Publications

1. Dzikowski M, Pollin G, Gunia V, Butler S, Enkhtuul B, Chavez JG, Zimmermann MT, Mathison A, Urrutia R, Lomberk G. Prmt5 inhibition triggers functional atm deficiency and sensitizes pancreatic cancer to chk1 blockade. Frontiers in Cell and Developmental Biology. 2026 Mar 11; 14:1748541
   
2. Pollin G, Mathison AJ, Leverence EN, De Assuncao TM, Iovanna J, Hong JC, Zimmermann MT, Urrutia R, Lomberk G. Mutant KRAS Heterogeneity Shapes Nuclear Architecture During Pancreatic Cancer Initiation. Epigenomes. 2026 Mar 10; 10 (1)
   View PubMed
3. Hong J, Pham TX, Lee J, Raslan AA, Nicolas K, Sharov A, Meridew JA, Urrutia RA, Lomberk G, Huang SK, Ligresti G. Targeting the Epigenetic Regulator CBX5 Promotes Fibroblast Metabolic Reprogramming and Inhibits Lung Fibrosis. Am J Respir Cell Mol Biol. 2025 Jun; 72 (6):627-642
   View PubMed
4. Kim J, Zimmermann MT, Mathison AJ, Lomberk G, Urrutia R, Hong JC. Transcriptional Profiling Underscores the Role of Preprocurement Allograft Metabolism and Innate Immune Status on Outcomes in Human Liver Transplantation. Ann Surg Open. 2024 Jun; 5 (2):e444 Epub 2024 May 13
   View PubMed
5. Santofimia-Castano P, Fraunhoffer N, Liu X, Bessone IF, di Magliano MP, Audebert S, Camoin L, Estaras M, Breniere M, Modesti M, Lomberk G, Urrutia R, Soubeyran P, Neira JL, Iovanna J. Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in Kras(G12D)-driven tumors. EMBO Mol Med. 2024 Mar; 16 (3):475-505 Epub 2024 Feb 15
   View PubMed
6. Pollin G, Mathison AJ, de Assuncao TM, Thomas A, Zeighami A, Salmonson A, Liu H, Urrutia G, Vankayala P, Pandol SJ, Hong JC, Zimmermann MT, Iovanna J, Jin VX, Urrutia R, Lomberk G. Ehmt2 inactivation in pancreatic epithelial cells shapes the transcriptional landscape and inflammation response of the whole pancreas. Front Genet. 2024; 15:1412767 Epub 2024 June 14
   View PubMed
7. Pollin G, De Assuncao TM, Doria Jorge S, Chi YI, Charlesworth MC, Madden B, Iovanna J, Zimmermann MT, Urrutia R, Lomberk G. Writers and readers of H3K9me2 form distinct protein networks during the cell cycle that include candidates for H3K9 mimicry. Biosci Rep. 2023 Oct 31; 43(10).
   View PubMed
8. Fraunhoffer NA, Moreno Vega AI, Abuelafia AM, Morvan M, Lebarbier E, Mary-Huard T, Zimmermann MT, Lomberk G, Urrutia R, Dusetti N, Blum Y, Nicolle R, Iovanna J. Priming therapy by targeting enhancer-initiated pathways in patient-derived pancreatic cancer cells. EBioMedicine. 2023 Jun; 92:104602 Epub 2023 May 04
   View PubMed
9. Yang Y, Bhargava D, Chen X, Zhou T, Dursuk G, Jiang W, Wang J, Zong Z, Katz SI, Lomberk GA, Urrutia RA, Katz JP. KLF5 and p53 comprise an incoherent feed-forward loop directing cell-fate decisions following stress. Cell Death Dis. 2023 May 2; 14 (5):299 Epub 2023 May 02
   View PubMed
10. Kim J, Zimmerman MA, Shin WY, Boettcher BT, Lee JS, Park JI, Ali M, Yang M, Mishra J, Hagen CE, McGraw JE, Mathison A, Woehlck HJ, Lomberk G, Camara AKS, Urrutia RA, Stowe DF, Hong JC. Effects of Subnormothermic Regulated Hepatic Reperfusion on Mitochondrial and Transcriptomic Profiles in a Porcine Model. Ann Surg. 2023 Feb 01; 277(2):e366-e375. Epub 2023 Jan 10.
    View PubMed
11. Ramos GP, Bamidele AO, Klatt EE, Sagstetter MR, Kurdi AT, Hamdan FH, Kosinsky RL, Gaballa JM, Nair A, Sun Z, Dasari S, Lanza IR, Rozeveld CN, Schott MB, Urrutia G, Westphal MS, Clarkson BD, Howe CL, Marietta EV, Luckey DH, Murray JA, Gonzalez M, Braga Neto MB, Gibbons HR, Smyrk TC, Johnsen S, Lomberk G, Faubion WA. G9a Modulates Lipid Metabolism in CD4 T Cells to Regulate Intestinal Inflammation. Gastroenterology. 2023 Feb; 164(2):256-271.e10. Epub 2022 Oct 20.
