Publications

  1. de Oliveira C, Khatua B, El-Kurdi B, Patel K, Mishra V, Navina S, Grim BJ, Gupta S, Belohlavek M, Cherry B, Yarger J, Green MD, Singh VP. Thermodynamic interference with bile acid demicelleization reduces systemic entry and injury during cholestasis. Sci Rep. 2020 May 21; 10 (1):8462
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  2. Zadori N, Gede N, Antal J, Szentesi A, Alizadeh H, Vincze A, Izbeki F, Papp M, Czako L, Varga M, de-Madaria E, Petersen OH, Singh VP, Mayerle J, Faluhelyi N, Miseta A, Reiber I, Hegyi P. EarLy Elimination of Fatty Acids iN hypertriglyceridemia-induced acuTe pancreatitis (ELEFANT trial): Protocol of an open-label, multicenter, adaptive randomized clinical trial. Pancreatology. 2020 Apr; 20 (3):369-376 Epub 2019 Dec 30
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  3. de Oliveira C, Khatua B, Noel P, Kostenko S, Bag A, Balakrishnan B, Patel KS, Guerra AA, Martinez MN, Trivedi S, McCullough A, Lam-Himlin DM, Navina S, Faigel DO, Fukami N, Pannala R, Phillips AE, Papachristou GI, Kershaw EE, Lowe ME, Singh VP. Pancreatic triglyceride lipase mediates lipotoxic systemic inflammation. J Clin Invest. 2020 Apr 1; 130 (4):1931-1947
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  4. Faraj KS, Judge NZ, Rose KM, Eversman S, Richards J, Blodgett G, Singh V, DeLucia NM, Humphreys MR, Castle EP, Tyson MD 2nd. How the Beneficial Effects of Alvimopan Differ With Surgical Approach for Radical Cystectomy. Urology. 2020 Feb 27 [Epub ahead of print]
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  5. Khatua B, Yaron JR, El-Kurdi B, Kostenko S, Papachristou GI, Singh VP. Ringer's Lactate Prevents Early Organ Failure by Providing Extracellular Calcium. J Clin Med. 2020 Jan 18; 9 (1)
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  6. Navaratnam A, Faraj K, Rose K, Abdul-Muhsin H, Singh V, Schwartz A, Beauchamp C, Castle EP. Robot Assisted Cystectomy With Holmium Laser Debridement for Osteomyelitis of the Pubic Symphysis With Urinary Fistula. Urology. 2019 Dec; 134:124-134 Epub 2019 Sept 19
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  7. Sternby H, Mahle M, Linder N, Erichson-Kirst L, Verdonk RC, Dimova A, Ignatavicius P, Ilzarbe L, Koiva P, Penttila A, Regner S, Bollen TL, Brill R, Stangl F, Wohlgemuth WA, Singh V, Busse H, Michl P, Beer S, Rosendahl J. Mean muscle attenuation correlates with severe acute pancreatitis unlike visceral adipose tissue and subcutaneous adipose tissue. United European Gastroenterol J. 2019 Dec; 7 (10):1312-1320 Epub 2019 Oct 09
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  8. El Kurdi B, Babar S, El Iskandarani M, Bataineh A, Lerch MM, Young M, Singh VP. Factors That Affect Prevalence of Small Intestinal Bacterial Overgrowth in Chronic Pancreatitis: A Systematic Review, Meta-Analysis, and Meta-Regression. Clin Transl Gastroenterol. 2019 Sep; 10 (9):e00072
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  9. Khatua B, Trivedi RN, Noel P, Patel K, Singh R, de Oliveira C, Trivedi S, Mishra V, Lowe M, Singh VP. Carboxyl Ester Lipase May Not Mediate Lipotoxic Injury during Severe Acute Pancreatitis. Am J Pathol. 2019 Jun; 189 (6):1226-1240 Epub 2019 Apr 05
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  10. Garg PK, Singh VP. Organ Failure Due to Systemic Injury in Acute Pancreatitis. Gastroenterology. 2019 May; 156 (7):2008-2023 Epub 2019 Feb 12
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  11. de Oliveira C, Khatua B, Bag A, El-Kurdi B, Patel K, Mishra V, Navina S, Singh VP. Multimodal Transgastric Local Pancreatic Hypothermia Reduces Severity of Acute Pancreatitis in Rats and Increases Survival. Gastroenterology. 2019 Feb; 156 (3):735-747.e10 Epub 2018 Oct 25
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  12. Kostenko S, Heu CC, Yaron JR, Singh G, de Oliveira C, Muller WJ, Singh VP. c-Src regulates cargo transit via the Golgi in pancreatic acinar cells. Sci Rep. 2018 Aug 9; 8 (1):11903 Epub 2018 Aug 09
