Publications

  1. Knupp KG, Scheffer IE, Ceulemans B, Sullivan JE, Nickels KC, Lagae L, Guerrini R, Zuberi SM, Nabbout R, Riney K, Shore S, Agarwal A, Lock M, Farfel GM, Galer BS, Gammaitoni AR, Davis R, Gil-Nagel A. Efficacy and Safety of Fenfluramine for the Treatment of Seizures Associated With Lennox-Gastaut Syndrome: A Randomized Clinical Trial. JAMA Neurol. 2022 Jun 1; 79 (6):554-564
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  2. Kerezoudis P, Gyftopoulos A, Alexander AY, Keith Starnes D, Nickels KC, Worrell GA, Wirrell EC, Lundstrom BN, Van Gompel JJ, Miller KJ. Safety and efficacy of responsive neurostimulation in the pediatric population: Evidence from institutional review and patient-level meta-analysis. Epilepsy Behav. 2022 Apr; 129:108646 Epub 2022 Mar 14
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  3. Triplet EM, Nickels K, Wong-Kisiel L, Fine A, Wirrell EC. A tale of two cohorts: Differing outcomes in infantile-onset focal epilepsy. Epilepsia. 2022 Apr; 63 (4):950-960 Epub 2022 Feb 10
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  4. Knupp KG, Coryell J, Singh RK, Gaillard WD, Shellhaas RA, Koh S, Mitchell WG, Harini C, Millichap JJ, May A, Dlugos D, Nickels K, Mytinger JR, Keator C, Yozawitz E, Singhal N, Lockrow J, Thomas JF, Juarez-Colunga E. Comparison of Cosyntropin, Vigabatrin, and Combination Therapy in New-Onset Infantile Spasms in a Prospective Randomized Trial. J Child Neurol. 2022 Mar; 37 (3):186-193 Epub 2022 Jan 19
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  5. Fine AL, Wong-Kisiel LC, Nickels KC, Wirrell EC. Masking for School-Age Children With Epilepsy: We Do Have Consensus! J Child Neurol. 2022 Feb; 37 (2):127-132 Epub 2022 Jan 05
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  6. Joshi C, Nickels K, Demarest S, Eltze C, Cross JH, Wirrell E. Results of an international Delphi consensus in epilepsy with myoclonic atonic seizures/ Doose syndrome. Seizure. 2021 Feb; 85:12-18 Epub 2020 Dec 28
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  7. Nickels K, Kossoff EH, Eschbach K, Joshi C. Epilepsy with myoclonic-atonic seizures (Doose syndrome): Clarification of diagnosis and treatment options through a large retrospective multicenter cohort. Epilepsia. 2021 Jan; 62 (1):120-127 Epub 2020 Nov 14
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  8. Grinspan ZM, Mytinger JR, Baumer FM, Ciliberto MA, Cohen BH, Dlugos DJ, Harini C, Hussain SA, Joshi SM, Keator CG, Knupp KG, McGoldrick PE, Nickels KC, Park JT, Pasupuleti A, Patel AD, Shahid AM, Shellhaas RA, Shrey DW, Singh RK, Wolf SM, Yozawitz EG, Yuskaitis CJ, Waugh JL, Pearl PL. Management of Infantile Spasms During the COVID-19 Pandemic. J Child Neurol. 2020 Oct; 35 (12):828-834 Epub 2020 June 23
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  9. Cordeddu V, Macke EL, Radio FC, Lo Cicero S, Pantaleoni F, Tatti M, Bellacchio E, Ciolfi A, Agolini E, Bruselles A, Brunetti-Pierri N, Suri M, Josephs KS, McEntagart M, Lanpher B, Nickels KC, Haworth A, Reed L, Cappuccio G, Mammi I, Tarnowski JM, Novelli A, Melis D, Callewaert B, Dallapiccola B, Klee E, Tartaglia M, Deciphering Developmental Disorders Study. Refinement of the clinical and mutational spectrum of UBE2A deficiency syndrome. Clin Genet. 2020 Aug; 98 (2):172-178 Epub 2020 June 03
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  10. Wilton KM, Morales-Rosado JA, Selcen D, Muthusamy K, Ewing S, Agre K, Nickels K, Klee EW, Ho ML, Morava E. Developmental brain abnormalities and acute encephalopathy in a patient with myopathy with extrapyramidal signs secondary to pathogenic variants in MICU1. JIMD Rep. 2020 May; 53 (1):22-28 Epub 2020 Mar 20
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  11. Nickels K. Earlier Is Not Always Better: Outcomes When Epilepsy Occurs in Early Life Versus Adolescence. Epilepsy Curr. 2020 Jan-Feb; 20 (1):27-29 Epub 2019 Dec 03
