Publications

1. Komatsu Y, Takeuchi D, Tokunaga T, Sakurai H, Makino A, Honda T, Ikeda Y, Tomonaga K. RNA Virus-Based Episomal Vector with a Fail-Safe Switch Facilitating Efficient Genetic Modification and Differentiation of iPSCs. Mol Ther Methods Clin Dev. 2019 Sep 13; 14:47-55 Epub 2019 May 28
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2. Zhu Y, Tonne JM, Liu Q, Schreiber CA, Zhou Z, Rakshit K, Matveyenko AV, Terzic A, Wigle D, Kudva YC, Ikeda Y. Targeted Derivation of Organotypic Glucose- and GLP-1-Responsive beta Cells Prior to Transplantation into Diabetic Recipients. Stem Cell Reports. 2019 Aug 13; 13 (2):307-321 Epub 2019 Aug 01
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3. Wang Q, Vossen A, Ikeda Y, Devaux P. Measles vector as a multigene delivery platform facilitating iPSC reprogramming. Gene Ther. 2019 May; 26 (5):151-164 Epub 2019 Feb 04
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4. Lu B, Tonne JM, Munoz-Gomez M, Ikeda Y. Hyperinsulinemic hypoglycemia subtype glucokinase V91L mutant induces necrosis in beta-cells via ATP depletion. Biochem Biophys Rep. 2019 Mar; 17:108-113 Epub 2018 Dec 20
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5. Lu B, Kurmi K, Munoz-Gomez M, Jacobus Ambuludi EJ, Tonne JM, Rakshit K, Hitosugi T, Kudva YC, Matveyenko AV, Ikeda Y. Impaired beta-cell glucokinase as an underlying mechanism in diet-induced diabetes. Dis Model Mech. 2018 Jun 13; 11 (6) Epub 2018 June 13
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6. Lu B, Munoz-Gomez M, Ikeda Y. The two major glucokinase isoforms show conserved functionality in beta-cells despite different subcellular distribution. Biol Chem. 2018 May 24; 399 (6):565-576
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7. Ohmine S, Salisbury JL, Ingle J, Pettinato G, Haddox CL, Haddad T, Galanis E, Ikeda Y, D'assoro AB. Aurora-A overexpression is linked to development of aggressive teratomas derived from human iPS cells. Oncol Rep. 2018 Apr; 39 (4):1725-1730 Epub 2018 Jan 31
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8. Willenbring RC, Ikeda Y, Pease LR, Johnson AJ. Human perforin gene variation is geographically distributed. Mol Genet Genomic Med. 2018 Jan; 6 (1):44-55 Epub 2017 Dec 07
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9. Morsy SG, Tonne JM, Zhu Y, Lu B, Budzik K, Krempski JW, Ali SA, El-Feky MA, Ikeda Y. Divergent susceptibilities to AAV-SaCas9-gRNA vector-mediated genome-editing in a single-cell-derived cell population. BMC Res Notes. 2017 Dec 8; 10 (1):720 Epub 2017 Dec 08
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10. Zhu Y, Liu Q, Zhou Z, Ikeda Y. PDX1, Neurogenin-3, and MAFA: critical transcription regulators for beta cell development and regeneration. Stem Cell Res Ther. 2017 Nov 2; 8 (1):240 Epub 2017 Nov 02
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11. Holditch SJ, Schreiber CA, Harris PC, LaRusso NF, Ramirez-Alvarado M, Cataliotti A, Torres VE, Ikeda Y. B-type natriuretic peptide overexpression ameliorates hepatorenal fibrocystic disease in a rat model of polycystic kidney disease. Kidney Int. 2017 Sep; 92 (3):657-668 Epub 2017 Apr 14
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12. Schreiber CA, Holditch SJ, Generous A, Ikeda Y. Sustained ELABELA Gene Therapy in High-salt Diet-induced Hypertensive Rats. Curr Gene Ther. 2017; 16 (5):349-360
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13. Hickey RD, Mao SA, Glorioso J, Elgilani F, Amiot B, Chen H, Rinaldo P, Marler R, Jiang H, DeGrado TR, Suksanpaisan L, O'Connor MK, Freeman BL, Ibrahim SH, Peng KW, Harding CO, Ho CS, Grompe M, Ikeda Y, Lillegard JB, Russell SJ, Nyberg SL. Curative ex vivo liver-directed gene therapy in a pig model of hereditary tyrosinemia type 1. Sci Transl Med. 2016 Jul 27; 8 (349):349ra99
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14. Li X, Cheng KKY, Liu Z, Yang JK, Wang B, Jiang X, Zhou Y, Hallenborg P, Hoo RLC, Lam KSL, Ikeda Y, Gao X, Xu A. The MDM2-p53-pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic beta-cells. Nat Commun. 2016 Jun 6; 7:11740 Epub 2016 June 06
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15. Schafer MJ, White TA, Evans G, Tonne JM, Verzosa GC, Stout MB, Mazula DL, Palmer AK, Baker DJ, Jensen MD, Torbenson MS, Miller JD, Ikeda Y, Tchkonia T, van Deursen JM, Kirkland JL, LeBrasseur NK. Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue. Diabetes. 2016 Jun; 65 (6):1606-15 Epub 2016 Mar 16
