung. 2017 May - Jun; 46 (3):187-191 Epub 2017 Feb 23
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  16. Tobaldini E, Covassin N, Calvin A, Singh P, Bukartyk J, Wang S, Montano N, Somers VK. Cardiac autonomic control and complexity during sleep are preserved after chronic sleep restriction in healthy subjects. Physiol Rep. 2017 Apr; 5 (7)
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  17. Hoffmann M, Wolf J, Szyndler A, Singh P, Somers VK, Narkiewicz K. Serum of obstructive sleep apnea patients impairs human coronary endothelial cell migration. Arch Med Sci. 2017 Feb 1; 13 (1):223-227 Epub 2015 Dec 16
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  18. Covassin N, Singh P, Somers VK. Keeping Up With the Clock: Circadian Disruption and Obesity Risk. Hypertension. 2016 Nov; 68 (5):1081-1090 Epub 2016 Sept 12
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  19. Pusalavidyasagar S, Sert Kuniyoshi FH, Shamsuzzaman AS, Singh P, Maharaj S, Leinveber P, Nykodym J, Somers VK. Comparison of Endothelial Function in Asian Indians Versus Caucasians. Metab Syndr Relat Disord. 2016 Sep; 14 (7):363-7 Epub 2016 May 12
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  20. Xie J, Sert Kuniyoshi FH, Covassin N, Singh P, Gami AS, Wang S, Chahal CA, Wei Y, Somers VK. Nocturnal Hypoxemia Due to Obstructive Sleep Apnea Is an Independent Predictor of Poor Prognosis After Myocardial Infarction. J Am Heart Assoc. 2016 Jul 27; 5 (8) Epub 2016 July 27
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  21. Wolk R, Bertolet M, Singh P, Brooks MM, Pratley RE, Frye RL, Mooradian AD, Rutter MK, Calvin AD, Chaitman BR, Somers VK, BARI 2D Study Group. Prognostic Value of Adipokines in Predicting Cardiovascular Outcome: Explaining the Obesity Paradox. Mayo Clin Proc. 2016 Jul; 91 (7):858-66 Epub 2016 June 09
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  22. Covassin N, Singh P. Sleep Duration and Cardiovascular Disease Risk: Epidemiologic and Experimental Evidence. Sleep Med Clin. 2016 Mar; 11 (1):81-9 Epub 2016 Jan 09
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  23. Singh P, Sharma P, Sahakyan KR, Davison DE, Sert-Kuniyoshi FH, Romero-Corral A, Swain JM, Jensen MD, Lopez-Jimenez F, Kara T, Somers VK. Differential effects of leptin on adiponectin expression with weight gain versus obesity. Int J Obes (Lond). 2016 Feb; 40 (2):266-74 Epub 2015 Sept 16
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  24. Wolk R, Bertolet M, Brooks MM, Pratley RE, Sobel BE, Frye RL, Singh P, Calvin AD, Rutter MK, Mooradian AD, Somers VK, BARI 2D study group. Differential effects of insulin sensitization and insulin provision treatment strategies on concentrations of circulating adipokines in patients with diabetes and coronary artery disease in the BARI 2D trial. Eur J Prev Cardiol. 2016 Jan; 23 (1):50-8 Epub 2014 July 29
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  25. Sahakyan KR, Somers VK, Rodriguez-Escudero JP, Hodge DO, Carter RE, Sochor O, Coutinho T, Jensen MD, Roger VL, Singh P, Lopez-Jimenez F. Normal-weight central obesity: implications for total and cardiovascular mortality Annals Of Internal Medicine. 2015 Dec 1; 163: (11)827-35.
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  26. Soucek F, Covassin N, Singh P, Ruzek L, Kara T, Suleiman M, Lerman A, Koestler C, Friedman PA, Lopez-Jimenez F, Somers VK. Effects of Atorvastatin (80 mg) Therapy on Quantity of Epicardial Adipose Tissue in Patients Undergoing Pulmonary Vein Isolation for Atrial Fibrillation. Am J Cardiol. 2015 Nov 1; 116 (9):1443-6 Epub 2015 Aug 14
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  27. Batsis JA, Sahakyan KR, Singh P, Bartels SJ, Somers VK, Lopez-Jimenez F. Leptin, adiposity, and mortality: results from the National Health and Nutrition Examination Survey III, 1988 to 1994. Mayo Clin Proc. 2015 Apr; 90(4):481-91.
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  28. Calvin AD, Covassin N, Kremers WK, Adachi T, Macedo P, Albuquerque FN, Bukartyk J, Davison DE, Levine JA, Singh P, Wang S, Somers VK. Experimental sleep restriction causes endothelial dysfunction in healthy humans. J Am Heart Assoc. 2014 Nov 25; 3 (6):e001143
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  29. Cundrle I Jr, Somers VK, Singh P, Johnson BD, Scott CG, van der Walt C, Olson LJ. Leptin deficiency promotes central sleep apnea in patients with heart failure. Chest. 2014 Jan; 145 (1):72-78
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  30. Cundrle I, Somers VK, Singh P, Johnson BD, Scott CG, Olson LJ. The relationship between leptin and ventilatory control in heart failure. J Card Fail. 2014; 20(5):376.e9-14.
