Publications

1. Yuan G, Yang S, Ng A, Fu C, Oursler MJ, Xing L, Yang S. RGS12 Is a Novel Critical NF-kappaB Activator in Inflammatory Arthritis. iScience. 2020 Jun 26; 23 (6):101172 Epub 2020 May 19
   View PubMed
2. Weivoda MM, Chew CK, Monroe DG, Farr JN, Atkinson EJ, Geske JR, Eckhardt B, Thicke B, Ruan M, Tweed AJ, McCready LK, Rizza RA, Matveyenko A, Kassem M, Andersen TL, Vella A, Drake MT, Clarke BL, Oursler MJ, Khosla S. Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism. Nat Commun. 2020 Jan 7; 11 (1):87 Epub 2020 Jan 07
   View PubMed
3. Ng AYH, Li Z, Jones MM, Yang S, Li C, Fu C, Tu C, Oursler MJ, Qu J, Yang S. Regulator of G protein signaling 12 enhances osteoclastogenesis by suppressing Nrf2-dependent antioxidant proteins to promote the generation of reactive oxygen species. Elife. 2019 Sep 6; 8 Epub 2019 Sept 06
   View PubMed
4. Mattson AM, Begun DL, Molstad DHH, Meyer MA, Oursler MJ, Westendorf JJ, Bradley EW. Deficiency in the phosphatase PHLPP1 suppresses osteoclast-mediated bone resorption and enhances bone formation in mice. J Biol Chem. 2019 Aug 2; 294 (31):11772-11784 Epub 2019 June 12
   View PubMed
5. Li Z, Liu T, Gilmore A, Gomez NM, Fu C, Lim J, Yang S, Mitchell CH, Li YP, Oursler MJ, Yang S. Regulator of G Protein Signaling Protein 12 (Rgs12) Controls Mouse Osteoblast Differentiation via Calcium Channel/Oscillation and Galphai-ERK Signaling. J Bone Miner Res. 2019 Apr; 34 (4):752-764 Epub 2019 Jan 28
   View PubMed
6. Ng AY, Tu C, Shen S, Xu D, Oursler MJ, Qu J, Yang S. Comparative Characterization of Osteoclasts Derived From Murine Bone Marrow Macrophages and RAW 264.7 Cells Using Quantitative Proteomics. JBMR Plus. 2018 Nov; 2 (6):328-340 Epub 2018 July 07
   View PubMed
7. Farr JN, Xu M, Weivoda MM, Monroe DG, Fraser DG, Onken JL, Negley BA, Sfeir JG, Ogrodnik MB, Hachfeld CM, LeBrasseur NK, Drake MT, Pignolo RJ, Pirtskhalava T, Tchkonia T, Oursler MJ, Kirkland JL, Khosla S. Targeting cellular senescence prevents age-related bone loss in mice. Nat Med. 2017 Sep; 23 (9):1072-1079 Epub 2017 Aug 21
   View PubMed
8. Drake MT, Clarke BL, Oursler MJ, Khosla S. Cathepsin K Inhibitors for Osteoporosis: Biology, Potential Clinical Utility, and Lessons Learned. Endocr Rev. 2017 Aug 1; 38 (4):325-350
   View PubMed
9. Weivoda MM, Youssef SJ, Oursler MJ. Sclerostin expression and functions beyond the osteocyte. Bone. 2017 Mar; 96:45-50 Epub 2016 Nov 23
   View PubMed
10. Carpio LR, Bradley EW, McGee-Lawrence ME, Weivoda MM, Poston DD, Dudakovic A, Xu M, Tchkonia T, Kirkland JL, van Wijnen AJ, Oursler MJ, Westendorf JJ. Histone deacetylase 3 supports endochondral bone formation by controlling cytokine signaling and matrix remodeling. Sci Signal. 2016 Aug 9; 9 (440):ra79 Epub 2016 Aug 09
    View PubMed
