Publications

  1. Karpyak VM, Geske JR, Hall-Flavin DK, Loukianova LL, Schneekloth TD, Skime MK, Seppala M, Dawson G, Frye MA, Choi DS, Biernacka JM. Sex-specific association of depressive disorder and transient emotional states with alcohol consumption in male and female alcoholics. Drug Alcohol Depend. 2019 Mar 1; 196:31-39 Epub 2019 Jan 11
    View PubMed
  2. Ahmed AT, Biernacka JM, Jenkins G, Rush AJ, Shinozaki G, Veldic M, Kung S, Bobo WV, Hall-Flavin DK, Weinshilboum RM, Wang L, Frye MA. Pharmacokinetic-Pharmacodynamic interaction associated with venlafaxine-XR remission in patients with major depressive disorder with history of citalopram / escitalopram treatment failure. J Affect Disord. 2019 Mar 1; 246:62-68 Epub 2018 Dec 17
    View PubMed
  3. Vadodaria KC, Ji Y, Skime M, Paquola A, Nelson T, Hall-Flavin D, Fredlender C, Heard KJ, Deng Y, Le AT, Dave S, Fung L, Li X, Marchetto MC, Weinshilboum R, Gage FH. Serotonin-induced hyperactivity in SSRI-resistant major depressive disorder patient-derived neurons. Mol Psychiatry. 2019 Jan 30 [Epub ahead of print]
    View PubMed
  4. Amare AT, Schubert KO, Tekola-Ayele F, Hsu YH, Sangkuhl K, Jenkins G, Whaley RM, Barman P, Batzler A, Altman RB, Arolt V, Brockmoller J, Chen CH, Domschke K, Hall-Flavin DK, Hong CJ, Illi A, Ji Y, Kampman O, Kinoshita T, Leinonen E, Liou YJ, Mushiroda T, Nonen S, Skime MK, Wang L, Kato M, Liu YL, Praphanphoj V, Stingl JC, Bobo WV, Tsai SJ, Kubo M, Klein TE, Weinshilboum RM, Biernacka JM, Baune BT. The association of obesity and coronary artery disease genes with response to SSRIs treatment in major depression. J Neural Transm (Vienna). 2019 Jan; 126 (1):35-45 Epub 2019 Jan 04
    View PubMed
  5. Ahmed AT, Frye MA, Rush AJ, Biernacka JM, Craighead WE, McDonald WM, Bobo WV, Riva-Posse P, Tye SJ, Mayberg HS, Hall-Flavin DK, Skime MK, Jenkins GD, Wang L, Krishnan RR, Weinshilboum RM, Kaddurah-Daouk R, Dunlop BW, Mood Disorders Precision Medicine Consortium (MDPMC). Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders. J Affect Disord. 2018 Oct 1; 238:1-7 Epub 2018 May 26
    View PubMed
  6. Liu D, Ray B, Neavin DR, Zhang J, Athreya AP, Biernacka JM, Bobo WV, Hall-Flavin DK, Skime MK, Zhu H, Jenkins GD, Batzler A, Kalari KR, Boakye-Agyeman F, Matson WR, Bhasin SS, Mushiroda T, Nakamura Y, Kubo M, Iyer RK, Wang L, Frye MA, Kaddurah-Daouk R, Weinshilboum RM. Beta-defensin 1, aryl hydrocarbon receptor and plasma kynurenine in major depressive disorder: metabolomics-informed genomics. Transl Psychiatry. 2018 Jan 10; 8 (1):10
    View PubMed
  7. Amare AT, Schubert KO, Tekola-Ayele F, Hsu YH, Sangkuhl K, Jenkins G, Whaley RM, Barman P, Batzler A, Altman RB, Arolt V, Brockmoller J, Chen CH, Domschke K, Hall-Flavin DK, Hong CJ, Illi A, Ji Y, Kampman O, Kinoshita T, Leinonen E, Liou YJ, Mushiroda T, Nonen S, Skime MK, Wang L, Kato M, Liu YL, Praphanphoj V, Stingl JC, Bobo WV, Tsai SJ, Kubo M, Klein TE, Weinshilboum RM, Biernacka JM, Baune BT. Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder. Front Psychiatry. 2018; 9:65 Epub 2018 Mar 06