    View PubMed
12. Ratnasinghe BD, Haque N, Wagenknecht JB, Jensen DR, Valdivia Esparza GK, Leverence EN, Milech De Assuncao T, Mathison AJ, Lomberk G, Smith BC, Volkman BF, Urrutia R, Zimmermann MT. Beyond structural bioinformatics for genomics with dynamics characterization of an expanded KRAS mutational landscape. Comput Struct Biotechnol J. 2023; 21:4790-4803 Epub 2023 Oct 05
    View PubMed
13. Jorge SD, Chi YI, Mazaba JL, Haque N, Wagenknecht J, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R. Deep computational phenotyping of genomic variants impacting the SET domain of KMT2C reveal molecular mechanisms for their dysfunction. Front Genet. 2023; 14:1291307 Epub 2023 Nov 28
    View PubMed
14. Chi YI, Jorge SD, Jensen DR, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R. A multi-layered computational structural genomics approach enhances domain-specific interpretation of Kleefstra syndrome variants in EHMT1. Comput Struct Biotechnol J. 2023; 21:5249-5258 Epub 2023 Oct 13
    View PubMed
15. Fraunhoffer NA, Abuelafia AM, Bigonnet M, Gayet O, Roques J, Nicolle R, Lomberk G, Urrutia R, Dusetti N, Iovanna J. Multi-omics data integration and modeling unravels new mechanisms for pancreatic cancer and improves prognostic prediction. NPJ Precis Oncol. 2022 Aug 17; 6 (1):57
    View PubMed
16. Santofimia-Castano P, Huang C, Liu X, Xia Y, Audebert S, Camoin L, Peng L, Lomberk G, Urrutia R, Soubeyran P, Neira JL, Iovanna J. NUPR1 protects against hyperPARylation-dependent cell death. Commun Biol. 2022 Jul 22; 5 (1):732 Epub 2022 July 22
    View PubMed
17. Chi YI, Stodola TJ, De Assuncao TM, Leverence EN, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R. Structural bioinformatics enhances the interpretation of somatic mutations in KDM6A found in human cancers. Comput Struct Biotechnol J. 2022; 20:2200-2211 Epub 2022 Apr 28
    View PubMed
18. Stodola TJ, Chi YI, De Assuncao TM, Leverence EN, Tripathi S, Dsouza NR, Mathison AJ, Volkman BF, Smith BC, Lomberk G, Zimmermann MT, Urrutia R. Computational modeling reveals key molecular properties and dynamic behavior of disruptor of telomeric silencing 1-like (DOT1L) and partnering complexes involved in leukemogenesis. Proteins. 2022 Jan; 90 (1):282-298 Epub 2021 Sept 12
    View PubMed
19. Mathison AJ, Kerketta R, de Assuncao TM, Leverence E, Zeighami A, Urrutia G, Stodola TJ, di Magliano MP, Iovanna JL, Zimmermann MT, Lomberk G, Urrutia R. Kras(G12D) induces changes in chromatin territories that differentially impact early nuclear reprogramming in pancreatic cells. Genome Biol. 2021 Oct 14; 22 (1):289
    View PubMed
20. Kaoutari AE, Fraunhoffer NA, Hoare O, Teyssedou C, Soubeyran P, Gayet O, Roques J, Lomberk G, Urrutia R, Dusetti N, Iovanna J. Metabolomic profiling of pancreatic adenocarcinoma reveals key features driving clinical outcome and drug resistance. EBioMedicine. 2021 Apr; 66:103332 Epub 2021 Apr 13
    View PubMed
21. Chi YI, Stodola TJ, De Assuncao TM, Leverence EN, Tripathi S, Dsouza NR, Mathison AJ, Basel DG, Volkman BF, Smith BC, Lomberk G, Zimmermann MT, Urrutia R. Molecular mechanics and dynamic simulations of well-known Kabuki syndrome-associated KDM6A variants reveal putative mechanisms of dysfunction. Orphanet J Rare Dis. 2021 Feb 5; 16 (1):66 Epub 2021 Feb 05
    View PubMed
22. He L, Lomberk G. Collateral Victim or Rescue Worker?-The Role of Histone Methyltransferases in DNA Damage Repair and Their Targeting for Therapeutic Opportunities in Cancer. Front Cell Dev Biol. 2021; 9:735107 Epub 2021 Nov 16
    View PubMed
23. Zimmermann MT, Williams MM, Klee EW, Lomberk GA, Urrutia R. Modeling post-translational modifications and cancer-associated mutations that impact the heterochromatin protein 1alpha-importin alpha heterodimers. Proteins. 2019 Nov; 87 (11):904-916 Epub 2019 June 14
    View PubMed
24. Williams MM, Mathison AJ, Christensen T, Greipp PT, Knutson DL, Klee EW, Zimmermann MT, Iovanna J, Lomberk GA, Urrutia RA. Aurora kinase B-phosphorylated HP1alpha functions in chromosomal instability. Cell Cycle. 2019 Jun; 18 (12):1407-1421 Epub 2019 May 26
    View PubMed
25. Ligresti G, Caporarello N, Meridew JA, Jones DL, Tan Q, Choi KM, Haak AJ, Aravamudhan A, Roden AC, Prakash YS, Lomberk G, Urrutia RA, Tschumperlin DJ. CBX5/G9a/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis. JCI Insight. 2019 May 16; 5
    View PubMed
26. Bamidele AO, Svingen PA, Sagstetter MR, Sarmento OF, Gonzalez M, Braga Neto MB, Kugathasan S, Lomberk G, Urrutia RA, Faubion WA Jr. Disruption of FOXP3-EZH2 Interaction Represents a Pathobiological Mechanism in Intestinal Inflammation. Cell Mol Gastroenterol Hepatol. 2019; 7 (1):55-71 Epub 2018 Sept 14
