Publications

  1. Ding Y, Yang J, Chen P, Lu T, Jiao K, Tester DJ, Giudicessi JR, Jiang K, Ackerman MJ, Li Y, Wang DW, Lee HC, Wang DW, Xu X. Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy. J Am Heart Assoc. 2020 Sep; 9 (17):e017055 Epub 2020 Aug 18
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  2. Wang XL, Lu T, Sun X, Lee HC. Membrane trafficking of large conductance Ca(2+)- and voltage-activated K(+) (BK) channels is regulated by Rab4 GTPase. Biochim Biophys Acta Mol Cell Res. 2020 Apr; 1867 (4):118646 Epub 2020 Jan 08
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  3. Sun X, Qian LL, Li Y, Pfiefer TM, Wang XL, Lee HC, Lu T. Regulation of KCNMA1 transcription by Nrf2 in coronary arterial smooth muscle cells. J Mol Cell Cardiol. 2020 Mar; 140:68-76 Epub 2020 Mar 05
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  4. He T, Sun R, Santhanam AV, d'Uscio LV, Lu T, Katusic ZS. Impairment of amyloid precursor protein alpha-processing in cerebral microvessels of type 1 diabetic mice. J Cereb Blood Flow Metab. 2019 Jun; 39 (6):1085-1098 Epub 2017 Dec 18
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  5. Ling TY, Yi F, Lu T, Wang XL, Sun X, Willis MS, Wu LQ, Shen WK, Adelman JP, Lee HC. F-box protein-32 down-regulates small-conductance calcium-activated potassium channel 2 in diabetic mouse atria. J Biol Chem. 2019 Mar 15; 294 (11):4160-4168 Epub 2019 Jan 11
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  6. Lu T, Chai Q, Jiao G, Wang XL, Sun X, Furuseth JD, Stulak JM, Daly RC, Greason KL, Cha YM, Lee HC. Downregulation of BK channel function and protein expression in coronary arteriolar smooth muscle cells of type 2 diabetic patients. Cardiovasc Res. 2019 Jan 1; 115 (1):145-153
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  7. Qian LL, Sun MQ, Wang RX, Lu T, Wu Y, Dang SP, Tang X, Ji Y, Liu XY, Zhao XX, Wang W, Chai Q, Pan M, Yi F, Zhang DM, Lee HC. Mechanisms of BK Channel Activation by Docosahexaenoic Acid in Rat Coronary Arterial Smooth Muscle Cells. Front Pharmacol. 2018; 9:223 Epub 2018 Mar 27
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  8. Lu T, Wang XL, Chai Q, Sun X, Sieck GC, Katusic ZS, Lee HC. Role of the endothelial caveolae microdomain in shear stress-mediated coronary vasorelaxation. J Biol Chem. 2017 Nov 17; 292 (46):19013-19023 Epub 2017 Sept 18
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  9. Lu T, Sun X, Li Y, Chai Q, Wang XL, Lee HC. Role of Nrf2 Signaling in the Regulation of Vascular BK Channel beta1 Subunit Expression and BK Channel Function in High-Fat Diet-Induced Diabetic Mice. Diabetes. 2017 Oct; 66 (10):2681-2690 Epub 2017 May 02
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  10. Li Y, Wang XL, Sun X, Chai Q, Li J, Thompson B, Shen WK, Lu T, Lee HC. Regulation of vascular large-conductance calcium-activated potassium channels by Nrf2 signalling. Diab Vasc Dis Res. 2017 Jul; 14 (4):353-362 Epub 2017 Apr 21
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  11. Ling TY, Wang XL, Chai Q, Lu T, Stulak JM, Joyce LD, Daly RC, Greason KL, Wu LQ, Shen WK, Cha YM, Lee HC. Regulation of cardiac CACNB2 by microRNA-499: Potential role in atrial fibrillation. BBA Clin. 2017 Jun; 7:78-84.