11. McGee-Lawrence ME, Carpio LR, Schulze RJ, Pierce JL, McNiven MA, Farr JN, Khosla S, Oursler MJ, Westendorf JJ. Hdac3 Deficiency Increases Marrow Adiposity and Induces Lipid Storage and Glucocorticoid Metabolism in Osteochondroprogenitor Cells. J Bone Miner Res. 2016 Jan; 31 (1):116-28 Epub 2015 Aug 20
    View PubMed
12. Weivoda MM, Ruan M, Hachfeld CM, Pederson L, Howe A, Davey RA, Zajac JD, Kobayashi Y, Williams BO, Westendorf JJ, Khosla S, Oursler MJ. Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways. J Bone Miner Res. 2016 Jan; 31 (1):65-75 Epub 2015 Aug 19
    View PubMed
13. Weivoda MM, Ruan M, Pederson L, Hachfeld C, Davey RA, Zajac JD, Westendorf JJ, Khosla S, Oursler MJ. Osteoclast TGF-beta Receptor Signaling Induces Wnt1 Secretion and Couples Bone Resorption to Bone Formation. J Bone Miner Res. 2016 Jan; 31 (1):76-85 Epub 2015 Aug 06
    View PubMed
14. Yuan X, Cao J, Liu T, Li YP, Scannapieco F, He X, Oursler MJ, Zhang X, Vacher J, Li C, Olson D, Yang S. Regulators of G protein signaling 12 promotes osteoclastogenesis in bone remodeling and pathological bone loss. Cell Death Differ. 2015 Dec; 22 (12):2046-57 Epub 2015 Apr 24
    View PubMed
15. Weivoda MM, Oursler MJ. Developments in sclerostin biology: regulation of gene expression, mechanisms of action, and physiological functions. Curr Osteoporos Rep. 2014 Mar; 12 (1):107-14
    View PubMed
16. Weivoda MM, Oursler MJ. The Roles of Small GTPases in Osteoclast Biology. Orthop Muscular Syst. 2014; 3
    View PubMed
17. Ota K, Quint P, Weivoda MM, Ruan M, Pederson L, Westendorf JJ, Khosla S, Oursler MJ. Transforming growth factor beta 1 induces CXCL16 and leukemia inhibitory factor expression in osteoclasts to modulate migration of osteoblast progenitors. Bone. 2013 Nov; 57 (1):68-75 Epub 2013 July 25
    View PubMed
18. Ota K, Quint P, Ruan M, Pederson L, Westendorf JJ, Khosla S, Oursler MJ. TGF-beta induces Wnt10b in osteoclasts from female mice to enhance coupling to osteoblasts. Endocrinology. 2013 Oct; 154 (10):3745-52 Epub 2013 July 16
    View PubMed
19. Ota K, Quint P, Ruan M, Pederson L, Westendorf JJ, Khosla S, Oursler MJ. Sclerostin is expressed in osteoclasts from aged mice and reduces osteoclast-mediated stimulation of mineralization. J Cell Biochem. 2013 Aug; 114 (8):1901-1907
    View PubMed
20. van Wijnen AJ, van de Peppel J, van Leeuwen JP, Lian JB, Stein GS, Westendorf JJ, Oursler MJ, Im HJ, Taipaleenmaki H, Hesse E, Riester S, Kakar S. MicroRNA functions in osteogenesis and dysfunctions in osteoporosis. Curr Osteoporos Rep. 2013 Jun; 11 (2):72-82
    View PubMed
21. Quint P, Ruan M, Pederson L, Kassem M, Westendorf JJ, Khosla S, Oursler MJ. Sphingosine 1-phosphate (S1P) receptors 1 and 2 coordinately induce mesenchymal cell migration through S1P activation of complementary kinase pathways. J Biol Chem. 2013 Feb 22; 288 (8):5398-406 Epub 2013 Jan 07
    View PubMed
22. Khosla S, Oursler MJ, Monroe DG. Estrogen and the skeleton. Trends Endocrinol Metab. 2012 Nov; 23 (11):576-81 Epub 2012 May 16
