Publications

1. van Zutphen T, Stroeve JHM, Yang J, Bloks VW, Jurdzinski A, Roelofsen H, Huijkman NCA, van Dijk TH, Vonk RJ, van Deursen J, Staels B, Groen AK, Kuipers F. FXR overexpression alters adipose tissue architecture in mice and limits its storage capacity leading to metabolic derangements. J Lipid Res. 2019 Sep; 60 (9):1547-1561 Epub 2019 June 28
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2. Limzerwala JF, van Deursen JM. Crystallizing BubR1's kinase activity. Cell Res. 2019 Aug; 29 (8):605-606
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3. Lee JS, Mo Y, Gan H, Burgess RJ, Baker DJ, van Deursen JM, Zhang Z. Pak2 kinase promotes cellular senescence and organismal aging. Proc Natl Acad Sci U S A. 2019 Jul 2; 116 (27):13311-13319 Epub 2019 June 17
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4. Aguayo-Mazzucato C, Andle J, Lee TB Jr, Midha A, Talemal L, Chipashvili V, Hollister-Lock J, van Deursen J, Weir G, Bonner-Weir S. Acceleration of beta Cell Aging Determines Diabetes and Senolysis Improves Disease Outcomes. Cell Metab. 2019 Jul 2; 30 (1):129-142.e4 Epub 2019 May 30
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5. Aziz K, Limzerwala JF, Sturmlechner I, Hurley E, Zhang C, Jeganathan KB, Nelson G, Bronk S, Fierro Velasco RO, van Deursen EJ, O'Brien DR, Kocher JA, Youssef SA, van Ree JH, de Bruin A, van den Bos H, Spierings DCJ, Foijer F, van de Sluis B, Roberts LR, Gores GJ, Li H, van Deursen JM. Ccne1 Overexpression Causes Chromosome Instability in Liver Cells and Liver Tumor Development in Mice. Gastroenterology. 2019 Jul; 157 (1):210-226.e12 Epub 2019 Mar 13
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6. Simmons AJ, Park R, Sterling NA, Jang MH, van Deursen JMA, Yen TJ, Cho SH, Kim S. Nearly complete deletion of BubR1 causes microcephaly through shortened mitosis and massive cell death. Hum Mol Genet. 2019 Jun 1; 28 (11):1822-1836
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7. Postmus AC, Sturmlechner I, Jonker JW, van Deursen JM, van de Sluis B, Kruit JK. Senescent cells in the development of cardiometabolic disease. Curr Opin Lipidol. 2019 Jun; 30 (3):177-185
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8. van Deursen JM. Senolytic therapies for healthy longevity. Science. 2019 May 17; 364 (6441):636-637
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9. Cho CH, Yoo KH, Oliveros A, Paulson S, Hussaini SMQ, van Deursen JM, Jang MH. sFRP3 inhibition improves age-related cellular changes in BubR1 progeroid mice. Aging Cell. 2019 Apr; 18 (2):e12899 Epub 2019 Jan 04
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10. Bussian TJ, Aziz A, Meyer CF, Swenson BL, van Deursen JM, Baker DJ. Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline. Nature. 2018 Oct; 562 (7728):578-582 Epub 2018 Sept 19
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11. Sieben CJ, Sturmlechner I, van de Sluis B, van Deursen JM. Two-Step Senescence-Focused Cancer Therapies. Trends Cell Biol. 2018 Sep; 28 (9):723-737 Epub 2018 May 17
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12. Aziz K, Sieben CJ, Jeganathan KB, Hamada M, Davies BA, Velasco ROF, Rahman N, Katzmann DJ, van Deursen JM. Mosaic-variegated aneuploidy syndrome mutation or haploinsufficiency in Cep57 impairs tumor suppression. J Clin Invest. 2018 Aug 1; 128 (8):3517-3534 Epub 2018 July 23
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13. Nowsheen S, Aziz K, Luo K, Deng M, Qin B, Yuan J, Jeganathan KB, Yu J, Zhang H, Ding W, van Deursen JM, Lou Z. ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage. Nat Commun. 2018 Jul 16; 9 (1):2736 Epub 2018 July 16
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14. Fedoseienko A, Wijers M, Wolters JC, Dekker D, Smit M, Huijkman N, Kloosterhuis N, Klug H, Schepers A, Willems van Dijk K, Levels JHM, Billadeau DD, Hofker MH, van Deursen J, Westerterp M, Burstein E, Kuivenhoven JA, van de Sluis B. The COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR Trafficking. Circ Res. 2018 Jun 8; 122 (12):1648-1660 Epub 2018 Mar 15
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15. Dou C, Liu Z, Tu K, Zhang H, Chen C, Yaqoob U, Wang Y, Wen J, van Deursen J, Sicard D, Tschumperlin D, Zou H, Huang WC, Urrutia R, Shah VH, Kang N. P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts. Gastroenterology. 2018 Jun; 154 (8):2209-2221.e14 Epub 2018 Feb 15
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16. Childs BG, Li H, van Deursen JM. Senescent cells: a therapeutic target for cardiovascular disease. J Clin Invest. 2018 Apr 2; 128 (4):1217-1228 Epub 2018 Apr 02
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17. Nowsheen S, Aziz K, Aziz A, Deng M, Qin B, Luo K, Jeganathan KB, Zhang H, Liu T, Yu J, Deng Y, Yuan J, Ding W, van Deursen JM, Lou Z. L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. Nat Cell Biol. 2018 Apr; 20 (4):455-464 Epub 2018 Mar 26
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18. Heim JB, McDonald CA, Wyles SP, Sominidi-Damodaran S, Squirewell EJ, Li M, Motsonelidze C, Bottcher RT, van Deursen J, Meves A. FAK auto-phosphorylation site tyrosine 397 is required for development but dispensable for normal skin homeostasis. PLoS One. 2018; 13 (7):e0200558 Epub 2018 July 12
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19. Choi KM, Hong SJ, van Deursen JM, Kim S, Kim KH, Lee CK. Caloric Restriction and Rapamycin Differentially Alter Energy Metabolism in Yeast. J Gerontol A Biol Sci Med Sci. 2017 Dec 12; 73 (1):29-38
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20. van der Pol A, Gil A, Sillje HHW, Tromp J, Ovchinnikova ES, Vreeswijk-Baudoin I, Hoes M, Domian IJ, van de Sluis B, van Deursen JM, Voors AA, van Veldhuisen DJ, van Gilst WH, Berezikov E, van der Harst P, de Boer RA, Bischoff R, van der Meer P. Accumulation of 5-oxoproline in myocardial dysfunction and the protective effects of OPLAH. Sci Transl Med. 2017 Nov 8; 9 (415)
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21. Riedlinger T, Dommerholt MB, Wijshake T, Kruit JK, Huijkman N, Dekker D, Koster M, Kloosterhuis N, Koonen DPY, de Bruin A, Baker D, Hofker MH, van Deursen J, Jonker JW, Schmitz ML, van de Sluis B. NF-kappaB p65 serine 467 phosphorylation sensitizes mice to weight gain and TNFalpha-or diet-induced inflammation. Biochim Biophys Acta Mol Cell Res. 2017 Oct; 1864 (10):1785-1798 Epub 2017 July 16
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22. Childs BG, Gluscevic M, Baker DJ, Laberge RM, Marquess D, Dananberg J, van Deursen JM. Senescent cells: an emerging target for diseases of ageing. Nat Rev Drug Discov. 2017 Oct; 16 (10):718-735 Epub 2017 July 21
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23. El Yakoubi W, Buffin E, Cladiere D, Gryaznova Y, Berenguer I, Touati SA, Gomez R, Suja JA, van Deursen JM, Wassmann K. Mps1 kinase-dependent Sgo2 centromere localisation mediates cohesin protection in mouse oocyte meiosis I. Nat Commun. 2017 Sep 25; 8 (1):694 Epub 2017 Sept 25
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24. Zhu S, Zhang X, Weichert-Leahey N, Dong Z, Zhang C, Lopez G, Tao T, He S, Wood AC, Oldridge D, Ung CY, van Ree JH, Khan A, Salazar BM, Lummertz da Rocha E, Zimmerman MW, Guo F, Cao H, Hou X, Weroha SJ, Perez-Atayde AR, Neuberg DS, Meves A, McNiven MA, van Deursen JM, Li H, Maris JM, Look AT. LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis. Cancer Cell. 2017 Sep 11; 32 (3):310-323.e5 Epub 2017 Aug 31