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  12. He T, Santhanam AV, Lu T, d'Uscio LV, Katusic ZS. Role of prostacyclin signaling in endothelial production of soluble amyloid precursor protein-alpha in cerebral microvessels. J Cereb Blood Flow Metab. 2017 Jan; 37 (1):106-122 Epub 2015 Nov 20
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  13. Tang X, Qian LL, Wang RX, Yao Y, Dang SP, Wu Y, Wang W, Ji Y, Sun MQ, Xia DY, Liu XY, Zhang DM, Chai Q, Lu T. Regulation of Coronary Arterial Large Conductance Ca2+-Activated K+ Channel Protein Expression and Function by n-3 Polyunsaturated Fatty Acids in Diabetic Rats. J Vasc Res. 2017; 54 (6):329-343 Epub 2017 Oct 18
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  14. Zakeri R, Moulay G, Chai Q, Ogut O, Hussain S, Takahama H, Lu T, Wang XL, Linke WA, Lee HC, Redfield MM. Left Atrial Remodeling and Atrioventricular Coupling in a Canine Model of Early Heart Failure With Preserved Ejection Fraction. Circ Heart Fail. 2016 Oct; 9 (10) Epub 2016 Oct 10
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  15. Lu T, Jiang B, Wang XL, Lee HC. Coronary arterial BK channel dysfunction exacerbates ischemia/reperfusion-induced myocardial injury in diabetic mice. Appl Physiol Nutr Metab. 2016 Sep; 41 (9):992-1001
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  16. Qian LL, Wang RX, Sun MQ, Xia DY, Tang X, Ji Y, Wu Y, Liu XY, Dang SP, Chai Q, Lu T. [Composition of potassium channels in normal rat coronary smooth muscle cells and activation effects of docosahexaenoic acid]. Zhonghua Xin Xue Guan Bing Za Zhi. 2016 Jul 24; 44 (7):600-4
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  17. Sun MQ, Qian LL, Dang SP, Wu Y, Tang X, Ji Y, Wang XY, Xia DY, Wang W, Chai Q, Lu T, Wang RX. [Docosahexaenoic acids activate large conductance calcium-activated potassium channels via phospholipase C- inositol triphosphate- calcium pathway in normal rat coronary smooth muscle cells]. Zhonghua Xin Xue Guan Bing Za Zhi. 2016 Jun 24; 44 (6):530-5
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  18. Huang Y, Lu T. Correlation between arachidonic acid metabolites and vascular endothelial dysfunction in Chinese elderly with type 2 diabetes mellitus Cardiology Plus.2016;2:(1)8-13.
  19. Yi F, Ling TY, Lu T, Wang XL, Li J, Claycomb WC, Shen WK, Lee HC. Down-regulation of the small conductance calcium-activated potassium channels in diabetic mouse atria. J Biol Chem. 2015 Mar 13; 290 (11):7016-26 Epub 2015 Jan 20
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  20. Chai Q, Lu T, Wang XL, Lee HC. Hydrogen sulfide impairs shear stress-induced vasodilation in mouse coronary arteries. Pflugers Arch. 2015 Feb; 467 (2):329-40 Epub 2014 May 06
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  21. Yi F, Wang H, Chai Q, Wang X, Shen WK, Willis MS, Lee HC, Lu T. Regulation of large conductance Ca2+-activated K+ (BK) channel beta1 subunit expression by muscle RING finger protein 1 in diabetic vessels. J Biol Chem. 2014 Apr 11; 289 (15):10853-64 Epub 2014 Feb 25
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  22. Lu T, de Grandis E, Gloviczki P, Glockner J, Shepherd RF. May-Thurner syndrome associated with Klippel-Trenaunay syndrome. Perspect Vasc Surg Endovasc Ther. 2012 Sep; 24(3):155-60.
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  23. Lu T, Chai Q, Yu L, d'Uscio LV, Katusic ZS, He T, Lee HC. Reactive oxygen species signaling facilitates FOXO-3a/FBXO-dependent vascular BK channel beta1 subunit degradation in diabetic mice. Diabetes. 2012 Jul; 61 (7):1860-8 Epub 2012 May 14
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  24. Wang RX, Shi HF, Chai Q, Wu Y, Sun W, Ji Y, Yao Y, Li KL, Zhang CY, Zheng J, Guo SX, Li XR, Lu T. Molecular mechanisms of diabetic coronary dysfunction due to large conductance Ca2(+)-activated K(+) channel impairment. Chin Med J (Engl). 2012 Jul; 125(14):2548-55.