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  12. Weber D, Sarva H, Weaver J, Wang F, Chou J, Cornes S, Nickels K, Safdieh JE, Poncelet A, Stern BJ. Current state of educational compensation in academic neurology: Results of a US national survey. Neurology. 2019 Jul 2; 93 (1):30-34 Epub 2019 May 17
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  13. Jagadish S, Payne ET, Wong-Kisiel L, Nickels KC, Eckert S, Wirrell EC. The Ketogenic and Modified Atkins Diet Therapy for Children With Refractory Epilepsy of Genetic Etiology. Pediatr Neurol. 2019 May; 94:32-37 Epub 2018 Dec 29
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  14. Smith KM, Youssef PE, Wirrell EC, Nickels KC, Payne ET, Britton JW, Shin C, Cascino GD, Patterson MC, Wong-Kisiel LC. Jeavons Syndrome: Clinical Features and Response to Treatment. Pediatr Neurol. 2018 Sep; 86:46-51 Epub 2018 July 10
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  15. Nickels K, Thibert R, Rau S, Demarest S, Wirrell E, Kossoff EH, Joshi C, Nangia S, Shellhaas R, Pediatric Epilepsy Research Consortium. How do we diagnose and treat epilepsy with myoclonic-atonic seizures (Doose syndrome)? Results of the Pediatric Epilepsy Research Consortium survey. Epilepsy Res. 2018 Aug; 144:14-19 Epub 2018 Apr 25
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  16. Wirrell EC, Vanderwiel AJ, Nickels L, Vanderwiel SL, Nickels KC. Impact of Prior Authorization of Antiepileptic Drugs in Children With Epilepsy. Pediatr Neurol. 2018 Jun; 83:38-41 Epub 2018 Apr 03
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  17. Wirrell E, Eckert S, Wong-Kisiel L, Payne E, Nickels K. Ketogenic Diet Therapy in Infants: Efficacy and Tolerability. Pediatr Neurol. 2018 May; 82:13-18 Epub 2018 Jan 31
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  18. Demarest ST, Shellhaas RA, Gaillard WD, Keator C, Nickels KC, Hussain SA, Loddenkemper T, Patel AD, Saneto RP, Wirrell E, Sanchez Fernandez I, Chu CJ, Grinspan Z, Wusthoff CJ, Joshi S, Mohamed IS, Stafstrom CE, Stack CV, Yozawitz E, Bluvstein JS, Singh RK, Knupp KG, Pediatric Epilepsy Research Consortium. The impact of hypsarrhythmia on infantile spasms treatment response: Observational cohort study from the National Infantile Spasms Consortium. Epilepsia. 2017 Dec; 58 (12):2098-2103 Epub 2017 Nov 03
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  19. Nickels KC, Wirrell EC. Cognitive and Social Outcomes of Epileptic Encephalopathies. Semin Pediatr Neurol. 2017 Nov; 24 (4):264-275 Epub 2017 Oct 07
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  20. Sadleir LG, Mountier EI, Gill D, Davis S, Joshi C, DeVile C, Kurian MA, Mandelstam S, Wirrell E, Nickels KC, Murali HR, Carvill G, Myers CT, Mefford HC, Scheffer IE, DDD Study. Not all SCN1A epileptic encephalopathies are Dravet syndrome: Early profound Thr226Met phenotype. Neurology. 2017 Sep 5; 89 (10):1035-1042 Epub 2017 Aug 09
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  21. Dubey D, Singh J, Britton JW, Pittock SJ, Flanagan EP, Lennon VA, Tillema JM, Wirrell E, Shin C, So E, Cascino GD, Wingerchuk DM, Hoerth MT, Shih JJ, Nickels KC, McKeon A. Predictive models in the diagnosis and treatment of autoimmune epilepsy. Epilepsia. 2017 Jul; 58 (7):1181-1189 Epub 2017 May 26
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  22. Nickels KC, Wirrell EC. Stiripentol in the Management of Epilepsy. CNS Drugs. 2017 May; 31 (5):405-416
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  23. Whealy M, Wirrell E, Wong-Kisiel L, Nickels K, Payne ET. Prevalence and Risk Factors of Peri-ictal Autonomic Changes in Children With Temporal Lobe Seizures. Pediatr Neurol. 2017 Feb; 67:36-39 Epub 2016 Oct 11