    View PubMed
23. Monroe DG, McGee-Lawrence ME, Oursler MJ, Westendorf JJ. Update on Wnt signaling in bone cell biology and bone disease. Gene. 2012 Jan 15; 492 (1):1-18 Epub 2011 Nov 03
    View PubMed
24. Kumar A, Ruan M, Clifton K, Syed F, Khosla S, Oursler MJ. TGF-beta mediates suppression of adipogenesis by estradiol through connective tissue growth factor induction. Endocrinology. 2012 Jan; 153 (1):254-63 Epub 2011 Nov 08
    View PubMed
25. Modder UI, Roforth MM, Hoey K, McCready LK, Peterson JM, Monroe DG, Oursler MJ, Khosla S. Effects of estrogen on osteoprogenitor cells and cytokines/bone-regulatory factors in postmenopausal women. Bone. 2011 Aug; 49 (2):202-7 Epub 2011 Apr 29
    View PubMed
26. Modder UI, Oursler MJ, Khosla S, Monroe DG. Wnt10b activates the Wnt, notch, and NFkappaB pathways in U2OS osteosarcoma cells. J Cell Biochem. 2011 May; 112 (5):1392-402
    View PubMed
27. Hawse JR, Cicek M, Grygo SB, Bruinsma ES, Rajamannan NM, van Wijnen AJ, Lian JB, Stein GS, Oursler MJ, Subramaniam M, Spelsberg TC. TIEG1/KLF10 modulates Runx2 expression and activity in osteoblasts. PLoS One. 2011 Apr 29; 6 (4):e19429
    View PubMed
28. Cicek M, Vrabel A, Sturchio C, Pederson L, Hawse JR, Subramaniam M, Spelsberg TC, Oursler MJ. TGF-beta inducible early gene 1 regulates osteoclast differentiation and survival by mediating the NFATc1, AKT, and MEK/ERK signaling pathways. PLoS One. 2011 Mar 14; 6 (3):e17522
    View PubMed
29. Modder UI, Clowes JA, Hoey K, Peterson JM, McCready L, Oursler MJ, Riggs BL, Khosla S. Regulation of circulating sclerostin levels by sex steroids in women and in men. J Bone Miner Res. 2011 Jan; 26 (1):27-34
    View PubMed
30. Syed FA, Modder UI, Roforth M, Hensen I, Fraser DG, Peterson JM, Oursler MJ, Khosla S. Effects of chronic estrogen treatment on modulating age-related bone loss in female mice. J Bone Miner Res. 2010 Nov; 25 (11):2438-46
    View PubMed
31. Oursler MJ. Recent advances in understanding the mechanisms of osteoclast precursor fusion. J Cell Biochem. 2010 Aug 1; 110 (5):1058-62
    View PubMed
32. Ruan M, Pederson L, Bradley EW, Bamberger AM, Oursler MJ. Transforming growth factor-{beta} coordinately induces suppressor of cytokine signaling 3 and leukemia inhibitory factor to suppress osteoclast apoptosis. Endocrinology. 2010 Apr; 151 (4):1713-22 Epub 2010 Feb 24
    View PubMed
33. Subramaniam M, Hawse JR, Bruinsma ES, Grygo SB, Cicek M, Oursler MJ, Spelsberg TC. TGFbeta inducible early gene-1 directly binds to, and represses, the OPG promoter in osteoblasts. Biochem Biophys Res Commun. 2010 Jan 29; 392 (1):72-6 Epub 2010 Jan 06
    View PubMed
34. Subramaniam M, Hawse JR, Bruinsma ES, Grygo SB, Cicek M, Oursler MJ, Spelsberg TC. TGF beta inducible early gene-1 directly binds to, and represses, the OPG promoter in osteoblasts. Biochem Biophys Res Commun. 2010; 392(1):72-6.