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25. Jeon OH, Kim C, Laberge RM, Demaria M, Rathod S, Vasserot AP, Chung JW, Kim DH, Poon Y, David N, Baker DJ, van Deursen JM, Campisi J, Elisseeff JH. Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment. Nat Med. 2017 Jun; 23 (6):775-781 Epub 2017 Apr 24
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26. Yang Z, Jun H, Choi CI, Yoo KH, Cho CH, Hussaini SMQ, Simmons AJ, Kim S, van Deursen JM, Baker DJ, Jang MH. Age-related decline in BubR1 impairs adult hippocampal neurogenesis. Aging Cell. 2017 Jun; 16 (3):598-601 Epub 2017 Apr 06
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27. Maskey RS, Flatten KS, Sieben CJ, Peterson KL, Baker DJ, Nam HJ, Kim MS, Smyrk TC, Kojima Y, Machida Y, Santiago A, van Deursen JM, Kaufmann SH, Machida YJ. Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis. Nucleic Acids Res. 2017 May 5; 45 (8):4564-4576
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28. Baker DJ, Alimirah F, van Deursen JM, Campisi J, Hildesheim J. Oncogenic senescence: a multi-functional perspective. Oncotarget. 2017 Apr 18; 8 (16):27661-27672
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29. Heim JB, Squirewell EJ, Neu A, Zocher G, Sominidi-Damodaran S, Wyles SP, Nikolova E, Behrendt N, Saunte DM, Lock-Andersen J, Gaonkar KS, Yan H, Sarkaria JN, Krendel M, van Deursen J, Sprangers R, Stehle T, Bottcher RT, Lee JH, Ordog T, Meves A. Myosin-1E interacts with FAK proline-rich region 1 to induce fibronectin-type matrix. Proc Natl Acad Sci U S A. 2017 Apr 11; 114 (15):3933-3938 Epub 2017 Mar 27
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30. Aguayo-Mazzucato C, van Haaren M, Mruk M, Lee TB Jr, Crawford C, Hollister-Lock J, Sullivan BA, Johnson JW, Ebrahimi A, Dreyfuss JM, Van Deursen J, Weir GC, Bonner-Weir S. beta Cell Aging Markers Have Heterogeneous Distribution and Are Induced by Insulin Resistance. Cell Metab. 2017 Apr 4; 25 (4):898-910.e5
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31. de Boer JF, Schonewille M, Boesjes M, Wolters H, Bloks VW, Bos T, van Dijk TH, Jurdzinski A, Boverhof R, Wolters JC, Kuivenhoven JA, van Deursen JM, Oude Elferink RPJ, Moschetta A, Kremoser C, Verkade HJ, Kuipers F, Groen AK. Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice. Gastroenterology. 2017 Apr; 152 (5):1126-1138.e6 Epub 2017 Jan 05
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32. Naylor RM, van Deursen JM. Singling Out Chromosome Gains in Tumor Evolution. Cancer Cell 2017 Feb 13; 31 (2):165-166
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33. Sturmlechner I, Durik M, Sieben CJ, Baker DJ, van Deursen JM. Cellular senescence in renal ageing and disease. Nat Rev Nephrol. 2017 Feb; 13 (2):77-89 Epub 2016 Dec 28
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34. Wang X, Yamada S, LaRiviere WB, Ye H, Bakeberg JL, Irazabal MV, Chebib FT, van Deursen J, Harris PC, Sussman CR, Behfar A, Ward CJ, Torres VE. Generation and phenotypic characterization of Pde1a mutant mice. PLoS One. 2017; 12 (7):e0181087 Epub 2017 July 27
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35. van Ree JH, van Deursen JM. Deciphering the tumor suppressive mechanisms of Pten. Cell Cycle 2016 Dec 16; 15 (24):3329-3330 Epub 2016 Aug 30
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36. Naylor RM, van Deursen JM. Aneuploidy in Cancer and Aging. Annu Rev Genet. 2016 Nov 23; 50:45-66
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37. Childs BG, Baker DJ, Wijshake T, Conover CA, Campisi J, van Deursen JM. Senescent intimal foam cells are deleterious at all stages of atherosclerosis. Science. 2016 Oct 28; 354 (6311):472-477 Epub 2016 Oct 27
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38. Kanakkanthara A, Jeganathan KB, Limzerwala JF, Baker DJ, Hamada M, Nam HJ, van Deursen WH, Hamada N, Naylor RM, Becker NA, Davies BA, van Ree JH, Mer G, Shapiro VS, Maher LJ 3rd, Katzmann DJ, van Deursen JM. Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation. Science. 2016 Sep 30; 353 (6307):1549-1552
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39. Choi CI, Yoo KH, Hussaini SM, Jeon BT, Welby J, Gan H, Scarisbrick IA, Zhang Z, Baker DJ, van Deursen JM, Rodriguez M, Jang MH. The progeroid gene BubR1 regulates axon myelination and motor function. Aging (Albany NY). 2016 Sep 12; 8 (11):2667-2688
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40. Weaver RL, Limzerwala JF, Naylor RM, Jeganathan KB, Baker DJ, van Deursen JM. BubR1 alterations that reinforce mitotic surveillance act against aneuploidy and cancer. Elife. 2016 Aug 16; 5
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41. Booij HG, Yu H, De Boer RA, van de Kolk CW, van de Sluis B, Van Deursen JM, Van Gilst WH, Sillje HH, Westenbrink BD. Overexpression of A kinase interacting protein 1 attenuates myocardial ischaemia/reperfusion injury but does not influence heart failure development. Cardiovasc Res. 2016 Aug 1; 111 (3):217-26 Epub 2016 June 14
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42. van Ree JH, Nam HJ, Jeganathan KB, Kanakkanthara A, van Deursen JM. Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes. Nat Cell Biol. 2016 Jul; 18 (7):814-21 Epub 2016 May 30
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43. Schafer MJ, White TA, Evans G, Tonne JM, Verzosa GC, Stout MB, Mazula DL, Palmer AK, Baker DJ, Jensen MD, Torbenson MS, Miller JD, Ikeda Y, Tchkonia T, van Deursen JM, Kirkland JL, LeBrasseur NK. Exercise Prevents Diet-Induced Cellular Senescence in Adipose Tissue. Diabetes. 2016 Jun; 65 (6):1606-15 Epub 2016 Mar 16
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44. Ye H, Wang X, Sussman CR, Hopp K, Irazabal MV, Bakeberg JL, LaRiviere WB, Manganiello VC, Vorhees CV, Zhao H, Harris PC, van Deursen J, Ward CJ, Torres VE. Modulation of Polycystic Kidney Disease Severity by Phosphodiesterase 1 and 3 Subfamilies. J Am Soc Nephrol. 2016 May; 27 (5):1312-20 Epub 2015 Sept 15
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45. Kakkar V, Mansson C, de Mattos EP, Bergink S, van der Zwaag M, van Waarde MAWH, Kloosterhuis NJ, Melki R, van Cruchten RTP, Al-Karadaghi S, Arosio P, Dobson CM, Knowles TPJ, Bates GP, van Deursen JM, Linse S, van de Sluis B, Emanuelsson C, Kampinga HH. The S/T-Rich Motif in the DNAJB6 Chaperone Delays Polyglutamine Aggregation and the Onset of Disease in a Mouse Model. Mol Cell. 2016 Apr 21; 62 (2):272-283 Epub 2016 Apr 14
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46. Yamazaki Y, Baker DJ, Tachibana M, Liu CC, van Deursen JM, Brott TG, Bu G, Kanekiyo T. Vascular Cell Senescence Contributes to Blood-Brain Barrier Breakdown. Stroke. 2016 Apr; 47 (4):1068-77 Epub 2016 Feb 16
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47. Baker DJ, Childs BG, Durik M, Wijers ME, Sieben CJ, Zhong J, Saltness RA, Jeganathan KB, Verzosa GC, Pezeshki A, Khazaie K, Miller JD, van Deursen JM. Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan. Nature. 2016 Feb 11; 530 (7589):184-9 Epub 2016 Feb 03
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48. Kim TD, Jin F, Shin S, Oh S, Lightfoot SA, Grande JP, Johnson AJ, van Deursen JM, Wren JD, Janknecht R. Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1. J Clin Invest. 2016 Feb 1; 126: (2)706-20.