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  25. He T, Smith LA, Lu T, Joyner MJ, Katusic ZS. Activation of peroxisome proliferator-activated receptor-{delta} enhances regenerative capacity of human endothelial progenitor cells by stimulating biosynthesis of tetrahydrobiopterin. Hypertension. 2011 Aug; 58 (2):287-94 Epub 2011 June 27
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  26. Wang RX, Chai Q, Lu T, Lee HC. Activation of vascular BK channels by docosahexaenoic acid is dependent on cytochrome P450 epoxygenase activity. Cardiovasc Res. 2011 May 1; 90 (2):344-52 Epub 2010 Dec 27
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  27. Wang RX, Li KL, Zhang CY, Zheng J, Guo SX, Wu Y, Li XR, Chai Q, Lu T, Lee HC. [Mechanism related to docosahexaenoic acid induced large conductance calcium-activated potassium channel currents increase in coronary smooth muscle cells]. Zhonghua Xin Xue Guan Bing Za Zhi. 2011 Apr; 39(4):348-52.
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  28. Huang YL, Wang Y, Deng X, Shen R, Wu L, Lu T. Correlation analysis of epoxyeicosatrienoic acids with vascular endothelial dysfunction in senile diabetes mellitus. Academic Journal of Second Military Medical University. 2011; 32(3):271-275.
  29. Wang ZH, Zhen L, Sun N, Wang ZJ, Lu T. Pathological injury of diesel exhaust particulate on lung of pregnant mice and fetal mice Medical Research Journal. 2011; 40(3):75-77.
  30. Huang YL, Guo RH, Pan XL, Gu W, Shen RY, Tang DH, Lu T. Relevance of Cytochrome P-450 Epoxygenase Metabolites of Arachidonic Acid on Endothelium-dependent Vasorelaxation in Aging. Chinese Journal of Geriatrics. 2011; 30(5):374-377.
  31. Zhang DM, He T, Katusic ZS, Lee HC, Lu T. Muscle-specific f-box only proteins facilitate bk channel beta(1) subunit downregulation in vascular smooth muscle cells of diabetes mellitus. Circ Res. 2010 Dec 10; 107 (12):1454-9 Epub 2010 Oct 21
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  32. Wang RX, Li XR, Yang ZY, Zheng J, Li KL, Zhang CY, Guo SX, Sun LP, Lu T. [Changes of large conductance Ca(2+)-activated K(+) channels on coronary smooth muscle cells from diabetic rats]. Zhonghua Xin Xue Guan Bing Za Zhi. 2010 Dec; 38(12):1098-101.
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  33. Wang RX, Li XR, Yang ZY, Li KL, Zheng J, Zhang CY, Guo SX, Sun LP, Lu T. [Regulation of vascular tension in diabetic coronary artery by large conductance Ca(2+)-activated K(+) channel in rats]. Zhonghua Yi Xue Za Zhi. 2010 Sep 28; 90(36):2575-8.
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  34. Lu T, Wang RX, Jiang B. Cardiac Voltage-gated K+ Channels. Chinese Journal of Cardiac Electrophysiology and Pacing. 2010 Jun; 24(3):201-9.
  35. Lu T, Zhang DM, Wang XL, He T, Wang RX, Chai Q, Katusic ZS, Lee HC. Regulation of coronary arterial BK channels by caveolae-mediated angiotensin II signaling in diabetes mellitus. Circ Res. 2010 Apr 2; 106 (6):1164-73 Epub 2010 Feb 18
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  36. Huang YL, Wang Y, Lu T. Endothelial progenitor cells: Functions and clinical application in cardiac and vascular diseases. Academic Journal of Second Military Medical University. 2010; 31(5):545-8.
  37. Lu T, Jiang B. Inward Rectifier K+ Channels. Chinese Journal of Cardiac Electrophysiology and Pacing. 2009 Jun; 23(3):189-95.
  38. Lu T, Ye D, He T, Wang XL, Wang HL, Lee HC. Impaired Ca2+-dependent activation of large-conductance Ca2+-activated K+ channels in the coronary artery smooth muscle cells of Zucker Diabetic Fatty rats. Biophys J. 2008 Dec; 95 (11):5165-77 Epub 2008 Sept 12
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  39. Lu T, Jiang WP. Cardiac Voltage-gated Na+ channels. Chinese Journal of Cardiac Electrophysiology and Pacing. 2008 Dec; 22(6):471-6.