    View PubMed
  8. Gupta M, Neavin D, Liu D, Biernacka J, Hall-Flavin D, Bobo WV, Frye MA, Skime M, Jenkins GD, Batzler A, Kalari K, Matson W, Bhasin SS, Zhu H, Mushiroda T, Nakamura Y, Kubo M, Wang L, Kaddurah-Daouk R, Weinshilboum RM. TSPAN5, ERICH3 and selective serotonin reuptake inhibitors in major depressive disorder: pharmacometabolomics-informed pharmacogenomics. Mol Psychiatry. 2016 Dec; 21 (12):1717-1725 Epub 2016 Feb 23
    View PubMed
  9. Biernacka JM, Sangkuhl K, Jenkins G, Whaley RM, Barman P, Batzler A, Altman RB, Arolt V, Brockmoller J, Chen CH, Domschke K, Hall-Flavin DK, Hong CJ, Illi A, Ji Y, Kampman O, Kinoshita T, Leinonen E, Liou YJ, Mushiroda T, Nonen S, Skime MK, Wang L, Baune BT, Kato M, Liu YL, Praphanphoj V, Stingl JC, Tsai SJ, Kubo M, Klein TE, Weinshilboum R. The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response. Transl Psychiatry. 2016 Nov 01; 6: (11)e937.
    View PubMed
  10. Karpyak VM, Biernacka JM, Geske JR, Abulseoud OA, Brunner MD, Chauhan M, Hall-Flavin DK, Lewis KA, Loukianova LL, Melnyk GJ, Onsrud DA, Proctor BD, Schneekloth TD, Skime MK, Wittkopp JE, Frye MA, Mrazek DA. Gender-specific effects of comorbid depression and anxiety on the propensity to drink in negative emotional states. Addiction. 2016 Aug; 111 (8):1366-75 Epub 2016 May 05
    View PubMed
  11. Bobo WV, Anglero GC, Jenkins G, Hall-Flavin DK, Weinshilboum R, Biernacka JM. Validation of the 17-item Hamilton Depression Rating Scale definition of response for adults with major depressive disorder using equipercentile linking to Clinical Global Impression scale ratings: analysis of Pharmacogenomic Research Network Antidepressant Medication Pharmacogenomic Study (PGRN-AMPS) data. Hum Psychopharmacol. 2016 May; 31 (3):185-92 Epub 2016 Mar 21
    View PubMed
  12. Altar CA, Carhart J, Allen JD, Hall-Flavin D, Winner J, Dechairo B. Clinical Utility of Combinatorial Pharmacogenomics-Guided Antidepressant Therapy: Evidence from Three Clinical Studies. Mol Neuropsychiatry. 2015 Oct; 1 (3):145-55 Epub 2015 July 31
    View PubMed
  13. Altar CA, Carhart JM, Allen JD, Hall-Flavin DK, Dechairo BM, Winner JG. Clinical validity: Combinatorial pharmacogenomics predicts antidepressant responses and healthcare utilizations better than single gene phenotypes. Pharmacogenomics J. 2015 Oct; 15 (5):443-51 Epub 2015 Feb 17
    View PubMed
  14. Leung JG, Hall-Flavin D, Nelson S, Schmidt KA, Schak KM. The role of gabapentin in the management of alcohol withdrawal and dependence. Ann Pharmacother. 2015 Aug; 49 (8):897-906 Epub 2015 May 12
    View PubMed
  15. Kolla BP, Schneekloth T, Mansukhani MP, Biernacka JM, Hall-Flavin D, Karpyak V, Geske J, Frye MA. The association between sleep disturbances and alcohol relapse: A 12-month observational cohort study. Am J Addict. 2015 Jun; 24: (4)362-7.