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16. Holditch SJ, Schreiber CA, Burnett JC, Ikeda Y. Arterial Remodeling in B-Type Natriuretic Peptide Knock-Out Females. Sci Rep. 2016 May 10; 6:25623
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17. Turner EC, Huang CL, Sawhney N, Govindarajan K, Clover AJ, Martin K, Browne TC, Whelan D, Kumar AH, Mackrill JJ, Wang S, Schmeckpeper J, Stocca A, Pierce WG, Leblond AL, Cai L, O'Sullivan DM, Buneker CK, Choi J, MacSharry J, Ikeda Y, Russell SJ, Caplice NM. A Novel Selectable Islet 1 Positive Progenitor Cell Reprogrammed to Expandable and Functional Smooth Muscle Cells. Stem Cells. 2016 May; 34 (5):1354-68 Epub 2016 Mar 28
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18. El Khatib MM, Ohmine S, Jacobus EJ, Tonne JM, Morsy SG, Holditch SJ, Schreiber CA, Uetsuka K, Fusaki N, Wigle DA, Terzic A, Kudva YC, Ikeda Y. Tumor-Free Transplantation of Patient-Derived Induced Pluripotent Stem Cell Progeny for Customized Islet Regeneration. Stem Cells Transl Med. 2016 May; 5 (5):694-702 Epub 2016 Mar 17
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19. Ikeda Y, Makino A, Matchett WE, Holditch SJ, Lu B, Dietz AB, Tomonaga K. A novel intranuclear RNA vector system for long-term stem cell modification. Gene Ther. 2016 Mar; 23 (3):256-62 Epub 2015 Dec 03
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20. Schreiber CA, Sakuma T, Izumiya Y, Holditch SJ, Hickey RD, Bressin RK, Basu U, Koide K, Asokan A, Ikeda Y. An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated Viruses. PLoS Pathog. 2015 Aug; 11 (8):e1005082 Epub 2015 Aug 05
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21. Holditch SJ, Schreiber CA, Nini R, Tonne JM, Peng KW, Geurts A, Jacob HJ, Burnett JC, Cataliotti A, Ikeda Y. B-Type Natriuretic Peptide Deletion Leads to Progressive Hypertension, Associated Organ Damage, and Reduced Survival: Novel Model for Human Hypertension. Hypertension. 2015 Jul; 66 (1):199-210 Epub 2015 May 11
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22. De Assuncao TM, Sun Y, Jalan-Sakrikar N, Drinane MC, Huang BQ, Li Y, Davila JI, Wang R, O'Hara SP, Lomberk GA, Urrutia RA, Ikeda Y, Huebert RC. Development and characterization of human-induced pluripotent stem cell-derived cholangiocytes. Lab Invest. 2015 Jun; 95 (6):684-96 Epub 2015 Apr 13
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23. El Khatib MM, Sakuma T, Tonne JM, Mohamed MS, Holditch SJ, Lu B, Kudva YC, Ikeda Y. beta-Cell-targeted blockage of PD1 and CTLA4 pathways prevents development of autoimmune diabetes and acute allogeneic islets rejection. Gene Ther. 2015 May; 22 (5):430-8 Epub 2015 Mar 19
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24. Trevino MB, Machida Y, Hallinger DR, Garcia E, Christensen A, Dutta S, Peake DA, Ikeda Y, Imai Y. Perilipin 5 regulates islet lipid metabolism and insulin secretion in a cAMP-dependent manner: implication of its role in the postprandial insulin secretion. Diabetes. 2015 Apr; 64 (4):1299-310 Epub 2014 Nov 12
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25. Hickey RD, Mao SA, Amiot B, Suksanpaisan L, Miller A, Nace R, Glorioso J, O'Connor MK, Peng KW, Ikeda Y, Russell SJ, Nyberg SL. Noninvasive 3-dimensional imaging of liver regeneration in a mouse model of hereditary tyrosinemia type 1 using the sodium iodide symporter gene. Liver Transpl. 2015 Apr; 21 (4):442-53 Epub 2015 Mar 12
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26. Driscoll CB, Tonne JM, El Khatib M, Cattaneo R, Ikeda Y, Devaux P. Nuclear reprogramming with a non-integrating human RNA virus. Stem Cell Res Ther. 2015 Mar 26; 6:48
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27. Tonne JM, Sakuma T, Munoz-Gomez M, El Khatib M, Barry MA, Kudva YC, Ikeda Y. Beta cell regeneration after single-round immunological destruction in a mouse model. Diabetologia. 2015 Feb; 58 (2):313-23 Epub 2014 Oct 23
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28. O'Reilly M, Federoff HJ, Fong Y, Kohn DB, Patterson AP, Ahmed N, Asokan A, Boye SE, Crystal RG, De Oliveira S, Gargiulo L, Harper SQ, Ikeda Y, Jambou R, Montgomery M, Prograis L, Rosenthal E, Sterman DH, Vandenberghe LH, Zoloth L, Abedi M, Adair J, Adusumilli PS, Goins WF, Gray J, Monahan P, Popplewell L, Sena-Esteves M, Tannous B, Weber T, Wierda W, Gopal-Srivastava R, McDonald CL, Rosenblum D, Corrigan-Curay J. Gene therapy: charting a future course--summary of a National Institutes of Health Workshop, April 12, 2013. Hum Gene Ther. 2014 Jun; 25(6):488-97.