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49. Naylor RM, Jeganathan KB, Cao X, van Deursen JM. Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy. J Clin Invest. 2016 Feb 1; 126: (2)543-59.
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50. Giotopoulos G, Chan WI, Horton SJ, Ruau D, Gallipoli P, Fowler A, Crawley C, Papaemmanuil E, Campbell PJ, Gottgens B, Van Deursen JM, Cole PA, Huntly BJ. The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia. Oncogene. 2016 Jan 21; 35 (3):279-89 Epub 2015 Apr 20
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51. van Ree JH, Nam HJ, van Deursen JM. Mitotic kinase cascades orchestrating timely disjunction and movement of centrosomes maintain chromosomal stability and prevent cancer. Chromosome Res. 2016 Jan; 24 (1):67-76
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52. Childs BG, Durik M, Baker DJ, van Deursen JM. Cellular senescence in aging and age-related disease: from mechanisms to therapy. Nat Med. 2015 Dec; 21 (12):1424-35
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53. Li H, Koo Y, Mao X, Sifuentes-Dominguez L, Morris LL, Jia D, Miyata N, Faulkner RA, van Deursen JM, Vooijs M, Billadeau DD, van de Sluis B, Cleaver O, Burstein E. Endosomal sorting of Notch receptors through COMMD9-dependent pathways modulates Notch signaling. J Cell Biol. 2015 Nov 9; 211 (3):605-17
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54. Lee SB, Kim JJ, Nam HJ, Gao B, Yin P, Qin B, Yi SY, Ham H, Evans D, Kim SH, Zhang J, Deng M, Liu T, Zhang H, Billadeau DD, Wang L, Giaime E, Shen J, Pang YP, Jen J, van Deursen JM, Lou Z. Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1. Mol Cell. 2015 Oct 1; 60 (1):21-34 Epub 2015 Sept 17
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55. Cannon MV, Sillje HH, Sijbesma JW, Vreeswijk-Baudoin I, Ciapaite J, van der Sluis B, van Deursen J, Silva GJ, de Windt LJ, Gustafsson JA, van der Harst P, van Gilst WH, de Boer RA. Cardiac LXRalpha protects against pathological cardiac hypertrophy and dysfunction by enhancing glucose uptake and utilization. EMBO Mol Med. 2015 Sep; 7 (9):1229-43
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56. Smeets CJ, Jezierska J, Watanabe H, Duarri A, Fokkens MR, Meijer M, Zhou Q, Yakovleva T, Boddeke E, den Dunnen W, van Deursen J, Bakalkin G, Kampinga HH, van de Sluis B, Verbeek DS. Elevated mutant dynorphin A causes Purkinje cell loss and motor dysfunction in spinocerebellar ataxia type 23. Brain. 2015 Sep; 138 (Pt 9):2537-52 Epub 2015 July 12
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57. van Deursen J, Powell K. Jan van Deursen: From knockout pioneer to antiaging innovator. J Cell Biol. 2015 Aug 3; 210: (3)366-7.
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58. Touati SA, Buffin E, Cladiere D, Hached K, Rachez C, van Deursen JM, Wassmann K. Mouse oocytes depend on BubR1 for proper chromosome segregation but not for prophase I arrest. Nat Commun. 2015 Apr 21; 6:6946
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59. Dhanasekaran R, Nakamura I, Hu C, Chen G, Oseini AM, Seven ES, Miamen AG, Moser CD, Zhou W, van Kuppevelt TH, van Deursen JM, Mounajjed T, Fernandez-Zapico ME, Roberts LR. Activation of the transforming growth factor-beta/SMAD transcriptional pathway underlies a novel tumor-promoting role of sulfatase 1 in hepatocellular carcinoma. Hepatology. 2015 Apr; 61 (4):1269-83 Epub 2015 Feb 13
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60. Nam HJ, Naylor RM, van Deursen JM. Centrosome dynamics as a source of chromosomal instability. Trends Cell Biol. 2015 Feb; 25 (2):65-73 Epub 2014 Nov 07
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61. Luo L, Zhu G, Xu H, Yao S, Zhou G, Zhu Y, Tamada K, Huang L, Flies AD, Broadwater M, Ruff W, van Deursen JM, Melero I, Zhu Z, Chen L. B7-H3 Promotes Pathogenesis of Autoimmune Disease and Inflammation by Regulating the Activity of Different T Cell Subsets. PLoS One. 2015; 10 (6):e0130126 Epub 2015 June 11
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62. Maskey RS, Kim MS, Baker DJ, Childs B, Malureanu LA, Jeganathan KB, van Deursen JM, Machida YJ. Spartan deficiency causes genomic instability and progeroid phenotypes. Nat Commun. 2014 Dec 11; 5:5744
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63. Childs BG, Baker DJ, Kirkland JL, Campisi J, van Deursen JM. Senescence and apoptosis: dueling or complementary cell fates? EMBO Rep. 2014 Nov; 15 (11):1139-53 Epub 2014 Oct 13
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64. North BJ, Rosenberg MA, Jeganathan KB, Hafner AV, Michan S, Dai J, Baker DJ, Cen Y, Wu LE, Sauve AA, van Deursen JM, Rosenzweig A, Sinclair DA. SIRT2 induces the checkpoint kinase BubR1 to increase lifespan. EMBO J. 2014 Jul 1; 33 (13):1438-53 Epub 2014 May 12
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65. Nam HJ, van Deursen JM. Cyclin B2 and p53 control proper timing of centrosome separation. Nat Cell Biol. 2014 Jun; 16 (6):538-49 Epub 2014 Apr 28
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66. van Deursen JM. The role of senescent cells in ageing. Nature. 2014 May 22; 509 (7501):439-46
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67. Ding L, Chen S, Liu P, Pan Y, Zhong J, Regan KM, Wang L, Yu C, Rizzardi A, Cheng L, Zhang J, Schmechel SC, Cheville JC, Van Deursen J, Tindall DJ, Huang H. CBP loss cooperates with PTEN haploinsufficiency to drive prostate cancer: implications for epigenetic therapy. Cancer Res. 2014 Apr 1; 74 (7):2050-61 Epub 2014 Feb 03
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68. Zhong J, Ding L, Bohrer LR, Pan Y, Liu P, Zhang J, Sebo TJ, Karnes RJ, Tindall DJ, van Deursen J, Huang H. p300 acetyltransferase regulates androgen receptor degradation and PTEN-deficient prostate tumorigenesis. Cancer Res. 2014 Mar 15; 74 (6):1870-1880 Epub 2014 Jan 30
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69. Behrens A, van Deursen JM, Rudolph KL, Schumacher B. Impact of genomic damage and ageing on stem cell function. Nat Cell Biol. 2014 Mar; 16 (3):201-7
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70. Meehan AM, Saenz DT, Guevera R, Morrison JH, Peretz M, Fadel HJ, Hamada M, van Deursen J, Poeschla EM. A cyclophilin homology domain-independent role for Nup358 in HIV-1 infection. PLoS Pathog. 2014 Feb; 10 (2):e1003969 Epub 2014 Feb 20
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71. Mahmud H, Candido WM, van Genne L, Vreeswijk-Baudoin I, Yu H, van de Sluis B, van Deursen J, van Gilst WH, Sillje HH, de Boer RA. Cardiac function and architecture are maintained in a model of cardiorestricted overexpression of the prorenin-renin receptor. PLoS One. 2014; 9 (2):e89929 Epub 2014 Feb 25
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72. Baker DJ, Weaver RL, van Deursen JM. p21 both attenuates and drives senescence and aging in BubR1 progeroid mice. Cell Rep. 2013 Apr 25; 3 (4):1164-74 Epub 2013 Apr 18
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73. Sedivy JM, van Deursen JM. Why do we grow old: is it because our cells just wear out, we run out of cells (or both), and what can we do about it? Longev Healthspan. 2013 Apr 22; 2(1):7.