    View PubMed
27. Martin-Mateos R, De Assuncao TM, Arab JP, Jalan-Sakrikar N, Yaqoob U, Greuter T, Verma VK, Mathison AJ, Cao S, Lomberk G, Mathurin P, Urrutia R, Huebert RC, Shah VH. Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-beta Dependent Hepatic Stellate Cell Activation and Liver Fibrosis. Cell Mol Gastroenterol Hepatol. 2019; 7 (1):197-209 Epub 2018 Sept 15
    View PubMed
28. Seo S, Mathison A, Grzenda A, Podratz J, Calvo E, Brimijoin S, Windebank A, Iovanna J, Lomberk G, Urrutia R. Mechanisms Underlying the Regulation of HP1gamma by the NGF-PKA Signaling Pathway. Sci Rep. 2018 Oct 10; 8 (1):15077
    View PubMed
29. Polonis K, Blackburn PR, Urrutia RA, Lomberk GA, Kruisselbrink T, Cousin MA, Boczek NJ, Hoppman NL, Babovic-Vuksanovic D, Klee EW, Pichurin PN. Co-occurrence of a maternally inherited DNMT3A duplication and a paternally inherited pathogenic variant in EZH2 in a child with growth retardation and severe short stature: atypical Weaver syndrome or evidence of a DNMT3A dosage effect? Cold Spring Harb Mol Case Stud. 2018 Aug; 4 (4) Epub 2018 Aug 01
    View PubMed
30. Lomberk G, Blum Y, Nicolle R, Nair A, Gaonkar KS, Marisa L, Mathison A, Sun Z, Yan H, Elarouci N, Armenoult L, Ayadi M, Ordog T, Lee JH, Oliver G, Klee E, Moutardier V, Gayet O, Bian B, Duconseil P, Gilabert M, Bigonnet M, Garcia S, Turrini O, Delpero JR, Giovannini M, Grandval P, Gasmi M, Secq V, De Reynies A, Dusetti N, Iovanna J, Urrutia R. Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes. Nat Commun. 2018 May 17; 9 (1):1978
    View PubMed
31. Marks DL, Olson RL, Urrutia R, Billadeau DD, Roy N, Calin GA, Fabbri M, Koutsioumpa M, Iliopoulos D, Ordog T, Huebert R, Sarmento O, Bamidele AO, Faubion W, Lomberk GL, Siveke J, Ahuja N, Iovanna J, Hlady RA, Robertson K, Kisiel J, Pin CL, Fernandez-Zapico ME. Epigenetics of gastrointestinal diseases: notes from a workshop. Epigenetics. 2018; 13 (4):449-457 Epub 2018 July 30
    View PubMed
32. Drinane MC, Yaqoob U, Yu H, Luo F, Greuter T, Arab JP, Kostallari E, Verma VK, Maiers J, De Assuncao TM, Simons M, Mukhopadhyay D, Kisseleva T, Brenner DA, Urrutia R, Lomberk G, Gao Y, Ligresti G, Tschumperlin DJ, Revzin A, Cao S, Shah VH. Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms. JCI Insight. 2017 Dec 21; 2 (24)
    View PubMed
33. Mathison A, Salmonson A, Missfeldt M, Bintz J, Williams M, Kossak S, Nair A, de Assuncao TM, Christensen T, Buttar N, Iovanna J, Huebert R, Lomberk G. Combined AURKA and H3K9 Methyltransferase Targeting Inhibits Cell Growth By Inducing Mitotic Catastrophe. Mol Cancer Res. 2017 Aug; 15 (8):984-997 Epub 2017 Apr 25
    View PubMed
34. Cousin MA, Zimmermann MT, Mathison AJ, Blackburn PR, Boczek NJ, Oliver GR, Lomberk GA, Urrutia RA, Deyle DR, Klee EW. Functional validation reveals the novel missense V419L variant in TGFBR2 associated with Loeys-Dietz syndrome (LDS) impairs canonical TGF-beta signaling. Cold Spring Harb Mol Case Stud. 2017 Jul; 3 (4) Epub 2017 July 05
    View PubMed
35. Bian B, Bigonnet M, Gayet O, Loncle C, Maignan A, Gilabert M, Moutardier V, Garcia S, Turrini O, Delpero JR, Giovannini M, Grandval P, Gasmi M, Ouaissi M, Secq V, Poizat F, Nicolle R, Blum Y, Marisa L, Rubis M, Raoul JL, Bradner JE, Qi J, Lomberk G, Urrutia R, Saul A, Dusetti N, Iovanna J. Gene expression profiling of patient-derived pancreatic cancer xenografts predicts sensitivity to the BET bromodomain inhibitor JQ1: implications for individualized medicine efforts. EMBO Mol Med. 2017 Apr; 9 (4):482-497
    View PubMed
36. Blackburn PR, Tischer A, Zimmermann MT, Kemppainen JL, Sastry S, Knight Johnson AE, Cousin MA, Boczek NJ, Oliver G, Misra VK, Gavrilova RH, Lomberk G, Auton M, Urrutia R, Klee EW. A Novel Kleefstra Syndrome-associated Variant That Affects the Conserved TPLX Motif within the Ankyrin Repeat of EHMT1 Leads to Abnormal Protein Folding. J Biol Chem. 2017 Mar 03; 292(9):3866-3876. Epub 2017 Jan 05.
    View PubMed
37. Blackburn PR, Williams M, Cousin MA, Boczek NJ, Beek GJ, Lomberk GA, Urrutia RA, Babovic-Vuksanovic D, Klee EW. A novel de novo frameshift deletion in EHMT1 in a patient with Kleefstra Syndrome results in decreased H3K9 dimethylation. Mol Genet Genomic Med. 2017 Mar; 5 (2):141-146 Epub 2017 Jan 26
    View PubMed
38. Kalinec GM, Lomberk G, Urrutia RA, Kalinec F. Resolution of Cochlear Inflammation: Novel Target for Preventing or Ameliorating Drug-, Noise- and Age-related Hearing Loss. Front Cell Neurosci. 2017; 11:192.