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  24. Knupp KG, Leister E, Coryell J, Nickels KC, Ryan N, Juarez-Colunga E, Gaillard WD, Mytinger JR, Berg AT, Millichap J, Nordli DR Jr, Joshi S, Shellhaas RA, Loddenkemper T, Dlugos D, Wirrell E, Sullivan J, Hartman AL, Kossoff EH, Grinspan ZM, Hamikawa L, Pediatric Epilepsy Research Consortium. Response to second treatment after initial failed treatment in a multicenter prospective infantile spasms cohort. Epilepsia. 2016 Nov; 57 (11):1834-1842 Epub 2016 Sept 12
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  25. Lundstrom BN, Van Gompel J, Britton J, Nickels K, Wetjen N, Worrell G, Stead M. Chronic Subthreshold Cortical Stimulation to Treat Focal Epilepsy. JAMA Neurol. 2016 Nov 1; 73 (11):1370-1372
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  26. Nickels KC. Routine Versus Extended Outpatient EEG: Too Short, Too Long, or Just Right? Epilepsy Curr. 2016 Nov-Dec; 16 (6):382-383
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  27. Kenney DL, Kelly-Williams KM, Krecke KN, Witte RJ, Watson RE Jr, Kotsenas AL, Wirrell EC, Nickels KC, Wong-Kisiel LC, So E. Usefulness of repeat review of head magnetic resonance images during presurgical epilepsy conferences. Epilepsy Res. 2016 Oct; 126:106-8 Epub 2016 July 01
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  28. Nickels KC, Zaccariello MJ, Hamiwka LD, Wirrell EC. Cognitive and neurodevelopmental comorbidities in paediatric epilepsy. Nat Rev Neurol. 2016 Aug; 12 (8):465-76 Epub 2016 July 22
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  29. Burkholder DB, Britton JW, Rajasekaran V, Fabris RR, Cherian PJ, Kelly-Williams KM, So EL, Nickels KC, Wong-Kisiel LC, Lagerlund TD, Cascino GD, Worrell GA, Wirrell EC. Routine vs extended outpatient EEG for the detection of interictal epileptiform discharges. Neurology. 2016 Apr 19; 86 (16):1524-30 Epub 2016 Mar 16
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  30. Knupp KG, Coryell J, Nickels KC, Ryan N, Leister E, Loddenkemper T, Grinspan Z, Hartman AL, Kossoff EH, Gaillard WD, Mytinger JR, Joshi S, Shellhaas RA, Sullivan J, Dlugos D, Hamikawa L, Berg AT, Millichap J, Nordli DR Jr, Wirrell E, Pediatric Epilepsy Research Consortium. Response to treatment in a prospective national infantile spasms cohort. Ann Neurol. 2016 Mar; 79 (3):475-84 Epub 2016 Feb 13
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  31. Mrelashvili A, Witte RJ, Wirrell EC, Nickels KC, Wong-Kisiel LC. Seizure Freedom in Children With Pathology-Confirmed Focal Cortical Dysplasia. Pediatr Neurol. 2015 Dec; 53 (6):513-8 Epub 2015 Sept 12
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  32. Sun PY, Wyatt K, Nickels KC, Wong-Kisiel LC, Mandrekar J, Wirrell E. Predictors of Length of Stay in Children Admitted for Presurgical Evaluation for Epilepsy Surgery. Pediatr Neurol. 2015 Sep; 53: (3)207-10.
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  33. Fine AL, Wirrell EC, Wong-Kisiel LC, Nickels KC. Acetazolamide for electrical status epilepticus in slow-wave sleep. Epilepsia. 2015 Sep; 56: (9)e134-8.
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  34. Haque OJ, Mandrekar J, Wyatt K, Nickels KC, Wong-Kisiel L, Wetjen N, Wirrell EC. Yield and Predictors of Epilepsy Surgery Candidacy in Children Admitted for Surgical Evaluation. Pediatr Neurol. 2015 Jul; 53: (1)58-64.
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  35. Bower RS, Wirrell EC, Eckel LJ, Wong-Kisiel LC, Nickels KC, Wetjen NM. Repeat resective surgery in complex pediatric refractory epilepsy: lessons learned. J Neurosurg Pediatr. 2015 Jul; 16 (1):94-100 Epub 2015 Apr 24
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  36. Nickels K. Seizure and Psychosocial Outcomes of Childhood and Juvenile Onset Generalized Epilepsies: Wolf in Sheep's Clothing, or Well-Dressed Wolf? Epilepsy Curr. 2015 May-Jun; 15 (3):114-7
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  37. Fine A, Nickels K. Temporoparietal resection in a patient with Landau-Kleffner syndrome. Semin Pediatr Neurol. 2014 Jun; 21: (2)96-100.
