Publications

  1. Zhang Y, He L, Gundelach J, Ge A, Edlund H, Norlin S, Bram RJ. Tail Anchored protein insertion mediated by CAML and TRC40 links to neuromuscular function in mice. PLoS Genet. 2025 Jan; 21 (1):e1011547 Epub 2025 Jan 17
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  2. Zhang Y, Pignolo RJ, Bram RJ. Accelerated Aging in Cyclophilin B-Deficient Mice Downstream of p21-Cip1/Waf1. JBMR Plus. 2022 Oct; 6 (10):e10674 Epub 2022 Sept 09
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  3. Laffey KG, Stiles RJ, Ludescher MJ, Davis TR, Khwaja SS, Bram RJ, Wettstein PJ, Ramachandran V, Parks CA, Reyes EE, Ferrer A, Canfield JM, Johnson CE, Hammer RD, Gil D, Schrum AG. Early expression of mature alphabeta TCR in CD4(-)CD8(-) T cell progenitors enables MHC to drive development of T-ALL bearing NOTCH mutations. Proc Natl Acad Sci U S A. 2022 Jul 5; 119 (27):e2118529119 Epub 2022 June 29
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  4. Schuelke MR, Gundelach JH, Coffey M, West E, Scott K, Johnson DR, Samson A, Melcher A, Vile RG, Bram RJ. Phase I trial of sargramostim/pelareorep therapy in pediatric patients with recurrent or refractory high-grade brain tumors. Neurooncol Adv. 2022 Jan-Dec; 4 (1):vdac085 Epub 2022 June 17
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  5. de Mattos Barbosa MG, Lefferts AR, Huynh D, Liu H, Zhang Y, Fu B, Barnes J, Samaniego M, Bram RJ, Geha RS, Shikanov A, Prak ETL, Farkash EA, Platt JL, Cascalho M. TNFRSF13B genotypes control immune-mediated pathology by regulating the functions of innate B cells. JCI Insight. 2021 Sep 8; 6 (17) Epub 2021 Sept 08
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  6. Platt JL, de Mattos Barbosa MG, Huynh D, Lefferts AR, Katta J, Kharas C, Freddolino P, Bassis CM, Wobus C, Geha R, Bram R, Nunez G, Kamada N, Cascalho M. TNFRSF13B polymorphisms counter microbial adaptation to enteric IgA. JCI Insight. 2021 Jul 22; 6 (14) Epub 2021 July 22
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  7. Grasset EK, Chorny A, Casas-Recasens S, Gutzeit C, Bongers G, Thomsen I, Chen L, He Z, Matthews DB, Oropallo MA, Veeramreddy P, Uzzan M, Mortha A, Carrillo J, Reis BS, Ramanujam M, Sintes J, Magri G, Maglione PJ, Cunningham-Rundles C, Bram RJ, Faith J, Mehandru S, Pabst O, Cerutti A. Gut T cell-independent IgA responses to commensal bacteria require engagement of the TACI receptor on B cells. Sci Immunol. 2020 Jul 31; 5 (49)
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  8. Sarro E, Duran M, Rico A, Bou-Teen D, Fernandez-Majada V, Croatt AJ, Nath KA, Salcedo MT, Gundelach JH, Batlle D, Bram RJ, Meseguer A. Cyclophilins A and B oppositely regulate renal tubular epithelial cell phenotype. J Mol Cell Biol. 2020 Jul 1; 12 (7):499-514
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  9. Wyatt KD, Bram RJ. Immunotherapy in pediatric B-cell acute lymphoblastic leukemia. Hum Immunol. 2019 Jun; 80 (6):400-408 Epub 2019 Feb 01
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  10. Zhang Y, Gundelach J, Lindquist LD, Baker DJ, van Deursen J, Bram RJ. Chemotherapy-induced cellular senescence suppresses progression of Notch-driven T-ALL. PLoS One. 2019; 14 (10):e0224172 Epub 2019 Oct 29
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  11. Shing JC, Bram RJ. Yet another hump for CAML: support of cell survival independent of tail-anchored protein insertion. Cell Death Dis 2017 Jul 27; 8 (7):e2960 Epub 2017 July 27