    
35. Clowes JA, Eghbali-Fatourechi GZ, McCready L, Oursler MJ, Khosla S, Riggs BL. Estrogen action on bone marrow osteoclast lineage cells of postmenopausal women in vivo. Osteoporos Int. 2009 May; 20 (5):761-9 Epub 2008 Sept 04
    View PubMed
36. Pederson L, Ruan M, Westendorf JJ, Khosla S, Oursler MJ. Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate. Proc Natl Acad Sci U S A. 2008 Dec 30; 105 (52):20764-9 Epub 2008 Dec 15
    View PubMed
37. Bradley EW, Ruan MM, Oursler MJ. PAK1 is a novel MEK-independent raf target controlling expression of the IAP survivin in M-CSF-mediated osteoclast survival. J Cell Physiol. 2008 Dec; 217 (3):752-8
    View PubMed
38. Gingery A, Bradley EW, Pederson L, Ruan M, Horwood NJ, Oursler MJ. TGF-beta coordinately activates TAK1/MEK/AKT/NFkB and SMAD pathways to promote osteoclast survival. Exp Cell Res. 2008 Sep 10; 314(15):2725-38. Epub 2008 Jun 13.
    View PubMed
39. Syed FA, Oursler MJ, Hefferanm TE, Peterson JM, Riggs BL, Khosla S. Effects of estrogen therapy on bone marrow adipocytes in postmenopausal osteoporotic women. Osteoporos Int. 2008 Sep; 19 (9):1323-30 Epub 2008 Feb 15
    View PubMed
40. Hawse JR, Subramaniam M, Monroe DG, Hemmingsen AH, Ingle JN, Khosla S, Oursler MJ, Spelsberg TC. Estrogen receptor beta isoform-specific induction of transforming growth factor beta-inducible early gene-1 in human osteoblast cells: an essential role for the activation function 1 domain. Mol Endocrinol. 2008 Jul; 22 (7):1579-95 Epub 2008 May 15
    View PubMed
41. Bradley EW, Ruan MM, Vrable A, Oursler MJ. Pathway crosstalk between Ras/Raf and PI3K in promotion of M-CSF-induced MEK/ERK-mediated osteoclast survival. J Cell Biochem. 2008 Jul 1; 104 (4):1439-51
    View PubMed
42. Hawse JR, Iwaniec UT, Bensamoun SF, Monroe DG, Peters KD, Ilharreborde B, Rajamannan NM, Oursler MJ, Turner RT, Spelsberg TC, Subramaniam M. TIEG-null mice display an osteopenic gender-specific phenotype. Bone. 2008 Jun; 42 (6):1025-31 Epub 2008 Mar 04
    View PubMed
43. Sanyal A, Hoey KA, Modder UI, Lamsam JL, McCready LK, Peterson JM, Achenbach SJ, Oursler MJ, Khosla S. Regulation of bone turnover by sex steroids in men. J Bone Miner Res. 2008 May; 23 (5):705-14
    View PubMed
44. Bradley EW, Ruan MM, Oursler MJ. Novel pro-survival functions of the Kruppel-like transcription factor Egr2 in promotion of macrophage colony-stimulating factor-mediated osteoclast survival downstream of the MEK/ERK pathway. J Biol Chem. 2008 Mar 21; 283(12):8055-64. Epub 2008 Jan 15.