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29. Holditch SJ, Terzic A, Ikeda Y. Concise review: pluripotent stem cell-based regenerative applications for failing beta-cell function. Stem Cells Transl Med. 2014 May; 3 (5):653-61 Epub 2014 Mar 19
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30. Tonne JM, Holditch SJ, Oehler EA, Schreiber CA, Ikeda Y, Cataliotti A. Cardiac BNP gene delivery prolongs survival in aged spontaneously hypertensive rats with overt hypertensive heart disease. Aging (Albany NY). 2014 Apr; 6 (4):311-9
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31. Sakuma T, Davila JI, Malcolm JA, Kocher JP, Tonne JM, Ikeda Y. Murine leukemia virus uses NXF1 for nuclear export of spliced and unspliced viral transcripts. J Virol. 2014 Apr; 88 (8):4069-82 Epub 2014 Jan 29
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32. Sakuma T, Tonne JM, Ikeda Y. Murine leukemia virus uses TREX components for efficient nuclear export of unspliced viral transcripts. Viruses. 2014 Mar 10; 6 (3):1135-48
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33. D'Assoro AB, Liu T, Quatraro C, Amato A, Opyrchal M, Leontovich A, Ikeda Y, Ohmine S, Lingle W, Suman V, Ecsedy J, Iankov I, Di Leonardo A, Ayers-Inglers J, Degnim A, Billadeau D, McCubrey J, Ingle J, Salisbury JL, Galanis E. The mitotic kinase Aurora--a promotes distant metastases by inducing epithelial-to-mesenchymal transition in ERalpha(+) breast cancer cells. Oncogene. 2014 Jan 30; 33 (5):599-610 Epub 2013 Jan 21
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34. Sukegawa S, Sakuma R, Ohmine S, Takeuchi H, Ikeda Y, Yamaoka S. Suppressor of cytokine signaling 1 counteracts rhesus macaque TRIM5alpha-induced inhibition of human immunodeficiency virus type-1 production. PLoS One. 2014; 9 (10):e109640 Epub 2014 Oct 13
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35. Tonne JM, Sakuma T, Deeds MC, Munoz-Gomez M, Barry MA, Kudva YC, Ikeda Y. Global gene expression profiling of pancreatic islets in mice during streptozotocin-induced beta-cell damage and pancreatic Glp-1 gene therapy. Dis Model Mech. 2013 Sep; 6 (5):1236-45 Epub 2013 July 04
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36. Yamada S, Nelson TJ, Kane GC, Martinez-Fernandez A, Crespo-Diaz RJ, Ikeda Y, Perez-Terzic C, Terzic A. Induced pluripotent stem cell intervention rescues ventricular wall motion disparity, achieving biological cardiac resynchronization post-infarction. J Physiol. 2013 Sep 1; 591 (17):4335-49 Epub 2013 Apr 08
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37. Ohmine S, Singh RD, Marks DL, Meyer MA, Pagano RE, Ikeda Y. Viral attachment induces rapid recruitment of an innate immune sensor (TRIM5alpha) to the plasma membrane. J Innate Immun. 2013; 5 (4):414-24 Epub 2013 Mar 21
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38. Thatava T, Kudva YC, Edukulla R, Squillace K, De Lamo JG, Khan YK, Sakuma T, Ohmine S, Terzic A, Ikeda Y. Intrapatient variations in type 1 diabetes-specific iPS cell differentiation into insulin-producing cells. Mol Ther. 2013 Jan; 21 (1):228-39 Epub 2012 Nov 27
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39. Yu Y, Liu H, Ikeda Y, Amiot BP, Rinaldo P, Duncan SA, Nyberg SL. Hepatocyte-like cells differentiated from human induced pluripotent stem cells: relevance to cellular therapies. Stem Cell Res. 2012 Nov; 9 (3):196-207 Epub 2012 June 28
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40. Macheret F, Heublein D, Costello-Boerrigter LC, Boerrigter G, McKie P, Bellavia D, Mangiafico S, Ikeda Y, Bailey K, Scott CG, Sandberg S, Chen HH, Malatino L, Redfield MM, Rodeheffer R, Burnett J Jr, Cataliotti A. Human hypertension is characterized by a lack of activation of the antihypertensive cardiac hormones ANP and BNP. J Am Coll Cardiol. 2012 Oct 16; 60(16):1558-65.
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41. Kudva YC, Ohmine S, Greder LV, Dutton JR, Armstrong A, De Lamo JG, Khan YK, Thatava T, Hasegawa M, Fusaki N, Slack JM, Ikeda Y. Transgene-free disease-specific induced pluripotent stem cells from patients with type 1 and type 2 diabetes. Stem Cells Transl Med. 2012 Jun; 1 (6):451-61 Epub 2012 May 30
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42. Sakuma T, Barry MA, Ikeda Y. Lentiviral vectors: basic to translational. Biochem J. 2012 May 1; 443(3):603-18.
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43. Zhou Y, Steffen I, Montalvo L, Lee TH, Zemel R, Switzer WM, Tang S, Jia H, Heneine W, Winkelman V, Tailor CS, Ikeda Y, Simmons G. Development and application of a high-throughput microneutralization assay: lack of xenotropic murine leukemia virus-related virus and/or murine leukemia virus detection in blood donors. Transfusion. 2012 Feb; 52(2):332-42.
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44. Ohmine S, Squillace KA, Hartjes KA, Deeds MC, Armstrong AS, Thatava T, Sakuma T, Terzic A, Kudva Y, Ikeda Y. Reprogrammed keratinocytes from elderly type 2 diabetes patients suppress senescence genes to acquire induced pluripotency. Aging (Albany NY). 2012 Jan; 4 (1):60-73
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45. Sakuma T, Tonne JM, Malcolm JA, Thatava T, Ohmine S, Peng KW, Ikeda Y. Long-term infection and vertical transmission of a gammaretrovirus in a foreign host species. PLoS One. 2012; 7 (1):e29682 Epub 2012 Jan 03
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46. Thatava T, Armstrong AS, De Lamo JG, Edukulla R, Khan YK, Sakuma T, Ohmine S, Sundsbak JL, Harris PC, Kudva YC, Ikeda Y. Successful disease-specific induced pluripotent stem cell generation from patients with kidney transplantation. Stem Cell Res Ther. 2011 Dec 6; 2 (6):48 Epub 2011 Dec 06
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47. Ohmine S, Dietz AB, Deeds MC, Hartjes KA, Miller DR, Thatava T, Sakuma T, Kudva YC, Ikeda Y. Induced pluripotent stem cells from GMP-grade hematopoietic progenitor cells and mononuclear myeloid cells. Stem Cell Res Ther. 2011 Nov 16; 2 (6):46
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48. Folmes CD, Nelson TJ, Martinez-Fernandez A, Arrell DK, Lindor JZ, Dzeja PP, Ikeda Y, Perez-Terzic C, Terzic A. Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming. Cell Metab. 2011 Aug 3; 14 (2):264-71