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  38. Toledano M, Britton JW, McKeon A, Shin C, Lennon VA, Quek AM, So E, Worrell GA, Cascino GD, Klein CJ, Lagerlund TD, Wirrell EC, Nickels KC, Pittock SJ. Utility of an immunotherapy trial in evaluating patients with presumed autoimmune epilepsy. Neurology. 2014 May 6; 82 (18):1578-86 Epub 2014 Apr 04
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  39. Shull S, Diaz-Medina G, Wong-Kisiel L, Nickels K, Eckert S, Wirrell E. Early efficacy of the ketogenic diet is not affected by initial body mass index percentile. Pediatr Neurol. 2014 May; 50 (5):469-73 Epub 2014 Jan 07
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  40. Wirrell EC, Wong-Kisiel LC, Nickels KC. Seizure outcome after AED failure in pediatric focal epilepsy: impact of underlying etiology. Epilepsy Behav. 2014 May; 34:20-4. Epub 2014 Mar 25.
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  41. Wyatt KD, Mandrekar J, Wong-Kisiel L, Nickels K, Wirrell E. Predictors of recording an event during prolonged inpatient video electroencephalogram monitoring in children. Pediatr Neurol. 2014 May; 50(5):458-63. Epub 2014 Jan 24.
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  42. Child ND, Stead M, Wirrell EC, Nickels KC, Wetjen NM, Lee KH, Klassen BT. Chronic subthreshold subdural cortical stimulation for the treatment of focal epilepsy originating from eloquent cortex. Epilepsia. 2014 Mar; 55(3):e18-21. Epub 2014 Feb 26.
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  43. Morris GL 3rd, Gloss D, Buchhalter J, Mack KJ, Nickels K, Harden C. Evidence-based guideline update: vagus nerve stimulation for the treatment of epilepsy: report of the guideline development subcommittee of the american academy of neurology. Epilepsy Curr. 2013 Nov; 13 (6):297-303
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  44. Morris GL 3rd, Gloss D, Buchhalter J, Mack KJ, Nickels K, Harden C. Evidence-based guideline update: vagus nerve stimulation for the treatment of epilepsy: report of the Guideline Development Subcommittee of the American Academy of Neurology. Neurology. 2013 Oct 15; 81 (16):1453-9 Epub 2013 Aug 28
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  45. Moseley BD, Wirrell EC, Wong-Kisiel LC, Nickels K. Early onset epilepsy is associated with increased mortality: a population-based study. Epilepsy Res. 2013 Aug; 105(3):410-4. Epub 2013 Apr 11.
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  46. Berg AT, Nickels K, Wirrell EC, Geerts AT, Callenbach PM, Arts WF, Rios C, Camfield PR, Camfield CS. Mortality risks in new-onset childhood epilepsy. Pediatrics. 2013 Jul; 132(1):124-31. Epub 2013 Jun 10.
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  47. Wirrell EC, Wong-Kisiel LC, Mandrekar J, Nickels KC. What predicts enduring intractability in children who appear medically intractable in the first 2 years after diagnosis? Epilepsia. 2013 Jun; 54 (6):1056-64 Epub 2013 Apr 03
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  48. Mirzaa GM, Paciorkowski AR, Marsh ED, Berry-Kravis EM, Medne L, Alkhateeb A, Grix A, Wirrell EC, Powell BR, Nickels KC, Burton B, Paras A, Kim K, Chung W, Dobyns WB, Das S. CDKL5 and ARX mutations in males with early-onset epilepsy. Pediatr Neurol. 2013 May; 48(5):367-77.
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  49. Nelson A, Dhamija R, Nickels K. Posttransplant lymphoproliferative disorder in an 11-year-old immunosuppressed boy. Pediatr Neurol. 2013 May; 48 (5):397-9
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  50. Wong-Kisiel LC, Nickels K. Electroencephalogram of age-dependent epileptic encephalopathies in infancy and early childhood. Epilepsy Res Treat. 2013; 2013:743203 Epub 2013 Aug 19
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  51. Nickels KC, Grossardt BR, Wirrell EC. Epilepsy-related mortality is low in children: a 30-year population-based study in Olmsted County, MN. Epilepsia. 2012 Dec; 53 (12):2164-71 Epub 2012 Sept 18
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  52. Wirrell E, Wong-Kisiel L, Mandrekar J, Nickels K. Predictors and course of medically intractable epilepsy in young children presenting before 36 months of age: a retrospective, population-based study. Epilepsia. 2012 Sep; 53 (9):1563-9 Epub 2012 June 27
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  53. Moseley BD, Nickels K, Wirrell EC. Surgical outcomes for intractable epilepsy in children with epileptic spasms. J Child Neurol. 2012 Jun; 27(6):713-20. Epub 2011 Nov 28.