    View PubMed
45. Rudnik V, Sanyal A, Syed FA, Monroe DG, Spelsberg TC, Oursler MJ, Khosla S. Loss of ERE binding activity by estrogen receptor-alpha alters basal and estrogen-stimulated bone-related gene expression by osteoblastic cells. J Cell Biochem. 2008 Feb 15; 103 (3):896-907
    View PubMed
46. Hawse JR, Subramaniam M, Ingle JN, Oursler MJ, Rajamannan NM, Spelsberg TC. Estrogen-TGFbeta cross-talk in bone and other cell types: role of TIEG, Runx2, and other transcription factors. J Cell Biochem. 2008 Feb 1; 103 (2):383-92
    View PubMed
47. Khosla S, Westendorf JJ, Oursler MJ. Building bone to reverse osteoporosis and repair fractures. J Clin Invest. 2008 Feb; 118 (2):421-8
    View PubMed
48. Bradley EW, Oursler MJ. Osteoclast culture and resorption assays. Methods Mol Biol. 2008; 455:19-35
    View PubMed
49. Cicek M, Iwaniec UT, Goblirsch MJ, Vrabel A, Ruan M, Clohisy DR, Turner RR, Oursler MJ. 2-Methoxyestradiol suppresses osteolytic breast cancer tumor progression in vivo. Cancer Res. 2007 Nov 1; 67 (21):10106-11
    View PubMed
50. Cicek M, Iwaniec UT, Goblirsch M, Vrabel A, Ruan M, Clohisy DC, Turner R, Oursler MJ. 2-Methoxyestradiol Suppressed Ostolytic Breast Cancer Tumor Progression In Vivo Cancer Research. 2007.
    
51. Cicek M, Oursler MJ. Breast cancer bone metastasis and current small therapeutics. Cancer Metastasis Rev. 2006 Dec; 25(4):635-44.
    View PubMed
52. Bensamoun SF, Hawse JR, Subramaniam M, Ilharreborde B, Bassillais A, Benhamou CL, Fraser DG, Oursler MJ, Amadio PC, An KN, Spelsberg TC. TGF beta inducible early gene-1 knockout mice display defects in bone strength and microarchitecture. Bone. 2006 Dec; 39(6):1244-51.
    
53. Bensamoun SF, Hawse JR, Subramaniam M, Ilharreborde B, Bassillais A, Benhamou CL, Fraser DG, Oursler MJ, Amadio PC, An KN, Spelsberg TC. TGFbeta inducible early gene-1 knockout mice display defects in bone strength and microarchitecture. Bone. 2006 Dec; 39(6):1244-51. Epub 2006 Jul 28.
    View PubMed
54. Maran A, Gorny G, Oursler MJ, Zhang M, Shogren KL, Yaszemski MJ, Turner RT. 2-methoxyestradiol inhibits differentiation and is cytotoxic to osteoclasts. J Cell Biochem. 2006 Oct 1; 99 (2):425-34
    View PubMed
55. Lotinun S, Evans GL, Turner RT, Oursler MJ. Deletion of membrane-bound steel factor results in osteopenia in mice. J Bone Miner Res. 2005 Apr; 20(4):644-52.
    View PubMed
56. Subramaniam M, Gorny G, Johnsen SA, Monroe DG, Evans GL, Fraser DG, Rickard DJ, Rasmussen K, van Deursen JM, Turner RT, Oursler MJ, Spelsberg TC. TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro. Mol Cell Biol. 2005 Feb; 25 (3):1191-9
    View PubMed
57. Oursler MJ, Bradley EW, Elfering SL, Giulivi C. Native, not nitrated, cytochrome c and mitochondria-derived hydrogen peroxide drive osteoclast apoptosis. Am J Physiol Cell Physiol. 2005 Jan; 288(1):C156-68.
    View PubMed
58. Karst M, Gorny G, Galvin RJ, Oursler MJ. Roles of stromal cell RANKL, OPG, and M-CSF expression in biphasic TGF-beta regulation of osteoclast differentiation. J Cell Physiol. 2004 Jul; 200(1):99-106.
    View PubMed
59. Gorny G, Shaw A, Oursler MJ. IL-6, LIF, and TNF-alpha regulation of GM-CSF inhibition of osteoclastogenesis in vitro. Exp Cell Res. 2004 Mar 10; 294(1):149-58.