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49. Tonne JM, Campbell JM, Cataliotti A, Ohmine S, Thatava T, Sakuma T, Macheret F, Huntley BK, Burnett JC Jr, Ikeda Y. Secretion of glycosylated pro-B-type natriuretic peptide from normal cardiomyocytes. Clin Chem. 2011 Jun; 57 (6):864-73 Epub 2011 Apr 11
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50. Sakuma T, Hue S, Squillace KA, Tonne JM, Blackburn PR, Ohmine S, Thatava T, Towers GJ, Ikeda Y. No evidence of XMRV in prostate cancer cohorts in the Midwestern United States. Retrovirology. 2011 Mar 29; 8:23
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51. Cataliotti A, Tonne JM, Bellavia D, Martin FL, Oehler EA, Harders GE, Campbell JM, Peng KW, Russell SJ, Malatino LS, Burnett JC Jr, Ikeda Y. Long-term cardiac pro-B-type natriuretic peptide gene delivery prevents the development of hypertensive heart disease in spontaneously hypertensive rats. Circulation. 2011 Mar 29; 123 (12):1297-305 Epub 2011 Mar 14
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52. Macheret F, Boerrigter G, McKie P, Costello-Boerrigter L, Lahr B, Heublein D, Sandberg S, Ikeda Y, Cataliotti A, Bailey K, Rodeheffer R, Burnett JC Jr. Pro-B-type natriuretic peptide(1-108) circulates in the general community: plasma determinants and detection of left ventricular dysfunction. J Am Coll Cardiol. 2011 Mar 22; 57 (12):1386-95
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53. Thatava T, Nelson TJ, Edukulla R, Sakuma T, Ohmine S, Tonne JM, Yamada S, Kudva Y, Terzic A, Ikeda Y. Indolactam V/GLP-1-mediated differentiation of human iPS cells into glucose-responsive insulin-secreting progeny. Gene Ther. 2011 Mar; 18 (3):283-93 Epub 2010 Nov 04
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54. Sakuma T, Tonne JM, Squillace KA, Ohmine S, Thatava T, Peng KW, Barry MA, Ikeda Y. Early events in retrovirus XMRV infection of the wild-derived mouse Mus pahari. J Virol. 2011 Feb; 85 (3):1205-13 Epub 2010 Nov 17
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55. Ohmine S, Sakuma R, Sakuma T, Thatava T, Takeuchi H, Ikeda Y. The antiviral spectra of TRIM5alpha orthologues and human TRIM family proteins against lentiviral production. PLoS One. 2011 Jan 14; 6 (1):e16121
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56. Furuta RA, Miyazawa T, Sugiyama T, Kuratsune H, Ikeda Y, Sato E, Misawa N, Nakatomi Y, Sakuma R, Yasui K, Yamaguti K, Hirayama F. No association of xenotropic murine leukemia virus-related virus with prostate cancer or chronic fatigue syndrome in Japan. Retrovirology. 2011; 8:20. Epub 2011 Mar 17.
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57. Sakuma T, De Ravin SS, Tonne JM, Thatava T, Ohmine S, Takeuchi Y, Malech HL, Ikeda Y. Characterization of retroviral and lentiviral vectors pseudotyped with xenotropic murine leukemia virus-related virus envelope glycoprotein. Hum Gene Ther. 2010 Dec; 21 (12):1665-73 Epub 2010 Sept 17
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58. Chiriac A, Terzic A, Park S, Ikeda Y, Faustino R, Nelson TJ. SDF-1-enhanced cardiogenesis requires CXCR4 induction in pluripotent stem cells. J Cardiovasc Transl Res. 2010 Dec; 3 (6):674-82 Epub 2010 Sept 15
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59. Ohmine S, Sakuma R, Sakuma T, Thatava T, Solis GP, Ikeda Y. Cytoplasmic body component TRIM5{alpha} requires lipid-enriched microdomains for efficient HIV-1 restriction. J Biol Chem. 2010 Nov 5; 285 (45):34508-17 Epub 2010 Sept 01
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60. Iankov ID, Msaouel P, Allen C, Federspiel MJ, Bulur PA, Dietz AB, Gastineau D, Ikeda Y, Ingle JN, Russell SJ, Galanis E. Demonstration of anti-tumor activity of oncolytic measles virus strains in a malignant pleural effusion breast cancer model. Breast Cancer Res Treat. 2010 Aug; 122 (3):745-54 Epub 2009 Nov 06
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61. Sakuma R, Sakuma T, Ohmine S, Silverman RH, Ikeda Y. Xenotropic murine leukemia virus-related virus is susceptible to AZT. Virology. 2010 Feb 5; 397 (1):1-6 Epub 2009 Dec 02
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62. Sakuma R, Ohmine S, Ikeda Y. Determinants for the rhesus monkey TRIM5alpha-mediated block of the late phase of HIV-1 replication. J Biol Chem. 2010 Feb 5; 285 (6):3784-93 Epub 2009 Dec 01
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63. Martinez-Fernandez A, Nelson TJ, Ikeda Y, Terzic A. c-MYC independent nuclear reprogramming favors cardiogenic potential of induced pluripotent stem cells. J Cardiovasc Transl Res. 2010 Feb; 3 (1):13-23
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64. Nelson TJ, Martinez-Fernandez A, Yamada S, Ikeda Y, Perez-Terzic C, Terzic A. Induced pluripotent stem cells: advances to applications. Stem Cells Cloning. 2010 Jan 1; 3:29-37
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65. Martinez-Fernandez A, Nelson TJ, Yamada S, Reyes S, Alekseev AE, Perez-Terzic C, Ikeda Y, Terzic A. iPS programmed without c-MYC yield proficient cardiogenesis for functional heart chimerism. Circ Res. 2009 Sep 25; 105 (7):648-56 Epub 2009 Aug 20
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66. Schmeckpeper J, Ikeda Y, Kumar AH, Metharom P, Russell SJ, Caplice NM. Lentiviral tracking of vascular differentiation in bone marrow progenitor cells. Differentiation. 2009 Sep-Oct; 78(2-3):169-76. Epub 2009 Feb 20.
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67. Nelson TJ, Martinez-Fernandez A, Yamada S, Perez-Terzic C, Ikeda Y, Terzic A. Repair of acute myocardial infarction by human stemness factors induced pluripotent stem cells. Circulation. 2009 Aug 4; 120 (5):408-16 Epub 2009 July 20
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68. Muders MH, Vohra PK, Dutta SK, Wang E, Ikeda Y, Wang L, Udugamasooriya DG, Memic A, Rupasinghe CN, Baretton GB, Aust DE, Langer S, Datta K, Simons M, Spaller MR, Mukhopadhyay D. Targeting GIPC/synectin in pancreatic cancer inhibits tumor growth. Clin Cancer Res. 2009 Jun 15; 15 (12):4095-103 Epub 2009 June 09
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69. Nelson TJ, Martinez-Fernandez A, Yamada S, Mael AA, Terzic A, Ikeda Y. Induced pluripotent reprogramming from promiscuous human stemness related factors. Clin Transl Sci. 2009 Apr; 2 (2):118-26
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70. Greene WC, Debyser Z, Ikeda Y, Freed EO, Stephens E, Yonemoto W, Buckheit RW, Este JA, Cihlar T. Novel targets for HIV therapy. Antiviral Res. 2008 Dec; 80(3):251-65. Epub 2008 Sep 30.
