Search Results 1-6 of 6 for brca1%20and%20brca2%20genes%20and%20breast%20cancer
Variants of uncertain significance in the BRCA1 and BRCA2 breast and ovarian cancer genes.
In the case of PARP inhibitors, work from the Kaufmann laboratory has shown that these agents selectively kill BRCA1- and BRCA2-deficient cells by enhancing activation of an error-prone DNA repair pathway (the nonhomologous end-joini...
These four protein kinases, with the help of mediator proteins, phosphorylate a number of downstream effector proteins, including tumor suppressors p53 and BRCA1.
For many years, it has been understood that the BRCA1 and BRCA2 genes contribute to the etiology of breast cancer.
Current studies in his laboratory concentrate on the mechanisms of action of several DNA double-strand break repair proteins, including 53BP1 and BRCA1-BARD1, and on understanding the contribution of chromatin dynamics to the DNA dam...
CDK12 is mutationally inactivated in ovarian cancers, and this leads to decreased levels of DNA repair proteins, including BRCA1.