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  13. Chiu HS, Somvanshi S, Patel E, Chen TW, Singh VP, Zorman B, Patil SL, Pan Y, Chatterjee SS, Sood AK, Gunaratne PH, Sumazin P, Cancer Genome Atlas Research Network. Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context. Cell Rep. 2018 Apr 3; 23 (1):297-312.e12
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  14. Majumder S, Philip NA, Takahashi N, Levy MJ, Singh VP, Chari ST. Fatty Pancreas: Should We Be Concerned? Pancreas. 2017 Nov/Dec; 46 (10):1251-1258
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  15. Khatua B, El-Kurdi B, Singh VP. Obesity and pancreatitis. Curr Opin Gastroenterol. 2017 Sep; 33 (5):374-382
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  16. Easler JJ, de-Madaria E, Nawaz H, Moya-Hoyo N, Koutroumpakis E, Rey-Riveiro M, Singh VP, Acevedo-Piedra NG, Whitcomb DC, Yadav D, Papachristou GI. Patients With Sentinel Acute Pancreatitis of Alcoholic Etiology Are at Risk for Organ Failure and Pancreatic Necrosis: A Dual-Center Experience. Pancreas. 2016 Aug; 45 (7):997-1002
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  17. Patel K, Durgampudi C, Noel P, Trivedi RN, de Oliveira C, Singh VP. Fatty Acid Ethyl Esters Are Less Toxic Than Their Parent Fatty Acids Generated during Acute Pancreatitis. Am J Pathol. 2016 Apr; 186 (4):874-84 Epub 2016 Feb 12
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  18. de Oliveira C, Patel K, Mishra V, Trivedi RN, Noel P, Singh A, Yaron JR, Singh VP. Characterization and Predictive Value of Near Infrared 2-Deoxyglucose Optical Imaging in Severe Acute Pancreatitis. PLoS One. 2016; 11 (2):e0149073 Epub 2016 Feb 22
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  19. Noel P, Patel K, Durgampudi C, Trivedi RN, de Oliveira C, Crowell MD, Pannala R, Lee K, Brand R, Chennat J, Slivka A, Papachristou GI, Khalid A, Whitcomb DC, DeLany JP, Cline RA, Acharya C, Jaligama D, Murad FM, Yadav D, Navina S, Singh VP. Peripancreatic fat necrosis worsens acute pancreatitis independent of pancreatic necrosis via unsaturated fatty acids increased in human pancreatic necrosis collections. Gut. 2016 Jan; 65 (1):100-11 Epub 2014 Dec 10
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  20. Nawaz H, Koutroumpakis E, Easler J, Slivka A, Whitcomb DC, Singh VP, Yadav D, Papachristou GI. Elevated serum triglycerides are independently associated with persistent organ failure in acute pancreatitis. Am J Gastroenterol. 2015 Oct; 110 (10):1497-503 Epub 2015 Sept 01
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  21. Patel KS, Singh VP. Experimental acute pancreatitis models relevant to lipids and obesity. Pancreapedia: Exocrine Pancreas Knowledge Base. 2015 Sep 9.
  22. Navina S, Singh VP. Relationship between obesity and pancreatitis. The Pancreapedia: Exocrine Pancreas Knowledge Base. 2015 Jun 13.
  23. Loverdos I, Swan MC, Shekherdimian S, Al-Rasheed AA, Schneider R, Fish JS, Ngan BY, Adeli K, Lowe ME, Singh VP, Sevilla WM, Langer JC, Gonska T. A case of pancreatitis, panniculitis and polyarthritis syndrome: Elucidating the pathophysiologic mechanisms of a rare condition. J Pediatr Surg Case Rep. 2015 May; 3 (5):223-226
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  24. Patel K, Trivedi RN, Durgampudi C, Noel P, Cline RA, DeLany JP, Navina S, Singh VP. Lipolysis of visceral adipocyte triglyceride by pancreatic lipases converts mild acute pancreatitis to severe pancreatitis independent of necrosis and inflammation. Am J Pathol. 2015 Mar; 185 (3):808-19 Epub 2015 Jan 08
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  25. Behari J, Li H, Liu S, Stefanovic-Racic M, Alonso L, O'Donnell CP, Shiva S, Singamsetty S, Watanabe Y, Singh VP, Liu Q. beta-catenin links hepatic metabolic zonation with lipid metabolism and diet-induced obesity in mice. Am J Pathol. 2014 Dec; 184(12):3284-98. Epub 2014 Oct 07.