    View PubMed
39. Kozub MM, Carr RM, Lomberk GL, Fernandez-Zapico ME. LSD1, a double-edged sword, confers dynamic chromatin regulation but commonly promotes aberrant cell growth. F1000Res. 2017; 6:2016 Epub 2017 Nov 16
    View PubMed
40. Loncle C, Molejon MI, Lac S, Tellechea JI, Lomberk G, Gramatica L, Fernandez Zapico MF, Dusetti N, Urrutia R, Iovanna JL. The pancreatitis-associated protein VMP1, a key regulator of inducible autophagy, promotes Kras(G12D)-mediated pancreatic cancer initiation. Cell Death Dis. 2016 Jul 14; 7 (7):e2295 Epub 2016 July 14
    View PubMed
41. Lomberk GA, Iovanna J, Urrutia R. The promise of epigenomic therapeutics in pancreatic cancer. Epigenomics. 2016 Jun; 8 (6):831-42 Epub 2016 June 23
    View PubMed
42. Velez G, Lin M, Christensen T, Faubion WA, Lomberk G, Urrutia R. Evidence supporting a critical contribution of intrinsically disordered regions to the biochemical behavior of full-length human HP1gamma. J Mol Model. 2016 Jan; 22 (1):12 Epub 2015 Dec 17
    View PubMed
43. Jalan-Sakrikar N, De Assuncao TM, Lu J, Almada LL, Lomberk G, Fernandez-Zapico ME, Urrutia R, Huebert RC. Hedgehog Signaling Overcomes an EZH2-Dependent Epigenetic Barrier to Promote Cholangiocyte Expansion. PLoS One. 2016; 11 (12):e0168266 Epub 2016 Dec 09
    View PubMed
44. Lopez MB, Garcia MN, Grasso D, Bintz J, Molejon MI, Velez G, Lomberk G, Neira JL, Urrutia R, Iovanna J. Functional Characterization of Nupr1L, A Novel p53-Regulated Isoform of the High-Mobility Group (HMG)-Related Protumoral Protein Nupr1. J Cell Physiol. 2015 Dec; 230 (12):2936-50
    View PubMed
45. Papadakis KA, Krempski J, Svingen P, Xiong Y, Sarmento OF, Lomberk GA, Urrutia RA, Faubion WA. Kruppel-like factor KLF10 deficiency predisposes to colitis through colonic macrophage dysregulation. Am J Physiol Gastrointest Liver Physiol. 2015 Dec 1; 309 (11):G900-9 Epub 2015 Oct 15
    View PubMed
46. Grasso D, Bintz J, Lomberk G, Molejon MI, Loncle C, Garcia MN, Lopez MB, Urrutia R, Iovanna JL. Pivotal Role of the Chromatin Protein Nupr1 in Kras-Induced Senescence and Transformation. Sci Rep. 2015 Nov 30; 5:17549
    View PubMed
47. Loncle C, Bonjoch L, Folch-Puy E, Lopez-Millan MB, Lac S, Molejon MI, Chuluyan E, Cordelier P, Dubus P, Lomberk G, Urrutia R, Closa D, Iovanna JL. IL17 Functions through the Novel REG3beta-JAK2-STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer. Cancer Res. 2015 Nov 15; 75 (22):4852-62 Epub 2015 Sept 24
    View PubMed
48. Lomberk GA, Urrutia R. The Triple-Code Model for Pancreatic Cancer: Cross Talk Among Genetics, Epigenetics, and Nuclear Structure. Surg Clin North Am. 2015 Oct; 95 (5):935-52 Epub 2015 July 23
    View PubMed
49. Mathison A, Escande C, Calvo E, Seo S, White T, Salmonson A, Faubion WA Jr, Buttar N, Iovanna J, Lomberk G, Chini EN, Urrutia R. Phenotypic Characterization of Mice Carrying Homozygous Deletion of KLF11, a Gene in Which Mutations Cause Human Neonatal and MODY VII Diabetes. Endocrinology. 2015 Oct; 156 (10):3581-95 Epub 2015 Aug 06
    View PubMed
50. De Assuncao TM, Sun Y, Jalan-Sakrikar N, Drinane MC, Huang BQ, Li Y, Davila JI, Wang R, O'Hara SP, Lomberk GA, Urrutia RA, Ikeda Y, Huebert RC. Development and characterization of human-induced pluripotent stem cell-derived cholangiocytes. Lab Invest. 2015 Jun; 95 (6):684-96 Epub 2015 Apr 13
    View PubMed
51. Leonard PH, Grzenda A, Mathison A, Morbeck DE, Fredrickson JR, de Assuncao TM, Christensen T, Salisbury J, Calvo E, Iovanna J, Coddington CC, Urrutia R, Lomberk G. The Aurora A-HP1gamma pathway regulates gene expression and mitosis in cells from the sperm lineage. BMC Dev Biol. 2015 May 29; 15:23
    View PubMed
52. Harris S, Johnson S, Duncan JW, Udemgba C, Meyer JH, Albert PR, Lomberk G, Urrutia R, Ou XM, Stockmeier CA, Wang JM. Evidence revealing deregulation of the KLF11-MAO A pathway in association with chronic stress and depressive disorders. Neuropsychopharmacology. 2015 May; 40 (6):1373-82 Epub 2014 Dec 15
    View PubMed
53. Papadakis KA, Krempski J, Reiter J, Svingen P, Xiong Y, Sarmento OF, Huseby A, Johnson AJ, Lomberk GA, Urrutia RA, Faubion WA. Kruppel-like factor KLF10 regulates transforming growth factor receptor II expression and TGF-beta signaling in CD8+ T lymphocytes. Am J Physiol Cell Physiol. 2015 Mar 1; 308 (5):C362-71 Epub 2014 Dec 03
    View PubMed