    View PubMed
60. Gingery A, Bradley E, Shaw A, Oursler MJ. Phosphatidylinositol 3-kinase coordinately activates the MEK/ERK and AKT/NFkappaB pathways to maintain osteoclast survival. J Cell Biochem. 2003 May 1; 89(1):165-79.
    View PubMed
61. Mizuta H, Sanyal A, Fukumoto T, Fitzsimmons JS, Matsui N, Bolander ME, Oursler MJ, O'Driscoll SW. The spatiotemporal expression of TGF-beta1 and its receptors during periosteal chondrogenesis in vitro. J Orthop Res. 2002 May; 20 (3):562-74
    View PubMed
62. Sanyal A, Oursler MJ, Clemens VR, Fukumoto T, Fitzsimmons JS, O'Driscoll SW. Temporal expression patterns of BMP receptors and collagen II (B) during periosteal chondrogenesis. J Orthop Res. 2002 Jan; 20(1):58-65.
    View PubMed
63. Gingery A, Oursler MJ. The roles of TGF-beta in metastatic cancer progression in bone. Recent Research Developments in Cancer. 2002; 4(13-24).
    
64. Pascoe D, Oursler MJ. The Src signaling pathway regulates osteoclast lysosomal enzyme secretion and is rapidly modulated by estrogen. J Bone Miner Res. 2001 Jun; 16(6):1028-36.
    View PubMed
65. Winding B, Misander H, Sveigaard C, Therkildsen B, Jakobsen M, Overgaard T, Oursler MJ, Foged NT. Human breast cancer cells induced angiogenesis, recruitment, and activation of osteoclasts in osteolytic metastasis. Journal of Cancer Research & Clinical Oncology. 2000 Nov; 126(11):631-40.
    View PubMed
66. Shaw A, Oursler MJ. Paracrine regulation of osteoclast activity in metastatic breast cancer. Cancer Research Alert. 2000; 1:124-7.
    
67. Pederson L, Winding B, Foged NT, Spelsberg TC, Oursler MJ. Identification of breast cancer cell line-derived paracrine factors that stimulate osteoclast activity. Cancer Res. 1999 Nov 15; 59(22):5849-55.
    View PubMed
68. Pederson L, Kremer M, Judd J, Pascoe D, Spelsberg TC, Riggs BL, Oursler MJ. Androgens regulate bone resorption activity of isolated osteoclasts in vitro. Proc Natl Acad Sci U S A. 1999 Jan 19; 96 (2):505-10
    View PubMed
69. Oursler MJ. Mechanisms of steroid action on osteoclasts and osteoblasts. Biochem Soc Trans. 1998 Feb; 26(1):33-8.
    View PubMed
70. Collin-Osdoby P, Li L, Rothe L, Anderson F, Kirsch D, Oursler MJ, Osdoby P. Inhibition of avian osteoclast bone resorption by monoclonal antibody 121F: a mechanism involving the osteoclast free radical system. J Bone Miner Res. 1998 Jan; 13(1):67-78.
    View PubMed
71. Oursler MJ. Estrogen regulation of gene expression in osteoblasts and osteoclasts. Crit Rev Eukaryot Gene Expr. 1998; 8(2):125-40.
    View PubMed
72. Pederson L, Kremer M, Foged NT, Winding B, Ritchie C, Fitzpatrick LA, Oursler MJ. Evidence of a correlation of estrogen receptor level and avian osteoclast estrogen responsiveness. J Bone Miner Res. 1997 May; 12(5):742-52.
    View PubMed
73. Clohisy DR, Palkert D, Ramnaraine ML, Pekurovsky I, Oursler MJ. Human breast cancer induces osteoclast activation and increases the number of osteoclasts at sites of tumor osteolysis. J Orthop Res. 1996 May; 14(3):396-402.
