Publications

  1. Massey SC, Whitmire P, Doyle TE, Ippolito JE, Mrugala MM, Hu LS, Canoll P, Anderson ARA, Wilson MA, Fitzpatrick SM, McCarthy MM, Rubin JB, Swanson KR. Sex differences in health and disease: A review of biological sex differences relevant to cancer with a spotlight on glioma. Cancer Lett. 2020 Oct 29 [Epub ahead of print]
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  2. Boxerman JL, Quarles CC, Hu LS, Erickson BJ, Gerstner ER, Smits M, Kaufmann TJ, Barboriak DP, Huang RH, Wick W, Weller M, Galanis E, Kalpathy-Cramer J, Shankar L, Jacobs P, Chung C, van den Bent MJ, Chang S, Al Yung WK, Cloughesy TF, Wen PY, Gilbert MR, Rosen BR, Ellingson BM, Schmainda KM, Jumpstarting Brain Tumor Drug Development Coalition Imaging Standardization Steering Committee. Consensus recommendations for a dynamic susceptibility contrast MRI protocol for use in high-grade gliomas. Neuro Oncol. 2020 Sep 29; 22 (9):1262-1275
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  3. Mitchell JR, Kamnitsas K, Singleton KW, Whitmire SA, Clark-Swanson KR, Ranjbar S, Rickertsen CR, Johnston SK, Egan KM, Rollison DE, Arrington J, Krecke KN, Passe TJ, Verdoorn JT, Nagelschneider AA, Carr CM, Port JD, Patton A, Campeau NG, Liebo GB, Eckel LJ, Wood CP, Hunt CH, Vibhute P, Nelson KD, Hoxworth JM, Patel AC, Chong BW, Ross JS, Boxerman JL, Vogelbaum MA, Hu LS, Glocker B, Swanson KR. Deep neural network to locate and segment brain tumors outperformed the expert technicians who created the training data. J Med Imaging (Bellingham). 2020 Sep; 7 (5):055501 Epub 2020 Oct 16
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  4. Morris B, Curtin L, Hawkins-Daarud A, Hubbard ME, Rahman R, Smith SJ, Auer D, Tran NL, Hu LS, Eschbacher JM, Smith KA, Stokes A, Swanson KR, Owen MR. Identifying the spatial and temporal dynamics of molecularly-distinct glioblastoma sub-populations. Math Biosci Eng. 2020 Jul 16; 17 (5):4905-4941
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  5. Hu LS, Swanson KR. Roadmap for the clinical integration of radiomics in neuro-oncology. Neuro Oncol 2020 Jun 9; 22 (6):743-745
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  6. Bell LC, Semmineh N, An H, Eldeniz C, Wahl R, Schmainda KM, Prah MA, Erickson BJ, Korfiatis P, Wu C, Sorace AG, Yankeelov TE, Rutledge N, Chenevert TL, Malyarenko D, Liu Y, Brenner A, Hu LS, Zhou Y, Boxerman JL, Yen YF, Kalpathy-Cramer J, Beers AL, Muzi M, Madhuranthakam AJ, Pinho M, Johnson B, Quarles CC. Evaluating the Use of rCBV as a Tumor Grade and Treatment Response Classifier Across NCI Quantitative Imaging Network Sites: Part II of the DSC-MRI Digital Reference Object (DRO) Challenge. Tomography. 2020 Jun; 6 (2):203-208
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  7. Whitmire P, Rickertsen CR, Hawkins-Daarud A, Carrasco E Jr, Lorence J, De Leon G, Curtin L, Bayless S, Clark-Swanson K, Peeri NC, Corpuz C, Lewis-de Los Angeles CP, Bendok BR, Gonzalez-Cuyar L, Vora S, Mrugala MM, Hu LS, Wang L, Porter A, Kumthekar P, Johnston SK, Egan KM, Gatenby R, Canoll P, Rubin JB, Swanson KR. Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients. BMC Cancer. 2020 May 19; 20 (1):447
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  8. Hu LS, Hawkins-Daarud A, Wang L, Li J, Swanson KR. Imaging of intratumoral heterogeneity in high-grade glioma. Cancer Lett. 2020 May 1; 477:97-106 Epub 2020 Feb 27
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  9. Ranjbar S, Singleton KW, Jackson PR, Rickertsen CR, Whitmire SA, Clark-Swanson KR, Mitchell JR, Swanson KR, Hu LS. A Deep Convolutional Neural Network for Annotation of Magnetic Resonance Imaging Sequence Type. J Digit Imaging. 2020 Apr; 33 (2):439-446