    
74. Ricke RM, van Deursen JM. Aneuploidy in health, disease, and aging. J Cell Biol. 2013 Apr 1; 201 (1):11-21
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75. Tchkonia T, Zhu Y, van Deursen J, Campisi J, Kirkland JL. Cellular senescence and the senescent secretory phenotype: therapeutic opportunities. J Clin Invest. 2013 Mar; 123 (3):966-72 Epub 2013 Mar 01
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76. Zanivan S, Meves A, Behrendt K, Schoof EM, Neilson LJ, Cox J, Tang HR, Kalna G, van Ree JH, van Deursen JM, Trempus CS, Machesky LM, Linding R, Wickstrom SA, Fassler R, Mann M. In vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis. Cell Rep. 2013 Feb 21; 3(2):552-66. Epub 2013 Jan 31.
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77. Naylor RM, Baker DJ, van Deursen JM. Senescent cells: a novel therapeutic target for aging and age-related diseases. Clin Pharmacol Ther. 2013 Jan; 93 (1):105-16 Epub 2012 Dec 05
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78. Baker DJ, Dawlaty MM, Wijshake T, Jeganathan KB, Malureanu L, van Ree JH, Crespo-Diaz R, Reyes S, Seaburg L, Shapiro V, Behfar A, Terzic A, van de Sluis B, van Deursen JM. Increased expression of BubR1 protects against aneuploidy and cancer and extends healthy lifespan. Nat Cell Biol. 2013 Jan; 15 (1):96-102 Epub 2012 Dec 16
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79. Ricke RM, Jeganathan KB, Malureanu L, Harrison AM, van Deursen JM. Bub1 kinase activity drives error correction and mitotic checkpoint control but not tumor suppression. J Cell Biol. 2012 Dec 10; 199 (6):931-49 Epub 2012 Dec 03
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80. Zhang Y, Foreman O, Wigle DA, Kosari F, Vasmatzis G, Salisbury JL, van Deursen J, Galardy PJ. USP44 regulates centrosome positioning to prevent aneuploidy and suppress tumorigenesis. J Clin Invest. 2012 Dec; 122 (12):4362-74 Epub 2012 Nov 26
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81. Hiddinga HJ, Sakagashira S, Ishigame M, Madde P, Sanke T, Nanjo K, Kudva YC, Lee JJ, van Deursen J, Eberhardt NL. Expression of wild-type and mutant S20G hIAPP in physiologic knock-in mouse models fails to induce islet amyloid formation, but induces mild glucose intolerance. J Diabetes Investig. 2012 Mar 28; 3 (2):138-47
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82. Ricke RM, van Deursen JM. Sgo1 as a "guardian spirit" for preventing colon tumorigenesis. Cell Cycle. 2012 Feb 15; 11(4). [Epub ahead of print]
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83. Madsen HB, Navaratnarajah S, Farrugia J, Djouma E, Ehrlich M, Mantamadiotis T, Van Deursen J, Lawrence AJ. CREB1 and CREB-binding protein in striatal medium spiny neurons regulate behavioural responses to psychostimulants. Psychopharmacology (Berl). 2012 Feb; 219(3):699-713.
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84. Wijshake T, Malureanu LA, Baker DJ, Jeganathan KB, van de Sluis B, van Deursen JM. Reduced life- and healthspan in mice carrying a mono-allelic BubR1 MVA mutation. PLoS Genet. 2012; 8 (12):e1003138 Epub 2012 Dec 27
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85. Hamada M, Malureanu LA, Wijshake T, Zhou W, van Deursen JM. Reprogramming to pluripotency can conceal somatic cell chromosomal instability. PLoS Genet. 2012; 8 (8):e1002913 Epub 2012 Aug 30
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86. Bakeberg JL, Tammachote R, Woollard JR, Hogan MC, Tuan HF, Li M, van Deursen JM, Wu Y, Huang BQ, Torres VE, Harris PC, Ward CJ. Epitope-tagged Pkhd1 tracks the processing, secretion, and localization of fibrocystin. J Am Soc Nephrol. 2011 Dec; 22 (12):2266-77 Epub 2011 Oct 21
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87. Chan WI, Hannah RL, Dawson MA, Pridans C, Foster D, Joshi A, Gottgens B, Van Deursen JM, Huntly BJ. The transcriptional coactivator Cbp regulates self-renewal and differentiation in adult hematopoietic stem cells. Mol Cell Biol. 2011 Dec; 31(24):5046-60. Epub 2011 Oct 17.
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88. Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B, Kirkland JL, van Deursen JM. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature. 2011 Nov 2; 479 (7372):232-6 Epub 2011 Nov 02
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89. Ricke RM, van Deursen JM. Aurora B hyperactivation by Bub1 overexpression promotes chromosome missegregation. Cell Cycle. 2011 Nov 1; 10 (21):3645-51 Epub 2011 Nov 01
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90. Chan KM, Zhang H, Malureanu L, van Deursen J, Zhang Z. Diverse factors are involved in maintaining X chromosome inactivation. Proc Natl Acad Sci U S A. 2011 Oct 4; 108 (40):16699-704 Epub 2011 Sept 21
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91. Hamada M, Haeger A, Jeganathan KB, van Ree JH, Malureanu L, Walde S, Joseph J, Kehlenbach RH, van Deursen JM. Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability. J Cell Biol. 2011 Aug 22; 194 (4):597-612
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92. Ricke RM, van Deursen JM. Correction of microtubule-kinetochore attachment errors: mechanisms and role in tumor suppression. Semin Cell Dev Biol. 2011 Aug; 22 (6):559-65 Epub 2011 Mar 23
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93. Ricke RM, Jeganathan KB, van Deursen JM. Bub1 overexpression induces aneuploidy and tumor formation through Aurora B kinase hyperactivation. J Cell Biol. 2011 Jun 13; 193 (6):1049-64 Epub 2011 June 06
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94. Zhang Y, van Deursen J, Galardy PJ. Overexpression of ubiquitin specific protease 44 (USP44) induces chromosomal instability and is frequently observed in human T-cell leukemia. PLoS One. 2011; 6 (8):e23389 Epub 2011 Aug 11
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95. van Ree J, Zhou W, Li M, van Deursen JM. Transgenesis in mouse embryonic stem cells. Methods Mol Biol. 2011; 693:143-62.