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71. Metharom P, Liu C, Wang S, Stalboerger P, Chen G, Doyle B, Ikeda Y, Caplice NM. Myeloid lineage of high proliferative potential human smooth muscle outgrowth cells circulating in blood and vasculogenic smooth muscle-like cells in vivo. Atherosclerosis. 2008 May; 198(1):29-38. Epub 2007 Oct 25.
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72. Lopes L, Dewannieux M, Gileadi U, Bailey R, Ikeda Y, Whittaker C, Collin MP, Cerundolo V, Tomihari M, Ariizumi K, Collins MK. Immunization with a lentivector that targets tumor antigen expression to dendritic cells induces potent CD8+ and CD4+ T-cell responses. J Virol. 2008 Jan; 82(1):86-95. Epub 2007 Oct 24.
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73. Shimojima M, Ikeda Y, Kawaoka Y. The mechanism of Axl-mediated Ebola virus infection. J Infect Dis. 2007 Nov 15; 196 Suppl 2:S259-63.
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74. Naumann N, De Ravin SS, Choi U, Moayeri M, Whiting-Theobald N, Linton GF, Ikeda Y, Malech HL. Simian immunodeficiency virus lentivector corrects human X-linked chronic granulomatous disease in the NOD/SCID mouse xenograft. Gene Ther. 2007 Nov; 14(21):1513-24. Epub 2007 Aug 30.
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75. Sakuma R, Mael AA, Ikeda Y. Alpha interferon enhances TRIM5alpha-mediated antiviral activities in human and rhesus monkey cells. J Virol. 2007 Sep; 81 (18):10201-6 Epub 2007 July 03
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76. Noser JA, Mael AA, Sakuma R, Ohmine S, Marcato P, Lee PW, Ikeda Y. The RAS/Raf1/MEK/ERK signaling pathway facilitates VSV-mediated oncolysis: implication for the defective interferon response in cancer cells. Mol Ther. 2007 Aug; 15 (8):1531-6 Epub 2007 May 15
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77. Sakuma R, Noser JA, Ohmine S, Ikeda Y. Rhesus monkey TRIM5alpha restricts HIV-1 production through rapid degradation of viral Gag polyproteins. Nat Med. 2007 May; 13 (5):631-5 Epub 2007 Apr 15
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78. Pichlmair A, Diebold SS, Gschmeissner S, Takeuchi Y, Ikeda Y, Collins MK, Reis e Sousa C. Tubulovesicular structures within vesicular stomatitis virus G protein-pseudotyped lentiviral vector preparations carry DNA and stimulate antiviral responses via Toll-like receptor 9. J Virol. 2007 Jan; 81(2):539-47. Epub 2006 Nov 01.
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79. Sakuma R, Noser JA, Ohmine S, Ikeda Y. Inhibition of HIV-1 replication by simian restriction factors, TRIM5alpha and APOBEC3G. Gene Ther. 2007 Jan; 14(2):185-9. Epub 2006 Aug 31.
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80. Muders MH, Baretton GB, Aust DE, Dutta SK, Wang E, Ikeda Y, Spaller MR, Datta K, Mukhopadhyay D. [GIPC: a new target for therapy in pancreatic adenocarcinoma?]. Verh Dtsch Ges Pathol. 2007; 91:286-93.
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81. Hasegawa K, Nakamura T, Harvey M, Ikeda Y, Oberg A, Figini M, Canevari S, Hartmann LC, Peng KW. The use of a tropism-modified measles virus in folate receptor-targeted virotherapy of ovarian cancer. Clin Cancer Res. 2006 Oct 15; 12(20 Pt 1):6170-8.
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82. Lopes L, Fletcher K, Ikeda Y, Collins M. Lentiviral vector expression of tumour antigens in dendritic cells as an immunotherapeutic strategy. Cancer Immunol Immunother. 2006 Aug; 55(8):1011-6. Epub 2005 Nov 26.
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83. Noser JA, Towers GJ, Sakuma R, Dumont JM, Collins MK, Ikeda Y. Cyclosporine increases human immunodeficiency virus type 1 vector transduction of primary mouse cells. J Virol. 2006 Aug; 80 (15):7769-74
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84. Rowe HM, Lopes L, Ikeda Y, Bailey R, Barde I, Zenke M, Chain BM, Collins MK. Immunization with a lentiviral vector stimulates both CD4 and CD8 T cell responses to an ovalbumin transgene. Mol Ther. 2006 Feb; 13(2):310-9. Epub 2005 Nov 04.
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85. Relander T, Johansson M, Olsson K, Ikeda Y, Takeuchi Y, Collins M, Richter J. Gene transfer to repopulating human CD34+ cells using amphotropic-, GALV-, or RD114-pseudotyped HIV-1-based vectors from stable producer cells. Mol Ther. 2005 Mar; 11(3):452-9.
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86. Chau KY, Keane-Myers AM, Fedele M, Ikeda Y, Creusot RJ, Menozzi L, Cousins DJ, Manfioletti G, Feigenbaum L, Fusco A, Ono SJ. IFN-gamma gene expression is controlled by the architectural transcription factor HMGA1. Int Immunol. 2005 Mar; 17(3):297-306. Epub 2005 Feb 14.
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87. Strang BL, Takeuchi Y, Relander T, Richter J, Bailey R, Sanders DA, Collins MK, Ikeda Y. Human immunodeficiency virus type 1 vectors with alphavirus envelope glycoproteins produced from stable packaging cells. J Virol. 2005 Feb; 79(3):1765-71.
