Search Results 1-10 of 20 for brca1%20and%20brca2%20genes%20and%20breast%20cancer
They have also shown response rates of 30% to 60% in BRCA1 or BRCA2 (BRCA1/2) mutation carriers with platinum-sensitive relapsed ovarian cancer.
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However, it has been more difficult to identify women at elevated risk of triple-negative breast cancer because only inherited mutations in BRCA1 have been linked to this subtype of breast cancer.
PARP inhibitors sensitize ovarian cancer cells with either wild type or mutant BRCA1 / BRCA2 proteins to the topoisomerase I poison topotecan and the ATR kinase inhibitor VE-821.
Variants of uncertain significance in the BRCA1 and BRCA2 breast and ovarian cancer genes.
This analysis identified single nucleotide polymorphisms in ZNF423, a previously unrecognized regulator of BRCA1 expression, as a critical determinant of selective estrogen receptor modulator efficacy in the adjuvant setting.
"We were able to confirm that genes, including BRCA1, BRCA2, CHEK2, ATM and PALB2, play a role in breast cancer development, which was not surprising," Dr.
In the case of PARP inhibitors, work from the Kaufmann laboratory has shown that these agents selectively kill BRCA1- and BRCA2-deficient cells by enhancing activation of an error-prone DNA repair pathway (the nonhomologous end-joini...
These four protein kinases, with the help of mediator proteins, phosphorylate a number of downstream effector proteins, including tumor suppressors p53 and BRCA1.
Food and Drug Administration approval of rucaparib and the extended use of PARPi beyond high-grade serous ovarian cancers with germline BRCA1 or BRCA2 mutations.