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  10. Hoxworth JM, Eschbacher JM, Gonzales AC, Singleton KW, Leon GD, Smith KA, Stokes AM, Zhou Y, Mazza GL, Porter AB, Mrugala MM, Zimmerman RS, Bendok BR, Patra DP, Krishna C, Boxerman JL, Baxter LC, Swanson KR, Quarles CC, Schmainda KM, Hu LS. Performance of Standardized Relative CBV for Quantifying Regional Histologic Tumor Burden in Recurrent High-Grade Glioma: Comparison against Normalized Relative CBV Using Image-Localized Stereotactic Biopsies. AJNR Am J Neuroradiol. 2020 Mar; 41 (3):408-415 Epub 2020 Mar 12
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  11. Hu LS, Brat DJ, Bloch O, Ramkissoon S, Lesser GJ. The Practical Application of Emerging Technologies Influencing the Diagnosis and Care of Patients With Primary Brain Tumors. Am Soc Clin Oncol Educ Book. 2020 Mar; 40:1-12
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  12. Massey SC, White H, Whitmire P, Doyle T, Johnston SK, Singleton KW, Jackson PR, Hawkins-Daarud A, Bendok BR, Porter AB, Vora S, Sarkaria JN, Hu LS, Mrugala MM, Swanson KR. Image-based metric of invasiveness predicts response to adjuvant temozolomide for primary glioblastoma. PLoS One. 2020; 15 (3):e0230492 Epub 2020 Mar 27
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  13. Singleton KW, Porter AB, Hu LS, Johnston SK, Bond KM, Rickertsen CR, De Leon G, Whitmire SA, Clark-Swanson KR, Mrugala MM, Swanson KR. Days gained response discriminates treatment response in patients with recurrent glioblastoma receiving bevacizumab-based therapies. Neurooncol Adv. 2020 Jan-Dec; 2 (1):vdaa085 Epub 2020 July 09
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  14. Johnston SK, Whitmire P, Massey SC, Kumthekar P, Porter AB, Raghunand N, Gonzalez-Cuyar LF, Mrugala MM, Hawkins-Daarud A, Jackson PR, Hu LS, Sarkaria JN, Wang L, Gatenby RA, Egan KM, Canoll P, Swanson KR, ENDURES consortium. ENvironmental Dynamics Underlying Responsive Extreme Survivors (ENDURES) of Glioblastoma: A Multidisciplinary Team-based, Multifactorial Analytical Approach. Am J Clin Oncol. 2019 Aug; 42 (8):655-661
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  15. Gaw N, Hawkins-Daarud A, Hu LS, Yoon H, Wang L, Xu Y, Jackson PR, Singleton KW, Baxter LC, Eschbacher J, Gonzales A, Nespodzany A, Smith K, Nakaji P, Mitchell JR, Wu T, Swanson KR, Li J. Integration of machine learning and mechanistic models accurately predicts variation in cell density of glioblastoma using multiparametric MRI. Sci Rep. 2019 Jul 11; 9 (1):10063 Epub 2019 July 11
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  16. Schmainda KM, Prah MA, Hu LS, Quarles CC, Semmineh N, Rand SD, Connelly JM, Anderies B, Zhou Y, Zhou Y, Liu Y, Logan B, Stokes A, Baird G, Boxerman JL. Moving Toward a Consensus DSC-MRI Protocol: Validation of a Low-Flip Angle Single-Dose Option as a Reference Standard for Brain Tumors. AJNR Am J Neuroradiol. 2019 Apr; 40 (4):626-633 Epub 2019 Mar 28
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  17. Dhamija R, Wood CP, Porter AB, Hu LS, Weindling SM, Hoxworth JM. Updated Imaging Features of Dysplastic Cerebellar Gangliocytoma. J Comput Assist Tomogr. 2019 Mar/Apr; 43 (2):277-281
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  18. Hu LS, Yoon H, Eschbacher JM, Baxter LC, Dueck AC, Nespodzany A, Smith KA, Nakaji P, Xu Y, Wang L, Karis JP, Hawkins-Daarud AJ, Singleton KW, Jackson PR, Anderies BJ, Bendok BR, Zimmerman RS, Quarles C, Porter-Umphrey AB, Mrugala MM, Sharma A, Hoxworth JM, Sattur MG, Sanai N, Koulemberis PE, Krishna C, Mitchell JR, Wu T, Tran NL, Swanson KR, Li J. Accurate Patient-Specific Machine Learning Models of Glioblastoma Invasion Using Transfer Learning. AJNR Am J Neuroradiol. 2019 Mar; 40 (3):418-425 Epub 2019 Feb 28