    View PubMed
74. Robinson JA, Riggs BL, Spelsberg TC, Oursler MJ. Osteoclasts and transforming growth factor-beta: estrogen-mediated isoform-specific regulation of production. Endocrinology. 1996 Feb; 137(2):615-21.
    View PubMed
75. Subramaniam M, Harris SA, Oursler MJ, Rasmussen K, Riggs BL, Spelsberg TC. Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts. Nucleic Acids Res. 1995 Dec 11; 23 (23):4907-12
    View PubMed
76. Schutze N, Oursler MJ, Nolan J, Riggs BL, Spelsberg TC. Zeolite A inhibits osteoclast-mediated bone resorption in vitro. J Cell Biochem. 1995 May; 58 (1):39-46
    View PubMed
77. Kremer M, Judd J, Rifkin B, Auszmann J, Oursler MJ. Estrogen modulation of osteoclast lysosomal enzyme secretion. J Cell Biochem. 1995 Feb; 57 (2):271-9
    View PubMed
78. Subramaniam M, Oursler MJ, Rasmussen K, Riggs BL, Spelsberg TC. TGF-beta regulation of nuclear proto-oncogenes and TGF-beta gene expression in normal human osteoblast-like cells. J Cell Biochem. 1995 Jan; 57(1):52-61.
    View PubMed
79. Collin-Osdoby P, Oursler MJ, Rothe L, Webber D, Anderson F, Osdoby P. Osteoclast 121F antigen expression during osteoblast conditioned medium induction of osteoclast-like cells in vitro: relationship to calcitonin responsiveness, tartrate resistant acid phosphatase levels, and bone resorptive activity. J Bone Miner Res. 1995 Jan; 10(1):45-58.
    View PubMed
80. Khosla S, Oursler MJ, Schroeder MJ, Eberhardt NL. Transforming growth factor-beta 1 induces growth inhibition of a human medullary thyroid carcinoma cell line despite an increase in steady state c-myc messenger ribonucleic acid levels. Endocrinology. 1994 Nov; 135(5):1887-93.
    View PubMed
81. Oursler MJ, Pederson L, Fitzpatrick L, Riggs BL, Spelsberg T. Human giant cell tumors of the bone (osteoclastomas) are estrogen target cells. Proc Natl Acad Sci U S A. 1994 Jun 7; 91 (12):5227-31
    View PubMed
82. Oursler MJ. Osteoclast synthesis and secretion and activation of latent transforming growth factor beta. J Bone Miner Res. 1994 Apr; 9 (4):443-52
    View PubMed
83. Sarrel PM, Lufkin EG, Oursler MJ, Keefe D. Estrogen actions in arteries, bone, and brain. Scientific American Science and Medicine. 1994; 1(3):44-53.
    
84. Oursler MJ, Riggs BL, Spelsberg TC. Glucocorticoid-induced activation of latent transforming growth factor-beta by normal human osteoblast-like cells. Endocrinology. 1993 Nov; 133(5):2187-96.
    View PubMed
85. Oursler MJ, Landers JP, Riggs BL, Spelsberg TC. Oestrogen effects on osteoblasts and osteoclasts. Ann Med. 1993 Aug; 25(4):361-71.
    View PubMed
86. Oursler MJ, Pederson L, Pyfferoen J, Osdoby P, Fitzpatrick L, Spelsberg TC. Estrogen modulation of avian osteoclast lysosomal gene expression. Endocrinology. 1993 Mar; 132(3):1373-80.
    View PubMed
87. Oursler MJ, Riggs BL, Fitzpatrick L, Spelsberg TC. Estrogen action on bone cells: the osteoclasts. Fourth International Symposium on Osteoporosis. 1993; 386-91.
    
88. Keeting PE, Oursler MJ, Wiegand KE, Bonde SK, Spelsberg TC, Riggs BL. Zeolite A increases proliferation, differentiation, and transforming growth factor beta production in normal adult human osteoblast-like cells in vitro. J Bone Miner Res. 1992 Nov; 7(11):1281-9.