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  12. Grausam KB, Dooyema SDR, Bihannic L, Premathilake H, Morrissy AS, Forget A, Schaefer AM, Gundelach JH, Macura S, Maher DM, Wang X, Heglin AH, Ge X, Zeng E, Puget S, Chandrasekar I, Surendran K, Bram RJ, Schuller U, Talyor MD, Ayrault O, Zhao H. ATOH1 Promotes Leptomeningeal Dissemination and Metastasis of Sonic Hedgehog Subgroup Medulloblastomas. Cancer Res. 2017 Jul 15; 77 (14):3766-3777 Epub 2017 May 10
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  13. Wang L, Gundelach JH, Bram RJ. Cycloheximide promotes paraptosis induced by inhibition of cyclophilins in glioblastoma multiforme. Cell Death Dis. 2017 May 18; 8 (5):e2807
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  14. Jabara HH, Lee JJ, Janssen E, Ullas S, Liadaki K, Garibyan L, Benson H, Sannikova T, Bram R, Hammarstrom L, Cruz AC, Siegel R, Manis J, Malley R, Geha RS. Heterozygosity for transmembrane activator and calcium modulator ligand interactor A144E causes haploinsufficiency and pneumococcal susceptibility in mice. J Allergy Clin Immunol. 2017 Apr; 139 (4):1293-1301.e4 Epub 2016 Sept 05
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  15. Ilett E, Kottke T, Thompson J, Rajani K, Zaidi S, Evgin L, Coffey M, Ralph C, Diaz R, Pandha H, Harrington K, Selby P, Bram R, Melcher A, Vile R. Prime-boost using separate oncolytic viruses in combination with checkpoint blockade improves anti-tumour therapy. Gene Ther. 2017 Jan; 24 (1):21-30 Epub 2016 Oct 25
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  16. Wang L, Gundelach JH, Bram RJ. Protein synthesis inhibition enhances paraptotic death induced by inhibition of cyclophilins in glioblastoma cells. Cancer Cell Microenviron. 2017; 4(3). Epub 2017 Oct 02.
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  17. Shing JC, Lindquist LD, Borgese N, Bram RJ. CAML mediates survival of Myc-induced lymphoma cells independent of tail-anchored protein insertion. Cell Death Discov. 2017; 3:16098 Epub 2017 May 29
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  18. Colombo SF, Cardani S, Maroli A, Vitiello A, Soffientini P, Crespi A, Bram RF, Benfante R, Borgese N. Tail-anchored Protein Insertion in Mammals: FUNCTION AND RECIPROCAL INTERACTIONS OF THE TWO SUBUNITS OF THE TRC40 RECEPTOR. J Biol Chem. 2016 Jul 15; 291 (29):15292-306 Epub 2016 May 23
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  19. Chan SL, Lindquist LD, Hansen MJ, Girtman MA, Pease LR, Bram RJ. Calcium-Modulating Cyclophilin Ligand Is Essential for the Survival of Activated T Cells and for Adaptive Immunity. J Immunol. 2015 Dec 15; 195 (12):5648-56 Epub 2015 Nov 11
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  20. Dickinson GS, Akkoyunlu M, Bram RJ, Alugupalli KR. BAFF receptor and TACI in B-1b cell maintenance and antibacterial responses. Ann N Y Acad Sci. 2015 Dec; 1362:57-67 Epub 2015 May 11
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  21. Shing JC, Choi JW, Chapman R, Schroeder MA, Sarkaria JN, Fauq A, Bram RJ. A novel synthetic 1,3-phenyl bis-thiourea compound targets microtubule polymerization to cause cancer cell death. Cancer Biol Ther. 2014 Jul; 15 (7):895-905 Epub 2014 Apr 22
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  22. Vogelaar JL, Loar RW, Bram RJ, Fischer PR, Kaushik R. Anasarca, hypoalbuminemia, and anemia: what is the correlation? Clin Pediatr (Phila). 2014 Jun; 53: (7)710-2.