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88. Ikeda Y, Ylinen LM, Kahar-Bador M, Towers GJ. Influence of gag on human immunodeficiency virus type 1 species-specific tropism. J Virol. 2004 Nov; 78(21):11816-22.
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89. Strang BL, Ikeda Y, Cosset FL, Collins MK, Takeuchi Y. Characterization of HIV-1 vectors with gammaretrovirus envelope glycoproteins produced from stable packaging cells. Gene Ther. 2004 Apr; 11(7):591-8.
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90. Ikeda Y, Miyazawa T, Nishimura Y, Nakamura K, Tohya Y, Mikami T. High genetic stability of TM1 and TM2 strains of subtype B feline immunodeficiency virus in long-term infection. J Vet Med Sci. 2004 Mar; 66(3):287-9.
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91. Shimojima M, Miyazawa T, Ikeda Y, McMonagle EL, Haining H, Akashi H, Takeuchi Y, Hosie MJ, Willett BJ. Use of CD134 as a primary receptor by the feline immunodeficiency virus. Science. 2004 Feb 20; 303(5661):1192-5.
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92. Palmowski MJ, Lopes L, Ikeda Y, Salio M, Cerundolo V, Collins MK. Intravenous injection of a lentiviral vector encoding NY-ESO-1 induces an effective CTL response. J Immunol. 2004 Feb 1; 172(3):1582-7.
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93. Ikeda Y, Takeuchi Y, Martin F, Cosset FL, Mitrophanous K, Collins M. Continuous high-titer HIV-1 vector production. Nat Biotechnol. 2003 May; 21(5):569-72. Epub 2003 Apr 07.
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94. Nakamura K, Suzuki Y, Ikeo K, Ikeda Y, Sato E, Nguyen NT, Gojobori T, Mikami T, Miyazawa T. Phylogenetic analysis of Vietnamese isolates of feline immunodeficiency virus: genetic diversity of subtype C. Arch Virol. 2003 Apr; 148(4):783-91.
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95. Kohmoto M, Ikeda Y, Sato E, Nishimura Y, Inoshima Y, Shimojima M, Tohya Y, Mikami T, Miyazawa T. Experimental mucosal infection with molecularly cloned feline immunodeficiency viruses. Clin Diagn Lab Immunol. 2003 Jan; 10(1):185-8.
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96. Ikeda Y, Collins MK, Radcliffe PA, Mitrophanous KA, Takeuchi Y. Gene transduction efficiency in cells of different species by HIV and EIAV vectors. Gene Ther. 2002 Jul; 9(14):932-8.
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97. Ikeda Y, Nakamura K, Miyazawa T, Takahashi E, Mochizuki M. Feline host range of canine parvovirus: recent emergence of new antigenic types in cats. Emerg Infect Dis. 2002 Apr; 8(4):341-6.
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98. Nakamura K, Ikeda Y, Miyazawa T, Tohya Y, Takahashi E, Mochizuki M. Characterisation of cross-reactivity of virus neutralising antibodies induced by feline panleukopenia virus and canine parvoviruses. Res Vet Sci. 2001 Dec; 71(3):219-22.
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99. Phung HT, Ikeda Y, Miyazawa T, Nakamura K, Mochizuki M, Izumiya Y, Sato E, Nishimura Y, Tohya Y, Takahashi E, Mikami T. Genetic analyses of feline foamy virus isolates from domestic and wild feline species in geographically distinct areas. Virus Res. 2001 Aug; 76(2):171-81.
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100. Neil S, Martin F, Ikeda Y, Collins M. Postentry restriction to human immunodeficiency virus-based vector transduction in human monocytes. J Virol. 2001 Jun; 75(12):5448-56.
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101. Nakamura K, Sakamoto M, Ikeda Y, Sato E, Kawakami K, Miyazawa T, Tohya Y, Takahashi E, Mikami T, Mochizuki M. Pathogenic potential of canine parvovirus types 2a and 2c in domestic cats. Clin Diagn Lab Immunol. 2001 May; 8(3):663-8.
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102. Ikeda Y, Nakamura K, Miyazawa T, Chen MC, Kuo TF, Lin JA, Mikami T, Kai C, Takahashi E. Seroprevalence of canine distemper virus in cats. Clin Diagn Lab Immunol. 2001 May; 8(3):641-4.
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103. Sato E, Miyazawa T, Nishimura Y, Ikeda Y, Kawakami K, Mochizuki M, Yokoyama N, Maeda K, Fujita K, Kohmoto M, Takahashi E, Mikami T. Further development of a recombinant feline herpesvirus type 1 expressing the Gag protein of feline immunodeficiency virus. Arch Virol. 2001; 146(2):379-87.
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104. Ikeda Y, Mochizuki M, Naito R, Nakamura K, Miyazawa T, Mikami T, Takahashi E. Predominance of canine parvovirus (CPV) in unvaccinated cat populations and emergence of new antigenic types of CPVs in cats. Virology. 2000 Dec 5; 278(1):13-9.
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105. Nishimura Y, Shimojima M, Miyazawa T, Sato E, Nakamura K, Izumiya Y, Ikeda Y, Mikami T, Takahashi E. Molecular cloning of the cDNAs encoding the feline B-lymphocyte activation antigen B7-1 (CD80) and B7-2 (CD86) homologues which interact with human CTLA4-Ig. Eur J Immunogenet. 2000 Oct-Dec; 27(5-6):427-30.
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106. Sato E, Yokoyama N, Miyazawa T, Maeda K, Ikeda Y, Nishimura Y, Fujita K, Kohmoto M, Takahashi E, Mikami T. Efficient expression of the envelope protein of feline immunodeficiency virus in a recombinant feline herpesvirus type 1 (FHV-1) using the gC promoter of FHV-1. Virus Res. 2000 Sep; 70(1-2):13-23.
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107. Nakamura K, Miyazawa T, Ikeda Y, Sato E, Nishimura Y, Nguyen NT, Takahashi E, Mochizuki M, Mikami T. Contrastive prevalence of feline retrovirus infections between northern and southern Vietnam. J Vet Med Sci. 2000 Aug; 62(8):921-3.