  40. Lu T, Jiang B. Cardiac Ca2+ channels. Chinese Journal of Cardiac Electrophysiology and Pacing. 2008 Dec; 22(6):477-82.
  41. He T, Lu T, d'Uscio LV, Lam CF, Lee HC, Katusic ZS. Angiogenic function of prostacyclin biosynthesis in human endothelial progenitor cells. Circ Res. 2008 Jul 3; 103 (1):80-8 Epub 2008 May 29
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  42. Huang YL, Lu T. Aging and endothelial dysfunction. Advances in Cardiovascular Diseases. 2007; 29:766-9.
  43. Lu T, He T, Katusic ZS, Lee HC. Molecular mechanisms mediating inhibition of human large conductance Ca2+-activated K+ channels by high glucose. Circ Res. 2006 Sep 15; 99 (6):607-16 Epub 2006 Aug 24
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  44. Wang XL, Lu T, Cao S, Shah VH, Lee HC. Inhibition of ATP binding to the carboxyl terminus of Kir6.2 by epoxyeicosatrienoic acids. Biochim Biophys Acta. 2006 Sep; 1761 (9):1041-9 Epub 2006 July 08
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  45. Lu T, Ye D, Wang X, Seubert JM, Graves JP, Bradbury JA, Zeldin DC, Lee HC. Cardiac and vascular KATP channels in rats are activated by endogenous epoxyeicosatrienoic acids through different mechanisms. J Physiol. 2006 Sep 1; 575 (Pt 2):627-44 Epub 2006 June 22
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  46. Zhou W, Lu T, Spector AA, Lee HC. Inhibition of PGI2 signaling by miconazole in vascular smooth muscle cells. Prostaglandins Other Lipid Mediat. 2006 Jul; 80 (1-2):28-34 Epub 2006 May 11
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  47. Ye D, Zhou W, Lu T, Jagadeesh SG, Falck JR, Lee HC. Mechanism of rat mesenteric arterial KATP channel activation by 14,15-epoxyeicosatrienoic acid. Am J Physiol Heart Circ Physiol. 2006 Apr; 290 (4):H1326-36
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  48. Lu T, Wang XL, He T, Zhou W, Kaduce TL, Katusic ZS, Spector AA, Lee HC. Impaired arachidonic acid-mediated activation of large-conductance Ca2+-activated K+ channels in coronary arterial smooth muscle cells in Zucker Diabetic Fatty rats. Diabetes. 2005 Jul; 54 (7):2155-63
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  49. Lu T, Hong MP, Lee HC. Molecular determinants of cardiac K(ATP) channel activation by epoxyeicosatrienoic acids. J Biol Chem. 2005 May 13; 280 (19):19097-104 Epub 2005 Mar 10
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  50. Lu T, VanRollins M, Lee HC. Stereospecific activation of cardiac ATP-sensitive K(+) channels by epoxyeicosatrienoic acids: a structural determinant study. Mol Pharmacol. 2002 Nov; 62 (5):1076-83
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  51. Padanilam BJ, Lu T, Hoshi T, Padanilam BA, Shibata EF, Lee HC. Molecular determinants of intracellular pH modulation of human Kv1.4 N-type inactivation. Mol Pharmacol. 2002 Jul; 62(1):127-34.
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  52. Yarbrough TL, Lu T, Lee HC, Shibata EF. Localization of cardiac sodium channels in caveolin-rich membrane domains: regulation of sodium current amplitude. Circ Res. 2002 Mar 8; 90(4):443-9.
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  53. Lu T, Hoshi T, Weintraub NL, Spector AA, Lee HC. Activation of ATP-sensitive K(+) channels by epoxyeicosatrienoic acids in rat cardiac ventricular myocytes. J Physiol. 2001 Dec 15; 537(Pt 3):811-27.
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  54. Lu T, Katakam PV, VanRollins M, Weintraub NL, Spector AA, Lee HC. Dihydroxyeicosatrienoic acids are potent activators of Ca(2+)-activated K(+) channels in isolated rat coronary arterial myocytes. J Physiol. 2001 Aug 1; 534(Pt 3):651-67.
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  55. Zhang Y, Oltman CL, Lu T, Lee HC, Dellsperger KC, VanRollins M. EET homologs potently dilate coronary microvessels and activate large conductance Ca2+-activated potassium channels. American Journal of Physiology, Heart and Circulatory Physiology. 2001 Jun; 280(6):H2430-2440.