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  23. Choi JW, Schroeder MA, Sarkaria JN, Bram RJ. Cyclophilin B supports Myc and mutant p53-dependent survival of glioblastoma multiforme cells. Cancer Res. 2014 Jan 15; 74 (2):484-96 Epub 2013 Nov 22
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  24. Tsuji S, Stein L, Kamada N, Nunez G, Bram R, Vallance BA, Sousa AE, Platt JL, Cascalho M. TACI deficiency enhances antibody avidity and clearance of an intestinal pathogen. J Clin Invest. 2014; 124(11):4857-66.
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  25. Uslu K, Coleman AS, Allman WR, Katsenelson N, Bram RJ, Alugupalli KR, Akkoyunlu M. Impaired B cell receptor signaling is responsible for reduced TACI expression and function in X-Linked immunodeficient mice. J Immunol. 2014; 192(8):3582-95.
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  26. Dickinson GS, Sun G, Bram RJ, Alugupalli KR. Efficient B cell responses to Borrelia hermsii infection depend on BAFF and BAFFR but not TACI. Infect Immun. 2014 Jan; 82(1):453-9. Epub 2013 Nov 11.
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  27. Lopez De Padilla CM, McNallan KT, Crowson CS, Bilgic H, Bram RJ, Hein MS, Ytterberg SR, Amin S, Peterson EJ, Baechler EC, Reed AM. BAFF expression correlates with idiopathic inflammatory myopathy disease activity measures and autoantibodies. J Rheumatol. 2013 Mar; 40(3):294-302. Epub 2013 Jan 15.
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  28. Gundelach JH, Madhavan AA, Wettstein PJ, Bram RJ. The anticancer drug Dp44mT inhibits T-cell activation and CD25 through a copper-dependent mechanism. FASEB J. 2013 Feb; 27(2):782-92. Epub 2012 Nov 07.
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  29. Hershko K, Simhadri VL, Blaisdell A, Hunt RC, Newell J, Tseng SC, Hershko AY, Choi JW, Sauna ZE, Wu A, Bram RJ, Komar AA, Kimchi-Sarfaty C. Cyclosporin A impairs the secretion and activity of ADAMTS13 (a disintegrin and metalloprotease with thrombospondin type 1 repeat). J Biol Chem. 2012 Dec 28; 287(53):44361-71. Epub 2012 Nov 09.
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  30. Bryda EC, Johnson NT, Ohlemiller KK, Besch-Williford CL, Moore E, Bram RJ. Conditional deletion of calcium-modulating cyclophilin ligand causes deafness in mice. Mamm Genome. 2012 Apr; 23(3-4):270-6. Epub 2011 Dec 15.
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  31. Zane NA, Gundelach JH, Lindquist LD, Bram RJ. Essential role for CAML in follicular B cell survival and homeostasis. J Immunol. 2012 Apr 1; 188 (7):3009-18 Epub 2012 Feb 20
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  32. Allen JL, Flick LM, Divanovic S, Jackson SW, Bram R, Rawlings DJ, Finkelman FD, Karp CL. Cutting edge: regulation of TLR4-driven B cell proliferation by RP105 is not B cell autonomous. J Immunol. 2012 Mar 1; 188(5):2065-9. Epub 2012 Jan 30.
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  33. Bram RJ, Laack NNI. Protons: Moving therapy for hodgkin lymphoma in a positive direction. ONCOLOGY (United States). 2012; 26(5).
  34. Tsuji S, Cortesao C, Bram RJ, Platt JL, Cascalho M. TACI deficiency impairs sustained Blimp-1 expression in B cells decreasing long-lived plasma cells in the bone marrow. Blood. 2011 Nov 24; 118(22):5832-9. Epub 2011 Oct 07.