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96. Malureanu L, Jeganathan KB, Jin F, Baker DJ, van Ree JH, Gullon O, Chen Z, Henley JR, van Deursen JM. Cdc20 hypomorphic mice fail to counteract de novo synthesis of cyclin B1 in mitosis. J Cell Biol. 2010 Oct 18; 191 (2):313-29
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97. Tchkonia T, Morbeck DE, Von Zglinicki T, Van Deursen J, Lustgarten J, Scrable H, Khosla S, Jensen MD, Kirkland JL. Fat tissue, aging, and cellular senescence. Aging Cell. 2010 Oct; 9 (5):667-84 Epub 2010 Aug 15
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98. Jin F, Hamada M, Malureanu L, Jeganathan KB, Zhou W, Morbeck DE, van Deursen JM. Cdc20 is critical for meiosis I and fertility of female mice. PLoS Genet. 2010 Sep 30; 6 (9):e1001147 Epub 2010 Sept 30
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99. Chen G, Zou X, Watanabe H, van Deursen JM, Shen J. CREB binding protein is required for both short-term and long-term memory formation. J Neurosci. 2010 Sep 29; 30(39):13066-77.
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100. White TA, Johnson T, Zarzhevsky N, Tom C, Delacroix S, Holroyd EW, Maroney SA, Singh R, Pan S, Fay WP, van Deursen J, Mast AE, Sandhu GS, Simari RD. Endothelial-derived tissue factor pathway inhibitor regulates arterial thrombosis but is not required for development or hemostasis. Blood. 2010 Sep 9; 116 (10):1787-94 Epub 2010 June 01
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101. Hussain S, Foreman O, Perkins SL, Witzig TE, Miles RR, van Deursen J, Galardy PJ. The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling. Leukemia. 2010 Sep; 24 (9):1641-55 Epub 2010 June 24
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102. Li M, Fang X, Baker DJ, Guo L, Gao X, Wei Z, Han S, van Deursen, Zhang P. The ATM-p53 pathway suppresses aneuploidy-induced tumorigenesis. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14188-93. Epub 2010 Jul 27.
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103. Khwaja SS, Liu H, Tong C, Jin F, Pear WS, van Deursen J, Bram RJ. HIV-1 Rev-binding protein accelerates cellular uptake of iron to drive Notch-induced T cell leukemogenesis in mice. J Clin Invest. 2010 Jul; 120 (7):2537-48
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104. Baker DJ, van Deursen JM. Chromosome missegregation causes colon cancer by APC loss of heterozygosity. Cell Cycle. 2010 May; 9 (9):1711-6 Epub 2010 May 27
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105. Escande C, Chini CC, Nin V, Dykhouse KM, Novak CM, Levine J, van Deursen J, Gores GJ, Chen J, Lou Z, Chini EN. Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. J Clin Invest. 2010 Feb; 120 (2):545-58 Epub 2010 Jan 11
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106. van Ree JH, Jeganathan KB, Malureanu L, van Deursen JM. Overexpression of the E2 ubiquitin-conjugating enzyme UbcH10 causes chromosome missegregation and tumor formation. J Cell Biol. 2010 Jan 11; 188 (1):83-100
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107. Baker DJ, Jin F, Jeganathan KB, van Deursen JM. Whole chromosome instability caused by Bub1 insufficiency drives tumorigenesis through tumor suppressor gene loss of heterozygosity. Cancer Cell. 2009 Dec 8; 16 (6):475-86
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108. Shin S, Kim TD, Jin F, van Deursen JM, Dehm SM, Tindall DJ, Grande JP, Munz JM, Vasmatzis G, Janknecht R. Induction of prostatic intraepithelial neoplasia and modulation of androgen receptor by ETS variant 1/ETS-related protein 81. Cancer Res. 2009 Oct 15; 69(20):8102-10. Epub 2009 Sep 29
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109. Fukuyama T, Kasper LH, Boussouar F, Jeevan T, van Deursen J, Brindle PK. Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell development. Mol Cell Biol. 2009 Jul; 29(14):3894-904. Epub 2009 May 11.
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110. Liu Y, Malureanu L, Jeganathan KB, Tran DD, Lindquist LD, van Deursen JM, Bram RJ. CAML loss causes anaphase failure and chromosome missegregation. Cell Cycle. 2009 Mar 15; 8 (6):940-9 Epub 2009 Mar 26
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111. Zhu G, Augustine MM, Azuma T, Luo L, Yao S, Anand S, Rietz AC, Huang J, Xu H, Flies AS, Flies SJ, Tamada K, Colonna M, van Deursen JM, Chen L. B7-H4-deficient mice display augmented neutrophil-mediated innate immunity. Blood. 2009 Feb 19; 113(8):1759-67. Epub 2008 Dec 24.
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112. Malureanu LA, Jeganathan KB, Hamada M, Wasilewski L, Davenport J, van Deursen JM. BubR1 N terminus acts as a soluble inhibitor of cyclin B degradation by APC/C(Cdc20) in interphase. Dev Cell. 2009 Jan; 16 (1):118-31
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113. Chakraborty P, Wang Y, Wei JH, van Deursen J, Yu H, Malureanu L, Dasso M, Forbes DJ, Levy DE, Seemann J, Fontoura BM. Nucleoporin levels regulate cell cycle progression and phase-specific gene expression. Dev Cell. 2008 Nov; 15(5):657-67.
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114. Baker DJ, Jin F, van Deursen JM. The yin and yang of the Cdkn2a locus in senescence and aging. Cell Cycle. 2008 Sep 15; 7 (18):2795-802 Epub 2008 Sept 28
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115. Fu Z, Malureanu L, Huang J, Wang W, Li H, van Deursen JM, Tindall DJ, Chen J. Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression. Nat Cell Biol. 2008 Sep; 10 (9):1076-82
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116. Ricke RM, van Ree JH, van Deursen JM. Whole chromosome instability and cancer: a complex relationship. Trends Genet. 2008 Sep; 24 (9):457-66 Epub 2008 July 31
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117. Rensen SS, Niessen PM, van Deursen JM, Janssen BJ, Heijman E, Hermeling E, Meens M, Lie N, Gijbels MJ, Strijkers GJ, Doevendans PA, Hofker MH, De Mey JG, van Eys GJ. Smoothelin-B deficiency results in reduced arterial contractility, hypertension, and cardiac hypertrophy in mice. Circulation. 2008 Aug 19; 118(8):828-36. Epub 2008 Aug 04.