54. Shire A, Lomberk G, Lai JP, Zou H, Tsuchiya N, Aderca I, Moser CD, Gulaid KH, Oseini A, Hu C, Warsame O, Jenkins RB, Roberts LR. Restoration of epigenetically silenced SULF1 expression by 5-aza-2-deoxycytidine sensitizes hepatocellular carcinoma cells to chemotherapy-induced apoptosis. Med Epigenet. 2015 Jan-Apr; 3 (1):1-18
    View PubMed
55. Grasso D, Garcia MN, Hamidi T, Cano C, Calvo E, Lomberk G, Urrutia R, Iovanna JL. Genetic inactivation of the pancreatitis-inducible gene Nupr1 impairs PanIN formation by modulating Kras(G12D)-induced senescence. Cell Death Differ. 2014 Oct; 21 (10):1633-41 Epub 2014 June 06
    View PubMed
56. Xiong Y, Svingen PA, Sarmento OO, Smyrk TC, Dave M, Khanna S, Lomberk GA, Urrutia RA, Faubion WA Jr. Differential coupling of KLF10 to Sin3-HDAC and PCAF regulates the inducibility of the FOXP3 gene. Am J Physiol Regul Integr Comp Physiol. 2014 Sep 15; 307 (6):R608-20 Epub 2014 June 18
    View PubMed
57. Urrutia R, Velez G, Lin M, Lomberk G, Neira JL, Iovanna J. Evidence supporting the existence of a NUPR1-like family of helix-loop-helix chromatin proteins related to, yet distinct from, AT hook-containing HMG proteins. J Mol Model. 2014 Aug; 20 (8):2357 Epub 2014 July 24
    View PubMed
58. de Assuncao TM, Lomberk G, Cao S, Yaqoob U, Mathison A, Simonetto DA, Huebert RC, Urrutia RA, Shah VH. New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids. J Biol Chem. 2014 May 30; 289 (22):15798-809 Epub 2014 Apr 23
    View PubMed
59. Calvo E, Grzenda A, Lomberk G, Mathison A, Iovanna J, Urrutia R. Single and combinatorial chromatin coupling events underlies the function of transcript factor Kruppel-like factor 11 in the regulation of gene networks. BMC Mol Biol. 2014 May 25; 15:10
    View PubMed
60. Ou XM, Udemgba C, Wang N, Dai X, Lomberk G, Seo S, Urrutia R, Wang J, Duncan J, Harris S, Fairbanks CA, Zhang X. Diabetes-causing gene, kruppel-like factor 11, modulates the antinociceptive response of chronic ethanol intake. Alcohol Clin Exp Res. 2014 Feb; 38(2):401-8. Epub 2014 Jan 15.
    View PubMed
61. Grasso D, Garcia MN, Hamidi T, Cano C, Calvo E, Lomberk G, Urrutia R, Iovanna JL. Pancreatitis promotes oncogenic Kras(G12D)-induced pancreatic transformation through activation of Nupr1. Mol Cell Oncol. 2014; 1 (1):e29913 Epub 2014 July 28
    View PubMed
62. Opyrchal M, Salisbury JL, Zhang S, McCubrey J, Hawse J, Goetz MP, Lomberk GA, Haddad T, Degnim A, Lange C, Ingle JN, Galanis E, D'Assoro AB. Aurora-A mitotic kinase induces endocrine resistance through down-regulation of ERalpha expression in initially ERalpha+ breast cancer cells. PLoS One. 2014; 9 (5):e96995 Epub 2014 May 09
    View PubMed
63. Gilabert M, Vaccaro MI, Fernandez-Zapico ME, Calvo EL, Turrini O, Secq V, Garcia S, Moutardier V, Lomberk G, Dusetti N, Urrutia R, Iovanna JL. Novel role of VMP1 as modifier of the pancreatic tumor cell response to chemotherapeutic drugs. J Cell Physiol. 2013 Sep; 228(9):1834-43.
    View PubMed
64. Grzenda A, Leonard P, Seo S, Mathison AJ, Urrutia G, Calvo E, Iovanna J, Urrutia R, Lomberk G. Functional impact of Aurora A-mediated phosphorylation of HP1gamma at serine 83 during cell cycle progression. Epigenetics Chromatin. 2013 Jul 5; 6 (1):21 Epub 2013 July 05
    View PubMed
65. Lomberk G, Grzenda A, Mathison A, Escande C, Zhang JS, Calvo E, Miller LJ, Iovanna J, Chini EN, Fernandez-Zapico ME, Urrutia R. Kruppel-like factor 11 regulates the expression of metabolic genes via an evolutionarily conserved protein interaction domain functionally disrupted in maturity onset diabetes of the young. J Biol Chem. 2013 Jun 14; 288 (24):17745-58 Epub 2013 Apr 15
    View PubMed
66. Seo S, Grzenda A, Lomberk G, Ou XM, Cruciani RA, Urrutia R. Epigenetics: a promising paradigm for better understanding and managing pain. J Pain. 2013 Jun; 14 (6):549-57 Epub 2013 Apr 19
    View PubMed
67. Grzenda A, Lomberk G, Svingen P, Mathison A, Calvo E, Iovanna J, Xiong Y, Faubion W, Urrutia R. Functional characterization of EZH2beta reveals the increased complexity of EZH2 isoforms involved in the regulation of mammalian gene expression. Epigenetics Chromatin. 2013 Feb 28; 6 (1):3
    View PubMed
68. McCleary-Wheeler AL, Lomberk GA, Weiss FU, Schneider G, Fabbri M, Poshusta TL, Dusetti NJ, Baumgart S, Iovanna JL, Ellenrieder V, Urrutia R, Fernandez-Zapico ME. Insights into the epigenetic mechanisms controlling pancreatic carcinogenesis. Cancer Lett. 2013 Jan 28; 328(2):212-21. Epub 2012 Oct 13.