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108. Nishimura Y, Miyazawa T, Ikeda Y, Izumiya Y, Nakamura K, Sato E, Mikami T, Takahashi E. Molecular cloning and sequencing of a cDNA encoding the feline cytotoxic T-lymphocyte-associated protein 4 (CTLA4) homologue. Eur J Immunogenet. 2000 Apr; 27(2):99-101.
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109. Nishimura Y, Miyazawa T, Ikeda Y, Izumiya Y, Nakamura K, Sato E, Mikami T, Takahashi E. Molecular cloning and sequencing of the cDNA encoding the feline FcgammaRIIIA (CD16) homologue. Vet Immunol Immunopathol. 2000 Mar 15; 73(3-4):353-9.
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110. Nakamura K, Ikeda Y, Miyazawa T, Nguyen NT, Duong DD, Le KH, Vo SD, Phan LV, Mikami T, Takahashi E. Comparison of prevalence of feline herpesvirus type 1, calicivirus and parvovirus infections in domestic and leopard cats in Vietnam. J Vet Med Sci. 1999 Dec; 61(12):1313-5.
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111. Nishimura Y, Miyazawa T, Ikeda Y, Izumiya Y, Nakamura K, Sato E, Mikami T, Takahashi E. Molecular cloning and sequencing of a cDNA encoding the feline T-cell activation antigen CD26 homologue. Immunogenetics. 1999 Dec; 50(5-6):366-8.
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112. Iwatsuki K, Ikeda Y, Ohashi K, Nakamura K, Kai C. Establishment of a persistent mutant of canine distemper virus. Microbes Infect. 1999 Oct; 1(12):987-91.
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113. Izumiya Y, Jang HK, Sugawara M, Ikeda Y, Miura R, Nishimura Y, Nakamura K, Miyazawa T, Kai C, Mikami T. Identification and transcriptional analysis of the homologues of the herpes simplex virus type 1 UL30 to UL40 genes in the genome of nononcogenic Marek's disease virus serotype 2. J Gen Virol. 1999 Sep; 80 ( Pt 9):2417-22.
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114. Ikeda Y, Miyazawa T, Nakamura K, Naito R, Inoshima Y, Tung KC, Lee WM, Chen MC, Kuo TF, Lin JA, Mikami T. Serosurvey for selected virus infections of wild carnivores in Taiwan and Vietnam. J Wildl Dis. 1999 Jul; 35(3):578-81.
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115. Yamaguchi H, Ikeda Y, Moreno JI, Katsumura M, Miyazawa T, Takahashi E, Imakawa K, Sakai S, Christenson RK. Identification of a functional transcriptional factor AP-1 site in the sheep interferon tau gene that mediates a response to PMA in JEG3 cells. Biochem J. 1999 Jun 15; 340 ( Pt 3):767-73.
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116. Yamaguchi H, Ikeda Y, Taylor A, Katsumura M, Miyazawa T, Takahashi E, Imakawa K, Sakai S. Effects of PMA and transcription factors on ovine interferon-tau transactivation in various cell lines. Endocr J. 1999 Jun; 46(3):383-8.
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117. Nishimura Y, Miyazawa T, Ikeda Y, Izumiya Y, Nakamura K, Cai JS, Sato E, Kohmoto M, Mikami T, Takahashi E. Characterization of feline CD56 molecule expressed on insect cells by the baculovirus expression system. J Vet Med Sci. 1999 Jun; 61(6):701-3.
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118. Uema M, Ikeda Y, Miyazawa T, Lin JA, Chen MC, Kuo TF, Kai C, Mikami T, Takahashi E. Feline immunodeficiency virus subtype C is prevalent in northern part of Taiwan. J Vet Med Sci. 1999 Feb; 61(2):197-9.
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119. Nishimura Y, Miyazawa T, Ikeda Y, Izumiya Y, Nakamura K, Cai JS, Sato E, Kohmoto M, Mikami T. Molecular cloning and sequencing of feline CD56 (N-CAM). Eur J Immunogenet. 1999 Feb; 26(1):29-32.
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120. Kurosawa K, Ikeda Y, Miyazawa T, Izumiya Y, Nishimura Y, Nakamura K, Sato E, Mikami T, Kai C, Takahashi E. Development of restriction fragment-length polymorphism method to differentiate five subtypes of feline immunodeficiency virus. Microbiol Immunol. 1999; 43(8):817-20.
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121. Miyazawa T, Ikeda Y, Nakamura K, Naito R, Mochizuki M, Tohya Y, Vu D, Mikami T, Takahashi E. Isolation of feline parvovirus from peripheral blood mononuclear cells of cats in northern Vietnam. Microbiol Immunol. 1999; 43(6):609-12.
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122. Miyazawa T, Ikeda Y, Maeda K, Horimoto T, Tohya Y, Mochizuki M, Vu D, Vu GD, Cu DX, Ono K, Takahashi E, Mikami T. Seroepidemiological survey of feline retrovirus infections in domestic and leopard cats in northern Vietnam in 1997. J Vet Med Sci. 1998 Nov; 60(11):1273-5.
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123. Nishimura Y, Miyazawa T, Ikeda Y, Izumiya Y, Nakamura K, Cai JS, Sato E, Kohmoto M, Mikami T. Molecular cloning and expression of feline CD3epsilon. Vet Immunol Immunopathol. 1998 Sep 16; 65(1):43-50.
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124. Ikeda Y, Shinozuka J, Miyazawa T, Kurosawa K, Izumiya Y, Nishimura Y, Nakamura K, Cai J, Fujita K, Doi K, Mikami T. Apoptosis in feline panleukopenia virus-infected lymphocytes. J Virol. 1998 Aug; 72(8):6932-6.
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125. Nishimura Y, Miyazawa T, Ikeda Y, Izumiya Y, Nakamura K, Cai JS, Sato E, Kohmoto M, Mikami T. Molecular cloning and sequencing of feline stromal cell-derived factor-1 alpha and beta. Eur J Immunogenet. 1998 Aug; 25(4):303-5.