  31. Hoffmann MS, Singh P, Wolk R, Narkiewicz K, Somers VK. Obstructive sleep apnea and intermittent hypoxia increase expression of dual specificity phosphatase 1. Atherosclerosis. 2013 Dec; 231 (2):378-83 Epub 2013 Oct 11
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  32. Cundrle I Jr, Somers VK, Singh P, Johnson BD, Scott CG, Olson LJ. The relationship between leptin and ventilatory control in heart failure. J Card Fail. 2013 Nov; 19 (11):756-61 Epub 2013 Oct 18
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  33. Diaz-Melean CM, Somers VK, Rodriguez-Escudero JP, Singh P, Sochor O, Llano EM, Lopez-Jimenez F. Mechanisms of adverse cardiometabolic consequences of obesity. Curr Atheroscler Rep. 2013 Nov; 15 (11):364
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  34. Singh P, Peterson TE, Sert-Kuniyoshi FH, Glenn JA, Davison DE, Romero-Corral A, Pusalavidyasagar S, Jensen MD, Somers VK. Leptin signaling in adipose tissue: role in lipid accumulation and weight gain. Circ Res. 2012 Aug 17; 111 (5):599-603 Epub 2012 June 22
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  35. Singh P, Somers VK, Romero-Corral A, Sert-Kuniyoshi FH, Pusalavidyasagar S, Davison DE, Jensen MD. Effects of weight gain and weight loss on regional fat distribution. Am J Clin Nutr. 2012 Aug; 96 (2):229-33 Epub 2012 July 03
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  36. Singh P, Peterson TE, Sert-Kuniyoshi FH, Jensen MD, Somers VK. Leptin upregulates caveolin-1 expression: implications for development of atherosclerosis. Atherosclerosis. 2011 Aug; 217 (2):499-502 Epub 2010 Oct 16
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  37. Sert Kuniyoshi FH, Singh P, Gami AS, Garcia-Touchard A, van der Walt C, Pusalavidyasagar S, Wright RS, Vasquez EC, Lopez-Jimenez F, Somers VK. Patients with obstructive sleep apnea exhibit impaired endothelial function after myocardial infarction. Chest. 2011 Jul; 140 (1):62-67 Epub 2011 Feb 24
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  38. Adachi T, Sert-Kuniyoshi FH, Calvin AD, Singh P, Romero-Corral A, van der Walt C, Davison DE, Bukartyk J, Konecny T, Pusalavidyasagar S, Sierra-Johnson J, Somers VK. Effect of weight gain on cardiac autonomic control during wakefulness and sleep. Hypertension. 2011 Apr; 57 (4):723-30 Epub 2011 Feb 28
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  39. Romero-Corral A, Sert-Kuniyoshi FH, Sierra-Johnson J, Orban M, Gami A, Davison D, Singh P, Pusalavidyasagar S, Huyber C, Votruba S, Lopez-Jimenez F, Jensen MD, Somers VK. Modest visceral fat gain causes endothelial dysfunction in healthy humans. J Am Coll Cardiol. 2010 Aug 17; 56 (8):662-6
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  40. Kuniyoshi FH, Pusalavidyasagar S, Singh P, Somers VK. Cardiovascular consequences of obstructive sleep apnoea. Indian J Med Res. 2010 Feb; 131:196-205.
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  41. Singh P, Peterson TE, Barber KR, Kuniyoshi FS, Jensen A, Hoffmann M, Shamsuzzaman AS, Somers VK. Leptin upregulates the expression of plasminogen activator inhibitor-1 in human vascular endothelial cells. Biochem Biophys Res Commun. 2010 Jan 29; 392 (1):47-52 Epub 2010 Jan 05
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  42. Romero-Corral A, Sierra-Johnson J, Lopez-Jimenez F, Thomas RJ, Singh P, Hoffmann M, Okcay A, Korinek J, Wolk R, Somers VK. Relationships between leptin and C-reactive protein with cardiovascular disease in the adult general population. Nat Clin Pract Cardiovasc Med. 2008 Jul; 5(7):418-25. Epub 2008 Apr 22.
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  43. Singh P, Hoffmann M, Wolk R, Shamsuzzaman AS, Somers VK. Leptin induces C-reactive protein expression in vascular endothelial cells. Arterioscler Thromb Vasc Biol. 2007 Sep; 27(9):e302-7. Epub 2007 Jul 05.
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  44. Hoffmann MS, Singh P, Wolk R, Romero-Corral A, Raghavakaimal S, Somers VK. Microarray studies of genomic oxidative stress and cell cycle responses in obstructive sleep apnea. Antioxid Redox Signal. 2007 Jun; 9(6):661-9.
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  45. Deb DK, Dahiya P, Srivastava KK, Srivastava R, Srivastava BS. Selective identification of new therapeutic targets of Mycobacterium tuberculosis by IVIAT approach. Tuberculosis (Edinb). 2002; 82(4-5):175-82.
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