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  26. Mishra V, Patel K, Trivedi RN, Noel P, Durgampudi C, Acharya C, Holmes JA, Narla S, Singh VP. Hypothermia slows sequential and parallel steps initiated during caerulein pancreatitis. Pancreatology. 2014 Nov-Dec; 14(6):459-64. Epub 2014 Jul 03.
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  27. Acharya C, Navina S, Singh VP. Role of pancreatic fat in the outcomes of pancreatitis. Pancreatology. 2014 Sep-Oct; 14 (5):403-8 Epub 2014 July 01
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  28. Navina S, McGrath K, Chennat J, Singh V, Pal T, Zeh H, Krasinskas AM. Adequacy assessment of endoscopic ultrasound-guided, fine-needle aspirations of pancreatic masses for theranostic studies: optimization of current practices is warranted. Arch Pathol Lab Med. 2014 Jul; 138(7):923-8.
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  29. Patel KS, Noel P, Singh VP. Potential influence of intravenous lipids on the outcomes of acute pancreatitis. Nutr Clin Pract. 2014 Jun; 29 (3):291-4 Epub 2014 Mar 31
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  30. Durgampudi C, Noel P, Patel K, Cline R, Trivedi RN, DeLany JP, Yadav D, Papachristou GI, Lee K, Acharya C, Jaligama D, Navina S, Murad F, Singh VP. Acute lipotoxicity regulates severity of biliary acute pancreatitis without affecting its initiation. Am J Pathol. 2014 Jun; 184 (6):1773-84
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  31. Scherer J, Singh VP, Pitchumoni CS, Yadav D. Issues in hypertriglyceridemic pancreatitis: an update. J Clin Gastroenterol. 2014 Mar; 48(3):195-203.
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  32. Mahmoud AM, Ding X, Dutta D, Singh VP, Kim K. Detecting hepatic steatosis using ultrasound-induced thermal strain imaging: an ex vivo animal study. Phys Med Biol. 2014 Feb 21; 59(4):881-95. Epub 2014 Feb 03.
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  33. Acharya C, Cline RA, Jaligama D, Noel P, Delany JP, Bae K, Furlan A, Baty CJ, Karlsson JM, Rosario BL, Patel K, Mishra V, Dugampudi C, Yadav D, Navina S, Singh VP. Fibrosis reduces severity of acute-on-chronic pancreatitis in humans. Gastroenterology. 2013 Aug; 145(2):466-75. Epub 2013 May 15.
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  34. Muili KA, Wang D, Orabi AI, Sarwar S, Luo Y, Javed TA, Eisses JF, Mahmood SM, Jin S, Singh VP, Ananthanaravanan M, Perides G, Williams JA, Molkentin JD, Husain SZ. Bile acids induce pancreatic acinar cell injury and pancreatitis by activating calcineurin. J Biol Chem. 2013 Jan 4; 288(1):570-80. Epub 2012 Nov 12.
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  35. Mishra V, Cline R, Noel P, Karlsson J, Baty CJ, Orlichenko L, Patel K, Trivedi RN, Husain SZ, Acharya C, Durgampudi C, Stolz DB, Navina S, Singh VP. Src Dependent Pancreatic Acinar Injury Can Be Initiated Independent of an Increase in Cytosolic Calcium. PLoS One. 2013; 8(6):e66471. Epub 2013 Jun 18
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  36. Working Group IAP/APA. IAP/APA evidence-based guidelines for the management of acute pancreatitis. Pancreatology. 2013; 13:e1-e15.