    View PubMed
89. Greenfield EM, Alvarez JI, McLaurine EA, Oursler MJ, Blair HC, Osdoby P, Teitelbaum SL, Ross FP. Avian osteoblast conditioned media stimulate bone resorption by targeting multinucleating osteoclast precursors. Calcif Tissue Int. 1992 Oct; 51(4):317-23.
    View PubMed
90. Keeting PE, Scott RE, Colvard DS, Anderson MA, Oursler MJ, Spelsberg TC, Riggs BL Jr. Development and characterization of a rapidly proliferating, well-differentiated cell line derived from adult human osteoblast-like cells transfected with SV40 large T antigen. J Bone Miner Res. 1992 Feb; 7:127-36.
    View PubMed
91. Osdoby P, Oursler MJ, Pyfferoen J, Riggs BL Jr, Spelsberg TC. The regulation of osteoclast activity. Int Congr Ser. 1992; 1002:339-46.
    
92. Oursler MJ, Cortese C, Keeting P, Anderson MA, Bonde SK, Riggs BL, Spelsberg TC. Modulation of transforming growth factor-beta production in normal human osteoblast-like cells by 17 beta-estradiol and parathyroid hormone. Endocrinology. 1991 Dec; 129(6):3313-20.
    View PubMed
93. Collin-Osdoby P, Oursler MJ, Webber D, Osdoby P. Osteoclast-specific monoclonal antibodies coupled to magnetic beads provide a rapid and efficient method of purifying avian osteoclasts. J Bone Miner Res. 1991 Dec; 6(12):1353-65.
    View PubMed
94. Oursler MJ, Osdoby P, Pyfferoen J, Riggs BL, Spelsberg TC. Avian osteoclasts as estrogen target cells. Proc Natl Acad Sci U S A. 1991 Aug 1; 88 (15):6613-7
    View PubMed
95. Oursler MJ, Collin-Osdoby P, Li L, Schmitt E, Osdoby P. Evidence for an immunological and functional relationship between superoxide dismutase and a high molecular weight osteoclast plasma membrane glycoprotein. J Cell Biochem. 1991 Aug; 46(4):331-44.
    View PubMed
96. Oursler MJ, Li L, Osdoby P. Purification and characterization of an osteoclast membrane glycoprotein with homology to manganese superoxide dismutase. J Cell Biochem. 1991 Jul; 46(3):219-33.
    View PubMed
97. Oursler MJ, Collin-Osdoby P, Anderson F, Li L, Webber D, Osdoby P. Isolation of avian osteoclasts: improved techniques to preferentially purify viable cells. J Bone Miner Res. 1991 Apr; 6(4):375-85.
    View PubMed
98. Oursler MJ, Osdoby P. Characterization of an osteoclast membrane protein related to superoxide dismutase. Excerpta Medica: International Congress Series. 1990; 886(10):214-20.
    
99. Oursler MJ, Osdoby P. Osteoclast development in marrow cultured in calvaria-conditioned media. Dev Biol. 1988 May; 127(1):170-8.
    View PubMed
100. Osdoby P, Oursler MJ, Salino-Hugg T, Krukowski M. Osteoclast development: the cell surface and the bone environment. Ciba Found Symp. 1988; 136:108-24.
     View PubMed
101. Osdoby P, Krukowski M, Oursler MJ, Salino-Hugg T. The origin, development and regulation of osteoclasts. Bioessays. 1987 Jul; 7(1):30-4.
     View PubMed
102. Oursler MJ, Bell LV, Clevinger B, Osdoby P. Identification of osteoclast-specific monoclonal antibodies. J Cell Biol. 1985 May; 100(5):1592-600.
     View PubMed
103. Richter GW, Velasquez MJ, Shedd R. Ferritin in rat kidneys with specific lesions due to a single dose of lead. Am J Pathol. 1979 Mar; 94(3):483-95.
     View PubMed