    View PubMed
  16. Hitschfeld MJ, Schneekloth TD, Ebbert JO, Hall-Flavin DK, Karpyak VM, Abulseoud OA, Patten CA, Geske JR, Frye MA. Female smokers have the highest alcohol craving in a residential alcoholism treatment cohort. Drug Alcohol Depend. 2015 May 1; 150:179-82 Epub 2015 Feb 25
    View PubMed
  17. Biernacka JM, Sangkuhl K, Jenkins G, Whaley RM, Barman P, Batzler A, Altman RB, Arolt V, Brockmoller J, Chen CH, Domschke K, Hall-Flavin DK, Hong CJ, Illi A, Ji Y, Kampman O, Kinoshita T, Leinonen E, Liou YJ, Mushiroda T, Nonen S, Skime MK, Wang L, Baune BT, Kato M, Liu YL, Praphanphoj V, Stingl JC, Tsai SJ, Kubo M, Klein TE, Weinshilboum R. The International SSRI Pharmacogenomics Consortium (ISPC): a genome-wide association study of antidepressant treatment response. Transl Psychiatry. 2015 Apr 21; 5:e553
    View PubMed
  18. Cuellar-Barboza AB, Frye MA, Grothe K, Prieto ML, Schneekloth TD, Loukianova LL, Hall-Flavin DK, Clark MM, Karpyak VM, Miller JD, Abulseoud OA. Change in consumption patterns for treatment-seeking patients with alcohol use disorder post-bariatric surgery. J Psychosom Res. 2015 Mar; 78 (3):199-204 Epub 2014 Sept 07
    View PubMed
  19. Karpyak VM, Biernacka JM, Geske JR, Jenkins GD, Cunningham JM, Ruegg J, Kononenko O, Leontovich AA, Abulseoud OA, Hall-Flavin DK, Loukianova LL, Schneekloth TD, Skime MK, Frank J, Nothen MM, Rietschel M, Kiefer F, Mann KF, Weinshilboum RM, Frye MA, Choi DS. Genetic markers associated with abstinence length in alcohol-dependent subjects treated with acamprosate. Transl Psychiatry. 2014 Oct 7; 4:e462 Epub 2014 Oct 07
    View PubMed
  20. Ji Y, Schaid DJ, Desta Z, Kubo M, Batzler AJ, Snyder K, Mushiroda T, Kamatani N, Ogburn E, Hall-Flavin D, Flockhart D, Nakamura Y, Mrazek DA, Weinshilboum RM. Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations. Br J Clin Pharmacol. 2014 Aug; 78 (2):373-83
    View PubMed
  21. Mrazek DA, Biernacka JM, McAlpine DE, Benitez J, Karpyak VM, Williams MD, Hall-Flavin DK, Netzel PJ, Passov V, Rohland BM, Shinozaki G, Hoberg AA, Snyder KA, Drews MS, Skime MK, Sagen JA, Schaid DJ, Weinshilboum R, Katzelnick DJ. Treatment outcomes of depression: the pharmacogenomic research network antidepressant medication pharmacogenomic study. J Clin Psychopharmacol. 2014 Jun; 34 (3):313-7
    View PubMed
  22. Karpyak VM, Winham SJ, Biernacka JM, Cunningham JM, Lewis KA, Geske JR, Colby CL, Abulseoud OA, Hall-Flavin DK, Loukianova LL, Schneekloth TD, Frye MA, Heit JA, Mrazek DA. Association of GATA4 sequence variation with alcohol dependence. Addict Biol. 2014 Mar; 19 (2):312-5 Epub 2012 Aug 02
    View PubMed
  23. Kolla BP, Schneekloth T, Biernacka J, Mansukhani M, Geske J, Karpyak V, Hall-Flavin D, Louikianova L, Frye MA. The course of sleep disturbances in early alcohol recovery: an observational cohort study. Am J Addict. 2014 Jan-Feb; 23: (1)21-6.