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  35. Wolf AI, Mozdzanowska K, Quinn WJ 3rd, Metzgar M, Williams KL, Caton AJ, Meffre E, Bram RJ, Erickson LD, Allman D, Cancro MP, Erikson J. Protective antiviral antibody responses in a mouse model of influenza virus infection require TACI. J Clin Invest. 2011 Oct; 121(10):3954-64. Epub 2011 Sep 01.
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  36. Gor DO, Ding X, Li Q, Sultana D, Mambula SS, Bram RJ, Greenspan NS. Enhanced immunogenicity of pneumococcal surface adhesin A (PsaA) in mice via fusion to recombinant human B lymphocyte stimulator (BLyS). Biol Direct. 2011; 6:9. Epub 2011 Feb 09.
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  37. Lee JJ, Jabara HH, Garibyan L, Rauter I, Sannikova T, Dillon SR, Bram R, Geha RS. The C104R mutant impairs the function of transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) through haploinsufficiency. J Allergy Clin Immunol. 2010 Dec; 126(6):1234-41.e2.
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  38. Edgar CE, Lindquist LD, McKean DL, Strasser A, Bram RJ. CAML regulates Bim-dependent thymocyte death. Cell Death Differ. 2010 Oct; 17 (10):1566-76 Epub 2010 Mar 19
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  39. Khwaja SS, Liu H, Tong C, Jin F, Pear WS, van Deursen J, Bram RJ. HIV-1 Rev-binding protein accelerates cellular uptake of iron to drive Notch-induced T cell leukemogenesis in mice. J Clin Invest. 2010 Jul; 120 (7):2537-48
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  40. Choi JW, Sutor SL, Lindquist L, Evans GL, Madden BJ, Bergen HR 3rd, Hefferan TE, Yaszemski MJ, Bram RJ. Severe osteogenesis imperfecta in cyclophilin B-deficient mice. PLoS Genet. 2009 Dec; 5 (12):e1000750 Epub 2009 Dec 04
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  41. Lee JJ, Rauter I, Garibyan L, Ozcan E, Sannikova T, Dillon SR, Cruz AC, Siegel RM, Bram R, Jabara H, Geha RS. The murine equivalent of the A181E TACI mutation associated with common variable immunodeficiency severely impairs B-cell function. Blood. 2009 Sep 10; 114(11):2254-62. Epub 2009 Jul 15.
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  42. Ozcan E, Garibyan L, Lee JJ, Bram RJ, Lam KP, Geha RS. Transmembrane activator, calcium modulator, and cyclophilin ligand interactor drives plasma cell differentiation in LPS-activated B cells. J Allergy Clin Immunol. 2009 Jun; 123(6):1277-86.e5. Epub 2009 May 08.
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  43. Liu Y, Malureanu L, Jeganathan KB, Tran DD, Lindquist LD, van Deursen JM, Bram RJ. CAML loss causes anaphase failure and chromosome missegregation. Cell Cycle. 2009 Mar 15; 8 (6):940-9 Epub 2009 Mar 26
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  44. Kanswal S, Katsenelson N, Selvapandiyan A, Bram RJ, Akkoyunlu M. Deficient TACI expression on B lymphocytes of newborn mice leads to defective Ig secretion in response to BAFF or APRIL. J Immunol. 2008 Jul 15; 181(2):976-90.
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  45. Yuan X, Yao J, Norris D, Tran DD, Bram RJ, Chen G, Luscher B. Calcium-modulating cyclophilin ligand regulates membrane trafficking of postsynaptic GABA(A) receptors. Mol Cell Neurosci. 2008 Jun; 38(2):277-89. Epub 2008 Mar 13.
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  46. Mantchev GT, Cortesao CS, Rebrovich M, Cascalho M, Bram RJ. TACI is required for efficient plasma cell differentiation in response to T-independent type 2 antigens. J Immunol. 2007 Aug 15; 179 (4):2282-8
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  47. Treml LS, Carlesso G, Hoek KL, Stadanlick JE, Kambayashi T, Bram RJ, Cancro MP, Khan WN. TLR stimulation modifies BLyS receptor expression in follicular and marginal zone B cells. J Immunol. 2007 Jun 15; 178(12):7531-9.