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126. Ikeda Y, Miyazawa T, Kurosawa K, Naito R, Hatama S, Kai C, Mikami T. New quantitative methods for detection of feline parvovirus (FPV) and virus neutralizing antibody against FPV using a feline T lymphoid cell line. J Vet Med Sci. 1998 Aug; 60(8):973-4.
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127. Kohmoto M, Uetsuka K, Ikeda Y, Inoshima Y, Shimojima M, Sato E, Inada G, Toyosaki T, Miyazawa T, Doi K, Mikami T. Eight-year observation and comparative study of specific pathogen-free cats experimentally infected with feline immunodeficiency virus (FIV) subtypes A and B: terminal acquired immunodeficiency syndrome in a cat infected with FIV petaluma strain. J Vet Med Sci. 1998 Mar; 60(3):315-21.
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128. Ikeda Y, Inoshima Y, Kawaguchi Y, Maeda K, Kohmoto M, Kai C, Miyazawa T, Mikami T. Protein-binding properties of the putative AP-1 and ATF sequences in the feline immunodeficiency virus long terminal repeat. J Gen Virol. 1998 Jan; 79 ( Pt 1):95-9.
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129. Kohmoto M, Miyazawa T, Sato E, Uetsuka K, Nishimura Y, Ikeda Y, Inada G, Doi K, Mikami T. Cats are protected against feline immunodeficiency virus infection following vaccination with a homologous AP-1 binding site-deleted mutant. Arch Virol. 1998; 143(9):1839-45.
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130. Sato E, Yokoyama N, Maeda K, Inoshima Y, Kohmoto M, Ikeda Y, Miyazawa T, Mikami T. Construction of a recombinant feline herpesvirus type 1 expressing Gag precursor protein of feline immunodeficiency virus. Arch Virol. 1998; 143(3):453-66.
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131. Inoshima Y, Miyazawa T, Kohmoto M, Ikeda Y, Sato E, Hohdatsu T, Mathiason-Dubard C, Hoover EA, Mikami T. Cross virus neutralizing antibodies against feline immunodeficiency virus genotypes A, B, C, D and E. Arch Virol. 1998; 143(1):157-62.
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132. Shimojima M, Miyazawa T, Kohmoto M, Ikeda Y, Nishimura Y, Maeda K, Tohya Y, Mikami T. Expansion of CD8alpha+beta- cells in cats infected with feline immunodeficiency virus. J Gen Virol. 1998 Jan; 79 ( Pt 1):91-4.
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133. Ikeda Y, Kawaguchi Y, Inoshima Y, Kohmoto M, Shimojima M, Inada G, Sato E, Kai C, Miyazawa T, Mikami T. The effects of treatment with chemical agents or infection with feline viruses on protein-binding properties of the feline immunodeficiency virus long terminal repeat. Virus Res. 1997 Oct; 51(2):203-12.
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134. Ikeda Y, Itagaki S, Tsutsui S, Inoshima Y, Fukasawa M, Tomonaga K, Tohya Y, Maeda K, Mochizuki M, Miyazawa T, Mikami T. Replication of feline syncytial virus in feline T-lymphoblastoid cells and induction of apoptosis in the cells. Microbiol Immunol. 1997; 41(5):431-5.
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135. Inada G, Miyazawa T, Inoshima Y, Kohmoto M, Ikeda Y, Liu CH, Lin JA, Kuo TF, Mikami T. Phylogenetic analysis of feline immunodeficiency virus isolated from cats in Taiwan. Arch Virol. 1997; 142(7):1459-67.
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136. Inoshima Y, Kohmoto M, Ikeda Y, Yamada H, Kawaguchi Y, Tomonaga K, Miyazawa T, Kai C, Umemura T, Mikami T. Roles of the auxiliary genes and AP-1 binding site in the long terminal repeat of feline immunodeficiency virus in the early stage of infection in cats. J Virol. 1996 Dec; 70(12):8518-26.
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137. Inoshima Y, Ikeda Y, Kohmoto M, Pecoraro MR, Shimojima M, Shimojima Y, Inada G, Kawaguchi Y, Tomonaga K, Miyazawa T, Mikami T. Persistence of high virus neutralizing antibody titers in cats experimentally infected with feline immunodeficiency virus. J Vet Med Sci. 1996 Sep; 58(9):925-7.
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138. Ikeda Y, Tomonaga K, Kawaguchi Y, Kohmoto M, Inoshima Y, Tohya Y, Miyazawa T, Kai C, Mikami T. Feline immunodeficiency virus can infect a human cell line (MOLT-4) but establishes a state of latency in the cells. J Gen Virol. 1996 Aug; 77 ( Pt 8):1623-30.
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139. Ikeda Y, Kawaguchi Y, Tomonaga K, Inoshima Y, Kohmoto M, Miyazawa T, Mikami T. Regulatory properties of the integrated long terminal repeat of the feline immunodeficiency virus. Virus Res. 1996 Apr; 41(2):201-7.
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140. Tomonaga K, Inoshima Y, Ikeda Y, Mikami T. Temporal patterns of feline immunodeficiency virus transcripts in peripheral blood cells during the latent stage of infection. J Gen Virol. 1995 Sep; 76 ( Pt 9):2193-204.
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141. Inoshima Y, Tomonaga K, Ikeda Y, Miyazawa T, Mikami T. Quantification of feline immunodeficiency virus (FIV) proviral DNA in peripheral blood mononuclear cells of cats infected with Japanese strains of FIV. J Vet Med Sci. 1995 Jun; 57(3):487-92.
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142. Miyazawa T, Itagaki S, Tomonaga K, Ikeda Y, Mori T, Kawaguchi Y, Gemma T, Tohya Y, Mochizuki M, Mikami T. Establishment of carrier-state infection of a feline renal cell line with feline syncytial virus. J Vet Med Sci. 1995 Feb; 57(1):65-9.
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143. Miyazawa T, Inoshima Y, Kohmoto M, Ikeda Y, Mikami T. Growth properties of a feline immunodeficiency virus mutant which lacks an AP-1 binding site in primary peripheral blood mononuclear cells. J Vet Med Sci. 1994 Oct; 56(5):869-72.
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