    View PubMed
  24. Pathak J, Simon G, Li D, Biernacka JM, Jenkins GJ, Chute CG, Hall-Flavin DK, Weinshilboum RM. Detecting Associations between Major Depressive Disorder Treatment and Essential Hypertension using Electronic Health Records. AMIA Jt Summits Transl Sci Proc. 2014; 2014:91-6 Epub 2014 Apr 07
    View PubMed
  25. Hall-Flavin DK, Winner JG, Allen JD, Carhart JM, Proctor B, Snyder KA, Drews MS, Eisterhold LL, Geske J, Mrazek DA. Utility of integrated pharmacogenomic testing to support the treatment of major depressive disorder in a psychiatric outpatient setting. Pharmacogenet Genomics. 2013 Oct; 23: (10)535-48.
    View PubMed
  26. Abulseoud OA, Karpyak VM, Schneekloth T, Hall-Flavin DK, Loukianova LL, Geske JR, Biernacka JM, Mrazek DA, Frye MA. A retrospective study of gender differences in depressive symptoms and risk of relapse in patients with alcohol dependence. Am J Addict. 2013 Sep-Oct; 22 (5):437-42 Epub 2013 May 30
    View PubMed
  27. Karpyak VM, Winham SJ, Preuss UW, Zill P, Cunningham JM, Walker DL, Lewis KA, Geske JR, Colby CL, Abulseoud OA, Hall-Flavin DK, Loukianova LL, Schneekloth TD, Frye MA, Bazov I, Heit JA, Bakalkin G, Mrazek DA, Biernacka JM. Association of the PDYN gene with alcohol dependence and the propensity to drink in negative emotional states. Int J Neuropsychopharmacol. 2013 Jun; 16 (5):975-85 Epub 2012 Oct 29
    View PubMed
  28. Biernacka JM, Geske JR, Schneekloth TD, Frye MA, Cunningham JM, Choi DS, Tapp CL, Lewis BR, Drews MS, L Pietrzak T, Colby CL, Hall-Flavin DK, Loukianova LL, Heit JA, Mrazek DA, Karpyak VM. Replication of genome wide association studies of alcohol dependence: support for association with variation in ADH1C. PLoS One. 2013; 8 (3):e58798 Epub 2013 Mar 13
    View PubMed
  29. Schneekloth TD, Biernacka JM, Hall-Flavin DK, Karpyak VM, Frye MA, Loukianova LL, Stevens SR, Drews MS, Geske JR, Mrazek DA. Alcohol craving as a predictor of relapse. Am J Addict. 2012 Nov; 21 Suppl 1:S20-6.
    View PubMed
  30. Hall-Flavin DK, Winner JG, Allen JD, Jordan JJ, Nesheim RS, Snyder KA, Drews MS, Eisterhold LL, Biernacka JM, Mrazek DA. Using a pharmacogenomic algorithm to guide the treatment of depression. Transl Psychiatry. 2012 Oct 16; 2:e172
    View PubMed
  31. Kolla BP, Schneekloth TD, Biernacka JM, Frye MA, Mansukhani MP, Hall-Flavin DK, Karpyak VM, Loukianova LL, Lesnick TG, Mrazek D. Trazodone and alcohol relapse: a retrospective study following residential treatment. Am J Addict. 2011 Nov-Dec; 20: (6)525-9.
    View PubMed
  32. Hammer RR, Rian JD, Gregory JK, Bostwick JM, Barrett Birk C, Chalfant L, Scanlon PD, Hall-Flavin DK. Telling the patient's story: using theatre training to improve case presentation skills. Med Humanit. 2011 Jun; 37(1):18-22. Epub 2011 Feb 21
    View PubMed
  33. Hall-Flavin DK, Schneekloth TD, Loukianova LL, Karpyak VM, Lesnick TG, Biernacka JM, Mrazek DA, Frye MA. Utilization of residential alcoholism treatment in bipolar disorder. Am J Addict. 2011 Jan-Feb; 20: (1)40-4.
    View PubMed
  34. Abulseoud O, Karpyak V, Schneekloth T, Hall-Flavin D, Loukianova L, Geske J, Biernacka, Mrazek D, Frye M. Negatively Valenced Emotional Stimuli are Associated with Heavy Drinking among Women with Alcohol-Dependence. American Journal of Addiction (In press). 2011.