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118. Baker DJ, Perez-Terzic C, Jin F, Pitel KS, Niederlander NJ, Jeganathan K, Yamada S, Reyes S, Rowe L, Hiddinga HJ, Eberhardt NL, Terzic A, van Deursen JM. Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency. Nat Cell Biol. 2008 Jul; 10 (7):825-36 Epub 2008 May 30
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119. Huen MS, Sy SM, van Deursen JM, Chen J. Direct interaction between SET8 and proliferating cell nuclear antigen couples H4-K20 methylation with DNA replication. J Biol Chem. 2008 Apr 25; 283(17):11073-7. Epub 2008 Mar 03.
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120. Dawlaty MM, Malureanu L, Jeganathan KB, Kao E, Sustmann C, Tahk S, Shuai K, Grosschedl R, van Deursen JM. Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha. Cell. 2008 Apr 4; 133 (1):103-15
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121. Jeganathan K, Malureanu L, Baker DJ, Abraham SC, van Deursen JM. Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. J Cell Biol. 2007 Oct 22; 179 (2):255-67 Epub 2007 Oct 15
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122. Woollard JR, Punyashtiti R, Richardson S, Masyuk TV, Whelan S, Huang BQ, Lager DJ, vanDeursen J, Torres VE, Gattone VH, LaRusso NF, Harris PC, Ward CJ. A mouse model of autosomal recessive polycystic kidney disease with biliary duct and proximal tubule dilatation. Kidney Int. 2007 Aug; 72(3):328-36. Epub 2007 May 23.
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123. Hartman TK, Wengenack TM, Poduslo JF, van Deursen JM. Mutant mice with small amounts of BubR1 display accelerated age-related gliosis. Neurobiol Aging. 2007 Jun; 28 (6):921-7 Epub 2006 June 15
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124. Matsumoto T, Baker DJ, d'Uscio LV, Mozammel G, Katusic ZS, van Deursen JM. Aging-associated vascular phenotype in mutant mice with low levels of BubR1. Stroke. 2007 Mar; 38: (3)1050-6.
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125. Baker DJ, Dawlaty MM, Galardy P, van Deursen JM. Mitotic regulation of the anaphase-promoting complex. Cell Mol Life Sci. 2007 Mar; 64: (5)589-600.
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126. Satterly N, Tsai PL, van Deursen J, Nussenzveig DR, Wang Y, Faria PA, Levay A, Levy DE, Fontoura BMA. Influenza virus targets the mRNA export machinery and the nuclear pore complex. Proc Natl Acad Sci U S A. 2007 Feb 6; 104(6):1853-8. Epub 2007 Jan 31.
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127. Dawlaty MM, van Deursen JM. Gene targeting methods for studying nuclear transport factors in mice. Methods. 2006 Aug; 39(4):370-8.
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128. Jeganathan KB, van Deursen JM. Differential mitotic checkpoint protein requirements in somatic and germ cells. Biochem Soc Trans. 2006 Aug; 34(Pt 4):583-6.
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129. Xu W, Fukuyama T, Ney PA, Wang D, Rehg J, Boyd K, van Deursen JM, Brindle PK. Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cells. Blood. 2006 Jun 1; 107(11):4407-16. Epub 2006 Jan 19.
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130. Baker DJ, Jeganathan KB, Malureanu L, Perez-Terzic C, Terzic A, van Deursen JM. Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice. J Cell Biol. 2006 Feb 13; 172 (4):529-40
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131. Sommer SL, Berndt TJ, Frank E, Patel JB, Redfield MM, Dong X, Griffin MD, Grande JP, van Deursen JM, Sieck GC, Romero JC, Kumar R. Elevated blood pressure and cardiac hypertrophy after ablation of the gly96/IEX-1 gene. J Appl Physiol (1985). 2006 Feb; 100: (2)707-16.
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132. Kasper LH, Fukuyama T, Biesen MA, Boussouar F, Tong C, de Pauw A, Murray PJ, van Deursen JM, Brindle PK. Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell development. Mol Cell Biol. 2006 Feb; 26(3):789-809.
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133. Jeganathan KB, Baker DJ, van Deursen JM. Securin associates with APCCdh1 in prometaphase but its destruction is delayed by Rae1 and Nup98 until the metaphase/anaphase transition. Cell Cycle. 2006 Feb; 5: (4)366-70.
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134. Lou Z, Minter-Dykhouse K, Franco S, Gostissa M, Rivera MA, Celeste A, Manis JP, van Deursen J, Nussenzweig A, Paull TT, Alt FW, Chen J. MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell. 2006 Jan 20; 21(2):187-200.
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135. Graham DB, Bell MP, McCausland MM, Huntoon CJ, van Deursen J, Faubion WA, Crotty S, McKean DJ. Ly9 (CD229)-deficient mice exhibit T cell defects yet do not share several phenotypic characteristics associated with SLAM- and SAP-deficient mice. J Immunol. 2006 Jan 1; 176 (1):291-300
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136. Jeganathan KB, Malureanu L, van Deursen JM. The Rae1-Nup98 complex prevents aneuploidy by inhibiting securin degradation. Nature. 2005 Dec 15; 438: (7070)1036-9.
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137. Baker DJ, Chen J, van Deursen JM. The mitotic checkpoint in cancer and aging: what have mice taught us? Curr Opin Cell Biol. 2005 Dec; 17 (6):583-9 Epub 2005 Oct 13
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138. Niessen P, Rensen S, Van Deursen J, De Man J, De Laet A, Vanderwinden JM, Wedel T, Baker D, Doevendans P, Hofker M, Gijbels M, Van Eys G. Smoothelin-A is essential for functional intestinal smooth muscle contractility in mice. Gastroenterology. 2005 Nov; 129(5):1592-601.
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139. Tran DD, Edgar CE, Heckman KL, Sutor SL, Huntoon CJ, van Deursen J, McKean DL, Bram RJ. CAML is a p56Lck-interacting protein that is required for thymocyte development. Immunity. 2005 Aug; 23(2):139-52.
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140. Ward R, Johnson M, Shridhar V, van Deursen J, Couch FJ. CBP truncating mutations in ovarian cancer. J Med Genet. 2005 Jun; 42(6):514-8.
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141. Yu X, Minter-Dykhouse K, Malureanu L, Zhao WM, Zhang D, Merkle CJ, Ward IM, Saya H, Fang G, van Deursen J, Chen J. Chfr is required for tumor suppression and Aurora A regulation. Nat Genet. 2005 Apr; 37 (4):401-6 Epub 2005 Mar 27
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142. Juneja SC, van Deursen JM. A mouse model of familial oligoasthenoteratozoospermia. Hum Reprod. 2005 Apr; 20(4):881-93.
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143. Subramaniam M, Gorny G, Johnsen SA, Monroe DG, Evans GL, Fraser DG, Rickard DJ, Rasmussen K, van Deursen JM, Turner RT, Oursler MJ, Spelsberg TC. TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro. Mol Cell Biol. 2005 Feb; 25 (3):1191-9
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144. Huang H, Regan KM, Wang F, Wang D, Smith DI, van Deursen JM, Tindall DJ. Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation. Proc Natl Acad Sci U S A. 2005 Feb 1; 102 (5):1649-54 Epub 2005 Jan 24
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145. Faria PA, Chakraborty P, Levay A, Barber GN, Ezelle HJ, Enninga J, Arana C, van Deursen J, Fontoura BMA. VSV disrupts the Rae1/mrnp41 mRNA nuclear export pathway. Mol Cell. 2005 Jan 7; 17(1):93-102.
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146. Baker DJ, Jeganathan KB, Cameron JD, Thompson M, Juneja S, Kopecka A, Kumar R, Jenkins RB, de Groen PC, Roche P, van Deursen JM. BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat Genet. 2004 Jul; 36: (7)744-9.