    View PubMed
69. Hamidi T, Cano CE, Grasso D, Garcia MN, Sandi MJ, Calvo EL, Dagorn JC, Lomberk G, Goruppi S, Urrutia R, Carracedo A, Velasco G, Iovanna JL. NUPR1 works against the metabolic stress-induced autophagy-associated cell death in pancreatic cancer cells. Autophagy. 2013 Jan; 9(1):95-7. Epub 2012 Oct 09.
    View PubMed
70. Daftary GS, Zheng Y, Tabbaa ZM, Schoolmeester JK, Gada RP, Grzenda AL, Mathison AJ, Keeney GL, Lomberk GA, Urrutia R. A novel role of the Sp/KLF transcription factor KLF11 in arresting progression of endometriosis. PLoS One. 2013; 8 (3):e60165 Epub 2013 Mar 28
    View PubMed
71. Hayashi Y, Asuzu DT, Gibbons SJ, Aarsvold KH, Bardsley MR, Lomberk GA, Mathison AJ, Kendrick ML, Shen KR, Taguchi T, Gupta A, Rubin BP, Fletcher JA, Farrugia G, Urrutia RA, Ordog T. Membrane-to-nucleus signaling links insulin-like growth factor-1- and stem cell factor-activated pathways. PLoS One. 2013; 8 (10):e76822 Epub 2013 Oct 07
    View PubMed
72. Mathison A, Grzenda A, Lomberk G, Velez G, Buttar N, Tietz P, Hendrickson H, Liebl A, Xiong YY, Gores G, Fernandez-Zapico M, Larusso NF, Faubion W, Shah VH, Urrutia R. Role for Kruppel-like transcription factor 11 in mesenchymal cell function and fibrosis. PLoS One. 2013; 8 (9):e75311 Epub 2013 Sept 17
    View PubMed
73. Xiong Y, Khanna S, Grzenda AL, Sarmento OF, Svingen PA, Lomberk GA, Urrutia RA, Faubion WA Jr. Polycomb antagonizes p300/CREB-binding protein-associated factor to silence FOXP3 in a Kruppel-like factor-dependent manner. J Biol Chem. 2012 Oct 5; 287 (41):34372-85 Epub 2012 Aug 15
    View PubMed
74. Hamidi T, Cano CE, Grasso D, Garcia MN, Sandi MJ, Calvo EL, Dagorn JC, Lomberk G, Urrutia R, Goruppi S, Carracedo A, Velasco G, Iovanna JL. Nupr1-aurora kinase A pathway provides protection against metabolic stress-mediated autophagic-associated cell death. Clin Cancer Res. 2012 Oct 1; 18(19):5234-46. Epub 2012 Aug 16.
    View PubMed
75. Cano CE, Sandi MJ, Hamidi T, Calvo EL, Turrini O, Bartholin L, Loncle C, Secq V, Garcia S, Lomberk G, Kroemer G, Urrutia R, Iovanna JL. Homotypic cell cannibalism, a cell-death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer. EMBO Mol Med. 2012 Sep; 4(9):964-79. Epub 2012 Jul 23.
    View PubMed
76. Kitange GJ, Mladek AC, Carlson BL, Schroeder MA, Pokorny JL, Cen L, Decker PA, Wu W, Lomberk GA, Gupta SK, Urrutia RA, Sarkaria JN. Inhibition of histone deacetylation potentiates the evolution of acquired temozolomide resistance linked to MGMT upregulation in glioblastoma xenografts. Clin Cancer Res. 2012 Aug 1; 18 (15):4070-9 Epub 2012 June 06
    View PubMed
77. Grunewald M, Johnson S, Lu D, Wang Z, Lomberk G, Albert PR, Stockmeier CA, Meyer JH, Urrutia R, Miczek KA, Austin MC, Wang J, Paul IA, Woolverton WL, Seo S, Sittman DB, Ou XM. Mechanistic role for a novel glucocorticoid-KLF11 (TIEG2) protein pathway in stress-induced monoamine oxidase A expression. J Biol Chem. 2012 Jul 13; 287(29):24195-206. Epub 2012 May 24.
    View PubMed
78. Hamidi T, Algul H, Cano CE, Sandi MJ, Molejon MI, Riemann M, Calvo EL, Lomberk G, Dagorn JC, Weih F, Urrutia R, Schmid RM, Iovanna JL. Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis. J Clin Invest. 2012 Jun 1; 122(6):2092-103. Epub 2012 May 08.
    View PubMed
79. Seo S, Lomberk G, Mathison A, Buttar N, Podratz J, Calvo E, Iovanna J, Brimijoin S, Windebank A, Urrutia R. Krüppel-like factor 11 differentially couples to histone acetyltransferase and histone methyltransferase chromatin remodeling pathways to transcriptionally regulate dopamine D2 receptor in neuronal cells. J Biol Chem. 2012 Apr 13; 287(16):12723-35. Epub 2012 Feb 28.