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  19. Bell LC, Semmineh N, An H, Eldeniz C, Wahl R, Schmainda KM, Prah MA, Erickson BJ, Korfiatis P, Wu C, Sorace AG, Yankeelov TE, Rutledge N, Chenevert TL, Malyarenko D, Liu Y, Brenner A, Hu LS, Zhou Y, Boxerman JL, Yen YF, Kalpathy-Cramer J, Beers AL, Muzi M, Madhuranthakam AJ, Pinho M, Johnson B, Quarles CC. Evaluating Multisite rCBV Consistency from DSC-MRI Imaging Protocols and Postprocessing Software Across the NCI Quantitative Imaging Network Sites Using a Digital Reference Object (DRO). Tomography. 2019 Mar; 5 (1):110-117
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  20. Rayfield CA, Grady F, De Leon G, Rockne R, Carrasco E, Jackson P, Vora M, Johnston SK, Hawkins-Daarud A, Clark-Swanson KR, Whitmire S, Gamez ME, Porter A, Hu L, Gonzalez-Cuyar L, Bendok B, Vora S, Swanson KR. Distinct Phenotypic Clusters of Glioblastoma Growth and Response Kinetics Predict Survival. JCO Clin Cancer Inform. 2018 Dec; 2:1-14
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  21. Semmineh NB, Bell LC, Stokes AM, Hu LS, Boxerman JL, Quarles CC. Optimization of Acquisition and Analysis Methods for Clinical Dynamic Susceptibility Contrast MRI Using a Population-Based Digital Reference Object. AJNR Am J Neuroradiol. 2018 Nov; 39 (11):1981-1988 Epub 2018 Oct 11
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  22. Schmainda KM, Prah MA, Rand SD, Liu Y, Logan B, Muzi M, Rane SD, Da X, Yen YF, Kalpathy-Cramer J, Chenevert TL, Hoff B, Ross B, Cao Y, Aryal MP, Erickson B, Korfiatis P, Dondlinger T, Bell L, Hu L, Kinahan PE, Quarles CC. Multisite Concordance of DSC-MRI Analysis for Brain Tumors: Results of a National Cancer Institute Quantitative Imaging Network Collaborative Project. AJNR Am J Neuroradiol. 2018 Jun; 39 (6):1008-1016 Epub 2018 May 24
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  23. Dhamija R, Weindling SM, Porter AB, Hu LS, Wood CP, Hoxworth JM. Neuroimaging abnormalities in patients with Cowden syndrome: Retrospective single-center study. Neurol Clin Pract. 2018 Jun; 8 (3):207-213
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  24. Sarkaria JN, Hu LS, Parney IF, Pafundi DH, Brinkmann DH, Laack NN, Giannini C, Burns TC, Kizilbash SH, Laramy JK, Swanson KR, Kaufmann TJ, Brown PD, Agar NYR, Galanis E, Buckner JC, Elmquist WF. Is the blood-brain barrier really disrupted in all glioblastomas? A critical assessment of existing clinical data. Neuro Oncol. 2018 Jan 22; 20 (2):184-191
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  25. Tomblinson CM, Nagel TH, Hu LS, Zarka MA, Hoxworth JM. Median Lingual Lymph Nodes: Prevalence on Imaging and Potential Implications for Oral Cavity Cancer Staging. J Comput Assist Tomogr. 2017 Jul/Aug; 41 (4):528-534
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  26. Bell LC, Hu LS, Stokes AM, McGee SC, Baxter LC, Quarles CC. Characterizing the Influence of Preload Dosing on Percent Signal Recovery (PSR) and Cerebral Blood Volume (CBV) Measurements in a Patient Population With High-Grade Glioma Using Dynamic Susceptibility Contrast MRI. Tomography. 2017 Jun; 3 (2):89-95
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  27. Hu LS, Ning S, Eschbacher JM, Baxter LC, Gaw N, Ranjbar S, Plasencia J, Dueck AC, Peng S, Smith KA, Nakaji P, Karis JP, Quarles CC, Wu T, Loftus JC, Jenkins RB, Sicotte H, Kollmeyer TM, O'Neill BP, Elmquist W, Hoxworth JM, Frakes D, Sarkaria J, Swanson KR, Tran NL, Li J, Mitchell JR. Radiogenomics to characterize regional genetic heterogeneity in glioblastoma. Neuro Oncol. 2017 Jan; 19(1):128-137. Epub 2016 Aug 08.
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  28. Korfiatis P, Kline TL, Kelm ZS, Carter RE, Hu LS, Erickson BJ. Dynamic Susceptibility Contrast-MRI Quantification Software Tool: Development and Evaluation. Tomography. 2016 Dec; 2 (4):448-456
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  29. Plasencia JD, Hu LS, Turner GH, Bennett KM, Frakes DH. Design and verification of novel low-cost mr-guided small-animal stereotactic system Journal Of Medical And Biological Engineering. 2016 Aug; 36(4):526-35. Epub 1900 Jan 01.