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147. Selleri L, DiMartino J, van Deursen J, Brendolan A, Sanyal M, Boon E, Capellini T, Smith KS, Rhee J, Popperl H, Grosveld G, Cleary ML. The TALE homeodomain protein pbx2 is not essential for development and long-term survival. Mol Cell Biol. 2004 Jun; 24(12):5324-31.
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148. Kierszenbaum AL, Tres LL, Rivkin E, Kang-Decker N, van Deursen JM. The acroplaxome is the docking site of Golgi-derived myosin Va/Rab27a/b- containing proacrosomal vesicles in wild-type and Hrb mutant mouse spermatids. Biol Reprod. 2004 May; 70(5):1400-10 Epub 2004 Jan 14.
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149. Conover CA, Bale LK, Overgaard MT, Johnstone EW, Laursen UH, Fuchtbauer EM, Oxvig C, van Deursen J. Metalloproteinase pregnancy-associated plasma protein A is a critical growth regulatory factor during fetal development. Development. 2004 Mar; 131(5):1187-94.
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150. Dong H, Zhu G, Tamada K, Flies DB, van Deursen JM, Chen L. B7-H1 determines accumulation and deletion of intrahepatic CD8(+) T lymphocytes. Immunity. 2004 Mar; 20 (3):327-36
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151. Kang-Decker N, Tong C, Boussouar F, Baker DJ, Xu W, Leontovich AA, Taylor WR, Brindle PK, van Deursen JM. Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency. Cancer Cell. 2004 Feb; 5 (2):177-89
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152. Tran DD, Russell HR, Sutor SL, van Deursen J, Bram RJ. CAML is required for efficient EGF receptor recycling. Dev Cell. 2003 Aug; 5 (2):245-56
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153. Ward IM, Minn K, van Deursen J, Chen J. p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice. Mol Cell Biol. 2003 Apr; 23 (7):2556-63
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154. Perez-Terzic C, Behfar A, Mery A, van Deursen JMA, Terzic A, Puceat M. Structural adaptation of the nuclear pore complex in stem cell-derived cardiomyocytes. Circ Res. 2003 Mar 7; 92(4):444-52.
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155. Babu JR, Jeganathan KB, Baker DJ, Wu X, Kang-Decker N, van Deursen JM. Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation. J Cell Biol. 2003 Feb 3; 160 (3):341-53 Epub 2003 Jan 27
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156. Liu ST, van Deursen JM, Yen TJ. The role of mitotic checkpoint in maintaining genomic stability. Curr Top Dev Biol. 2003; 58:27-51.
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157. van Deursen J. Gene targeting in mouse embryonic stem cells. Methods Mol Biol. 2003; 209:145-58
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158. Kasper LH, Boussouar F, Ney PA, Jackson CW, Rehg J, van Deursen JM, Brindle PK. A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis. Nature. 2002 Oct 17; 419(6908):738-43.
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159. Tamada K, Ni J, Zhu G, Fiscella M, Teng B, van Deursen JM, Chen L. Cutting edge: selective impairment of CD8+ T cell function in mice lacking the TNF superfamily member LIGHT. J Immunol. 2002 May 15; 168 (10):4832-5
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160. Kang-Decker N, Mantchev GT, Juneja SC, McNiven MA, van Deursen JM. Lack of acrosome formation in Hrb-deficient mice. Science. 2001 Nov 16; 294(5546):1531-3.
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161. Wang X, Babu JR, Harden JM, Jablonski SA, Gazi MH, Lingle WL, de Groen PC, Yen TJ, van Deursen JM. The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins. J Biol Chem. 2001 Jul 13; 276 (28):26559-67 Epub 2001 May 14
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162. von Bulow GU, van Deursen JM, Bram RJ. Regulation of the T-independent humoral response by TACI. Immunity. 2001 May; 14(5):573-82.
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163. Wu X, Kasper LH, Mantcheva RT, Mantchev GT, Springett MJ, van Deursen JM. Disruption of the FG nucleoporin NUP98 causes selective changes in nuclear pore complex stoichiometry and function. Proc Natl Acad Sci U S A. 2001 Mar 13; 98 (6):3191-6
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164. von Kobbe C, van Deursen JMA, Rodrigues JP, Sitterlin D, Bachi A, Wu XS, Wilm M, Carmo-Fonseca M, Izaurralde E. Vesicular stomatitis virus matrix protein inhibits host cell gene expression by targeting the nucleoporin NUP98. Mol Cell. 2000 Nov; 6(5):1243-1252.
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165. Zindy F, van Deursen J, Grosveld G, Sherr CJ, Roussel MF. INK4d-deficient mice are fertile despite testicular atrophy. Mol Cell Biol. 2000 Jan; 20(1):372-8.
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166. Brown MP, Nosaka T, Tripp RA, Brooks J, van Deursen JM, Brenner MK, Doherty PC, Ihle JN. Reconstitution of early lymphoid proliferation and immune function in Jak3-deficient mice by interleukin-3. Blood. 1999 Sep 15; 94(6):1906-14.
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167. Pritchard CE, Fornerod M, Kasper LH, van Deursen JM. RAE1 is a shuttling mRNA export factor that binds to a GLEBS-like NUP98 motif at the nuclear pore complex through multiple domains. J Cell Biol. 1999 Apr 19; 145(2):237-54.
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168. Moriggl R, Topham DJ, Teglund S, Sexl V, McKay C, Wang D, Hoffmeyer A, van Deursen J, Sangster MY, Bunting KD, Grosveld GC, Ihle JN. Stat5 is required for IL-2-induced cell cycle progression of peripheral T cells. Immunity. 1999 Feb; 10(2):249-59.
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169. Kasper LH, Brindle PK, Schnabel CA, Pritchard CE, Cleary ML, van Deursen JM. CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity. Mol Cell Biol. 1999 Jan; 19(1):764-76.
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170. Steeghs K, Oerlemans F, de Haan A, Heerschap A, Verdoodt L, de Bie M, Ruitenbeek W, Benders A, Jost C, van Deursen J, Tullson P, Terjung R, Jap P, Jacob W, Pette D, Wieringa B. Cytoarchitectural and metabolic adaptations in muscles with mitochondrial and cytosolic creatine kinase deficiencies. Mol Cell Biochem. 1998 Jul; 184(1-2):183-94.
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171. Teglund S, McKay C, Schuetz E, van Deursen JM, Stravopodis D, Wang D, Brown M, Bodner S, Grosveld G, Ihle JN. Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell. 1998 May 29; 93(5):841-50.
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172. Parganas E, Wang D, Stravopodis D, Topham DJ, Marine JC, Teglund S, Vanin EF, Bodner S, Colamonici OR, van Deursen JM, Grosveld G, Ihle JN. Jak2 is essential for signaling through a variety of cytokine receptors. Cell. 1998 May 1; 93(3):385-95.
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173. Martin F, van Deursen JM, Shivdasani RA, Jackson CW, Troutman AG, Ney PA. Erythroid maturation and globin gene expression in mice with combined deficiency of NF-E2 and nrf-2. Blood. 1998 May 1; 91(9):3459-66.
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174. Okuda T, Cai Z, Yang S, Lenny N, Lyu CJ, van Deursen JM, Harada H, Downing JR. Expression of a knocked-in AML1-ETO leukemia gene inhibits the establishment of normal definitive hematopoiesis and directly generates dysplastic hematopoietic progenitors. Blood. 1998 May 1; 91(9):3134-43.