    View PubMed
80. Lomberk G, Mathison AJ, Grzenda A, Seo S, DeMars CJ, Ilyas SI, Bonilla-Velez J, Calvo E, Fernandez-Zapico ME, Iovanna J, Buttar NS, Urrutia R. Sequence-specific recruitment of heterochromatin protein 1 via interaction with Kruppel-like factor 11, a human transcription factor involved in tumor suppression and metabolic diseases. J Biol Chem. 2012 Apr 13; 287 (16):13026-39 Epub 2012 Feb 08
    View PubMed
81. Daftary GS, Lomberk GA, Buttar NS, Allen TW, Grzenda A, Zhang J, Zheng Y, Mathison AJ, Gada RP, Calvo E, Iovanna JL, Billadeau DD, Prendergast FG, Urrutia R. Detailed structural-functional analysis of the Kruppel-like factor 16 (KLF16) transcription factor reveals novel mechanisms for silencing Sp/KLF sites involved in metabolism and endocrinology. J Biol Chem. 2012 Mar 2; 287 (10):7010-25 Epub 2011 Dec 27
    View PubMed
82. Singh SK, Baumgart S, Singh G, Konig AO, Reutlinger K, Hofbauer LC, Barth P, Gress TM, Lomberk G, Urrutia R, Fernandez-Zapico ME, Ellenrieder V. Disruption of a nuclear NFATc2 protein stabilization loop confers breast and pancreatic cancer growth suppression by zoledronic acid. J Biol Chem. 2011 Aug 19; 286 (33):28761-28771 Epub 2011 May 31
    View PubMed
83. Bonnefond A, Lomberk G, Buttar N, Busiah K, Vaillant E, Lobbens S, Yengo L, Dechaume A, Mignot B, Simon A, Scharfmann R, Neve B, Tanyolac S, Hodoglugil U, Pattou F, Cave H, Iovanna J, Stein R, Polak M, Vaxillaire M, Froguel P, Urrutia R. Disruption of a novel Kruppel-like transcription factor p300-regulated pathway for insulin biosynthesis revealed by studies of the c.-331 INS mutation found in neonatal diabetes mellitus. J Biol Chem. 2011 Aug 12; 286(32):28414-24. Epub 2011 May 18.
    View PubMed
84. Thabut D, Routray C, Lomberk G, Shergill U, Glaser K, Huebert R, Patel L, Masyuk T, Blechacz B, Vercnocke A, Ritman E, Ehman R, Urrutia R, Shah V. Complementary vascular and matrix regulatory pathways underlie the beneficial mechanism of action of sorafenib in liver fibrosis. Hepatology. 2011 Aug; 54 (2):573-85 Epub 2011 June 26
    View PubMed
85. Lomberk GA. Epigenetic silencing of tumor suppressor genes in pancreatic cancer. J Gastrointest Cancer. 2011 Jun; 42 (2):93-9
    View PubMed
86. Fernandez-Zapico ME, Lomberk GA, Tsuji S, DeMars CJ, Bardsley MR, Lin YH, Almada LL, Han JJ, Mukhopadhyay D, Ordog T, Buttar NS, Urrutia R. A functional family-wide screening of SP/KLF proteins identifies a subset of suppressors of KRAS-mediated cell growth. Biochem J. 2011 Apr 15; 435 (2):529-37
    View PubMed
87. Xiao TZ, Bhatia N, Urrutia R, Lomberk GA, Simpson A, Longley BJ. MAGE I transcription factors regulate KAP1 and KRAB domain zinc finger transcription factor mediated gene repression. PLoS One. 2011; 6(8):e23747. Epub 2011 Aug 18.
    View PubMed
88. Bardsley MR, Horvath VJ, Asuzu DT, Lorincz A, Redelman D, Hayashi Y, Popko LN, Young DL, Lomberk GA, Urrutia RA, Farrugia G, Rubin BP, Ordog T. Kitlow stem cells cause resistance to Kit/platelet-derived growth factor alpha inhibitors in murine gastrointestinal stromal tumors. Gastroenterology. 2010 Sep; 139 (3):942-52 Epub 2010 June 04
    View PubMed
89. Ilyas SI, Demars CJ, Comba A, Gainullin VG, Rizvi Z, Almada LL, Wang K, Lomberk G, Fernandez-Zapico ME, Buttar NS. Combinatorial chemoprevention reveals a novel smoothened-independent role of GLI1 in esophageal carcinogenesis. Cancer Res. 2010 Sep 1; 70 (17):6787-96 Epub 2010 July 20
    View PubMed
90. Buttar NS, DeMars CJ, Lomberk G, Ilyas SI, Bonilla-Velez J, Achra S, Rashtak S, Wang KK, Fernandez-Zapico ME, Urrutia R. Distinct role of Kruppel-like factor 11 in the regulation of prostaglandin E2 biosynthesis. J Biol Chem. 2010 Apr 9; 285 (15):11433-44 Epub 2010 Feb 12