  37. Whitcomb DC, LaRusch J, Krasinskas AM, Klei L, Smith JP, Brand RE, Smith JP, Neoptolemos JP, Lerch MM, Tector M, Sandhu BS, Guda NM, Orlichenko L, Alkaade S, Amann ST, Anderson MA, Baillie J, Banks PA, Conwell D, Cote GA, Cotton PB, DiSario J, Farrer LA, Forsmark CE, Johnstone M, Gardner TB, Gelrud A, Greenhalf W, Haines JL, Hartman DJ, Hawes RA, Lawrence C, Lewis M, Mayerle J, Mayeux R, Melhem NM, Money ME, Muniraj T, Papachristou GI, Pericak-Vance MA, Romagnuolo J, Schellenberg GD, Sherman S, Simon P, Singh VP, Slivka A, Stolz D, Sutton R, Weiss FU, Wilcox CM, Zarnescu NO, Wisniewski SR, O'Connell MR, Kienholz ML, Roeder K, Barmada MM, Yadav D, Devlin B, Alzheimer's Disease Genetics Consortium. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Nat Genet. 2012 Dec; 44 (12):1349-54 Epub 2012 Nov 11
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  38. Orlichenko L, Stolz DB, Noel P, Behari J, Liu S, Singh VP. ADP-ribosylation factor 1 protein regulates trypsinogen activation via organellar trafficking of procathepsin B protein and autophagic maturation in acute pancreatitis. J Biol Chem. 2012 Jul 13; 287(29):24284-93. Epub 2012 May 08.
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  39. Husain SZ, Orabi AI, Muili KA, Luo Y, Sarwar S, Mahmood SM, Wang D, Choo-Wing R, Singh VP, Parness J, Ananthanaravanan M, Bhandari V, Perides G. Ryanodine receptors contribute to bile acid-induced pathological calcium signaling and pancreatitis in mice. Am J Physiol Gastrointest Liver Physiol. 2012 Jun 15; 302(12):G1423-33. Epub 2012 Apr 19.
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  40. Liu S, Yeh TH, Singh VP, Shiva S, Krauland L, Li H, Zhang P, Kharbanda K, Ritov V, Monga SP, Scott DK, Eagon PK, Behari J. beta-catenin is essential for ethanol metabolism and protection against alcohol-mediated liver steatosis in mice. Hepatology. 2012 Mar; 55(3):931-40.
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  41. Singh VP. Src: Regulation and function in the exocrine pancreas. The Pancreapedia: Exocrine Pancreas Knowledge Base. 2012.
  42. Orabi AI, Luo Y, Ahmad MU, Shah AU, Mannan Z, Wang D, Sarwar S, Muili KA, Shugrue C, Kolodecik TR, Singh VP, Lowe ME, Thrower E, Chen J, Husain SZ. IP3 receptor type 2 deficiency is associated with a secretory defect in the pancreatic acinar cell and an accumulation of zymogen granules. PLoS One. 2012; 7(11):e48465. Epub 2012 Nov 21.
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  43. Navina S, Acharya C, DeLany JP, Orlichenko LS, Baty CJ, Shiva SS, Durgampudi C, Karlsson JM, Lee K, Bae KT, Furlan A, Behari J, Liu S, McHale T, Nichols L, Papachristou GI, Yadav D, Singh VP. Lipotoxicity causes multisystem organ failure and exacerbates acute pancreatitis in obesity. Sci Transl Med. 2011 Nov 2; 3(107):107ra110.
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  44. Yeh TH, Krauland L, Singh V, Zou B, Devaraj P, Stolz DB, Franks J, Monga SP, Sasatomi E, Behari J. Liver-specific beta-catenin knockout mice have bile canalicular abnormalities, bile secretory defect, and intrahepatic cholestasis. Hepatology. 2010 Oct; 52(4):1410-9.
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  45. Orlichenko LS, Behari J, Yeh TH, Liu S, Stolz DB, Saluja AK, Singh VP. Transcriptional regulation of CXC-ELR chemokines KC and MIP-2 in mouse pancreatic acini. Am J Physiol Gastrointest Liver Physiol. 2010 Oct; 299(4):G867-76. Epub 2010 Jul 29.
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  46. Singh VP, Bren GD, Algeciras-Schimnich A, Schnepple D, Navina S, Rizza SA, Dawra RK, Saluja AK, Chari ST, Vege SS, Badley AD. Nelfinavir/ritonavir reduces acinar injury but not inflammation during mouse caerulein pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2009 May; 296 (5):G1040-6 Epub 2009 Mar 12
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  47. Singh V, Alexander JA. The evaluation and management of obscure and occult gastrointestinal bleeding. Abdom Imaging. 2009 May-Jun; 34(3):311-9.