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175. Boer JM, van Deursen JM, Croes HJ, Fransen JA, Grosveld GC. The nucleoporin CAN/Nup214 binds to both the cytoplasmic and the nucleoplasmic sides of the nuclear pore complex in overexpressing cells. Exp Cell Res. 1997 Apr 10; 232(1):182-5.
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176. Steeghs K, Benders A, Oerlemans F, de Haan A, Heerschap A, Ruitenbeek W, Jost C, van Deursen J, Perryman B, Pette D, Bruckwilder M, Koudijs J, Jap P, Veerkamp J, Wieringa B. Altered Ca2+ responses in muscles with combined mitochondrial and cytosolic creatine kinase deficiencies. Cell. 1997 Apr 4; 89(1):93-103.
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177. Fornerod M, van Deursen J, van Baal S, Reynolds A, Davis D, Murti KG, Fransen J, Grosveld G. The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88. EMBO J. 1997 Feb 17; 16(4):807-16.
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178. Steeghs K, Heerschap A, de Haan A, Ruitenbeek W, Oerlemans F, van Deursen J, Perryman B, Pette D, Bruckwilder M, Koudijs J, Jap P, Wieringa B. Use of gene targeting for compromising energy homeostasis in neuro-muscular tissues: the role of sarcomeric mitochondrial creatine kinase. J Neurosci Methods. 1997 Jan; 71(1):29-41.
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179. van Deursen J, Boer J, Kasper L, Grosveld G. G2 arrest and impaired nucleocytoplasmic transport in mouse embryos lacking the proto-oncogene CAN/Nup214. EMBO J. 1996 Oct 15; 15(20):5574-83.
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180. Thierfelder WE, van Deursen JM, Yamamoto K, Tripp RA, Sarawar SR, Carson RT, Sangster MY, Vignali DA, Doherty PC, Grosveld GC, Ihle JN. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature. 1996 Jul 11; 382(6587):171-4.
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181. Shimoda K, van Deursen J, Sangster MY, Sarawar SR, Carson RT, Tripp RA, Chu C, Quelle FW, Nosaka T, Vignali DA, Doherty PC, Grosveld G, Paul WE, Ihle JN. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature. 1996 Apr 18; 380(6575):630-3.
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182. Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR. AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell. 1996 Jan 26; 84(2):321-30.
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183. Nosaka T, van Deursen JM, Tripp RA, Thierfelder WE, Witthuhn BA, McMickle AP, Doherty PC, Grosveld GC, Ihle JN. Defective lymphoid development in mice lacking Jak3. Science. 1995 Nov 3; 270(5237):800-2.
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184. Veksler VI, Kuznetsov AV, Anflous K, Mateo P, van Deursen J, Wieringa B, Ventura-Clapier R. Muscle creatine kinase-deficient mice. II. Cardiac and skeletal muscles exhibit tissue-specific adaptation of the mitochondrial function. J Biol Chem. 1995 Aug 25; 270(34):19921-9.
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185. Ventura-Clapier R, Kuznetsov AV, d'Albis A, van Deursen J, Wieringa B, Veksler VI. Muscle creatine kinase-deficient mice. I. Alterations in myofibrillar function. J Biol Chem. 1995 Aug 25; 270(34):19914-20.
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186. Van Deursen J, Fornerod M, Van Rees B, Grosveld G. Cre-mediated site-specific translocation between nonhomologous mouse chromosomes. Proc Natl Acad Sci U S A. 1995 Aug 1; 92(16):7376-80.
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187. van Ree JH, Hofker MH, van den Broek WJ, van Deursen JM, van der Boom H, Frants RR, Wieringa B, Havekes LM. Increased response to cholesterol feeding in apolipoprotein C1-deficient mice. Biochem J. 1995 Feb 1; 305(Pt 3):905-11.
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188. van Deursen J, Ruitenbeek W, Heerschap A, Jap P, ter Laak H, Wieringa B. Creatine kinase (CK) in skeletal muscle energy metabolism: a study of mouse mutants with graded reduction in muscle CK expression. Proc Natl Acad Sci U S A. 1994 Sep 13; 91(19):9091-5.
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189. van Deursen J, Jap P, Heerschap A, ter Laak H, Ruitenbeek W, Wieringa B. Effects of the creatine analogue beta-guanidinopropionic acid on skeletal muscles of mice deficient in muscle creatine kinase. Biochim Biophys Acta. 1994 May 18; 1185(3):327-35.
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190. van Deursen J, Wieringa B. Approaching the multifaceted nature of energy metabolism: inactivation of the cytosolic creatine kinases via homologous recombination in mouse embryonic stem cells. Molecular & Cellular Biochemistry. 1994 Apr-May; 133-4, 263-74.
     
191. Oerlemans F, van den Broek W, van Deursen J, Wieringa B, Hendriks W. Van cellijn naar muizestam. Biotechniek. 1994; 33:33-6.
     
192. van Deursen J, Heerschap A, Oerlemans F, Ruitenbeek W, Jap P, ter Laak H, Wieringa B. Skeletal muscles of mice deficient in muscle creatine kinase lack burst activity. Cell. 1993 Aug 27; 74(4):621-31.
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193. van Deursen J, Wieringa B. Targeting of the creatine kinase M gene in embryonic stem cells using isogenic and nonisogenic vectors. Nucleic Acids Res. 1992 Aug 11; 20(15):3815-20.
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194. Stassen AP, Zaman GJ, van Deursen JM, Schoenmakers JG, Konings RN. Selection and characterization of randomly produced mutants of gene V protein of bacteriophage M13. Eur J Biochem. 1992 Mar 15; 204(3):1003-4.
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195. van Deursen J, Schepens J, Peters W, Meijer D, Grosveld G, Hendriks W, Wieringa B. Genetic variability of the murine creatine kinase B gene locus and related pseudogenes in different inbred strains of mice. Genomics. 1992 Feb; 12(2):340-9.
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196. van Deursen J, Lovell-Badge R, Oerlemans F, Schepens J, Wieringa B. Modulation of gene activity by consecutive gene targeting of one creatine kinase M allele in mouse embryonic stem cells. Nucleic Acids Res. 1991 May 25; 19(10):2637-43.
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197. Wieringa B, Steeghs K, Sistermans E, van Deursen J. De transgene muis ALS model voor erfelijke aandoeningen. Biotechniek. 1991; 30:6-9.
     
198. Fries HC, Lamers MB, van Deursen J, Ponnudurai T, Meuwissen JH. Biosynthesis of the 25-kDa protein in the macrogametes/zygotes of Plasmodium falciparum. Exp Parasitol. 1990 Aug; 71(2):229-35.
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199. Gorris LG, van Deursen JM, van der Drift C, Vogels GD. Biofilm development in laboratory methanogenic fluidized bed reactors. Biotechnol Bioeng. 1989 Feb 5; 33(6):687-93.
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200. Gorris LGM, van Deursen JMA, van der Drift C, Vogels GD. Inhibition of propionate degradation by acetate in methanogenic fluidized bed reactors. Biotechnol Lett. 1989; 11:61-66.
     
201. Gorris LGM, van Deursen JMA, van der Drift C, Vogels GD. Influence of wastewater composition on biofilm development in laboratory methanogenic fluidized bed reactors. Appl Microbiol Biotechnol. 1988; 29:95-102.
     
202. Vermeulen AN, van Deursen J, Brakenhoff RH, Lensen TH, Ponnudurai T, Meuwissen JH. Characterization of Plasmodium falciparum sexual stage antigens and their biosynthesis in synchronised gametocyte cultures. Molecular & Biochemical Parasitology. 1986 Aug; 20(2):155-63.
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