    View PubMed
91. Lomberk G. Angiogenesis. Pancreatology. 2010; 10(2-3):112-3. Epub 2010 May 12.
    View PubMed
92. Lomberk G. The extracellular matrix and cell migration. Pancreatology. 2010; 10(1):4-5. Epub 2010 Mar 19.
    View PubMed
93. Lomberk GA, Imoto I, Gebelein B, Urrutia R, Cook TA. Conservation of the TGFbeta/Labial homeobox signaling loop in endoderm-derived cells between Drosophila and mammals. Pancreatology. 2010; 10 (1):74-84 Epub 2010 Mar 26
    View PubMed
94. Mathison A, Liebl A, Bharucha J, Mukhopadhyay D, Lomberk G, Shah V, Urrutia R. Pancreatic stellate cell models for transcriptional studies of desmoplasia-associated genes. Pancreatology. 2010; 10 (4):505-16 Epub 2010 Sept 16
    View PubMed
95. Grzenda A, Lomberk G, Zhang JS, Urrutia R. Sin3: master scaffold and transcriptional corepressor. Biochim Biophys Acta. 2009 Jun-Aug; 1789 (6-8):443-50 Epub 2009 June 06
    View PubMed
96. Truty MJ, Lomberk G, Fernandez-Zapico ME, Urrutia R. Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling. J Biol Chem. 2009 Mar 6; 284 (10):6291-300 Epub 2008 Dec 15
    View PubMed
97. Lomberk G. Microscopy. Pancreatology. 2009; 9(5):554-5. Epub 2009 Jun 28.
    View PubMed
98. Lomberk G. Diabetes. Pancreatology. 2009; 9: (3)200-2.
    View PubMed
99. Lomberk G. Lipid biology. Pancreatology. 2009; 9(6):722-3. Epub 2009 Dec 16.
    View PubMed
100. Lomberk G. Funding opportunities for rare pancreatic diseases. Pancreatology. 2009; 9(4):327-8. Epub 2009 May 20.
     View PubMed
101. Lomberk G. Educational websites--Bioinformatics Tools II. Pancreatology. 2009; 9(1-2):4-5. Epub 2008 Dec 12.
     View PubMed
102. Lomberk G, Urrutia R. Primers on molecular pathways--the insulin pathway. Pancreatology. 2009; 9(3):203-5. Epub 2009 Mar 20.
     View PubMed
103. Lomberk G, Urrutia R. Primers on molecular pathways--caspase pathway. Pancreatology. 2009; 9(1-2):6-8. Epub 2008 Dec 12.
     View PubMed
104. Lomberk G, Mathison AJ, Grzenda A, Urrutia R. The sunset of somatic genetics and the dawn of epigenetics: a new frontier in pancreatic cancer research. Curr Opin Gastroenterol. 2008 Sep; 24(5):597-602.
     View PubMed
105. Lomberk G. Pharmacogenomics. Pancreatology. 2008; 8(1):4-5. Epub 2008 Jan 31.
     View PubMed
106. Lomberk G. Patient advocacy. Pancreatology. 2008; 8(4-5):420-1. Epub 2008 Aug 20.
     View PubMed
107. Lomberk G. Pain management. Pancreatology. 2008; 8(6):542-3. Epub 2008 Sep 26.
     View PubMed
108. Lomberk G, Cruciani R, Urrutia R. Primers on molecular pathways--pain and opioid receptors, I. Pancreatology. 2008; 8(6):544-5. Epub 2008 Sep 26.
     View PubMed
109. Lomberk G, Urrutia R. Primers on molecular pathways--notch. Pancreatology. 2008; 8(2):103-4. Epub 2008 Apr 01.
     View PubMed
110. Lomberk G. Laboratory skills. Pancreatology. 2007; 7 (1):7-8 Epub 2007 Jan 25
     View PubMed
111. Lomberk G. Alcohol and pancreas. Pancreatology. 2007; 7 (2-3):96-7 Epub 2007 June 14
     View PubMed
112. Lomberk G. Epigenetics. Pancreatology. 2007; 7 (5-6):396-7 Epub 2007 Sept 25
     View PubMed
113. Lomberk G. Stem cells. Pancreatology. 2007; 7 (4):314-6 Epub 2007 July 11
     View PubMed
114. Lomberk G, Bensi D, Fernandez-Zapico ME, Urrutia R. Evidence for the existence of an HP1-mediated subcode within the histone code. Nat Cell Biol. 2006 Apr; 8 (4):407-15 Epub 2006 Mar 12
     View PubMed
115. Lomberk G. Animal models. Pancreatology. 2006; 6(5):427-8. Epub 2006 Jul 13.
     View PubMed
116. Lomberk G, Wallrath L, Urrutia R. The Heterochromatin Protein 1 family. Genome Biol. 2006; 7 (7):228
     View PubMed
117. Lomberk G, Urrutia R. The family feud: turning off Sp1 by Sp1-like KLF proteins. Biochem J. 2005 Nov 15; 392 (Pt 1):1-11
     View PubMed
118. Lomberk G, Fernandez-Zapico ME, Urrutia R. When developmental signaling pathways go wrong and their impact on pancreatic cancer development. Curr Opin Gastroenterol. 2005 Sep; 21 (5):555-60
     View PubMed
119. Fernandez-Zapico ME, Callahan G, Delgado S, Urrutia R. Expression profiling in pancreatic cancer research: the initial steps and the road ahead. Curr Opin Gastroenterol. 2003 Sep; 19 (5):467-72
     View PubMed
120. Denison SR, Callahan G, Becker NA, Phillips LA, Smith DI. Characterization of FRA6E and its potential role in autosomal recessive juvenile parkinsonism and ovarian cancer. Genes Chromosomes Cancer. 2003 Sep; 38: (1)40-52.
     View PubMed
121. Callahan G, Denison SR, Phillips LA, Shridhar V, Smith DI. Characterization of the common fragile site FRA9E and its potential role in ovarian cancer. Oncogene. 2003 Jan 30; 22(4):590-601.
     View PubMed
122. Huang H, Reed CP, Mordi A, Lomberk G, Wang L, Shridhar V, Hartmann L, Jenkins R, Smith DI. Frequent deletions within FRA7G at 7q31.2 in invasive epithelial ovarian cancer. Genes Chromosomes Cancer. 1999 Jan; 24(1):48-55.
     View PubMed