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  48. Singh VP, McNiven MA. Src-mediated cortactin phosphorylation regulates actin localization and injurious blebbing in acinar cells. Mol Biol Cell. 2008 May; 19 (5):2339-47 Epub 2008 Mar 19
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  49. Bhagat L, Singh VP, Dawra RK, Saluja AK. Sodium arsenite induces heat shock protein 70 expression and protects against secretagogue-induced trypsinogen and NF-kappaB activation. J Cell Physiol. 2008 Apr; 215(1):37-46.
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  50. Singh VP, Bhagat L, Navina S, Sharif R, Dawra RK, Saluja AK. Protease-activated receptor-2 protects against pancreatitis by stimulating exocrine secretion. Gut. 2007 Jul; 56 (7):958-64 Epub 2006 Nov 17
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  51. Song AM, Bhagat L, Singh VP, Van Acker GG, Steer ML, Saluja AK. Inhibition of cyclooxygenase-2 ameliorates the severity of pancreatitis and associated lung injury. Am J Physiol Gastrointest Liver Physiol. 2002 Nov; 283(5):G1166-74.
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  52. Van Acker GJ, Saluja AK, Bhagat L, Singh VP, Song AM, Steer ML. Cathepsin B inhibition prevents trypsinogen activation and reduces pancreatitis severity. Am J Physiol Gastrointest Liver Physiol. 2002 Sep; 283(3):G794-800.
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  53. Bhagat L, Singh VP, Song AM, van Acker GJ, Agrawal S, Steer ML, Saluja AK. Thermal stress-induced HSP70 mediates protection against intrapancreatic trypsinogen activation and acute pancreatitis in rats. Gastroenterology. 2002 Jan; 122(1):156-65.
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  54. Frossard JL, Bhagat L, Lee HS, Hietaranta AJ, Singh VP, Song AM, Steer ML, Saluja AK. Both thermal and non-thermal stress protect against caerulein induced pancreatitis and prevent trypsinogen activation in the pancreas. Gut. 2002 Jan; 50(1):78-83.
  55. Singh VP, Saluja AK, Bhagat L, van Acker GJ, Song AM, Soltoff SP, Cantley LC, Steer ML. Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis. J Clin Invest. 2001 Nov; 108(9):1387-95.
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  56. Hietaranta AJ, Singh VP, Bhagat L, van Acker GJ, Song AM, Mykoniatis A, Steer ML, Saluja AK. Water immersion stress prevents caerulein-induced pancreatic acinar cell nf-kappa b activation by attenuating caerulein-induced intracellular Ca2+ changes. J Biol Chem. 2001 Jun 1; 276(22):18742-7. Epub 2001 Feb 15.
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  57. Singh VP, Saluja AK, Bhagat L, Hietaranta AJ, Song A, Mykoniatis A, Van Acker GJ, Steer ML. Serine protease inhibitor causes F-actin redistribution and inhibition of calcium-mediated secretion in pancreatic acini. Gastroenterology. 2001 Jun; 120(7):1818-27.
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  58. Bhatia M, Saluja AK, Singh VP, Frossard JL, Lee HS, Bhagat L, Gerard C, Steer ML. Complement factor C5a exerts an anti-inflammatory effect in acute pancreatitis and associated lung injury. Am J Physiol Gastrointest Liver Physiol. 2001 May; 280(5):G974-8.
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  59. Hietaranta AJ, Saluja AK, Bhagat L, Singh VP, Song AM, Steer ML. Relationship between NF-kappaB and trypsinogen activation in rat pancreas after supramaximal caerulein stimulation. Biochem Biophys Res Commun. 2001 Jan 12; 280(1):388-95.
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  60. Lee HS, Bhagat L, Frossard JL, Hietaranta A, Singh VP, Steer ML, Saluja AK. Water immersion stress induces heat shock protein 60 expression and protects against pancreatitis in rats. Gastroenterology. 2000 Jul; 119(1):220-9.
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  61. Bhagat L, Singh VP, Hietaranta AJ, Agrawal S, Steer ML, Saluja AK. Heat shock protein 70 prevents secretagogue-induced cell injury in the pancreas by preventing intracellular trypsinogen activation. J Clin Invest. 2000 Jul; 106(1):81-9.
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