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  56. Zink MH, Oltman C, Lu T, Katakam PVG, Kaduce TL, Lee HC, Dellsperger KC, Spector AA, Myers PR, Weintraub NL. 12-Lipoxygenase in the porcine coronary microcirculation: implications for coronary vasoregulation. American Journal of Physiology: Heart and Circulatory Physiology. 2001 Feb; 280(2):H693-704.
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  57. Lee HC, Lu T, Weintraub NL, VanRollins M, Spector AA, Shibata EF. Effects of epoxyeicosatrienoic acids on the cardiac sodium channels in isolated rat ventricular myocytes. J Physiol. 1999 Aug 15; 519 Pt 1:153-68.
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  58. Lu T, Lee HC, Kabat JA, Shibata EF. Modulation of cardiac sodium channel by G protein stimulatory subunit. The Journal of Physiology (London. 1999 Jul 15; 518(2):371-84.
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  59. Anderson ME, Braun AP, Wu Y, Lu T, Wu Y, Schulman H, Sung RJ. KN-93, an inhibitor of multifunctional Ca++/calmodulin-dependent protein kinase, decreases early afterdepolarizations in rabbit heart. J Pharmacol Exp Ther. 1998 Dec; 287 (3):996-1006
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  60. Lu T, Huang Y, Jiang W. The electrophysiologic effects of endothelin. A patch clamp study in guinea pig ventricular myocytes. Chin Med J (Engl). 1995 Aug; 108(8):618-25.
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  61. Huang YL, Lu T, Jiang WP. Investigated the mechanism of the endothelin-1-induced cardiac triggered activities of guinea pig ventricular myocytes: An ionic mechanism study. Chinese Journal of Cardiology. 1995; 23(5):381-383.
  62. Jiang WP, Wang KP, Lu T. The analysis of sudden death in 178 patients suffered from primary cardiomyopathy. Chinese Journal of Cardiology. 1994; 22:363-365.
  63. Lu T, Hu XZ. Catheter ablation treatment of cardiac ventricular tachycardia. Advances in Cardiovascular Diseases (Chinese). 1992; 13: 16-20.
  64. Hu XZ, Xu CX, Deng YL, Wu W, Wang WY, Lu T. Electrophysiological and pharmacological examinations in patients with wide-QRS complex ventricular tachycardia. Fujian Medical Journal. 1991; 13(2):13-15.
  65. Hu XZ, Deng YL, Xu CX, Chen XC, Wang WY, Wu W, Lu T. The Clinical practice of cardiac electrophysiological examination. Fujian Medical Journal. 1990; 12(3):17-20.
  66. Hu XZ, Xu CX, Deng YL, Cheng XC, Wang WY, Lu T. Invasive treatment of cardiac arrhythmias. Fujian Medical Journal. 1990; 12(4):15-17.
  67. Xu CX, Hu XZ, Deng YL, Lu T, Cheng L, Wu W. The clinical electrophysiological examinations on Wolff-Parkinson-White syndrome. Fujian Medical Journal. 1990; 12(3):3-7.
  68. Hu XZ, Xu CX, Deng YL, Lu T, Cheng XC, Wang WY. Inventive treatment of tachycardia patients. Fujian Medical Journal. 1990; 12(5):4-8.
  69. Chen Y, Li WR, Xie WQ, Lu T, Li MZ. The myocardial protective effects of F-contained free radical scavengers on heart surgery. Fujian Medical Journal. 1990; 12(6):12-15.
  70. Lu T, Hu XZ, Chen Y, Li MZ. The relationship between levels of oxygen free radicals and subtypes of cardiac ischemic reperfusion-induced arrhythmias. Chinese Journal of Cardiology. 1990; 20:48-49.
  71. Xie WQ, Chen T, Lu T. Surgical treatment of pre-excitation syndrome with 1 case report Academic Periodical of Fujian Medical University. 1988.
  72. Hu XZ, Deng YL, Lu T. Clinical practice of His bundle electrocardiogram. Fujian Medical Journal. 1987; 9(2):1-2.
  73. Hu X, Z, Deng Y, L, Lu T. A comparison between transesophagus electrocardiogram and sinus node electrocardiogram in diagnosing sinus node dysfunction. Fujian Medical Journal. 1987; 11(3):2-6.