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  54. Quek AM, Britton JW, McKeon A, So E, Lennon VA, Shin C, Klein C, Watson RE Jr, Kotsenas AL, Lagerlund TD, Cascino GD, Worrell GA, Wirrell EC, Nickels KC, Aksamit AJ, Noe KH, Pittock SJ. Autoimmune epilepsy: clinical characteristics and response to immunotherapy. Arch Neurol. 2012 May; 69 (5):582-93
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  55. Moseley BD, Dhamija R, Wirrell EC, Nickels KC. Historic, clinical, and prognostic features of epileptic encephalopathies caused by CDKL5 mutations. Pediatr Neurol. 2012 Feb; 46 (2):101-5
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  56. Nickels KC, Wong-Kisiel LC, Moseley BD, Wirrell EC. Temporal lobe epilepsy in children. Epilepsy Res Treat. 2012; 2012:849540 Epub 2011 Oct 20
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  57. Moseley BD, Wirrell EC, Nickels K, Johnson JN, Ackerman MJ, Britton J. Electrocardiographic and oximetric changes during partial complex and generalized seizures. Epilepsy Res. 2011 Aug; 95(3):237-45. Epub 2011 May 10
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  58. Moseley BD, Wirrell EC, Nickels K. Generalized periodic epileptiform discharges in a child with Dravet syndrome. J Child Neurol. 2011 Jul; 26(7):907-10. Epub 2011 Feb 18.
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  59. Wirrell EC, Grossardt BR, Wong-Kisiel LC, Nickels KC. Incidence and classification of new-onset epilepsy and epilepsy syndromes in children in Olmsted County, Minnesota from 1980 to 2004: a population-based study. Epilepsy Res. 2011 Jun; 95 (1-2):110-8 Epub 2011 Apr 08
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  60. Dhamija R, Renaud DL, Pittock SJ, McKeon A, Lachance DH, Nickels KC, Wirrell EC, Kuntz NL, King MD, Lennon VA. Neuronal voltage-gated potassium channel complex autoimmunity in children. Pediatr Neurol. 2011 Apr; 44 (4):275-81
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  61. Dhamija R, Nickels KC, Calero A, Doraiswamy B, Rosenberg J, Kizilbash SH, Kizilbash SJ, Agrawal R. Case 1: Foot deformities, asymmetric calf muscles, and frequent falls in an 8-year-old boy. Case 2: Seizures in a 5-month-old boy whose mother recently emigrated from Honduras. Case 3: A gradually increasing perianal mass in a teenage girl. Pediatr Rev. 2011 Apr; 32 (4):163-8
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  62. Wirrell EC, Grossardt BR, So EL, Nickels KC. A population-based study of long-term outcomes of cryptogenic focal epilepsy in childhood: cryptogenic epilepsy is probably not symptomatic epilepsy. Epilepsia. 2011 Apr; 52 (4):738-45 Epub 2011 Feb 14
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  63. Hnojcikova M, Nickels KC, Wetjen NM, Buchhalter JR, Raffel C, Wirrell EC. EEG and neuroimaging studies in young children having epilepsy surgery. Pediatr Neurol. 2010 Nov; 43(5):335-40.
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  64. Moseley BD, Nickels K, Britton J, Wirrell E. How common is ictal hypoxemia and bradycardia in children with partial complex and generalized convulsive seizures? Epilepsia. 2010 Jul; 51: (7)1219-24.
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  65. Wirrell E, Nickels KC. Pediatric epilepsy syndromes. Continuum. 2010 Jun; 16(3):57-85.
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  66. Nickels K, Wirrell E. Electrical status epilepticus in sleep. Semin Pediatr Neurol. 2008 Jun; 15(2):50-60.
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  67. Nickels K, Katusic SK, Colligan RC, Weaver AL, Voigt RG, Barbaresi WJ. Stimulant medication treatment of target behaviors in children with autism: a population-based study. J Dev Behav Pediatr. 2008 Apr; 29 (2):75-81
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  68. Nickels K. Development of the central nervous system. Perspectives (Montclair). 2007 Jun; 17(2):3-7.
  69. Lee PC, Arndt P, Nickels KC. Testicular abnormalities in male rats after lactational exposure to nonylphenols. Endocrine. 1999 Aug; 11(1):61-8.
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