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  48. Murali NS, Ackerman AW, Croatt AJ, Cheng J, Grande JP, Sutor SL, Bram RJ, Bren GD, Badley AD, Alam J, Nath KA. Renal upregulation of HO-1 reduces albumin-driven MCP-1 production: implications for chronic kidney disease. Am J Physiol Renal Physiol. 2007 Feb; 292 (2):F837-44 Epub 2006 Sept 12
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  49. Bischof D, Elsawa SF, Mantchev G, Yoon J, Michels GE, Nilson A, Sutor SL, Platt JL, Ansell SM, von Bulow G, Bram RJ. Selective activation of TACI by syndecan-2. Blood. 2006 Apr 15; 107 (8):3235-42 Epub 2005 Dec 15
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  50. Diaz-de-Durana Y, Mantchev GT, Bram RJ, Franco A. TACI-BLyS signaling via B-cell-dendritic cell cooperation is required for naive CD8+ T-cell priming in vivo. Blood. 2006 Jan 15; 107(2):594-601. Epub 2005 Sep 29.
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  51. Nagano J, Kitamura K, Hujer KM, Ward CJ, Bram RJ, Hopfer U, Tomita K, Huang CF, Miller RT. Fibrocystin interacts with CAML, a protein involved in Ca2+ signaling. Biochemical & Biophysical Research Communications. 2005 Dec 16; 338(2):880-9.
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  52. Seyler TM, Park YW, Takemura S, Bram RJ, Kurtin PJ, Goronzy JJ, Weyand CM. BLyS and APRIL in rheumatoid arthritis. J Clin Invest. 2005 Nov; 115(11):3083-92.
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  53. Tran DD, Edgar CE, Heckman KL, Sutor SL, Huntoon CJ, van Deursen J, McKean DL, Bram RJ. CAML is a p56Lck-interacting protein that is required for thymocyte development. Immunity. 2005 Aug; 23(2):139-52.
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  54. Castigli E, Wilson SA, Scott S, Dedeoglu F, Xu SL, Lam KP, Bram RJ, Jabara H, Geha RS. TACI and BAFF-R mediate isotype switching in B cells. J Exp Med. 2005 Jan 3; 201(1):35-9.
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  55. Novak AJ, Grote DM, Stenson M, Ziesmer SC, Witzig TE, Habermann TM, Harder B, Ristow KM, Bram RJ, Jelinek DF, Gross JA, Ansell SM. Expression of BLyS and its receptors in B-cell non-Hodgkin lymphoma: correlation with disease activity and patient outcome. Blood. 2004 Oct 15; 104 (8):2247-53 Epub 2004 July 13
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  56. O'Connor BP, Raman VS, Erickson LD, Cook WJ, Weaver LK, Ahonen C, Lin LL, Mantchev GT, Bram RJ, Noelle RJ. BCMA is essential for the survival of long-lived bone marrow plasma cells. J Exp Med. 2004 Jan 5; 199(1):91-7.
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  57. Tran DD, Russell HR, Sutor SL, van Deursen J, Bram RJ. CAML is required for efficient EGF receptor recycling. Dev Cell. 2003 Aug; 5 (2):245-56
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  58. Feng PH, Park J, Lee BS, Lee SH, Bram RJ, Jung JU. Kaposi's sarcoma-associated herpesvirus mitochondrial K7 protein targets a cellular calcium-modulating cyclophilin ligand to modulate intracellular calcium concentration and inhibit apoptosis. J Virol. 2002 Nov; 76(22):11491-504.
