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1. BRCA gene test for breast and ovarian cancer risk - Mayo Clinic

   The BRCA gene test looks for changes in the BRCA1 and BRCA2 genes. Other genes also can increase the risk of breast and ovarian cancer. Some genetic tests look ...

2. Beyond BRCA1/2: Pinpointing the risk of inherited breast cancer genes

   Immunohistochemistry for HER2 shows positive membrane staining in this infiltrating ductal carcinoma. At the molecular level, breast cancer is typically ...

3. Breast cancer: Predicting individual risk - Mayo Clinic News Network

   When a woman undergoes testing for the most common breast cancer genes, BRCA1 and BRCA2, it is usually because she wants to know if she will develop breast ...

4. Assessing breast cancer risk - Mayo Clinic News Network

   The discovery of the BRCA1 and BRCA2 genes in the 1990s enabled many women to learn they are at high risk of developing breast cancer. More than a dozen other ...

5. BRCA Gene Test Clinical Trials - Mayo Clinic Research

   The purpose of this trial is to compare denosumab to placebo for the prevention of breast cancer in women with a BRCA1 germline mutation. A germline mutation is ...

6. Researchers resolve uncertainty in BRCA2 testing, improving cancer risk assessment and patient care - Mayo Clinic News Network

   Many people with VUS may be notified about the reclassification of their VUS as the ClinVar BRCA1/2 expert panel and testing laboratories use the new ...

7. Mayo-led research team identifies genes that increase risk for triple-negative breast cancer

   However, he says it has been more difficult to identify women at elevated risk of triple-negative breast cancer because only inherited mutations in BRCA1 have ...

8. Studying the Effect of Denosumab on Preventing Breast Cancer in Women With a BRCA1 Germline Mutation - Mayo Clinic

   A germline mutation is an inherited gene change which, in the BRCA1 gene, is associated with an increased risk of breast and other cancers. Denosumab is a ...

9. "Jolie Effect" on Awareness of the Breast Cancer Genes - Mayo Clinic News Network

   What else do women need to know? More information on BRCA testing available online: BRCA gene test for breast cancer (Mayo Clinic) · BRCA1 and BRCA2: Cancer ...

10. Breast cancer - Symptoms and causes - Mayo Clinic

    The most well-known changes are called BRCA1 and BRCA2. These changes can greatly increase your risk of breast cancer and other cancers, but not everyone with ...