  30. Hu LS, Kelm Z, Korfiatis P, Dueck AC, Elrod C, Ellingson BM, Kaufmann TJ, Eschbacher JM, Karis JP, Smith K, Nakaji P, Brinkman D, Pafundi D, Baxter LC, Erickson BJ. Impact of Software Modeling on the Accuracy of Perfusion MRI in Glioma. AJNR Am J Neuroradiol. 2015 Dec; 36 (12):2242-9 Epub 2015 Sept 10
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  31. Hu LS, Ning S, Eschbacher JM, Gaw N, Dueck AC, Smith KA, Nakaji P, Plasencia J, Ranjbar S, Price SJ, Tran N, Loftus J, Jenkins R, O'Neill BP, Elmquist W, Baxter LC, Gao F, Frakes D, Karis JP, Zwart C, Swanson KR, Sarkaria J, Wu T, Mitchell JR, Li J. Multi-Parametric MRI and Texture Analysis to Visualize Spatial Histologic Heterogeneity and Tumor Extent in Glioblastoma. PLoS One. 2015; 10 (11):e0141506 Epub 2015 Nov 24
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  32. Pafundi DH, Laack NN, Youland RS, Parney IF, Lowe VJ, Giannini C, Kemp BJ, Grams MP, Morris JM, Hoover JM, Hu LS, Sarkaria JN, Brinkmann DH. Biopsy validation of 18F-DOPA PET and biodistribution in gliomas for neurosurgical planning and radiotherapy target delineation: results of a prospective pilot study. Neuro Oncol. 2013 Aug; 15 (8):1058-67 Epub 2013 Mar 03
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  33. Lehman VT, Luetmer PH, Sorenson EJ, Carter RE, Gupta V, Fletcher GP, Hu LS, Kotsenas AL. Cervical spine MR imaging findings of patients with Hirayama disease in North America: a multisite study. AJNR Am J Neuroradiol. 2013 Feb; 34(2):451-6. Epub 2012 Aug 9
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  34. Hu LS, Eschbacher JM, Heiserman JE, Dueck AC, Shapiro WR, Liu S, Karis JP, Smith KA, Coons SW, Nakaji P, Spetzler RF, Feuerstein BG, Debbins J, Baxter LC. Reevaluating the imaging definition of tumor progression: perfusion MRI quantifies recurrent glioblastoma tumor fraction, pseudoprogression, and radiation necrosis to predict survival. Neuro Oncol. 2012 Jul; 14 (7):919-30 Epub 2012 May 03
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  35. Hu LS, Eschbacher JM, Dueck AC, Heiserman JE, Liu S, Karis JP, Smith KA, Shapiro WR, Pinnaduwage DS, Coons SW, Nakaji P, Debbins J, Feuerstein BG, Baxter LC. Correlations between perfusion MR imaging cerebral blood volume, microvessel quantification, and clinical outcome using stereotactic analysis in recurrent high-grade glioma. AJNR Am J Neuroradiol. 2012 Jan; 33(1):69-76. Epub 2011 Nov 17.
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  36. Little AS, Liu S, Beeman S, Sankar T, Preul MC, Hu LS, Smith KA, Baxter LC. Brain retraction and thickness of cerebral neocortex: an automated technique for detecting retraction-induced anatomic changes using magnetic resonance imaging. Neurosurgery. 2010 Sep; 67(3 Suppl Operative):ons277-82; discussion ons282.
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  37. Shih P, Pinnaduwage T, Hu LS, Spetzler RF. A pediatric patient with a dissecting thrombotic anterior choroidal artery aneurysm: case report. Neurosurgery. 2010 Aug; 67(2):E518.
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  38. Hu LS, Baxter LC, Pinnaduwage DS, Paine TL, Karis JP, Feuerstein BG, Schmainda KM, Dueck AC, Debbins J, Smith KA, Nakaji P, Eschbacher JM, Coons SW, Heiserman JE. Optimized preload leakage-correction methods to improve the diagnostic accuracy of dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging in posttreatment gliomas. AJNR Am J Neuroradiol. 2010 Jan; 31 (1):40-8 Epub 2009 Sept 12
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  39. Hu LS, Baxter LC, Smith KA, Feuerstein BG, Karis JP, Eschbacher JM, Coons SW, Nakaji P, Yeh RF, Debbins J, Heiserman JE. Relative cerebral blood volume values to differentiate high-grade glioma recurrence from posttreatment radiation effect: direct correlation between image-guided tissue histopathology and localized dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging measurements. AJNR Am J Neuroradiol. 2009 Mar; 30 (3):552-8 Epub 2008 Dec 04
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  40. Hu LS, Caire J, Twickler DM. MR findings of complicated multifetal gestations. Pediatr Radiol. 2006 Jan; 36(1):76-81. Epub 2005 Nov 12.
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