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  59. Novak AJ, Bram RJ, Kay NE, Jelinek DF. Aberrant expression of B-lymphocyte stimulator by B chronic lymphocytic leukemia cells: a mechanism for survival. Blood. 2002 Oct 15; 100 (8):2973-9
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  60. von Bulow GU, van Deursen JM, Bram RJ. Regulation of the T-independent humoral response by TACI. Immunity. 2001 May; 14 (5):573-82
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  61. Tovey SC, Bootman MD, Lipp P, Berridge MJ, Bram RJ. Calcium-modulating cyclophilin ligand desensitizes hormone-evoked calcium release. Biochem Biophys Res Commun. 2000 Sep 16; 276(1):97-100.
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  62. von Bulow GU, Russell H, Copeland NG, Gilbert DJ, Jenkins NA, Bram RJ. Molecular cloning and functional characterization of murine transmembrane activator and CAML interactor (TACI) with chromosomal localization in human and mouse. Mamm Genome. 2000 Aug; 11 (8):628-32
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  63. Holloway MP, Bram RJ. Co-localization of Calcium-Modulating cyclophilin Ligand (CAML) with intracellular calcium pools. Journal of Biological Chemistry. 1998; 273:16346-50.
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  64. von Bulow GU, Bram RJ. NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily. Science. 1997 Oct 3; 278(5335):138-41.
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  65. Bram RJ. Isolation of a cDNA encoding the chicken homologue of the human calcium-modulating cyclophilin ligand. Gene. 1996 Oct 3; 174(2):307-9.
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  66. Holloway MP, Bram RJ. A hydrophobic domain of Ca2+-modulating cyclophilin ligand modulates calcium influx signaling in T lymphocytes. J Biol Chem. 1996 Apr 12; 271(15):8549-52.
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  67. Bram RJ, Valentine V, Shapiro DN, Jenkins NA, Gilbert DJ, Copeland NG. The gene for calcium-modulating cyclophilin ligand (CAMLG) is located on human chromosome 5q23 and a syntenic region of mouse chromosome 13. Genomics. 1996 Jan 15; 31(2):257-60.
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  68. Serafini AT, Lewis RS, Clipstone NA, Bram RJ, Fanger C, Fiering S, Herzenberg LA, Crabtree GR. Isolation of mutant T lymphocytes with defects in capacitative calcium entry. Immunity. 1995 Aug; 3(2):239-50.
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  69. Bram RJ, Crabtree GR. Calcium signalling in T cells stimulated by a cyclophilin B-binding protein. Nature. 1994 Sep 22; 371(6495):355-8.
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  70. Bram RJ, Hung DT, Martin PK, Schreiber SL, Crabtree GR. Identification of the immunophilins capable of mediating inhibition of signal transduction by cyclosporin A and FK506: roles of calcineurin binding and cellular location. Mol Cell Biol. 1993 Aug; 13(8):4760-9.
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  71. Flanagan WM, Corthesy B, Bram RJ, Crabtree GR. Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A. Nature. 1991 Aug 29; 352(6338):803-7.
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  72. Eichler I, Joris L, Hsu YP, Van Wye J, Bram R, Moss R. Nonopsonic antibodies in cystic fibrosis. Pseudomonas aeruginosa lipopolysaccharide-specific immunoglobulin G antibodies from infected patient sera inhibit neutrophil oxidative responses. Journal of Clinical Investigation. 1989; 84(6):1794-804.
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  73. Bram RJ, Kornberg RD. Isolation of a Saccharomyces cerevisiae centromere DNA-binding protein, its human homolog, and its possible role as a transcription factor. Mol Cell Biol. 1987 Jan; 7(1):403-9.
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  74. Bram RJ, Lue NF, Kornberg RD. A GAL family of upstream activating sequences in yeast: roles in both induction and repression of transcription. EMBO J. 1986 Mar; 5(3):603-8.
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  75. Bram RJ, Kornberg RD. Specific protein binding to far upstream activating sequences in polymerase II promoters. Proc Natl Acad Sci U S A. 1985 Jan; 82(1):43-7.
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  76. Bram RJ, Young RA, Steitz JA. The ribonuclease III site flanking 23S sequences in the 30S ribosomal precursor RNA of E. coli. Cell. 1980 Feb; 19(2):393-401.
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