  35. Boykoff N, Schneekloth TD, Hall-Flavin D, Loukianova L, Karpyak VM, Stevens SR, Biernacka JM, Mrazek DA, Frye MA. Gender differences in the relationship between depressive symptoms and cravings in alcoholism. Am J Addict. 2010 Jul-Aug; 19 (4):352-6
    View PubMed
  36. Hall-Flavin DK, Schneekloth TD, Frye MA, Mrazek DA. Addiction treatment in the era of translational medicine. Forum on Public Policy, Journal of the Oxford Round Table. 2010; 1:1-12.
  37. Hall-Flavin DK, Schneekloth TD, Allen JD. Translational psychiatry: Bringing pharmacogenomic testing into clinical practice. Primary Psychiatry. 2010; 17(5):39-44.
  38. Karpyak VM, Hall-Flavin DK, Mrazek DA. Can genetics predict risk for alcohol dependence? Current Psychiatry. 2008; 7(3):57-73.
  39. Patten CA, Vickers KS, Offord KP, Decker PA, Colligan RC, Bronars C, Reese MM, Seime RJ, Hall-Flavin DK, Hurt RD. Validation of the revised Self-Administered Alcohol Screening Test (SAAST-R). Am J Addict. 2006 Nov-Dec; 15: (6)409-21.
    View PubMed
  40. Schneekloth TD, Hall-Flavin DK, Jowsey SG. Methadone maintenance and chronic opioid analgesia in liver transplantation. Current Opinion in Organ Transplantation. 2006; 11(2):194-8.
  41. Vickers-Douglas KS, Patten CA, Decker PA, Offord KP, Colligan RC, Islam-Zwart KA, Wolter TD, Croghan IT, Hall-Flavin D, Hurt RD. Revision of the Self-Administered Alcoholism Screening Test (SAAST-R): a pilot study. Subst Use Misuse. 2005; 40(6):789-812.
    View PubMed
  42. Watabe JM, Hall-Flavin DK. Practice, not malpractice: 3 clinical habits can reduce liability risk. Current Psychiatry. 2003 Dec; 2(12).
  43. Lapid MI, Hall-Flavin DK, Cox LS, Lichty EJ, Krahn LE. Smokeless tobacco use among addiction patients: a brief report. J Addict Dis. 2002; 21(2):27-33.
    View PubMed
  44. Maxson PM, Berge KH, Hall-Flavin DK, Zietlow SP, Schroeder DR, Lange CM. Detectable blood alcohol after a motor vehicle crash and screening for alcohol abuse/dependence. Mayo Clin Proc. 2000 Mar; 75(3):231-4.
    View PubMed
  45. Morse RM, Flavin DK. The definition of alcoholism. The Joint Committee of the National Council on Alcoholism and Drug Dependence and the American Society of Addiction Medicine to Study the Definition and Criteria for the Diagnosis of Alcoholism. JAMA. 1992 Aug 26; 268(8):1012-4.
    View PubMed
  46. Flavin DK, Niven RG, Kelsey JE. Alcoholism and orthotopic liver transplantation. JAMA. 1988 Mar 11; 259: (10)1546-7.
    View PubMed
  47. Frances RJ, Franklin J, Flavin DK. Suicide and alcoholism. American Journal of Drug & Alcohol Abuse. 1987; 13(3):327-41.
    View PubMed
  48. Flavin DK, Frances RK. Risk-taking behavior, substance abuse disorders, and AIDS. Adv Alcohol Subst Abuse. 1987; 6(3):23-32.
    View PubMed
  49. Frances RJ, Franklin J, Flavin DK. Suicide and alcoholism. Ann N Y Acad Sci. 1986; 487:316-26.
    View PubMed
  50. Flavin DK, Franklin JE, Frances RJ. AIDS and suicidal behavior in alcohol-dependent homosexual men. Am J Psychiatry. 1986; 143(11):1440-1442.
    View PubMed
  51. Flavin DK, Fredrickson PA, Richardson JW, Merritt TC. Corticosteroid abuse--an unusual manifestation of drug dependence. Mayo Clin Proc. 1983 Nov; 58(11):764-6.
    View PubMed